Huei-Wen Chen, PhD

Associate Professor,

Department and Institute of Pharmacology,

College of Medicine,

National Yang-Ming University

TEL: +886-2-28267098

Email: hwchen@ym.edu.tw

 

Education:

National Taichung First Senior High School

Taipei Medical University

National Taiwan University, College of Medicine (PhD)

 

Antecedent:

Taipei Medical University, Center for Reproductive Medicine (Post-Doc.)

National Taiwan University Hospital (Post-Doc.)

Taipei Medical University (Assistant Professor)

National Chung-Hsing University (Assistant Professor)

National Yang-Ming University (Assistant Professor)

VCRB, OB/GYN, MGH, Harvard Medical School (Visiting Scientist)

 

Publications:

  Journal articles (2004~2008):

1. Chen HW, Lee JY, Huang JY, Wang CC, Chen WJ, Su SF, Huang CW, Ho CC, Chen JJ, Tsai MF, Yu SL, Yang PC. (2008) Curcumin inhibits lung cancer cell invasion and metastasis through the tumor suppressor HLJ1. Cancer Res. 68(18):7428-38.

2. Chen HW, Liu JCC, Chen JJW, Lee YM, Huang JL, Tzeng CR. (2008) The Genes and Pathways Involved in Pathogenesis of Leiomyoma and Altered by Gonadotropin Releasing Hormone Analogue. Fertil & Stertil. , (Feb 5; [Epub ahead of print], in press). (IF=3.114).

3. Chou CC, Hsiao HY, Hong QS, Chen CH, Peng YW, Chen HW *, Yang PC * (2008) Molecular Mechanisms of Single-Walled Carbon Nanotubes Induced Pulmonary Toxicity. Nano Letter 8(2):437-445. (1/32)(IF=9.96). *Equal to Corresponding author.

4. Yu SL, Singh S, Chen HW, Chen HY, Chen JJW, Chen WJ, Chen HS, Chen SC (2008) Intra-abdominal Adhesion Formation Induces Anti-oxidative Injury, Enhances Cell Proliferation, and Prevents Complement-mediated Lysis. Wound Repair and Regeneration (in press). (25/137)(IF=2.230).

5. Yu SL, Chen HY, Chang GC, Chen CY, Chen HW, Singh S, Cheng CL, Yu CJ, Lee YC, Chen HS, Su TJ, Chiang CC, Li HN, Hong QS, Su HY, Chen CC, Chen WJ, Liu CC, Chan WK, Chen WJ, Li KC, Chen JJ, Yang PC. (2008) MicroRNA signature in NSCLC. Cancer Cell 13(1):48-57. (IF=24.077).

6. Ho CC, Liao WY, Wang CY, Lu YH, Huang HY, Chen HY, Chan WK, Chen HW, Yang PC. (2008) TREM-1 Expression in Tumor-associated Macrophages and Clinical Outcome in Lung Cancer. American Journal of Respiratory and Critical Care Medicine 177(7):763-70. (SCI) (1/33) (IF=9.091).

7. Huang CH, Hsu CY, Chen HW, Tsai MS, Cheng HJ, Chang CH, Lee YT, Chen WJ. (2007) ERYTHROPOIETIN IMPROVES THE POSTRESUSCITATION MYOCARDIAL DYSFUNCTION AND SURVIVAL IN THE ASPHYXIA-INDUCED CARDIAC ARREST MODEL. SHOCK. 2007 Jul;28(1):53-58; May 3; [Epub ahead of print]. (SCI) (13/139) (IF=3.122).

8. Chen HW, Su SF, Chien CT, Lin WH, Yu SL, Chou CC, Chen JJW, and Yang PC. (2006) Titanium Dioxide Nanoparticles Induce Emphysema-like Lung Injury in Mice. FASEB J 20(13):2393-5. (SCI)(3/65) (IF=7.064).

9.  Chen HW, Tzeng CR. (2006) Applications of Microarray in Reproductive Medicine. [Review article]. Chang Gung Med J. 29(1):15-24.

10.  Chen WC*, Chen, HW*, Yu SL, Wang TD, Huang CH, Chen JJW, Chien CT, Yang PC, and Lee YT (2005) Gene Expression Profiles in Hypoxic Preconditioning using cDNA Microarray Analysis: Altered Expression of an Angiogenic Factor, CEACAM-1. SHOCK 24 (2):124-31. (SCI) (13/139) (IF=3.122). *Equal contribution to first author and corresponding author.

11. Chen, HW, Chen JJW, Yu SL, Li HN, Yang PC, Su CM, Au HK, Chang CW, Chien LW, Chen CS, and Tzeng CR (2005) Transcriptome Analysis in Blastocyst Hatching by cDNA Microarray. Human Reproduction 20(9):2492-501, (SCI) (4/57) (IF=3.669). (Cover story).

12. Yang WCV, Au HK, Chang CW, Chen HW, Chen PH, Chen CC, Tang YL, Wang IT, Tzeng CR. (2005) Matrix remodeling and endometriosis [Review article]. Reproductive Medicine and Biology. 4: 93-99.

13. Chen, HW, Yu, SL, Chen, WJ, Lee, YT, Yang, PC. (2004). Gene Expression Profile of Anti-invasive Activity of Curcumin in Lung Adenocarcinoma Cells. Molecular Pharmacology 65(1) 99-110. (SCI) (22/193) (IF=4.612).

14. Chen, HW, Yu, SL, Chen, WJ, Yang, PC, Tzeng, CR, Li, HN, Peck, K, Chen, JJW, Lee, YT. (2004). Profiling of Gene Expression Pattern during Postnatal Myocardial Development by cDNA Microarray. HEART 90(8): 927-934. (SCI) (8/72) (IF=3.786).

15. Yu, SL*, Chen HW*, Chen JJW, Yang PC, et al., (2004) Differential Gene Expression in Gram-Negative and Gram-Positive Sepsis. American Journal of Respiratory and Critical Care Medicine. 169,1135-1143. (SCI) (1/33) (IF=9.091). * Equal contribution to first author.

16. Chein CT, Chang WD, Chen, HW, et al., (2004) Ascorbate Supplement Reduces Oxidative Stress in Dyslipidemic Patients Undergoing Apheresis. Arterioscler. Thromb. Vasc. Biol. 24(6):1111-7 (SCI)(4/61) (IF=7.1).

17. Yang WC, Chen HW, Au HK, Chang CW, Huang CT, Yen YH, Tzeng CR. (2004) Serum and endometrial markers. [Review article]. Best Pract Res Clin Obstet Gynaecol. 18(2):305-318. (SCI) (28/57) (IF=1.512).

 

(1994~2003):

1.  Chen HW, Chien CT, Yu SL, Lee YT, and Chen WJ (2002) Cyclosporine A regulate oxidative stress-induced apoptosis in cardiomyocytes: mechanisms via ROS generation, iNOS and Hsp70. Br. J. Pharmacol. 137: 771-781. (SCI). (42/193) (IF=3.410).

2.  Chen HW, Jeremy JW. Chen, Tzeng CR, et al. (2002). Global Analysis of Differentially Expressed Genes in Early Gestational Decidua and Villi using a 9,600 Human cDNA Microarray. Mol. Human Reprod. 8(5), 475-484 (cover story) (4/24) (IF=3.191).

3.  Chen HW, Jiang WS, and Tzeng CR. (2001). Nitric oxide as a regulator in preimplantation embryo development and apoptosis. Fertil & Stertil. , 75(6), 1163-1171 (cover story) (6/57) (IF=3.114).

4.  Chen HW, Hsu MJ, Chien CT, & Huang HC. (2001). Effect of alisol B acetate, a plant triterpene, on apoptosis in vascular smooth muscle cells and lymphocytes. Eur J Pharmacol. 419(2-3), 127-138. (SCI). (63/193) (IF=2.477).

5.  Tzeng CR, Chen HW, Hang WS, et al., (1999). Increased apoptosis in granulosa cells following GnRHa- treatment in patients with endometriosis. In Vitro Fertilization & Human Reproductive Genetics. 147-151. (Original article).

6.  Chen HW and Huang HC (1998). Effect of curcumin on cell cycle progression and apoptosis in vascular smooth muscle cells. Br. J. Pharmacol. 124: 1029-1040. (SCI). (42/193) (IF=3.410).

7.  Lu LH, Lee YT, Chen HW, Chiang LY, Huang HC. (1998). The possible mechanisms of the antiproliferative effect of fullerenol polyhydroxylated C60, on vascular smooth muscle cells. Br. J. Pharmacol. 123, 1097-1102. (SCI). (42/193) (IF=3.410).

8.  Huang HC, Hsieh LM, Chen HW, Lin YS, and Chen JS. (1994). Effects of baicalein and esculetin on transduction signals and growth factors expression in T-lymphoid leukemia cells. Eur. J. Pharmacol. 268, 73-78. (SCI). (63/193) (IF=2.477).

 

Symposium papers (abstract only):

1.      Chen HW, Lee YM, Chen JJW, Tzeng CR (2007) Combining differential gene expression and pathway analyses to elucidate potential mechanisms of endometriosis (P-486), Human Reproduction Vol 22; Suppl1, i189. (SCI).

2.      Lee JY, Yu SL, Yang PC, Chen HW* (2007) Synergistic antitumor activity of epidermal growth factor receptor tyrosine kinase inhibitor gefitinib and curcumin in non-small-cell lung cancer. Proceedings of the AACR. Vol 48, #4783. *Corresponding author.

3.      Chen HW, Tzeng CR (2007) The novel serine proteases, prtn3 and prss23, in murine blastocyst development and hatching Fertility and SterilityVolume 88, Supplement 1, S312. (SCI).

4.      Chen HW, Hwang J and Tzeng C (2006) The genes and pathways involved in pathogenesis of leiomyoma and altered by gonadotropin releasing hormone analogue. Fertility and Sterility, Volume 86, Issue 3, Supplement 1, S343. (SCI).

5.      Chen HW, Su CM, Tzeng CR. (2005) Heme Oxygenase-1 as a Survival Factor in Pre-Implantation Embryo Development. Fertility and SterilityVolume 84, Supplement 1, S379-S380. (SCI).

6.      Chen HW, Chen JJW, Yang PC. (2006) Proceedings of the AACR. Vol 47, p1322.

7.      Chen HW, Yu SL, Lee YT, Yang PC, Chen JJW. (2004) Proceedings of the AACR. Vol 45, p264.

8.      Chen HW, Su CM, Chen JJW, Tzeng CR (2004) To identify the hatching-specific expressed genes in pre-implantation mice blastocysts Fertility and Sterility, Volume 82, Supplement 2, S272-S272. (SCI).
H.-W. Chen, C.-M. Su, J.J.W. Chen and C.-R. Tzeng

9.      Chen HW, Yu SL, Lee YT, Yang PC, Chen JJW. (2003) Microarray analysis of metastatic-related gene expression in curcumin-treated lung adenocarcinoma cell lines. Proceedings of the AACR. Vol 44, p2766.

10.  Chen, HW, Li, H.N.; Chen, Jeremy J.W.; Yang, Vivian W.C.; Yu, S.L.; Tzeng, CR. (2002) Identification of endometriosis-related genes by cDNA microarray. Fertil & Steril. 78, Suppl 1, pp. S199. (SCI).

11.  Chen HW, Li HN, Lee YT, Yang PC, Chen JJW, Tzeng CR. (2002). Global analysis of differentially expressed genes in endometrium with or without endometriosis using human cDNA microarray. Fertil & Steril. 77 Suppl 1:S16 (SCI).

 

Attend Symposium:

1.    Chen HW, Lee YM, Tzeng CR. (2007) The novel serine proteases, prtn3 and prss23, in mice blastocyst development and hatching The 63rd Annual Meeting of the American Society for Reproductive Medicine, (ASRM), Washington D.C., Oct. 13-17.

2.    Lee JY, Yu SL, Yang PC, Chen HW* (2007) Synergistic antitumor activity of epidermal growth factor receptor tyrosine kinase inhibitor gefitinib and curcumin in non-small-cell lung cancer. American Association of Cancer Research (AACR), 2007 Annual Meeting in LA, USA.

3.    Chen HW, Lee YM, Chen JJW, Tzeng CR (2007) Combining differential gene expression and pathway analyses to elucidate potential mechanisms of endometriosis The 23th Annual Meeting of European Society of Human Reproduction and Embryology (ESHRE) Leon, France.

4.    Chen HW, Wang CC, Chen JJW, Yang PC (2006) Curcumin induces a novel onco-suppressor gene, HLJ1 through JunD pathway and inhibits cancer cell invasion. American Association of Cancer Research (AACR), 2006 Annual Meeting in Washington D.C., March 31-April 5.

5.    Chen HW, Su CM, Tzeng CR (2006) The role of HO-1 in embryo development. The 22th Annual Meeting of European Society of Human Reproduction and Embryology (ESHRE), Prague, Czech June 18-21.

6.    Chen HW, Tzeng CR (2006) The Genes and Pathways Involved in Pathogenesis of Leiomyoma and Altered by Gonadotropin Releasing Hormone Analogue. The Annual Meeting of the American Society for Reproductive Medicine, (ASRM 2006), New Orleans, Louisiana. October 21-25.

7.    Chen HW (2006) Transcriptome analysis in blastocyst hatching by cDNA microarray. Royal International Twin Congress: 7th Congress on Reproductive Biomedicine & 2nd Congress on stem cell biology and Technology, Tehran, Iran, Sep. 13-15. [invited oral presentation].

8.    Chen HW, Su CM, and Tzeng CR, (2005) “Transcript profiling of hatching stage-specific genes during pre-implantation mouse development” presented at Ovarian Conference, Tokyo, Japan, Jun. 4.

9.    Chen HW, Li HN, Au HK, Chang CW, Chien LW, and Tzeng CR, (2005) “From transcript profiling of endometriosis to develop diagnostic markers for endometriosis”, presented at IX World Congress on Endometriosis, Maastricht, Sep. 14 – 17.

10. Chen HW, Su CM, Tzeng CR, (2005) “To study the role of heme oxygenase-1 in embryo survival during pre-implantation development” presented at Taiwan Society for Reproductive Medicine (TSRM), Taipei, Taiwan, Aug. 27-28.

11. Yang VWC, Chen HW, Huang YJ, Tzeng CR, (2005) “Altered expression of the extracellular matrix molecules in association with endometriosis”, presented at Taiwan Society for Reproductive Medicine (TSRM), Taipei, Taiwan, Aug. 27-28.

12. Chen HW, Su CM, Au HK, Chang CW, Chien LW, Chen PH, and Tzeng CR, (2005) “Heme oxygenase-1 expression during pre-implantation mouse development”, presented at American Society for Reproductive Medicine (ASRM), Montreal, Canada, Oct. 16-19.

13. Yang VWC, Chen HW, Huang YJ, Chen CS, Chen PH, Tzeng CR, (2005) “Altered Extracellular Matrix in Eutopic and Ectopic Endometrium of Endometriosis” presented at American Society for Reproductive Medicine (ASRM), Montreal, Canada, Oct. 16-19.

14. Chen HW, Yu SL, Chen JJW, Yang PC,.et al., (2004) Global Analysis of Gene Expression in Clarithromycin-treated Human Lung Adenocarcinoma CL1-5 Cells and Macrophage THP-1 Cells by Microarray. 95th American Association of Cancer Research (AACR), 2004 Annual Meeting in Orlando, Florida, March 27-31.

15. Chen HW, Su C, Chen J, Tzeng CR. (2004) “To identify the hatching-specific expressed genes in pre-implantation mice blastocysts”, presented at ASRM 2004 Annual Meeting, Philidelphia, USA, Oct. 16-20.

16.  Chen HW, Chen JJW, Liang YS, Tzeng CR. (2004) “To identify the hatching-specific expressed genes in preimplantation mouse blastocysts”, presented at The Society for the Study of Preproduction 37th Annual Meeting, Vancouver BC, Canada, Aug. 1-4.

17.              Tzeng CR, Chen HW, Lee HN, Chen CW. (2004) “The application of cDNA Microarray in Reproductive Medicine”, presented at the 97th Formosa Medical Association Annual Meeting, Taipei, Taiwan, Nov. 4-7.

18. Chen HW, Yu SL, Chen JJW, Lee YT, Yang PC (2003) 94th American Association of Cancer Research (AACR), 2003 Annual Meeting in Toronto, Ontario, Canada, April 4-9.

19.  Chen HW, Yu SL, Chen JJW, Tzeng CR, et al. (2003) The 19th Annual Meeting of European Society of Human Reproduction and Embryology (ESHRE), Madrid, Spain, June 30- July 3. (Post award).

20.  Chen HW, Han-Ni Li, Chii-Ruey Tzeng, et al. (2002) Global Analysis of Differentially Expressed Genes in Endometrium with or without Endometriosis Using Human cDNA Microarray. American Society of Reproductive Medicine (ASRM), VIII World Congress on Endometriosis. San Diego, California, USA. Feb. 24-27

21. Chen HW, Lee YT, Chen WJ, et al. (2002) Protective Effects of Cyclosporin A on Cardiomyocytes: Mechanisms through Preventing Mitochondrial Membrane Potential Loss and Inducing Preconditioning-like Effects. The 14th World Congress of Cardiology (WCC), Sydney, Australia, May. 5-9.

22.              Chen HW, Yu SL, Chen JW, et al. (2002) Profiling of Gene Expression Pattern during Postnatal Myocardial Development by cDNA Microarray. The 14th World Congress of Cardiology (WCC), Sydney, Australia, May. 5-9.

23.              Chen HW, Chen JW, Yang PC, et al., (2002). Global analysis of gene expression in curcumin-treated lung adenocarcinoma cell lines, CL1-0 and CL1-5. The 17th Meeting of the European Association for Cancer Research (EACR), Granada, Spain, June 8-11.

24.              Chen HW, Li HN, Chen JW, et al., (2002) The differentially expressed genes in eutopic endometrium with or without endometriosis and in ectopic endometrium following GnRH-analog treatment. The 18th Annual Meeting of European Society of Human Reproduction and Embryology (ESHRE), Vienna, Austria, June 30- July 3.

25.              Chen HW, Li HN, Chen JW, et al., (2002) Identification of endometriosis-related genes by cDNA microarray. 58th Annual Meeting of the American Society for Reproductive Medicine (ASRM), Seattle, Washington, October 12-17.

26. Chen HW, Li HN, Chang SJ, Cheng YF, Wang RS, Yang PS, Hung YC, Chen JW, TzengCR (2001). Global analysis of differentially expressed genes in early gestationl decidua and chorionic villi using human cDNA microarray. Presented at Taiwanese Society for Reproductive Medicine 2001 Annual Meeting,Sep 8-9,2001.

27.  Tzeng CR, Chen HW. (2001). MCL-1, BCL-2 and Bax expression in endometrium during the regular menstrual cycle and endometriotic tissues following GnRHa-treatment. The 6th International Symposium on GnRH Analogues in Cancer and Human Reproduction. Geneva, Switzerland, February 8-11.

28. Yang PS, Wang RS, Hung YC, AU HK, Chen HW, Cheng YF, Kuo SH, Tzeng CR. (2001). Anovulation induction Protocol without human menopausal gonadotropins followed by artificial insemination with husband can lead to high pregnancy rates in patients with polycyctic ovaries: a retrospective study. Presented at Taiwanese Society for Reproductive Medicine 2001 Annual Meeting, Sep 8-9.

29. Tzeng CR, Chen HW, Jeremy JW. Chen,. (2001) Gene expression profiling of early gestational decidua and villi. The 17th Annual Meeting of European Society of Human Reproduction and Embryology (ESHRE). Lausanne, Switzerland, July 1-5. (Poster Award).

30. Chen HW, Tzeng CR. (2001) Apoptosis and expression of MCL-1, BCL-2 and Bax in endometrium during the regular menstrual cycle and endometriotic tissues following GnRHa-treatment. American Society of Reproductive Medicine (ASRM), Orlado, Carlifornia, USA, Oct. 23-27.

31.  Chen HW*, Jeremy JW Chen, Tzeng CR (2001) Global Analysis of Differentially Expressed Genes in Early Gestational Decidua and Villi using a 9,600 Human cDNA Microarray. The 17th World Congress of Fertility and Sterility (IFFS), Melbourne, Australia, Nov. 25-30. *Oral presentation.

32.  Chen HW, Chen WJ, Lee YT, Chien CT. (2001). Cyclosporine A Regulates Oxidative Stress-Induced Apoptosis in Cardiomyocytes. The 1st Symposium on Free Radical Research, Taipei, Taiwan. Jan. 14.

33.  Chen HW, Jiang WS, Wu KI, Chien LW, Au HK, Sheen TC, Tzeng CR. (2000). Mcl-1, Bcl-2 and Bax expression in endometrium during the regular menstrual cycle and endometriotic tissues following GnRHa-treatment.  The 2000 annual meeting of the Taiwan Society for Reproductive Medicine. Taipei, Taiwan. Oct. 7-8.

34. Tzeng CR, Chen HW, Wu KY, Chang SJ, Sheen TC, Au HK. (2000). Long acting GnRHa-teatment increase apoptosis in cumulus granulosa cells (cGCs) of patients with endometriosis undergoing IVF program. 56th Annual Meeting, American Society for Reproductive Medicine. San Diego, CA, U.S.A. Oct. 21-25.

35.  Tzeng CR, Chen HW, Jiang WS, Wu KY, Chang SJ, Wen JY, Au HK. (1999). Increased apoptosis in granulosa cells following GnRHa treatment in patients with endometriosis. The 11th World Congress on In Vitro Fertilization and Human Reproductive Genetics. Sydney, Australia. May 9-14.

36. Chen HW, Jiang WS, Tzeng CR. (1999). Nitric Oxide as a regulator in pre-implantation embryonic development. The 55th Annual Meeting, American Society for Reproductive Medicine. Toronto, Ontario, Canada. Sep. 25-30.

37.  Chen HW, Lee CW, Huang HC. (1995). Suppression of c-jun/c-fos activities by curcumin. Combined Symposium of Biological and Medical Science, Taiwan.

 

Awards:

1.    2006, Nomination of International Royal Award in Human Reproduction. Royan Institute, Tehran, Iran. Sep. 12-15.

2.    2006, Prize Paper, Taiwan Society for Reproductive Medicine (TSRM), Taipei, Taiwan, Aug. 26-27.

3.    2006, 財團法人李鎡堯生殖醫學基金會優秀論文獎.

4.    2005, (1st) Prize Paper in Basic Research Taiwan Society for Reproductive Medicine (TSRM), Taipei, Taiwan, Aug. 27-28.

5.    2003, Best Poster Award, The 19th Annual Meeting of European Society of Human Reproduction and Embryology (ESHRE), Madrid, Spain, June 30- July 3.

6.    2002, Poster Award Candidate, the 58th Annual Meeting of the American Society for Reproductive Medicine (ASRM), Seattle, Washington, October 12-17.

7.    2001, Best Poster Award, The 17th Annual Meeting of European Society of Human Reproduction and Embryology (ESHRE). Lausanne, Switzerland, July 1-5.

8.    2001, Oral Communication Finalist, The 17th World Congress of Fertility and Sterility (IFFS), Melbourne, Australia, Nov. 25-30. *Oral presentation.

9.    2000, Poster Award, The 2000 Annual meeting of Taipei Medical College. Taipei, Taiwan.

10. 1999, Poster Award, The 1999 annual meeting of the Taiwan Society for Reproductive Medicine. Taipei, Taiwan.