研究成果

近五年代表著作及成果

1.以新世代睡眠分析系統探討實習醫師值班造成的身心壓力 (Stress, 2012)

2.發現休息對於值夜班的護理人員睡眠相關自主神經功能有改善的效果 (Industrial Health, 2012)

3.本團隊開發新的人體睡眠自動判期的程式,其結果與睡眠技師判讀結果類似 (Clinical Neurophysiology, 2012)

4.呼吸頻率對於感壓反射的靈敏度之基礎研究 (Journal of Hypertension, 2012)

5.開發新世代的動物多訊號記錄系統 (Journal of Medical and Biological Engineering, 2012)

6.探討不同抗精神病藥物對於大鼠睡眠相關自主神經功能之影響 (Neuropsychobiology, 2012)

7.α1腎上腺素對於高血壓大鼠睡眠功能之影響 (American Journal of Hypertension, 2012)

8.中大腦動脈阻塞後長時間監控自主神經功能及睡眠型態之研究 (Autonomic Neuroscience-Basic and Clinical, 2012)

9.利用大鼠探討睡眠後半期易引起心血管事件之原因 (Journal of Sleep Research, 2012)

10.探討神經痛引發之睡眠相關心血管反應 (International Journal of Developmental Neuroscience, 2012)

11.2013年部分開發之儀器現已商品化、取得專利權以及應用於研究中

12.追蹤12個月的研究發現,特別是男性實習醫師,其心臟之副交感神經調節功能較弱且具憂鬱之症狀 (Psychophysiology, 2013);另亦發現實習醫師於輪值日時,其快速動眼期睡眠顯著的較長 (PLoS One, 2013)

13.透過電刺激延腦鼻端腹外側核可促進大鼠清醒 (Sleep Medicine, 2013)

14.發現暴露於寒冷環境中將使得晨間血壓驟升幅度提高,並此現象與睡眠後期之交感神經功能活性上升有關 (Sleep Medicine, 2014)

15.發現大鼠在安靜睡眠時 (等同於人類之非快速動眼期睡眠) 較弱的感壓反射調控、副交感神經活性,以及主動睡眠時 (等同於人類之快速動眼期睡眠) 較低的交感神經活性,皆於較小的血壓下降幅度有關 (Journal of Hypertension, 2014)

16.發現自覺入睡困難者其白天副交感神經活性較弱;而慢速 (0.1 Hz)定量呼吸訓練,可有效降心率及調升整體自律神經功能,同時並能有效改善客觀睡眠品質,特別是縮短入睡時間以及提升睡眠效度 (Psychophysiology, 2015)

17.失眠者的入睡時間與心跳變動有關 (Psychiatry Research, 2015)

18.探討人體老化過程中 (20-80歲) 心血管功能及睡眠型態之改變情形,目前發現50歲為一重要分水嶺,老化造成睡眠品質改變的問題有可能是由於自律神經功能退化所造成,而50歲之後睡眠品質不好與交感神經活性較高有關 (Age, 2016)

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相關研究著作

1. Tsai, H. J., Kuo, T. B. J., Lee, G.-S., Yang, C. C. H.* (2015) Efficacy of paced breathing for insomnia: enhances vagal activity and improves sleep quality. Psychophysiology 52:388-396

2. Lin Y. H., Lin Y. C., Lee Y. H., Lin P. H., Lin S. H., Chang L. R., Tseng H. W., Yen L. Y., Yang C. C. H., Kuo T. B. J.* (2015) Time distortion associated with smartphone addiction: identifying smartphone addiction via a mobile application (App) Journal of Psychiatric Research 65:139-145

3. Huang W. L., Hwang B. T., Lai C. T., Li J. Y., Kuo T. B. J., Yang C. C. H.* (2015) Is heart rate variability related to season of birth? Clinical Cardiology 38:407-412

4. Wang, Y. B., Kuo, T. B. J., Lai C.T., Yang, C. C. H.* (2015) Effects of breathing frequency on the heart rate deceleration capacity and heart rate acceleration capacity. European Journal of Applied Physiology 115:2415-2420

5. Lai, C. T., Chen, C. Y., Kuo, T. B. J., Chern, C. H., Yang, C. C. H.* (2015) Sympathetichyperactivity, sleep fragmentation and wake-related blood pressure surge during late-light sleep in spontaneously hypertensive rats. American Journal of Hypertension 29:590-7

6. Tsai, H. J.†, Kuo, T. B. J., Lin, Y. C.†, Yang, C. C. H.* (2015) The association between prolonged sleep onset latency and heart rate dynamics among young sleep-onset insomniacs and good sleepers. Psychiatry Research 230:892-898

7. Kuo, T. B. J.†, Li, J. Y.†, Kuo, H. K., Chern, C. M., Yang, C. C. H.* (2016) Differential changes and interactions of autonomic functioning and sleep architecture before and after 50 years of age. Age 38:5

8. Kuo, T. B. J.†, Chen C. Y.†, Hsu, Y. C., Yang, C. C. H.* (2016) EEG beta power and heart rate variability describe the association between cortical and autonomic arousal across sleep. Autonomic Neuroscience: basic and clinical 194:32-7

9. Huang W. L., Liao S. C., Kuo, T. B. J., Chang, L .R., Chen, Z. T., Chen, I. M., Yang, C. C. H.* (2015) The effects of antidepressants and quetiapine on heart rate variability. Pharmacopsychiatry [Epub ahead of print]

10. Hong C. H. †, Kuo T. B. J. †, Huang B. C., Lin Y. C., Kuo K. L., Chern C. M., Yang C. C. H.* (2016) Cold exposure can induce an exaggerated early-morning blood pressure surge in young prehypertensives. PLoS One.11(2):e0150136

11. Lin, Y. C., Lin, Y. H., Lo, M Z., Peng, C. K., Huang, N. E., Yang, C. C. H., Kuo, T. B. J.* (2016) Novel application of multi dynamic trend analysis as a sensitive tool for detecting the effects of aging and congestive heart failure on heart rate variability. Chaos 26:023109

12. Kuo, T. B. J.†, Lai, C. T. , Chen, C. Y. †, Yang, Y. C., Yang, C. C. H.* (2016) The high-frequency component of heart rate variability during extended wakefulness is closely associated with the depth of the ensuing sleep in C57BL6 mice. Neuroscience 330: 257-66

13. Li, J. Y., Kuo, T. B. J., Yang, C. C. H.* (2016) Aged rats show the dominant modulation on lower frequency of hippocampal theta rhythm during running. Experimental Gerontology 83:63-70

14. Lin, W. L, Lo, L.W., Chen, H. R., Lai, C. T., Yamada, S., Liu, S. H., Chou. Y. H., Chen, S. A., Fu, Y. C., Kuo T. B. J.* (2016) Sleep-related changes in cardiovascular autonomic regulation in left coronary artery ligation rats: Neural mechanism facilitating arrhythmia after myocardial infarction. International Journal of Cardiology 225:65–72

15. Kung, Y. Y., Yang, C. C. H., Chiu, J. H. and Kuo, T. B. J.* (2016) The application of yin-yang concept on heart rate variability patterns in menopausal women with insomnia. Chinese Journal of Integrative Medicine 1-7

16. Huang, W. L., Liao, S. C., Yang, C. C. H., Kuo, T. B. J., Chen, T. T., Chen, I. M. and Gau, S. S.* (2017) Measures of Heart Rate Variability in Individuals With Somatic Symptom Disorder. Psychosomatic Medicine 79(1):34-42

17. Lin, Y. H., Lin, Y. C. †, Lin, S. H., Lee, Y. H., Lin, P. H., Chiang, C. L., Chang, L. R., Yang, C. C. H. and Kuo, T. B. J.* (2017) To use or not to use? Compulsive behavior and its role in smartphone addiction. Translation Psychiatry 7:1030-1038

18. Chen, C. W., Kuo, T. B. J. †, Chen, C. Y. and Yang, C. C. H.* (2017) Reduced capacity of autonomic and baroreflex control associated with sleep pattern in spontaneously hypertensive rats with a nondipping profile. Journal of Hypertension 35:558-570

19. Yang, C. C. H., Huang, S. S., Lai, C. Y., Kuo, T. B. J. and Chu, Y. C.* (2017) Changes in sleep architecture under sustained pain in adult male rats subjected to neonatal 2 short-lasting local inflammatory insult. Developmental Neuroscience 39(5):386-398

20. Lin, Y. H., Lin, P. H., Chiang, C. L., Lee, Y. H., Yang, C. C. H., Kuo, T. B. J. and Lin, S.H.* (2017) Incorporation of Mobile Application (App) Measures Into the Diagnosis of Smartphone Addiction. Journal of Clinical Psychiatry 78(7):866–872

Huang, W. L., Chang, L. R., Kuo, T. B. J., Lin, Y. H., Yang, J. L., Chen, Y. Z. and Yang, C. C. H.* (2017) Viral infection, psychopathology, and autonomic modulation among methadone users in Taiwan. Heroin Addiction And Related Clinical Problems 19(6):31-38

21. Kuo, T. B. J., Li, J. Y.†, Chen, C. Y., Lin, Y. C., Tsai, M. W., Lin, S. P. and Yang, C. C. H.* (2018) Influence of accelerometer placement and/or heart rate on physical activity energy expenditure prediction during uphill exercise. Journal of Motor Behavior 50(2):127-133

22. Lin, W. L., Chen, Y. R., Lai, C. T., Yamada, S., Liu, S. H., Chou, Y. H., Fu, Y. C., Yang, C. C. H., Kuo, T. B. J., Lo, L. W. and Chen, S. A.* (2018) Neural Mechanism of Angiotensin-Converting Enzyme Inhibitors in Improving Heart Rate Variability and Sleep Disturbance after Myocardial Infarction. Sleep Medicine 48:61-69

23. Chou, Y. H., Huang, W. L., Chang, C. H., Yang, C. C. H., Kuo, T. B. J., Lin, S. L., Chiang, W. C. * and Chu, T. S. (2019) Heart Rate Variability as a Predictor of Rapid Renal Function Deterioration in Chronic Kidney Disease Patients. Nephrology 24(8):806-813

24. Tzeng, N. S., Hsing, S. C., Chung, C. H., Chang, H. A., Kao, Y. C., Mao, W. C., Yang, C. C. H., Kuo, T. B. J., Chen, T. Y. * and Chien, W. C. (2019) The Risk of Hospitalization for Motor Vehicle Accident Injury in Narcolepsy and the Benefits of Stimulant Use: A Nationwide Cohort Study in Taiwan. Journal of Clinical Sleep Medicine 15(6):881-889

25. Huang, W. L., Liao, S. C.,* Tu, Y. K., Yang, C. C. H., Kuo, T. B. J. and Gau, S. S. F. (2019) Autonomic reactivity during reading of a somatic distress script in patients with somatic symptom disorder. Journal of Psychosomatic Research 123:109729

26. Li, J. Y. †, Chen, C. W. †, Liu, T. H., Kuo, T. B. J. and Yang, C. C. H.* (2019) Exercise prevents hypertension and disrupts the correlation between vascular sympathetic activity and age-related increase in blood pressure in SHRs. American Journal of Hypertension 32(11):1091-1100

27. Tsai, H. J., Kuo, T. B. J., Kuo, K. L. and Yang, C. C. H.* (2019) Failure to de-arouse during sleep-onset transitions in the heart rates of individuals with sleep-onset insomnia. Journal of Psychosomatic Research 126:109809

28. Chen, T. Y., Huang, C. H., Chung, C. H., Mao, W. C., Yeh, C. B., Yang, C. C. H., Kuo, T. B. J., Yang, S. S., Chien, W. C. and Tzeng, N. S.* (2020) Sex and age differences in the association between anxiety disorders and narcolepsy: A nationwide population-based case control study. Journal of Affective Disorders 264:130-137

29. Li, J. Y., Kuo, T. B. J.*, Yang, C. C. H.* (2020) Behavior consistency is a sensitive tool for distinguishing the effects of aging on physical activity. Behavioural Brain Research (Accepted)

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