Dr. Cheng-Chen Chen, Professor


London School of Hygiene and Tropical Medicine. Ph. D. 1982
National Defense Medical Center, M. Sc. 1975
National Chung-Hsing University, B. Sc. 1973


Tel: 2826-7074

Fax: 2821-4670

E-mail: mosquito@ym.edu.tw

Fields of Specialty:

Medical Entomology, Vector Biology, Mosquito innate immunity, Mosquito genome.

Research Description:

My work involves using genomic mass-screens, EST sequencing, microarray analysis, and proteomics, etc., to identify important mosquito defense factors. The potential candidate molecules are characterized and elucidated their biological functions by mosquito gene silencing technologies.

Selected Recent Publication (2001- 2005) :

  1. Huang, L.H., Christensen, B.M. and Chen, C.C.* 2001 Molecular cloning of a second prophenoloxidase cDNA from the mosquito Armigeres subalbatus: prophenoloxidase expression in blood-fed and microfilariae-inoculated mosquitoes. Insect Molecular Biology 10:87-95.
  2. Taft, A.S., Chen, C.C., Li, J. and Christensen, B.M. 2001. Molecular cloning of two prophenoloxidase genes from mosquito Aedes aegypti. Insect Molecular Biology 10:97-103.
  3. Shiao, H.S., Higgs, S., Adelman, Z., Christensen, B.M., Liu, S.H. and Chen, C.C.* 2001 Effect of prophenoloxidase expression knockout on the melanization of filarial worms in the mosquito, Armigeres subalbatus. Insect Molecular Biology 10:315-321.
  4. Lai, S.C., Chen, C.C. and Hou, R.F. 2001. Electron microscopic observation on wound healing in larvae of the mosquito Armigeres subalbatus (Diptera: Culicidae). Journal of Medical Entomology 38:836-843.
  5. Chang, T.T., Chang, T.Y., Chen, C.C., Young, K.C., Roan, J.N., Lee, Y.C., Cheng, R.N. and Wu, H.L. 2001 Existence of hepatitis C virus in Culex quinquefasciatus after ingestion of infected blood: experimental approach to evaluating transmission by mosquitoes. Journal of Clinical Microbiology 39:3353-3355.
  6. Lai, S.C., Chen, C.C. and Hou, R.F. 2002. Immunolocalization of prophenoloxidase during the wound healing in larvae of the mosquito Armigeres subalbatus (Diptera: Culicidase). Journal of Medical Entomology 39:266-274.
  7. Johnson, J.K., Rocheleau T.A., Hillier, J.F., Chen, C.C., Li, J. and Christensen, B.M. 2003. A potential role for phenylalanine hydroxylase in mosquito immune responses. Insect Biochemistry and Molecular Biology 33:345-354.
  8. Wang, X., Roucheleau, T.A., Fuchs, J.F., Hillyer, J.F., Chen, C.C. and Christensen, B.M. 2004 A novel lectin with a fibrinogen-like domain is involved in innate immune response of Armigeres subalbatus against bacteria. Insect Molecular Biology 13:273-282.
  9. Tamang, D., Tseng, S.M. Huang, C.Y., Tsao, I.Y., Chou, S.Z., Higgs, S., Christensen, B.M. and Chen, C.C.* 2004 The use of a double subgenomic Sindbis virus expression system to study mosquito gene function: effect of antisense nucleotide number and duration of viral infection on gene silencing efficiency. Insect Molecular Biology 13:595-602.
  10. Bartholomay, L.C., Cho, W.L., Rocheleau, T.A., Boyle, J.P., Beck, E.T., Fuchs, J.F., Liss, P., Rusch, M., Bulter, K.M., Wu, R.C.C., Lin, S.P., Kou, H.Y., Tsao, I.Y., Huang, C.Y., Wu, T.T., Hisao, K.J., Tsai, S.F., Yang, U.C., Nappi, A.J., Perna, N.T., Chen, C.C.* and Christensen, B.M.* 2004 Description of the Transcriptome of immune response-activated hemocytes from the Aedes aegypti and Armigeres subalbatus. Infection and Immunity 72: 4114-4126.
  11. Infanger, L.C., Rocheleau, T., Johnson, J.K., Fuchs, J., Bartholomay, L.C., Higgs, S., Chen, C.C. and B. M. Christensen. 2004. The role of phenyalanine hydroxylase in melanotic encapsulation of filarial worms in two species of mosquitoes. Insect Biochemistry and Molecular Biology 34:1329-1338.
  12. Wang, X., Fuchs, J.F., Infanger, L.C., Rocheleau, T.A., Hillyer, J.F., Chen, C.C. and Christensen, B.M. 2005 Mosquito innate immunity: involvement of ]1,3-glucan recognition protein in melanotic encapsulation immune responses in Armigeres subalbatus. Molecular and Biochemical Parasitology 139:65-73.
  13. Christensen, B.M., Li, J., Chen, C.C. and Nappi, A.J. 2005 Melanization immune responses in mosquito vectors. Trends in Parasitology 21: 192-199.
  14. Huang, C.Y., Chou, S.Y., Bartholomay, L.C., Christensen, B.M. and Chen, C.C.* 2005 The use of gene silencing to study the role of dopa decarboxylase in mosquito melanization reactions. Insect Molecular Biology 14:237-244.
  15. Huang, C.Y., Christensen, B.M. and Chen, C.C.* 2005 Role of dopachrome conversion enzyme in the melanization of filarial worms in mosquitoes. Insect Molecular Biology 14:675-682.