林怡彣 副教授 (Lin, Yi-Wen)

個人簡歷

  學歷

   

/肄業學校 

國別 

學位

1994/9- 1998/6

國立台北護理學院護理系

中華民國

學士

1998/9- 2000/6

國立陽明大學口腔生物學研究所

中華民國

碩士

2001/9- 2007/7

國防醫學院生命科學研究所

中華民國

博士

經歷

   

服務單位

職稱

2019.02-

國立陽明大學 口腔生物研究所

專任副教授

2015.02-2019.01

國立陽明大學 口腔生物研究所

兼任副教授

2010.08-2015.01

國立陽明大學 口腔生物研究所

兼任助理教授

2010.02-2019.01

國防醫學院 醫學系心臟血管外科

醫學研究員

2009.09-2010.01

輔仁大學醫學院基礎醫學研究所

專任助理教授

2007.08-2009.08

中央研究院 生物醫學研究所

博士後研究員

專長:細胞生物學、分子生物學、實驗動物學

單位:口腔生物學研究所

聯絡電話:(02)2826-7915

研究方向:

血栓調節因子(thrombomodulin) 單核球細胞之功能及其與心血管疾病的關係

牙周病與系統性疾病的相關性

電子郵件ywlin7@yahoo.com.tw

研究計畫(3年內):

年度

計畫名稱

計畫內擔任之工作

執行期間

經費提供單位

2020

單純皰疹病毒與口腔細菌的感染對於巨噬細胞功能的影響

(109-2314-B-010-008-MY2)

共同主持人

2020/08/012022/07/31

科技部

2020

探討牙周致病菌Aggregatibacter actinomycetemcomitans增加異體器官移植後血管病變發生之機制(108年科技部專題研究計畫之延續)(109-2314-B-016-048-)

共同主持人

2020/08/01~2021/07/31

科技部

2019

探討牙周致病菌Aggregatibacter actinomycetemcomitans對心臟移植後血管病變發生之影響及其調節機制之探討(108-2314-B-016-051-) 科技部已結案

 

共同主持人

2019/08/012020/07/31

科技部

2017

乙型利鈉肽對心房纖維化之影響及其機制之探討(106-

2314-B-016-037-MY3)  科技部已結案

 

共同主持人

2017/08/012020/07/31

科技部

Publications:

著作:

1.       Lin HH, Lin YW, Wu CY, Hsiao FP, Lai YL and Hung SL. Stimulatory effects of Porphyromonas gingivalis GroEL protein on interleukin-6 and interleukin-8 in human osteoblasts. J Formos Med Assoc. 2021;120:150-156.

2.     Lin FY, Shih CM, Huang CY, Tsai YT, Loh SH, Li CY, Lin CY, Lin YW* and Tsai CS*. Dipeptidyl Peptidase-4 Inhibitor Decreases Allograft Vasculopathy Via Regulating the Functions of Endothelial Progenitor Cells in Normoglycemic Rats. Cardiovasc Drugs Ther. 2020. (共同責任作者)

3.     Tsai YT, Lin FY, Lin CS, Loh SH, Li CY, Lin CY, Lin YW* and Tsai CS*. B-type natriuretic peptide enhances fibrotic effects via matrix metalloproteinase-2 expression in the mouse atrium in vivo and in human atrial myofibroblasts in vitro. Transl Res. 2019;208:30-46. (共同責任作者)

4.       Shih CM, Lin FY, Yeh JS, Lin YW, Loh SH, Tsao NW, Nakagami H, Morishita R, Sawamura T, Li CY, Lin CY and Huang CY. Dysfunctional high density lipoprotein failed to rescue the function of oxidized low density lipoprotein-treated endothelial progenitor cells: a novel index for the prediction of HDL functionality. Transl Res. 2019;205:17-32.

5.       Chen YC, Lin FY, Lin YW, Cheng SM, Lin RH, Chuang CL, Sheu JS, Chen SM, Chang CC and Tsai CS. DAPT Plus Cilostazol is Better Than Traditional DAPT or Aspirin Plus Ticagrelor as Elective PCI for Intermediate-to-Highly Complex Cases: Prospective, Randomized, PRU-Based Study in Taiwan. Am J Cardiovasc Drugs. 2019;19:75-86.

6.       Chen YC, Lin FY, Lin YW, Cheng SM, Chang CC, Lin RH, Chuang CL, Sheu JS, Chen SM and Tsai CS. Platelet MicroRNA 365-3p Expression Correlates with High  On-treatment Platelet Reactivity in Coronary Artery Disease Patients. Cardiovasc Drugs Ther. 2019;33:129-137.

7.     Lin YW, Huang CY, Shih CM, Tsai YT, Lin CS, Lin CY, Li CY, Loh SH, Lin CY, Lin FY and Tsai CS. Eotaxin-2 induces monocytic apoptosis in patients who have undergone coronary artery bypass surgery and in THP-1 cells in vitro regulated by thrombomodulin. Am J Transl Res. 2018;10:3133-3149. (第一作者)

8.       Pai CC, Lin YW, Tsai YT, Loh SH, Lin CY, Lin CS, Lin YC, Ke HY, Lin FY and Tsai CS. A Thrombomodulin Gene Polymorphism (C1418T) Is Associated with Early Outcomes in Patients Undergoing Coronary Artery Bypass Graft Surgery with a Conventional Cardiopulmonary Bypass during Hospitalization. Medicines (Basel). 2017;4.

9.       Lu HY, Huang CY, Shih CM, Lin YW, Tsai CS, Lin FY and Shih CC. A potential contribution of dipeptidyl peptidase-4 by the mediation of monocyte differentiation in the development and progression of abdominal aortic aneurysms. J Vasc Surg. 2017;66:1217-1226 e1.

10.   Tsai CS#, Lin YW#, Huang CY, Shih CM, Tsai YT, Tsao NW, Lin CS, Shih CC, Jeng H and Lin FY. Thrombomodulin regulates monocye differentiation  

via PKCdelta and ERK1/2 pathway in vitro and in atherosclerotic artery. Sci Rep. 2016;6:38421. (共同第一作者)

11.   Tsai CS, Huang CY, Chen CH, Lin YW, Shih CM, Tsao NW, Chiang KH, Lee CY, Jeng  H and Lin FY. Eotaxin-2 increased toll-like receptor 4 expression in endothelial cells in vitro and exacerbates high-cholesterol diet-induced atherogenesis in vivo. Am J Transl Res. 2016;8:5338-5353.

12.   Lu HY, Huang CY, Shih CM, Lin YW, Tsai CS, Lin FY and Shih CC. A potential contribution of dipeptidyl peptidase-4 by the mediation of monocyte differentiation in the development and progression of abdominal aortic aneurysms. J Vasc Surg. 2016.

13.   Huang CY, Shih CM, Tsao NW, Lin YW, Shih CC, Chiang KH, Shyue SK, Chang YJ, Hsieh CK and Lin FY. The GroEL protein of Porphyromonas gingivalis regulates atherogenic phenomena in endothelial cells mediated by upregulating toll-like receptor 4 expression. Am J Transl Res. 2016;8:384-404.

14.   Lin T. C., Lin F. Y., Lin Y. W., Hsu C. H., Huang G. S., Wu Z. F., Tsai Y. T., Lin C. Y., Li C. Y. and S. TC. Matrix Metalloproteinase-9 Production following Cardiopulmonary Bypass Was Not Associated with Pulmonary Dysfunction after Cardiac Surgery. Mediators Inflamm. 2015:2015: 341740.

15.   Lin FY, Tsao NW, Shih CM, Lin YW, Yeh JS, Chen JW, Nakagami H, Morishita R, Sawamura T and Huang CY. The biphasic effects of oxidized-low density lipoprotein on the vasculogenic function of endothelial progenitor cells. PLoS One. 2015;10:e0123971.

16.   Lin FY, Huang CY, Lu HY, Shih CM, Tsao NW, Shyue SK, Lin CY, Chang YJ, Tsai CS, Lin YW* and Lin SJ*. The GroEL protein of Porphyromonas gingivalis accelerates tumor growth by enhancing endothelial progenitor cell function and neovascularization. Mol Oral Microbiol. 2015;30:198-216. (共同責任作者)

17.   Chiang KH, Cheng WL, Shih CM, Lin YW, Tsao NW, Kao YT, Lin CT, Wu SC, Huang  CY and Lin FY. Statins, HMG-CoA Reductase Inhibitors, Improve Neovascularization  by Increasing the Expression Density of CXCR4 in Endothelial Progenitor Cells. PLoS One. 2015;10:e0136405.

18.   Tsai1 YT, Lin FY, Lin CS, Huang CY, Shih CM, Lin CY, Loh SH, Li CY, Lin CY, Lin YW* and Tsai1CS*. B-type Natriuretic Peptide Enhances Fibrotic Effects via Matrix Metalloproteinase-2 Expression in the Mouse Atrium in vivo and in Human Atrial Myofibroblasts in vitro. Transl Res. Published Online: February 19, 2019 (共同責任作者)

  1. Shih CM, Lin FY, Yeh JS, Lin YW, Loh SH, Tsao NW, Nakagami H, Morishita R, Sawamura T, Li CY, Lin CY and Huang CY. Dysfunctional high density lipoprotein failed to rescue the function of oxidized low density lipoprotein-treated endothelial progenitor cells: a novel index  for the prediction of HDL functionality. Transl Res. 2019;205:17-32.
  2. Lin YW, Huang CY, Shih CM, Tsai YT, Lin CS, Lin CY, Li CY, Loh SH, Lin CY, Lin FY and Tsai CS. Eotaxin-2 induces monocytic apoptosis in patients who have undergone coronary artery bypass surgery and in THP-1 cells in vitro regulated by thrombomodulin. Am J Transl Res. 2018;10:3133-3149. (第一作者)
  3. Pai CC, Lin YW, Tsai YT, Loh SH, Lin CY, Lin CS, Lin YC, Ke HY, Lin FY and Tsai CS. A Thrombomodulin Gene Polymorphism (C1418T) Is Associated with Early Outcomes in Patients Undergoing Coronary Artery Bypass Graft Surgery with a Conventional Cardiopulmonary Bypass during Hospitalization. Medicines (Basel). 2017; 23;4(2). pii: E22.
  4. Lu HY, Huang CY, Shih CM, Lin YW, Tsai CS, Lin FY and Shih CC. A potential contribution of dipeptidyl peptidase-4 by the mediation of monocyte differentiation in the development and progression of abdominal aortic aneurysms. Journal of vascular surgery. 2017;66:1217-1226.
  5. Tsai CS#, Lin YW#, Huang CY, Shih CM, Tsai YT, Tsao NW, Lin CS, Shih CC, Jeng H and Lin FY. Thrombomodulin regulates monocye differentiation via PKCdelta and ERK1/2 pathway in vitro and in atherosclerotic artery. Scientific reports. 2016;6:38421.(共同第一作者)
  6. Tsai CS, Huang CY, Chen CH, Lin YW, Shih CM, Tsao NW, Chiang KH, Lee CY, Jeng H and Lin FY. Eotaxin-2 increased toll-like receptor 4 expression in endothelial cells in vitro and exacerbates high-cholesterol diet-induced atherogenesis in vivo. American journal of translational research. 2016;8:5338-5353.
  7. Huang CY, Shih CM, Tsao NW, Lin YW, Shih CC, Chiang KH, Shyue SK, Chang YJ, Hsieh CK and Lin FY. The GroEL protein of Porphyromonas gingivalis regulates atherogenic phenomena in endothelial cells mediated by upregulating toll-like receptor 4 expression. American journal of translational research. 2016;8:384-404.
  8. Lin TC, Lin FY, Lin YW, Hsu CH, Huang GS, Wu ZF, Tsai YT, Lin CY, Li CY and S. TC. Matrix Metalloproteinase-9 Production following Cardiopulmonary Bypass Was Not Associated with Pulmonary Dysfunction after Cardiac Surgery. Mediators of inflammation. 2015:2015: 341740.
  9. Lin FY, Tsao NW, Shih CM, Lin YW, Yeh JS, Chen JW, Nakagami H, Morishita R, Sawamura T and Huang CY. The biphasic effects of oxidized-low density lipoprotein on the vasculogenic function of endothelial progenitor cells. PloS one. 2015;10:e0123971.
  10. Chiang KH, Cheng WL, Shih CM, Lin YW, Tsao NW, Kao YT, Lin CT, Wu SC, Huang CY and Lin FY. Statins, HMG-CoA Reductase Inhibitors, Improve Neovascularization by Increasing the Expression Density of CXCR4 in Endothelial Progenitor Cells. PloS one. 2015;10:e0136405.
  11. Tsai JC, Lin YW, Huang CY, Lin FY and Tsai CS. Calpain activity and Toll-like receptor 4 expression in platelet regulate haemostatic situation in patients undergoing cardiac surgery and coagulation in mice. Mediators of inflammation. 2014;2014:484510.
  12. Tsai JC, Lin YW, Huang CY, Lin CY, Tsai YT, Shih CM, Lee CY, Chen YH, Li CY, Chang NC, Lin FY and Tsai CS. The role of calpain-myosin 9-Rab7b pathway in mediating the expression of Toll-like receptor 4 in platelets: a novel mechanism involved in alpha-granules trafficking. PloS one. 2014;9:e85833.
  13. Shih CM, Chen YH, Lin YW, Tsao NW, Wu SC, Kao YT, Chiang KH, Li CY, Chang NC, Lin CY, Huang CY and Lin FY. MK-0626, a dipeptidyl peptidase-4 inhibitor, improves neovascularization by increasing both the number of circulating endothelial progenitor cells and endothelial nitric oxide synthetase expression. Current medicinal chemistry. 2014;21:2012-2022.
  14. Lin YW, Huang CY, Shih CM, Chang WL, Shyue SK, Tsai YT, Lin CY, Lee C Y., Chang YJ, Chang NC, Lin FY and Tsai CS. The C-terminal domain of thrombomodulin regulates monocytes migration with interleukin-6-stimulation. European Journal of Inflammation. 2014;12:27-39.(第一作者)
  15. Lin FY, Huang CY, Lu HY, Shih CM, Tsao NW, Shyue SK, Lin CY, Chang YJ, Tsai CS, Lin YW* and Lin SJ*. The GroEL protein of Porphyromonas gingivalis accelerates tumor growth by enhancing endothelial progenitor cell function and neovascularization. Molecular oral microbiology. 2015; 30:198-216.(共同責任作者)
  16. Lin FY, Hsiao FP, Huang CY, Shih CM, Tsao NW, Tsai CS, Yang SF, Chang NC, Hung SL* and Lin YW*. Porphyromonas gingivalis GroEL induces osteoclastogenesis of periodontal ligament cells and enhances alveolar bone resorption in rats. PloS one. 2014;9:e102450.(共同責任作者)
  17. Tsai CS#, Lin YW#, Shih CC, Chen YH, Lin CY, Tsai YT, Lee CY, Shih CM, Huang CY, Chung HH and Lin FY. Thrombomodulin gene polymorphism (C1418T) is associated with the development of coronary allograft vasculopathy. European Journal of Inflammation. 2013;11:685-696.(共同第一作者)
  18. Lin YW, Huang CY, Chen YH, Shih CM, Tsao NW, Lin CY, Chang NC, Tsai CS, Tsai HY, Tsai JC, Huang PH, Li CY and Lin FY. GroEL1, a heat shock protein 60 of Chlamydia pneumoniae, impairs neovascularization by decreasing endothelial progenitor cell function. PloS one. 2013;8:e84731.(第一作者)
  19. Lin YW, Hsu TH and Yen PH. Mouse sperm acquire a new structure on the apical hook during epididymal maturation. Asian journal of andrology. 2013;15:523-528.(第一作者)
  20. Huang CY, Shih CM, Tsao NW, Lin YW, Huang PH, Wu SC, Lee AW, Kao YT, Chang NC, Nakagami H, Morishita R, Ou KL, Hou WC, Lin CY, Shyu KG and Lin FY. Dipeptidyl peptidase-4 inhibitor improves neovascularization by increasing circulating endothelial progenitor cells. British journal of pharmacology. 2012;167:1506-1519.
  21. Huang CY, Shih CM, Tsao NW, Chen YH, Li CY, Chang YJ, Chang NC, Ou KL, Lin CY, Lin YW, Nien CH and Lin FY. GroEL1, from Chlamydia pneumoniae, induces vascular adhesion molecule 1 expression by p37(AUF1) in endothelial cells and hypercholesterolemic rabbit. PloS one. 2012;7:e42808.
  22. Lin YW, Hsu TH and Yen PH. Localization of ubiquitin specific protease 26 at blood-testis barrier and near Sertoli cell-germ cell interface in mouse testes. International journal of andrology. 2011;34:e368-377.(第一作者)
  23. Lin FY, Tsai YT, Lee CY, Lin CY, Lin YW, Li CY, Shih CM, Huang CY, Chang NC, Tsai JC, Chen TL and Tsai CS. TNF-alpha-decreased thrombomodulin expression in monocytes is inhibited by propofol through regulation of tristetraprolin and human antigen R activities. Shock. 2011;36:279-288.
  24. Lin FY, Lin YW, Huang CY, Chang YJ, Tsao NW, Chang NC, Ou KL, Chen TL, Shih CM and Chen YH. GroEL1, a heat shock protein 60 of Chlamydia pneumoniae, induces lectin-like oxidized low-density lipoprotein receptor 1 expression in endothelial cells and enhances atherogenesis in hypercholesterolemic rabbits. Journal of immunology. 2011;186:4405-4414.
  25. Lin YH, Lin YM, Wang YY, Yu IS, Lin YW, Wang YH, Wu CM, Pan HA, Chao SC, Yen PH, Lin SW and Kuo PL. The expression level of septin12 is critical for spermiogenesis. The American journal of pathology. 2009;174:1857-1868.
  26. Yu YH, Lin YW, Yu JF, Schempp W and Yen PH. Evolution of the DAZ gene and the AZFc region on primate Y chromosomes. BMC evolutionary biology. 2008;8:96.
  27. Huang WJ, Lin YW, Hsiao KN, Eilber KS, Salido EC and Yen PH. Restricted expression of the human DAZ protein in premeiotic germ cells. Human reproduction. 2008;23:1280-1289.
  28. Hsu LC, Chen HY, Lin YW, Chu WC, Lin MJ, Yan YT and Yen PH. DAZAP1, an hnRNP protein, is required for normal growth and spermatogenesis in mice. Rna. 2008;14:1814-1822.
  29. Lin YW, Hsu LC, Kuo PL, Huang WJ, Chiang HS, Yeh SD, Hsu TY, Yu YH, Hsiao KN, Cantor RM and Yen PH. Partial duplication at AZFc on the Y chromosome is a risk factor for impaired spermatogenesis in Han Chinese in Taiwan. Human mutation. 2007;28:486-494.(第一作者)
  30. Lin YW, Hsu CL and Yen PH. A two-step protocol for the detection of rearrangements at the AZFc region on the human Y chromosome. Molecular human reproduction. 2006;12:347-351.(第一作者)
  31. Lin FY, Chen YH, Lin YW, Tsai JS, Chen JW, Wang HJ, Chen YL, Li CY and Lin SJ. The role of human antigen R, an RNA-binding protein, in mediating the stabilization of toll-like receptor 4 mRNA induced by endotoxin: a novel mechanism involved in vascular inflammation. Arteriosclerosis, thrombosis, and vascular biology. 2006;26:2622-2629.
  32. Lin YW, Thi DA, Kuo PL, Hsu CC, Huang BD, Yu YH, Vogt PH, Krause W, Ferlin A, Foresta C, Bienvenu T, Schempp W and Yen PH. Polymorphisms associated with the DAZ genes on the human Y chromosome. Genomics. 2005;86:431-438.(第一作者)
  33. Hung SL, Lin YW, Chen YT and Ling LJ. Attachment of periodontal ligament cells onto various antibiotics-loaded GTR membranes. The International journal of periodontics & restorative dentistry. 2005;25:265-275.
  34. Hung SL, Lin YW, Wang YH, Chen YT, Su CY and Ling LJ. Permeability of Streptococcus mutans and Actinobacillus actinomycetemcomitans Through guided tissue regeneration membranes and their effects on attachment of periodontal ligament cells. Journal of periodontology. 2002;73:843-851.

   

回頁首