PET

          Positron Emission Tomography


   SPECT

                Single-photon Emission Computed Tomography


  MRI

        Magnetic Resonance Imaging


   CT

                 Computed Tomography


  Optical

          Optical Imaging


  TIL

          Translational Imaging Lab


知易。行難

我們尋求的是一個品質與應用並重的影像科學, 並藉此增進對於腦部疾病與癌症的了解。本實驗室致力於以科學方法評估新興核醫造影劑的臨床適用性或是現有核醫造影劑結合臨床藥物的老藥新用。與世界接軌的合作模式下, 善用且交流各方資源與人才使計畫執行顧及效率與完整性, 強化台灣團隊的科學訓練與涵養。

聽 影像說話

正子斷層掃描的分析原理在於生物體注射少量正子核種標誌的核醫造影劑後,體內循流的造影劑與標的物發生專一性的生物作用並同時發射"正子訊號",這些被掃描器偵測到的訊號經過一連串數學計算後,再處理成三維空間圖像。此三維空間影像提供了核醫造影劑與標的物發生作用的位置與強度,藉此資訊作為疾病診斷或治療追蹤的參考。

文字圖像化

分子影像的成像要點是利用專一性的核醫探針(probe)與生物體內的目標(target)結合,在輔以微正子掃描儀的高解析度使生物與造影劑交互作用的結果經再處理後得以視覺化、非侵入性(只需注射少量放射造影劑)且量化呈現。 Ref.
  1. US Biomedical Research--Basic, Translational, and Clinical Sciences, Elias A. Zerhouni, MD. JAMA. 2005; 294:1352-1358.
  2. http://evidencebasedliving.human.cornell.edu/2010/08/18/what-is-translational-research/

從實驗操作檯走到病床的橋梁

轉譯醫學須結合不同領域不同專長的人才,在以科學證據為軸的前提下,有效彙整細胞層級及小動物階段的醫學新發現,再進階導入臨床應用。


關於 TIL

在其位 作其事


葉信顯 助理研究員

轉譯影像實驗室位於國立陽明大學腦科學研究中心,並與高齡與健康研究中心、台灣小鼠診所-國家綜合小鼠表現型暨藥效分析中心合作合作。我們除了獨立發展臨床前試驗-癌症分子影像,腦神經影像;同時我們也提供影像專才與其它醫院、學校或機構合作。

我們的目標是成為指標性臨床前影像實驗室, 提供先進影像設備與研究環境予學術界及產業界。



















TIL內容

臨床前研究


驗室階段(Experimental stage)的臨床前研究在於提供健康與疾病體之間的相關生物資訊,進一步將此資訊轉化並使之適用於臨床階段


Picture source

目前進行中的研究有:

驗室階段(Experimental stage)的臨床前研究在於提供健康與疾病體之間的相關生物資訊,進一步將此資訊轉化並使之適用於臨床階段

基礎生理與病理研究:
  • 神經性退化性疾病:阿茲海默症Alzheimer's disease (AD)與亨氏舞蹈症Huntington’s Disease (HD)
  • 創傷壓力症候群Post-traumatic stress disorder (PTSD)
  • 老化
  • 癌症:非小型細胞肺癌、胰臟癌
  • 神經退化及代謝症候群疾病
核醫藥物開發
  • 以核醫影像建構治療藥物篩選平台
  • 開發影像導引式治療用生物標記
  • 新藥的早期階段測試
轉譯醫學與臨床應用
  • 新興核醫藥物臨床前測試
  • 治療藥物投藥劑量的預測










正子斷層掃描

正子影像造影

我們的首要目標為癌症與腦部疾病的正子造影;同時, 我們也進行另一種核醫影像-單光子放射斷層影像的研究。

關於正子斷層造影我們的研究內容與可以提供的協助有:

放射藥物

我們的研究團隊已參與多項國家型研究, 符合GMP標準的製藥環境同時供給臨床病人與臨床前實驗所需。.

Radiotracer Used to study Example
[11C] Acetate Acetate metabolism Brain tumor, Liver Cancer, Prostate Cancer
[11C] PIB fibrillar amyloid-beta (Aβ)plaques AD
[11C] Raclopride D2 receptor AD
[18F] Acetate Acetate metabolism Brain tumor, Liver Cancer, Prostate Cancer
[18F] ADAM Serotonin transport Depression, PTSD, Drug Addiction
[18F] FAHA Histone deacetylase activity for Class Iia AD, HD, PD, PTSD, Drug Addiction
[18F] TFAHA Histone deacetylase activity for Class Iia (more specific) AD, HD, PD, PTSD,Drug Addiction
[18F] FBPA Boron neutron capture therapy Brain tumor
[18F] FDG Glucose metabolism Most of tumor imaging and neuroimaging
[18F] FDOPA Dopamine synthesis PD, Drug Addiction
[18F] FEDL Lactose-binding protein Pancreatic Carcinoma
[18F] FLT Proliferation Glioblastoma
[18F] IPQA Active mutant L858R EGFR Non Small Lung Carcinoma Cancer
[18F] MISO Hypoxia Head and Neck Cancers


核醫影像多重驗證

我們的影像研究流程包括來自不同影像模組的交叉驗證; 這些驗證方法適用於開發中的新興核醫造影劑或是現有造影劑與臨床在線治療藥物的新應用。交叉驗證所延伸出的結果豐富了影像科學的完整性。



In vitro specificity

Enzyme assays
For substrate-type radiotracer
Radiotracer enzyme assays are based upon the enzymic conversion of radiotracer substrate to a radioactive metabolite (product). The rate of the enzyme-catalyzed retention is determined by radioassay of either the product or the unreacted substrate.

Irreversible binding of radiotracer
For receptor-type radiotracer
The selective binging of the radiotracer with different cell lines is determined by Western blot.



Protein quantification with ELISA
For receptor-type radiotracer
Enzyme-Linked ImmunoSorbent Assay has been used as a diagnostic tool to verify quantitatively the targets of radiotracers.



in vitro radiotracer uptake and washout assay
in vitro kinase assay usually is necessary for the identification of a specific kinase substrate and/or for the measurement of kinase activity. The results give the first view of the accumulations/retention of radiotracer and a possible prediction of in vivo imaging.



Regional tissue biodistribution of radiotracer
Tissue bioditribution studies have been often used when tissues can not be detected by PET imaging due to the limitation of image resolution. Radioactivity is expressed as %Injected Dose per g of tissue.



Digital Quantitative Autoradiography
Digital autoradiography provides biological research involving localization and quantitative measurement of radiotracers. The type of autoradiography has with greater pixel and spatial resolution (up to 5 µm) than previously possible with traditional autoradiography.


in vivo Single Label Digital Quantitative Autoradiography



Multi-label Digital Quantitative Autoradiography
One slice, two or more information

ex vivo Digital Quantitative Autoradiography V.S. Semi-quantification Immunohistochemistry staining

Extensive ex vivo digital autoradiography of tissue slice is performed to verify that the radiotracer accumulation as measured by PET represent true binding of the radiotracer.

Publications

Book chapter

  1. Yeh SH*, Kong F-L, Lin M-H. Visualization of Apoptosis: Annexin V imaging. In: Inoue T, Huang G, Yang DJ (eds), Personalized Pathway-Activated Systems Imaging in Oncology (Principle and Instrument), Springer-Verlag, Japan, 2017 (In press).
  2. Skye HH Yeh, Fang CK, Hwang JJ (2016):Book chapter “Effects of Club Drugs on Dopaminergic and Serotonergic Systems and Diagnosis with [18F]FDOPA, [99mTc]TRODAT-1 and [I*]ADAM”, pp391-405, Part II, Club Drugs in "Neuropathology of Drug addictions and Substance Misuse", Volume 2: Stimulants, Club and Dissociative Drugs, Hallucinogens, Steroids, Inhalants, and International Aspects. Edited by Victor R. Preedy. Academic Press, Elsevier Publishing Inc. ISBN: 978-0-12-800212-4

Peer-Reviewed Original Research Articles

  1. Hui-Ching Lin, Cheng-Ta Li, David Tat-Wei Tan, Chi-Wei Cheng, Ta-Kai Chou, Fan-Lin Kong, Tsung-Hsun Yu, Wen-Sheng Huang, Dong-Ping Su, Ren-Shyan Liu, Skye Hsin-Hsien Yeh*. Non-linear alteration of serotonin transport availability in posttraumatic stress disorder measured with 4-[18F]ADAM positron emission tomography. Current Molecular Imaging. 2015 Nov. DOI: 10.2174/2211555204 666151014224015 (SCI)
  2. Bonomi R, Mukhopadhyay U, Shavrin A, Yeh HH, Majhi A, Dewage SW, Najjar A, Lu X, Cisneros GA, Tong WP, Alauddin MM, Liu RS, Mangner TJ, Turkman N, Gelovani JG. Novel Histone Deacetylase Class IIa Selective Substrate Radiotracers for PET Imaging of Epigenetic Regulation in the Brain. PLoS One. 2015 Aug 5;10(8):e0133512. (IF: 3.057, Ranking:11/63, 17.46%)
  3. Chi-Wen Yeh, Skye Hsin-Hsien Yeh, Feng-Shiun Shie, Wen-Sung Lai, Hui-Kang Liu, Tsai-Teng Tzeng, Huey-Jen Tsay and Young-Ji Shiao. Impaired cognition and cerebral glucose regulation are associated with astrocyte activation in the parenchyma of metabolically stressed APPswe/PS1dE9 mice. Neurobiol Aging. 2015 Jul 18. pii: S0197-4580(15)00382-6. , (IF: 5.153, Ranking:36/256, 14.06%)
  4. Whitehouse A, Doherty K, Yeh HH, Robinson AC, Rollinson S, Pickering-Brown S, Snowden J, Thompson JC, Davidson YS, Mann DM.Histone deacetylases (HDACs) in Frontotemporal Lobar Degeneration. Neuropathol Appl Neurobiol 2014 May 27. doi: 10.1111/nan.12153. [Epub ahead of print] (Impact factor: 4.873; Rank:45/255, 17.85%)
  5. Skye Hsin-Hsien Yeh, Ming-Hsien Lin, Fan-Lin Kong, Chi-Wei Chang, Li-Chung Hwang, Chien-Feng Lin, Jeng-Jong Hwang, Ren-Shyan Liu. Evaluation of inhibitory effect of recreational drugs on dopaminergic terminal neuron by PET and whole-body autoradiography. Biomed Res Int. 2014;2014:157923. http://dx.doi.org/10.1155/2014/157923 (Impact factor: 2.880; Rank: 50/159, 31.04%)
  6. a-Ju Hsieh, Luen Hwu, Chien-Chih Ke, Skye Hsin-Hsien Yeh, Chien-Feng Lin, Fu-Du Chen, Hsin-Ell Wang, Kang-Ping Lin, Ran-Chou Chen and R. Liu. Rational Design of a Triple Reporter Gene for Multimodality Molecular Imaging. Biomed Res Int. 2014;2014:605358. doi: 10.1155/2014/605358. Epub 2014 Apr 7. (Impact factor: 2.880; Rank: 50/159, 31.04%)
  7. Hsieh YJ, Hwu L, Chen YC, Ke CC, Chen FD, Wang HE, Lin KP, Yeh HH, Chang CW, Liu RS. 21-Driven Multifusion Gene System for Evaluating the Efficacy of Histone Deacetylase Inhibitors by In Vivo Molecular Imaging and for Transcription Targeting Therapy of Cancer Mediated by Histone Deacetylase Inhibitor. J Nucl Med. 014 Apr;55(4):678-85. doi: 10.2967/jnumed.113.126573. Epub 2014 Mar 17. (Impact factor: 7.022, Ranking: 0.9%)
  8. Skye Hsin-Hsien Yeh, Chien-Feng Lin, Fan-Lin Kong,Hsin-Ell Wang, Ya-Ju Hsieh, Juri G. Gelovani, Ren-Shyan Liu. Molecular Imaging of Nonsmall Cell Lung Carcinomas Expressing Active Mutant EGFR Kinase Using PET with [124I]-Morpholino-IPQA. BioMed Research International, 2013. doi:10.1155/2013/549359. (SCI) (Impact factor: 2.880; Rank: 50/159, 31.04%) 3x6x5=90 7/17/2013
  9. Hsin-Hsien Yeh, Daniel Young, Juri Gelovani Karl Herholz, David Mann. Histone deacetylase (HDAC) class II immunohistochemistry in human brains with Huntington’s disease. Brain Res. 2013 Apr 4;1504:16-24. doi: 10.1016/j.brainres. 2013.02.012. Epub 2013 Feb 16. SCI) (Impact factor: 2.892; Rank: 126/251, 50.02%)
  10. Hsin-Hsien Yeh, Rainer Hinz, Suren Soghomonyan, Julius A. Balatoni, Uday Mukhopadhyay, Leo G. Flores, Asutosh Pal, Daniel Young, Hwan Jeong, Rajesh Uthamanthil, James Jackson, William Tong, Mei Tian, Mian M. Alauddin, Karl Herholz, Juri G. Gelovani. Quantification of HDAC activity in the forebrain, N.accumbens, and cerebellum in non-human primates using [18 F]FAHA PET/CT and an optimized pharmacokinetic model. Neuroimage. 2013 Jan 1;64:630-9. doi: 10.1016/j.neuroimage.2012.09.019. Epub 2012 Sep 17. (SCI) (Impact factor: 6.252, Ranking: 3/116, 2.6%).
  11. Flores LG 2nd, Yeh HH, Soghomonyan S, Young D, Bankson J, Hu Q, Alauddin M, Huff V, Gelovani JG. Monitoring Therapy with MEK Inhibitor U0126 in a Novel Wilms Tumor Model in Wt1 Knockout Igf2 Transgenic Mice Using [18F]-FDG PET with Dual-Contrast Enhanced CT and MRI: Early Metabolic Response Without Inhibition of Tumor Growth. Mol Imaging Biol. 2013 Apr;15(2):175-85. doi: 10.1007/s11307-012-0588-5. (SCI) (Impact factor: 3.844, Ranking: 12.1%)
  12. Nashaat Turkman, Aleksander Shavrin, Vincenzo Paolillo, Hsin Hsien Yeh, Leo Flores, Suren Soghomonian, Brian Rabinovich, Andrei Volgin, Juri Gelovani, Mian Alauddin Synthesis and preliminary evaluation of [(18)F]-labeled 2-oxoquinoline derivatives for PET imaging of cannabinoid CB(2) receptor. Nucl Med Biol 2012, 39(4):593-600.
  13. Paolillo V, Yeh H H, Mukhopadhyay U, Gelovani JG, Alauddin MM. Improved detection and measurement of low levels of [18F]fluoride metabolized from [18F]-labeled pyrimidine nucleoside analogues in biological samples. 2011 Nucl Med Biol. Nov;38(8):1129-34.
  14. Schwartz DL, Bankson J, Nishii R, Bidaut L, Yeh HH, He Y, Williams R, Volgin A, Lemos R, Titai-Kumar A, Oh J, Soghomonyan S, Mukhopadhyay, Allaudin M, Mushkudiani I, Kuno N, Krishnan S, Bornmann W, Lai SY, Powis G, Hazle J, Gelovani JG. HIF-1 dependent stromal adaptation to ischemia mediates in vivo tumor radiation resistance. 2010 Mol Cancer Res 2011 Mar;9(3):259-70.
  15. Yeh HH, Ogawa K, Balatoni J, Mukhapadhyay U, Pal A, Gonzalez-Lepera C, Shavrin A, Soghomonyan S, Flores L, Young D, Volgin AY, Najjar AM, Krasnykh V, Tong W, Alauddin MM, Gelovani JG. Molecular Imaging of Active Mutant L858R EGFR Kinase Expressing Non Small Cell Lung Carcinomas using PET/CT with [18F]F-PEG6-IPQA. 2011 Proc Natl Acad Sci USA, 108(4):1603-8. Epub 2011 Jan 10.
  16. Ying Y, Ghosh P, Guo L, Pal A, Mukhapadhyay U, Peng Z, Yeh HH, Bertolini S, Flores LG, Young D, Volgin A, Soghomonyan S, Bornmann W, Logsdon C, Alauddin MM, Gelovani JG. Synthesis and Ex Vivo Autoradiographic Evaluation of Ethyl-beta-D:-galactopyranosyl-(1,4')-2'-deoxy-2'-[(18)F]fluoro-beta-D:-gluco- pyranoside A Novel Radioligand for Lactose-Binding Protein: Implications for Early Detection of Pancreatic Carcinomas with PET. 2010 Mol Imaging Biol Jun;13(3):536-46.
  17. Leo Garcia Flores, Susanna Bertolini, Hsin Hsin Yeh, Danel Young, Uday Mukhapadhyay, Ashutosh Pal, Yunming Ying, Andrei Volgin, Aleksandr Shavrin, Suren Soghomonyan,William Tong, William Bornmann, Mian M. Alauddin, Craig Logsdon, and Juri G. Gelovani. Detection of pancreatic carcinomas by imaging lactose-binding protein expression in peritumoral pancreas using [18F]fluoroethyl-deoxylactose PET/CT. 2009 PLoS One 4(11):e7977.
  18. Uday Mukhopadhyay, Suren Soghomonyan, Hsin Hsien Yeh, Leo G. Flores, Aleksandr Shavrin, Andrei Y. Volgin, Juri G. Gelovani, Mian M. Alauddin. N3-Substituted thymidine analogues: V. Synthesis and preliminary PET imaging of N3-[18F]fluoroethyl thymidine and 5 N3-[18F]fluoropropyl thymidine. 2008 Nucl Med Biol 35(6):697-705.
  19. Lin KJ, Yen TC, Wey SP, Hwang JJ, Ye XX, KY, Ting, Chen JC. Characterization of the binding sites of [123I]ADAM and the relationship to serotonin transporter in rat and mouse brains using quantitative autoradiography. 2004 J Nucl Med. 45, 673-681.
  20. Ye XX, Hwang JJ, Shieh JF, JC Chen, YT Chou, KY Tu, Wey SP, Ting G. In Vivo Quantification of bound [123I]ADAM to Serotonin Transporters in the Brains of Rabbits by SPECT. 2004 Nucl Med Biol. 31(8):995-1003.
  21. Ye XX, JC Chen, Liu RS, Wey SP, Lee JS, Ting G, Hwang JJ. Microautoraduography of [123I]ADAM in Mice Treated with Fluoxetine and Serotonin Reuptake Inhibitors. 2004 Nucl Med Bio. 31, 557-562.
  22. Lin KJ, Ye XX, Yen TC, Wey SP, Tzen KY, Ting G, Hwang JJ. Biodistribution study of [123I]ADAM in mice: correlation with whole body autoradiography. 2002 Nucl Med Biol. 29, 643-650.


Abstracts

  1. Skye Hsin-Hsien Yeh, Jin-Cai Chen, Zuo-Hao Tang, Hui-Jing Lin, Cheng-Ta Li3, Ta-Kai Chou, Wen-Sheng Huang, Dong-Ping Su, Ren-Shyan Liu. PET/CT with [18F]ADAM using a biomarker for quantification of SERT change in the brain of PTSD rat model. (Oral presentation) 2013 World Molecular Imaging Congress, Savannah, Georgia.
  2. Yu-Ning Tang, Skye Hsin-Hsien Yeh, Jin-Cai Chen, Chin-Wei Cheng, Hsin-Ell Wang, Irene Han-Juo Cheng, Ren-Shyan Liu. Longitudinal coupled-imaging Alzheimer's disease mouse model using [11C]PIB and [18F]FDG PET.(Poster presentation) 2013 World Molecular Imaging Congress, Savannah, Georgia.
  3. Skye Hsin-Hsien Yeh, Jin-Cai Chen, Zuo-Hao Tang, Hui-Jing Lin, Cheng-Ta Li3, Ta-Kai Chou, Wen-Sheng Huang, Dong-Ping Su, Ren-Shyan Liu. PET/CT with [18F]ADAM using a biomarker for quantification of SERT change in the brain of PTSD rat model. (Poster presentation) 2013 Society of Nuclear Medicine and Molecular Imaging, Vancouver, BC, Canada.
  4. Yu-Ning Tang, Skye Hsin-Hsien Yeh, Jin-Cai Chen, Chin-Wei Cheng, Hsin-Ell Wang, Irene Han-Juo Cheng, Ren-Shyan Liu. Longitudinal coupled-imaging Alzheimer's disease mouse model using [11C]PIB and [18F]FDG PET. (Poster presentation) 2013 Society of Nuclear Medicine and Molecular Imaging, Vancouver, BC, Canada.
  5. Hsin-Hsien Yeh, Mei Tian, Leo G. Flores, Daniel Young, Vincenzo Paolillo, Kun-eek Kil, Uday Mukhopadhyay, Julius A. Balatoni, Suren Soghomonyan, Asutosh Pal, Rajesh Uthamanthil, James Jackson, WilliamTong, Daniel Young, Mian M Alauddin, Juri G. Gelovani. PET/CT/MRI with [18F]TFAHA using an optimized pharmacokinetic model for Quantification of HDAC class II expression –activity in the brain in non-human primates (Oral presentation) 2012 World Molecular Imaging Congress, Dublin, Ireland.
  6. Hsin-Hsien Yeh, LeoG.Flores II, Suren Soghomonyan, Kuneek Kil,Vincenzo Paolillo, Uday Mukhopadhyay, Julius Balatoni, Asutosh Pal,Aleksandr Shavrin, Daniel Young, Mian Alauddin, William Tong, Juri G. Gelovani. Quantification of Suberoylanilide Hydroxamic and Valproic Acid-Induced Inhibition of HDAC Activity in Rat Brain using In Vivo PET/CT Imaging with HDAC Class IIa-Specific Radiotracers. (Oral presentation) 2012 World Molecular Imaging Congress, Dublin, Ireland.
  7. Hsin-hsien Yeh, Leo G. Flores, Daniel Young, Patrick J. Gillespie, Uday Mukhopadhyay, Asutosh Pal, Hwan Jeong, Nobuyoshi Fukumitsu, William Tong, Mian M Alauddin, Juri G. Gelovani. PET Imaging of Epigentic Mediated by HDACs in a Transgenic Mouse Model of Huntington’s Disease (Poster presentation) 2012 World Molecular Imaging Congress, Dublin, Ireland.
  8. Hsin-Hsien Yeh, Mei Tian, Leo G. Flores, Daniel Young, Vincenzo Paolillo, Kun-eek Kil, Uday Mukhopadhyay, Julius A. Balatoni, Suren Soghomonyan, Asutosh Pal, Rajesh Uthamanthil, James Jackson, WilliamTong, Daniel Young, Mian M Alauddin, Juri G. Gelovani. PET/CT/MRI with [18F]TFAHA using an optimized pharmacokinetic model for Quantification of HDAC class II expression –activity in the brain in non-human primates (Oral presentation) 2011 World Molecular Imaging Congress, San Diego USA.
  9. Hsin-hsien Yeh, Leo G. Flores, Daniel Young, Patrick J. Gillespie, Uday Mukhopadhyay, Asutosh Pal, Hwan Jeong, Nobuyoshi Fukumitsu, William Tong, Mian M Alauddin, Juri G. Gelovani. PET Imaging of Epigentic Mediated by HDACs in a Transgenic Mouse Model of Huntington’s Disease (Oral presentation) 2011 World Molecular Imaging Congress, San Diego USA.
  10. HsinHsienYeh, Leo G. Flores II, Suren Soghomonyan, Kuneek Kil,VincenzoPaolillo,Uday Mukhopadhyay, Julius Balatoni, AsutoshPal, Aleksandr Shavrin, DanielYoung, Mian Alauddin,William Tong, JuriG. Gelovani. Quantification of Suberoylanilide Hydroxamic and Valproic Acid-Induced Inhibition of HDAC Activity in Rat Brain using In Vivo PET/CT Imaging with HDAC Class IIa-Specific Radiotracers. (Poster presentation) 2011 World Molecular Imaging Congress, San Diego USA.
  11. Hsin-Hsien Yeh, Leo G. Flores II, Kun-eek Kil, Vincenzo Paolillo, Uday Mukhopadhyay, Julius Balatoni, Suren Soghomonyan, Aleksander Shavrin, Daniel Young, Mian Alauddin, William Tong, Juri G. Gelovani. Imaging epigenetic regulation in the rat brain mediated by HDACs class IIa Enzymes using PET/CT with 18F-TFAHA and 18F-DFAHA (Poster presentation) 2011 World Molecular Imaging Congress, San Diego USA.
  12. Hsin-Hsien Yeh, Rainer Hinz, Suren Soghomonyan, Julius A. Balatoni, Uday Mukhopadhyay, Leo G. Flores, Asutosh Pal, Hwan Jeong, Rajesh Uthamanthil, James Jackson, William Tong, Mei Tian, Mian M. Alauddin, Karl Herholz, Juri G. Gelovani. Quantification of HDAC activity in the forebrain, N.accumbens, and cerebellum in non-human primates using [18F]FAHA PET/CT and an optimized pharmacokinetic model. (Oral presentation) 2010 World Molecular Imaging Congress, Kyoto Japan.
  13. N. Fukumitsu, H. Yeh, L.G. Flores, S. Soghomonyan, U. Mukhopadhyay, D. Young, M.M. Alauddin, W. Tong, J.G. Gelovani. The Role of HDAC Activation in Chemotherapy-Induced Neurotoxicity and Protective Effects of HDAC Inhibitors in Rats Demonstrated using PET/CT with 18 F-FAHA and 18F-FDG (Oral presentation) 2010 World Molecular Imaging Congress, Kyoto Japan.
  14. Leo Garcia Flores, HsinHsien Yeh et. al., A Novel Model of Renal Tumor in Transgenic Mice: Characterization with Repetitive 18FDG PET and Dual Contrast-Enhanced CT Imaging. (Poster presentation) 2010 World Molecular Imaging Congress, Kyoto Japan.
  15. JJ Jong, HH Yeh et, al., Multi-Tracer Molecular-Genetic Imaging Reveals Distinct Areas of Coupling and Uncoupling of Blood Flow and HIF1 Signaling in a Rat Brain Glioma Model. (Poster presentation) 2010 World Molecular Imaging Congress, Kyoto Japan.
  16. Hsin Hsien Yeh, Suren Soghomonyan, Uday Mukhapadhya, Daniel Young, Leo G. Flores, Asutosh Pal, Kazuma Ogawa, Mian Alauddin, Raymond Gibson, Willian Tong, Juri G. Gelovani. Assessment of SAHA-induced Dose-Dependent Inhibition of HDACs Activity in the Rat Brain using In Vivo PET Imaging with 18FAHA. (Oral presentation) 2008 World Molecular Imaging Congress, France Nice.
  17. Hsin-Hsien Yeh, Daniel Young, Raymond Gibson, William Tong, Juri G. Gelovani. (2008) Imaging Expression-Activity of HDACs in the Awake Rat Brain using Autoradiography with [14C]AHA as a Prototype for [11C]AHA and PET. 2008 World Molecular Imaging Congress, France Nice.
  18. Hsin-Hsien Yeh, Suren Soghomonyan, Uday Mukhapadhyay, Daniel Young, Leo G. Flores, Asutosh Pal, Kazuma Ogawa, Raymond Gibson, Thomas Miller, Mian Alauddin, William Tong, Juri G.Gelovani. Determination of Dose-Dependent Inhibition of HDACs Activity induced by para-Fluoro-SAHA in the Rat Brain using In Vivo PET Imaging with [18F]FAHA. 2008 World Molecular Imaging Congress, France Nice.
  19. HsinHsien Yeh, Suren Soghomonyan, Uday Mukhapadhayay, Daniel Young, Leo G. Flores,Asutosh Pal, Kazuma Ogawa, Raymond Gibson, Mian Alauddin, William Tong, Juri G. Gelovani. Quantification of Valporic Acid-induced Dose-Dependent Inhibition of HDACs Activity in the Rat Brain using In Vivo PET Imaging with 18FAHA. 2008 World Molecular Imaging Congress, France Nice.
  20. Hsin Hsien Yeh, Ryuichi Nishii, Julius Balatoni, Asutosh Pal, Suren Soghomonyan, Leo Flores1, Andrei Volgin, Daniel Yang, Juri G. Gelovani. (2008) PET with [124I]I-PEG6-IPQA for Imaging Expression-Activity and Mutational Status of EGFR in Four Different Non Small Cell Carcinoma Xenografts in Mice. 2008 World Molecular Imaging Congress, France Nice.
  21. Hsin Hsien Yeh, Asutosh Pal, Julius Balatoni, Kazuma Ogawa, Leo Flores, Andrei Volgin, Daniel Yang, Juri G. Gelovani.Imaging Expression-Activity and Mutational Status of EGFR in Intracerebral Glioma Xenografts in Mice with [124I]I-PEG6-IPQA and PET. 2008 World Molecular Imaging Congress, France Nice.
  22. Hsin Hsien Yeh, Kazuma Ogawa, Julius Balatoni, Uday Mukhapadhyay, Asutosh Pal, Daniel Yang, Andrei Volgin, Mian Alauddin, Juri G. Gelovani. Imaging the Expression-Activity and Mutational Status of EGFR in Four Different Non Small Cell Carcinoma Xenografts in Mice using PET with [18F]F-PEG6-IPQA. . (oral presentation) 2008 World Molecular Imaging Congress, France Nice.
  23. U. Mukhopadhyay, S. Soghomonyan, A. Y. Volgin, H. H. Yeh, L. G Flores, J. G. Gelovani and M. M. Alauddin. Synthesis and preliminary PET imaging of N3-[18F]fluoroethyl thymidine and N3-[18F]fluoropropyl thymidine. 2007 Joint Molecular Imaging Conference, Providence, Rhode Island, USA.
  24. Ryuichi Nishii, Uday Mukhopadhyay, Hsin Yeh, Suren Soghomonyan, Andrei Volgin, Mian Alauddin, William Tong, Juri Gelovani. PET imaging of histone deacetylase activity in a rat brain using 6-([18F]-fluoroacetamide)-1-hexanoicanilide ([18F]-FAHA). 2007 Joint Molecular Imaging Conference, Providence, Rhode Island, USA
  25. Ryuichi Nishii, Uday Mukhopadhyay,Hsin Yeh, Suren Soghomonyan, Andrei Volgin, Mian Alauddin, William Tong, Juri Gelovani. 2007 Non-invasive imaging of histone deacetylase activity in human breast carcinoma xenografts in rats using positron emission tomography (PET) with [18F]-FAHA. 2007 Joint Molecular Imaging Conference, Providence, Rhode Island, USA
  26. David Schwartz, Sunil Krishnan, Norihito Kuno, Ioseb Mushkudiani, Andrei Volgin, Hsin Hsien Yeh, Yi He, Suren Soghomonyan, Uday Mukhopadhyay, Mian Alauddin, Shujun Shentu, Garth Powis, Juri Gelovani Molecular-Genetic In Vitro and In Vivo Imaging of HIF-1 Signaling Response to Radiation and Targeted Inhibition. 2006 Joint Molecular Imaging Conference, Hilton Waikoloa Village on the Big Island of Hawaii
  27. Ryuchi Nishii, Asutosh Pal, Suren Soghomonyan, Julius Balatoni, Ioseb Mushkudiani, Hsin Hsien Yeh, Uday Mukhopadhyay, Andrei Volgin, Aleksander Shavrin, David Maxwell, William Tong, Mian Alauddin, William Bornmann, Juri Gelovani Molecular Imaging of Different EGFR Kinase Mutant NSCL Carcinomas with [124I]-Mipqa PET for Prediction of Responsiveness to EGFR Kinase Inhib. 2006 Joint Molecular Imaging Conference, Hilton Waikoloa Village on the Big Island of Hawaii .
  28. Ye XX,, Hwang JJ Chen JC, Shieh JF, YT Chou. SPECT Imaging of Serotonin Transporters in the Brains of Rabbits by [123I]ADAM. 2003 Annual Meeting of the Society of Nuclear Medicine, New Orleans, USA.
  29. Ye XX, Hwang JJ, Hsieh JF, Chen JC. In Vivo quantification of bound [123I]ADAM in serotonin transporters in the brains of rabbits by SPECT. (oral presentation) 2002 Annual Meeting of the Society of Nuclear Medicine, Los Angles, USA.
  30. Lin KJ, Ye XX, Yen TC, et al. Biodistribution study of [123I]ADAM in mice: correlation to whole body autoradiography. 2002 Annual Meeting of the Society of Nuclear Medicine, Los Angeles, USA.
  31. Ye XX, Hwang JJ, Chen JC, Shieh JF. In Vivo quantification of bound 123I-ADAM in serotonin transporters in rabbit by SPECT. 2001 Annual Meeting of the Society of Nuclear Medicine, Taipei, Taiwan.
  32. Lin KJ, Yen TC, Ye XX, et al. The biodistribution of I-123 ADAM in mouse with macroautoradiography. 2001 Annual Meeting of the Society of Nuclear Medicine, Taipei, Taiwan.



夥伴 共享的價值觀與願景

我們的研究重點是癌症分子影像,腦神經影像與影像導引式治療;為了更有效率的達成目標,我們的研究團隊成員包括:


影像中心/核心實驗室

  • 台灣動物設施聯盟-國家綜合小鼠表現型暨藥效分析中心(中央研究院 台北市 台灣)
  • 生醫光電暨分子影像研究中心(國立陽明大學 台北市 台灣)
  • 高齡與健康研究中心(國立陽明大學 台北市 台灣)
  • 磁振造影核心實驗室(國立陽明大學 台北市 台灣)
  • 台北市立聯合醫院 忠孝/仁愛/和平三院區(台北市 台灣)

核醫新藥開發

  • Juri G. Gelovani, M.D., Ph.D. (Professor and Chair Department of Biomedical Engineering, Center for Molecular Medicine and Genetics School of Medicine at Wayne State University, Ohio, USA)
  • 張智偉 博士(助理教授 台北榮民總醫院 核醫部 台北市 台灣)
  • 孔繁琳 博士 (博士後研究員,Department of Cancer System Imaging, The University of Texas& MD Anderson Cancer Center, Texas, USA)
  • Nobuyuki Okamura, M.D., Ph.D. (Professor, Department of Pharmacology, Tohoku Medical and Pharmaceutical University, Sendai, Japan)

小動物模式之癌症暨神經影像

  • Juri G. Gelovani, M.D., Ph.D. (Professor and Chair Department of Biomedical Engineering, Center for Molecular Medicine and Genetics School of Medicine at Wayne State University, Ohio, USA)
  • Leo G Flores, II, M.D., Ph.D. (Senior Research Scientist Department of Cancer System Imaging, The University of Texas& MD Anderson Cancer Center, Texas, USA)
  • 林明賢 醫師 (核醫科主任 台北市立聯合醫院忠孝院區 台北市 台灣)
  • 黃正仲 博士 (教授 國立陽明大學 生物醫影像暨放射科學研究所 台北市 台灣)
  • 黃文盛 醫師 (核醫部主任 台北榮民總醫院 核醫部 台北市 台灣)

神經退化性暨精神疾病動物模式

  • 蔡惠珍 博士(教授 國立陽明大學 神經科學研究所 台北市 台灣)
  • 林惠菁 博士(助理教授 國立陽明大學 生理學研究所 台北市 台灣)

老化

  • 蔡亭芬 博士 (教授 國立陽明大學 生命科學系暨基因體科學研究所 台北市 台灣)
  • 林慶波 博士(教授 國立陽明大學 神經科學研究所 台北市 台灣)

Radiogenomic

  • 黃貞祥 博士 (助理教授 國立清華大學 生命科學研究所 新竹市 台灣)
  • 王瑋馥 博士 (助理研究員 中央研究院 生物多樣性研究中心 台北市 台灣 )

臨床前正子造影試驗-靈長類動物模式

  • Juri G. Gelovani, M.D., Ph.D. (Professor and Chair Department of Biomedical Engineering, Center for Molecular Medicine and Genetics School of Medicine at Wayne State University, Ohio, USA)
  • Karl Herholz, M.D., FRCP (Professor Wolfson Molecular Imaging Centre at The University of Manchester)
  • Ryuichi Nishii, M.D., Ph.D. (Lecturer Department of Radiology, Faculty of Medicine University of Miyazaki, Japan)

核醫影像量化與藥物動力學

  • Rainer Hinz Ph.D. (Assistant Professor Wolfson Molecular Imaging Centre at The University of Manchester)

神經病理學

  • David Mann, Ph.D. (Professor and Chair Human Brain Bank, Institute of Brain, Behaviour and Mental Health at The University of Manchester, Manchester, UK)
  • Daniel Yang, M.D., M.S. (Senior Research Scientist Department of Cancer System Imaging, The University of Texas& MD Anderson Cancer Center, Texas, USA)

臨床試驗(coming soon)

轉譯醫學研究顧問

  • Mats Bergstroem, Ph.D. (Professor former head of Drug Development of University of Uppsala and Roche Inc.) kindly provides his huge knowledge and experiences for our growing lab.

Special Consultant for Radiochemistry

  • William Ping-Yiu Tong, Ph.D. (Professor former head of Analytical Chemistry, Chemistry Section, Department of Experimental Diagnostic Imaging, Division of Diagnostic Imaging, The University of Texas M. D. Anderson Cancer Center, Houston, TX)
  • David J Yang, Ph.D. (Professor Department of Experimental Diagnostic Imaging, The University of Texas M. D. Anderson Cancer Center, Houston, TX)

產學合作案

  • GE Healthcare Life Sciences USA
  • Neuroincubator, GE Healthcare Life Sciences Europe
  • Cell Point LLC, Texas USA
  • Vyripharm Biopharmaceuticals Texas USA

非常感謝這些為我們實驗室提供豐富知識與經驗的夥伴




Contact Details

葉信顯 醫學博士

國立陽明大學
腦科學研究中心
助理研究員

地址

國立陽明大學
腦科學研究中心
台北市北投區立農街二段155號

Email

skyeyeh@live.com

Phone

(02)2821-3496 (Office), (02)2821-3571 (Lab)

腦科學研究中心

http://bml.ym.edu.tw/~brc/infrastructure/members.html

小動物光學暨電腦斷層核心設施

小動物光學暨電腦斷層核心設施