Lien-Yu Chang (張蓮鈺副教授)



PHD, Department of Dentistry, School of Dentistry, National   Yang-Ming University, Taiwan (2008)
MS, Institute of Oral Biology, National Yang-Ming University, Taiwan (1998)
DDS, Department of Dentistry, National Yang-Ming University, Taiwan (1991)

Institute of Oral Biology, School of Dentistry, National Yang-Ming University

Associate Professor

Fields of Specialty:

Oral Pathology and Histology, Dentistry

Tel:  886-2-28267100

Fax: 886-2-28264053


Research Description

Areca-associated oral pathogenesis and immune regulation

Research Project

1. 2014/01/01—2014/12/31: Immunomodulatory effects of areca nut extract on the apoptosis of myofibroblasts  (PI) (grant 10301-62-018 from Department of Health, Taipei City Government)
2. 2014/01/01—2014/12/31: Role of macrophage polarization in the pathogenesis of periodontitis (Co-PI) (V103C-006, Taipei Veterans General Hospital)
3. 2012/08/01—2013/10/31: Analysis of immune dysregulation by areca nut extract using microarray profiling and protein-protein interaction networks (PI) (NSC 101-2314-B-010-049)
4. 2012/01/01—2013/3/31: Effects of areca nut extract on the apoptosis of human lymphocytes and monocytes) (PI) (grant 10101-62-036 from Department of Health, Taipei City Government)
5. 2010/08/01—2011/07/31: Modulation of the expression of surface adhesion molecules, migration and phagocytosis of human immune cells by areca nut extracts (PI)  (NSC: 99-2314-B-010-040-)
6. 2011/01/01—2011/12/31: Osteoclastogenic effects of MCP-1 and MMPs induced by areca nut extracts-treated human immune cells (PI) (grant 10001-62-046 from Department of Health, Taipei City Government)   
7. 2010/04/01—2011/03/31: Mechanisms involved in the expression of IL-1alpha, PGE2 and RANKL and cellular oxidative stress by immune cells treated with areca nut extracts) (PI)) (grant 99001-62-046 from Department of Health, Taipei City Government)

Publication (*corresponding author)

1. Lien-Yu Chang, Yu-Lin Lai, Tzu-Hsuan Yu, Yen-Ting Chen, Shan-Ling Hung*. Effects of areca nut extract on lipopolysaccharides-enhanced adhesion and migration of human mononuclear leukocytes. Journal of Periodontology, 2014; 85: 859-867. (SCI)
2. Shan-Ling Hung, Nin-Gi Lee, Lien-Yu Chang, Yen-Ting Chen, Yu-Lin Lai*. Stimulatory Effects of Glucose and Lipopolysaccharide of Porphyromonas Gingivalis on the Secretion of Inflammatory Mediators From Human Macrophages Journal of Periodontology. 2014 (Jan); 85:140-149. (SCI)
3. Guo-hao Lin, Lien-Yu Chang, Wen-Chun Lin,   Shyh-Yuan Lee, Yu-lin Lai*. Interdisciplinary Approach for Treating a Large Through-and-Through Periapical Defect Using Guided Tissue Regeneration: A Case Report. The international Journal of  Periodontics and Restorative Dentistry, 2014;34:XX–XX. doi: 10.11607/prd.1472.  (SCI)
4. Lien-Yu Chang, Hsiao-Ching Wan, Yu-Lin Lai, I-Chiang Chou, Yen-Ting Chen, Shan-Ling Hung*. Areca nut extracts increased the expression of cyclooxygenase-2, prostaglandin E2 and interleukin-1α in human immune cells via oxidative stress. Archives of Oral Biology, 2013; 58(10):1523-1531. (SCI)
5. Weng-Hang Ho, Ya-Yun Lee, L-Y Chang, Yen-Ting Chen, Tsung-Yun Liu, Shan-Ling Hung*. Effects of Areca Nut Extract on the Apoptosis Pathways in Human Neutrophils. Journal of Periodontal Research. 2010; 45 (3): 412-420. (SCI)
6. Lien-Yu Chang, Hsiao-Ching Wan, Yu-Lin Lai, Yu-Fu Kuo, Tsung-Yun Liu, Yen-Ting Chen and Shan-Ling Hung*. Areca nut extracts increased expression of inflammatory cytokines, tumor necrosis factor-α, interleukin-1β, interleukin-6 and interleukin-8, in peripheral blood mononuclear cells. Journal of Periodontal Research. 2009; 44: 175-183.  (SCI)
7. Lien-Yu Chang, Jung-Chen Lin, Ching-Wen Chang, Yen-Ting Chen, Ji-Lung Peng, Shan-Ling Hung*. Inhibitory Effects of Safrole on Phagocytosis, the Intracellular Reactive Oxygen Species and the Activity of Myeloperoxidase released by Human Polymorphonuclear Leukocytes.  Journal of Periodontology. 2009;80(8):1330-1337. (SCI)
8. Yu-Lin Lai, Hen-Li Chen, Lien-Yu Chang, Shyh-Yuan Lee*. Resubmerged technique for the management of soft tissue recession around an implant: a case report. The International Journal of Oral & Maxillofacial Implants. 2010 Jan-Feb;25(1):201-204. (SCI)
9. Lien-Yu Chang. Effects of areca nut extracts on the regulation of immune cell functions. 2008 (PhD Dissertation)
10. Lien-Yu Chang, Hsiao-Ching Wan, Yu-Lin Lai, Tsung-Yun Liu, and Shan-Ling Hung*. Enhancing effects of areca nut extracts on production of interleukin-6 and interleukin-8 by peripheral blood mononuclear cells. Journal of Periodontology 2006;77(12):1969-1977(SCI)
11. Hung S-L, Cheng Y-Y, Peng J-L, Chang L-Y, Liu T-Y, Chen Y-T*. Inhibitory effects of areca nut extracts on phagocytosis of Actinobacillus actinomycetemcomitans ATCC 33384 by neutrophils. Journal of Periodontology 2005;76(3):373-379 (SCI).
12. Chang L-Y, Lin S-C, Chang C-S, Wong Y-K, Hu Y-C, Chang K-W*. Telomerase activity and in situ telomerase RNS expression in oral carcinogenesis. Journal of Oral Pathology and Medicine 1999;28:389-396 (SCI).

Last updated: Monday, 2014-07-28 1:48 PM