李士元 教授 (Lee, Shyh-Yuan)

個人簡歷

學歷：

經歷：

現職：國立陽明大學牙醫學系特聘教授

台北榮民總醫院口腔醫學部兼任主治醫師

台北市立聯合醫院醫研部兼任研究員　

專長：牙科材料學、牙科贗復學、牙科植體學、數位牙醫學

職稱：教授

聯絡電話：(02) 2826-7235

傳真電話：(02) 2826-4053

電子郵件：sylee@ym.edu.tw

實驗室網址：  網址一      網址二

研究方向

(1)紅外光同調斷層掃瞄系統利用紅外光以及同調斷層掃描技術(Optical Coherence Tomography, OCT)可以穿透部分牙組織，取得牙齦下牙表面的訊號，經由程式回歸真實位置後再組成三維數位模型，相較於目前市售口掃機，本系統可以在免排齦的情況下，取得製作贋復牙所需之完整磨牙外觀與邊界，結合三維列印系統，便可以發展出獨特的數位贋復製造流程。另外，此系統亦有牙病偵測之發展潛力，可以偵測牙齦下牙結石、二次蛀牙、牙齒微裂縫等不易從表面觀測之疾病。
(2)三維列印系統整合研究樹脂與陶瓷類的贋復應用，包含臨時假牙、全口假牙、咬合板、手術導板，以及氧化鋯牙冠的製作。
(3)陶瓷、樹脂、與複合材料的合成與其物性的探討，其目的在於改善傳統材料的物性與研發新式的牙科複合材料以適用於臨床。尤其是在牙齒或材料的強度、顏色與光學的表現，以及生物相容性。
(4)相關的臨床操作與牙科材料之間的關係，如含氟材料的氟釋放以及再氟化的可行性及雷射於乳牙齲齒治療的應用；不同洗牙機器對復形材料的影響；以不同漂白方式處理牙本質，除了顏色的改變外，同時也造成牙本質硬度的降低；擁有不同單體的聚合物其顏色穩定性與染色能力之相關，及改變樹脂的聚合條件，會影響它的生物相容性與物理性質表現；陶瓷的種類與燒結條件則會影響其顏色與透明度的表現，及抗撓曲強度。

研究計畫（5年內）

發表著作（5年內）

1.     Hsu HJ, Lee SY, Jiang CP, Lin R. A comparison of the marginal fit and mechanical properties of a zirconia dental crown using CAM and 3DSP. Rapid Prototyping Journal 2019: Accepted (SCI)

2.     Lin CH, Lin YM, Lai YL, Lee SY. Mechanical properties, accuracy and cytotoxicity of the UV-cured 3D printing resins composed of BisEMA, UDMA and/or TEGDMA. Journal of Prosthetic Dentistry 2019: Accepted (SCI).

3.     Lin CH, Su JM, Lee SY, Lin YM. Stiffness Modification of Photopolymerizable Gelatin-Methacrylate Hydrogels Influences Endothelial Differentiation of Human Mesenchymal Stem Cells. Journal of Tissue Engineering and Regenerative Medicine 2018: DOI:10.1002/term.2745 (SCI).

4.     Lee PH, Yew T L, Lai YL, Lee SY and Chen HL*. Parathyroid hormone gene-activated matrix with DFDBA/collagen composite matrix enhances bone regeneration in rat calvarial bone defects. Journal of the Chinese Medical Association: JCMA 2018; 81(ahead):699-707 (SCI).

5.     Chang WT, Hsu HJ, Jiang CP, Lee SY, Lin YM. Effects of titanium dioxide and tartrazine lake on Z-axis resolution and physical properties of resins printed by visible-light 3D printers. RAPID PROTOTYPING JOURNAL 2018; 24(1):160-165 (SCI).

6.     Tzeng JJ, Hsiao YT, Wu YC, Chen H, Lee SY, Lin YM. Synthesis, Characterization, and Visible Light Curing Capacity of Polycaprolactone Acrylate. Biomed Research International 2018; 2018: Article ID 8719624, 8 pages (SCI).

7.     Lee SY, Wu SC, Chen S, Tsai LL, Tzeng JJ, Lin CH, Lin YM. Synthesis and characterization of polycaprolactone-based polyurethanes for the fabrication of elastic guided bone regeneration membrane. Biomed Research International 2018; 2018: Article ID 3240571, 13 pages (SCI).

8.     Lee CY, Chung CC, Chen GJ, Huang CC, Lee SY, Lin YH. Automated Segmentation of Dental Calculus in Optical Coherence Tomography Images. SENSORS AND MATERIALS 2018; 30(11):2517-2529 (SCI).

9.     Hsu FJ, Lee SY, Jiang CP. Technical Development of Multi-Resin Three-Dimensional Printer Using Bottom-Up Method. International Journal of Automation and Smart Technology 2018; 8(4):173-178 (OI).

10. Hsu HJ, Lee SY, Chang SK, Jiang CP. Surface Modification of High Density Ceramic Powder for Increasing Suspension Capacity in Three-Dimensional Printing Application. Material Science Forum 2018; 936:159-163 (EI).

11. Lee PH, Chen MY, Lai YL, Lee SY and Chen HL. Human Beta-Defensin-2 and -3 Mitigate the Negative Effects of Bacterial Contamination on Bone Healing in Rat Calvarial Defect. Tissue Engineering 2018; 24(7-8): doi: 10.1089/ten.TEA.2017.0219 (SCI).

12. Hsu HJ, Lee SY, Chang SL*, Lo CH, Lin YM. Shrinkage prediction using finite element analysis and experimental validation using three-dimension slurry printing system. International Journal of Advanced Manufacturing Technology 2017; 91(1-4):1289–1296 (SCI).

13. Lin CH, Chang MC, Hung SC, Lee SY, Lin YM. Bioactive surface modification of polycaprolactone using MG63-conditioned medium can induce osteogenic differentiation of mesenchymal stem cells. Journal of Materials Science 2017; 52(7):3967–3978 (SCI).

14. Chen HH, Lin YC, Lee SY, Chang LY, Chen BJ, Lai YL. Influence of sinus floor configuration on the grafted bone remodeling following osteotome sinus floor elevation. Journal of Periodontology 2017; 88(1):10-16 (SCI).

15. Lin CH, Lee SY, Lin YM. Plasma Treatment in Conjunction with EGM-2 Medium Increases Endothelial and Osteogenic Marker Expressions of Bone Marrow Mesenchymal Stem Cells. Journal of Materials Science 2016; 51(19):9145-54 (SCI).

16. Chung HK, Lee SY. Analysis of Dental Color Matching Devices and Systems. Journal of Family Dentistry 2016; 11(2):5-11 (OI).

17. Lin CH, Lin KF, Mar K, Lee SY, Lin YM. Antioxidant N-acetylcysteine and glutathione increase the viability and proliferation of MG63 cells encapsulated in the gelatin-methacrylate/VA-086/blue light hydrogel system. Tissue Engineering 2016; 22(8):792-800 (SCI).

18. Cheng YC, Lin DH, Jiang CP, Lee SY. Design improvement and dynamic finite element analysis of novel ITI dental implant under dynamic chewing loads. Bio-Medical Materials and Engineering 2015; 26(S):555-561 (SCI).

19. Chiou YT, Ho YC, Lee SY. Introduction of Digital Intraoral Scanner. Journal of Family Dentistry 2015; 10(3):4-13 (OI).

20. Chiu Yw, Lee SY, Lin YC, Lai YL. Significance of the width of keratinized mucosa on peri-implant health. Journal of the Chinese Medical Association 2015;78:(7);389-394 (SCI).

21. Lin YC, Lee YY, Ho YC, Shieh YC, Lai YL, Lee SY. Treatment of Large Apical Lesions with Mucosal Fenestration: A Clinical Study with Long-term Evaluation. Journal of Endodontics 2015; 41(4):563-567 (SCI).

22. Sun Cw, Ho YC, Lee SY. Sensing of Tooth Microleakage Based on Dental Optical Coherence Tomography. Journal of Sensors 2015; http://dx.doi.org/10.1155/2015/984627.

23. Lee SY, Jiang CP. Development of a three-dimensional slurry printing system using dynamic mask projection for fabricating zirconia dental implants. Materials and Manufacturing Processes 2014(575):214-218 (EI).

24. Shih YH, Lin DJ, Chang KW, Hsia SM, Ko SY, Lee SY, Hsue SS, Wang TH, Chen YL, Shieh TM. Evaluation Physical Characteristics and Comparison Antimicrobial and Anti-Inflammation Potentials of Dental Root Canal Sealers Containing Hinokitiol in Vitro. PLOS ONE 2014;9(6): e94941 (SCI).

25. Chou IC, Lee SY, Jiang JP. Effects of implant neck design on primary stability and overload in a type IV mandibular bone. International Journal for Numerical Methods in Biomedical Engineering 2014;30(11):1223-1237 (SCI).

26. Hsu HJ, Lee SY, Jiang CP. Development of maskless-curing slurry stereolithography for fabricating high strength ceramic parts. Advanced Materials Research 2014; 575:214-218 (EI).

27. Jiang CP, Hsu HJ, Lee SY. Development of Mask-less Projection Slurry Stereolithography for the Fabrication of Zirconia Dental Coping. International Journal of Precision Engineering and Manufacturing 2014;15(11):2413-2419 (SCI).

28. Chou IC, Lee SY, Wu MC, Sun CW, Jiang CP. Finite element modelling of implant designs and cortical bone thickness on stress distribution in maxillary type IV bone. Computer Methods in Biomechanics and Biomedical Engineering 2014;17(5):516-526 (SCI).

29. Sun CW, Lee SY, Lin KF. Optical scanning probe for bioimaging of optical coherence tomography. Journal of Medical and Biological Engineering 2014;34(1):95-100 (SCI).

30. Lin GH, Chang LY, Lin WC, Lee SY, Lai YL. Interdisciplinary approach for treating a large through-and-through periapical defect using guided tissue regeneration: A case report with seven-year follow-up. International Journal of Periodontics & Restorative Dentistry 2014;34(1): e1-e8 (SCI).

31. Huang YM, Chou IC, Jiang CP, Wu YS, Lee SY. Finite Element Analysis of Dental Implant Neck Effects on Primary Stability and Osseointegration in a Type IV Bone Mandible. Bio-Medical Materials and Engineering 2014;24(1):1407-1415 (SCI).

32. Lin CS, Hsieh JC, Yeh TC, Lee SY, Niddam DM. Functional dissociation within insular cortex: the effect of pre-stimulus anxiety on pain. Brain Research 2013;1493:40-47 (SCI).

33. Zhuang HB, Tu WS, Pan MC, Wu JW, Chen CS, Lee SY and Yang YC. Noncontact vibro-acoustic detection technique for dental osseointegration examination. Journal of Medical and Biological Engineering 2013;33(1):35-44 (SCI).

34. Pan MC, Zhuang HB, Chen CS, Wu JW, Lee SY. A noncontact resonance frequency detection technique for the assessment of the interfacial bone defect around a dental implant. Medical Engineering & Physics 2013;doi:10.1016/j.medengphy.2013.05.006 (SCI).

35. Hsieh YS, Lee SY, Ho YC, Chuang CC, Tsai JC, Lin KF, Su CW. Dental Optical Coherence Tomography. Sensors 2013; 13(7):8928-8949; doi:10.3390/s130708928 (SCI).

36. Lee WJ, Lai YL, Lee SY. Sleep Bruxism and Associated Physiological Changes. J Dent Sci 2013;31(1):16-26 (OI)

37. Sun CW, Hsieh YS, Ho YC, Jiang CP, Chuang CC, Lee SY.. Characterization of tooth structure and the dentin-enamel zone based on the Stokes-Mueller calculation. Journal of Biomedical Optics 2012;17(11):116026 (1-6) (SCI).

38. Wei YJ, Lin YJ, Kaung SS, Yang SF, Lee SY, Lai YL. Esthetic periodontal surgery for impacted dilacerated maxillary central incisors. American Journal of Orthodontics and Dentofacial Orthopedics 2012;142(4):546-51 (SCI).

專利

1.         咬合運動追蹤系統與其使用方法(2019),中華民國 發明專利號I630904, 發明人：鄭量元、許至瑜、李士元、林元敏　

2.         用於三維列印之生物可分解的光聚合組合物(2019),中華民國 發明專利號I654246，發明人：林元敏、江卓培、 李士元、 林賢達

3.         三維列印用牙科材料及其製備方法與應用(2018)，中華民國 發明專利號I630244，發明人：林元敏、陳翾、李士元、黃品儒

4.         可光緊合的生物可分解聚合物及其製備方法(2018)，中華民國發明專利號I614280，發明人：林元敏、江卓培、李士元、黃品儒

5.         光斷層掃描數位印模取像系統及其使用方法(2017)，中華民國發明專利號 I592145，發明人：李士元、呂志偉、呂東原、賴昱臻

6.         System and Method for Detecting Bone Defects (2017)， 美國發明專利號US 9788749，發明人:  潘敏俊、謝大誠、陳錦松、李士元

7.         具有多材料之三維列印方法(2016)，中華民國發明專利號I561369，發明人：江卓培，許煌展，李士元

8.         骨缺損檢測系統、裝置及方法(2016)，中華民國發明專利號I546060，發明人：潘敏俊、謝大誠、陳錦松、李士元

9.         一種牙結石成像方法(2015)，中華民國發明專利號I481392 ，發明人：李士元、孫家偉 、何怡青、謝曜聲、莊競程

10.     牙科植體不規則骨缺損檢測裝置及其方法(2012)，中華民國發明專利號I365736，發明人：潘敏俊、莊瀚伯、李士元

11.     Apparatus and Method of Irregular Bone Defect Detection of Dental Implant. (2012)美國發明專利號 US 8,167,614，發明人：潘敏俊、莊瀚伯、李士元

12.     小型電漿低溫消毒器(2011)，中華民國新型專利號M409073，發明人：黃穰基、王明誠、李士元、林明順、鄭書豪

獲獎（5年內）：

研究成果圖