Dr. Yuan-Min Lin, D.D.S., M.Sc.(Hons), Ph.D.
Resume

Education:

PhD in tissue Engineering, Department of Chemical Engineering, Imperial College London

MSc (hons) in Biomedical Materials, IRC in biomedical materials, Queen Mary, University of London

DDS, Doctor of Dental surgery, National Yang-Ming University

Current positionAssistant Professor, Department of Dentistry, National Yang-Ming University

Phone number(02)28267301 or (02)2826-7000 ext 7301

Fax(02) 2826-4053

Emailymlin@ym.edu.tw

Room numberRoom 326, Department of Dentistry

Research interests

1. tissue engineering

   Using techniques of tissue engineering, it is possible to “grow” human tissues that can be applied for clinical treatments in vitro, e.g. cartilage, alveolar bone, periodontal ligament, pulmonary epithelium and blood vessels. Topics such as tissue engineering scaffold, define of cell culture environment, cell-material interaction, extracellular matrix scale up of cells are of our interests.  We are currently working on the development of collagen/GAG scaffolds suitable for the culture of periodontal ligament stem cells. Also, we are developing the “bioprining” techniques to parepare tissue engineering scaffolds that possesses the vascular network. 

2. biomaterials

    We are interested in the synthesis of novel bioactive materials that can help the differentiation of stem cells into certain lineage and degrade within human bodies. Also, we are capable of modifying the surface of commercially-available biomaterials to enhance their biocompatibility. Currently, we are working on the development of hydrogels for the encapsulation of stem cells for the future cell therapy in clinical medicine and dentistry. 

3. Regenerative medicine and regenerative dentistry

     The so-called regenerative medicine is to differentiate various stem cells, such as embryonic stem cells, mesenchymal stem cells or induced pluripotent stem cells (iPSCs) into tissues of interests in vitro, then implant them into human bodies to restore the functions of target organs. In terms of dental stem cells, our lab is capable of isolating and culturing periodontal stem cells. Using these PDLSCs, we can turn them into cementum and surrounding supporting tissues for the periodontal regenerations.

 
Out current lab equipments
Items   Equipments for the synthesis and surface modifications of biomaterials
1  nanofiber electrospinning unit
2 Low frequency (40KHz) plasma reactor
3 spray dryer
4 3 axis CNC machine
5  rotary evaporator
6  contact angle meter
7 -80 degree Celsius cold trap
8 -40 degree Celsius low temperature circulator
9 vacuum pump
10 spin coater
11 DC stirrer
12  UV crosslinker
13 12 litre untrasonic cleaner
14 72 litre oven
15 pH meter
16 vacuum oven
17 4 digits scale
18 magnetic stirrer with temperature control
19 chemical hood

Items   

Equipments for cell culture

1 laminar flow hood
2 decontamination CO2 incubator
3 centrifuge
4 upright microscope
5 robotic bioprinter
6 a set of micropipettes
7 -4 degree Celsius fridge
8 -20 degree Celsius freezer
9 magnetic stirrer
10 diaphragm pump
 
Recent research project
Preparation of collagen/glycosaminoglycan nanofiber scaffolds for the culture of periodontal ligament stem cells (from Feb/01/2011 to Oct/31/2011)
Publications in the past year
  1. Yuan-Min Lin, Alison Zhang, Helen Rippon, Alexander Bismarck, Anne Bishop, Tissue engineering of lung: the effect of extracellular matrix on the differentiation of embryonic stem cells to pneumocytes, Tissue Engineering, 2010. 16(5): p.1515-26.
  2. Yuan-Min Lin, Wojciech Chrzanowski, Jonathan Knowles, Anne Bishop, Alexander Bismarck, Functionalized Poly(D,L-lactide) for pulmonary epithelial cell culture, Advanced Engineering Materials, 2010. 12(4): p. B101- B112.
  3. Yuan-Min Lin, Alison Zhang, Alexander Bismarck, Anne Bishop, Effects of fibroblast growth factors on the differentiation of pulmonary progenitors from murine embryonic stem cells, Experimental lung research, 2010. 36(5):p. 307-320.

 

Photos of our lab are shown below

 

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