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  Applied Neurophysiologic Laboratory
  Neurological Physical Therapy Laboratory
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  Musculoskeletal and Sports Sciences Laboratory
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  Neuromuscular System laboratory

Applied Neurophysiologic Laboratory

Professor in charge: Professor Ray-Yau Wang and Professor Yea-Ru Yang
E-MAIL: rywang@ym.edu.tw; yryang@ym.edu.tw

Main research areas/interests:
Applied neurophysiologic laboratory mainly investigates the recovery and mechanisms for the commonly seen neurological diseases using the neurophysiology concept and knowledge. Among neurological illnesses, stroke is the chief killer; it also causes disability. The common type of stroke is caused by the cerebral vascular infarction which then leads to brain ischemia. Brain infarction occurs most regularly in middle cerebral artery which branched out from internal carotid artery. Our laboratory has adopted an animal model with middle cerebral artery occlusion (MCAO) by using rat. This animal model is continually used in a series of related researches. Beside, our laboratory also created other animal models to expend our research fields of neurological diseases, such as Alzheimer's and Parkinson's rat models. Furthermore, our laboratory has also developed a number of assessment techniques from neurological and behavioral aspects such as employing TTC dye to measure the degree of brain infarction, adopting neurological scores to measure the extent of damage, motor behavior tests to examine the motor function, Morris water maze to measure the learning and memory ability, just the names of few.

Our research laboratory has received research grants from National Sciences Council, Ministry of Science and Technology, Cheng Hsin General Hospital and Veterans General Hospital University system of Taiwan-VGHUST from time to time, most of our research findings have been published in the international SCI journals. With the completion in more intensive and extensive researches in the near future, we expect to find out more details about stroke and other neurological diseases from the physiological and pathological perspectives, the effects of protective training and treatments, the effects of age factor on the recovery as well as the treatment outcomes. The researches are anticipated to provide more scientific knowledge and evidences on stroke recovery and mechanisms.

Research projects granted in most recent 3 years (year 2012 to 2015):

Research Project


Funding Organization

Neuroprotectvie effects on dopaminergic neurons during treadmill training in 6-OHDA rat model of Parkinson's disease


Cheng Hsin General Hospital

Effects of heat shock protein 70 on exercise training-mediated brain recovery in rats after brain ischemia


National Sciences Council

The effects of preconditioning treadmill training on neuroinflammatory injury and dopaminergic neuron in early stage of 6-OHDA-induced Parkinson's disease


National Sciences Council

Effects of hyperbaric oxygen and exercise training on neuroprotection and neural cell          migration in brain ischemic rats


Ministry of Science and Technology

Publications in recent 5 years:

  1. Yu SH, Huang CY, Lee SD, Hsu MF, Wang RY, Kao CL, Kuo CH. Decreased eccentric exercise-induced macrophage infiltration in skeletal muscle after supplementation with a class of ginseng-derived steroids. PLoS One, 9: e114649, 2014. (SCI)
  2. Chang HC, Yang YR, Wang PS, Wang RY. Quercetin enhances exercise-mediated neuroprotective effects in brain ischemic rats. Med Sci Sports Exer, 46: 1908-1916, 2014. (SCI)
  3. Shih PC, Yang YR, Wang RY. Effects of exercise intensity on spatial memory performance and hippocampal synaptic plasticity in transient brain ischemic rats. PLoS One, 8: e78163, 2013. (SCI)
  4. Chang HC, Yang YR, Wang PS, Kuo CH, Wang RY. The neuroprotective effects of intramuscular insulin-like growth factor-I treatment in brain ischemic rats. PLoS One, 8: e64015, 2013. (SCI)
  5. Tsai YW, Yang YR, Sun SH, Liang KC, Wang RY. Post ischemia intermittent hypoxia induces hippocampal neurogenesis and synaptic alterations and alleviates long-term memory impairment. J Cereb Blood Flow Metab, 33: 764-773, 2013. (SCI)
  6. Yang YR, Chang HC, Wang PS, Wang RY. Motor performance improved by exercises in cerebral ischemic rats. J Mot Behav, 44: 97-103, 2012. (SCI)
  7. Wang RY, Chang HC, Chen CH, Tsai YW, Yang YR. Effects of hyperbaric oxygenation on oxidative stress in acute transient focal cerebral ischemic rats, Eur J Appl Physiol, 112: 215-221, 2012. (SCI)
  8. Chang HC, Yang YR, Wang PS, Kuo CH, Wang RY*. IGF 1 signaling for brain recovery and exercise ability in brain ischemic rats. Med Sci Sports Exer, 43: 2274-2280, 2011. (SCI)
  9. Tsai YW, Yang YR, Wang PS, Wang RY. Intermittent hypoxia after transient focal ischemia induces hippocampal neurogenesis and c-Fos expression and reverses spatial memory deficits in rats. PLoS One, 6: e24001, 2011. (SCI)
  10. Chang HC, Yang YR, Wang PS, Kuo CH, Wang RY. Effects of insulin-like growth factor 1 on muscle atrophy and motor function in rats with brain ischemia. Chin J Physiol, 53: 337-348, 2010. (SCI)

The anticipation and requirements for graduate students:
Students who wish to involve in our research laboratory are required to go through the basic technical training on neurophysiology. Students must have the initiative and enthusiasm to learn, hardworking, and patience. Before graduation, it is required for students to submit a thesis and an extra paper based on your thesis for the purpose of publishing.