Bing-wen Soong, M.D. & Ph.D.
Curriulum Vitae

國防醫學院 醫學系畢業

M.D., National Defense Medical Center

台北榮民總醫院 神經內科

Resident, Taipei Veterans General Hospital,Taiwan

美國 神經學、醫學遺傳學專科醫師



Diplomate, American Board of Neurology & Psychiatry (Neurology)
Diplomate, American Board of Medical Genetics (Biochemical and Molecular Genetics)



 physician Staff , The Neurological Institute, Taipei Veterans General Hospital,Taiwan

臨床醫學研究所 博士

Ph.D. from National Yang-Ming University School of Medicine,Taipei,Taiwan

醫學系 專任教授

Professor, National Yang-Ming University School of Medicine,Taipei,Taiwan

美國神經學學院 院士

Fellow, American Academy of Neurology


Diplomate,American Board of Pathology and American Board of medical Genetis(Molecular Genetis Pathology)



1. Soong BW, Chia LG, Chu F. Motor neuron disease, a clinical analysis in the Chinese. Chinese Med J 1982;30:231-8.
2. Soong BW, Casamassima AC, Fink JK, Constantopoulos G, Horwitz AL. Multiple sulfatase deficiency. Neurology (Cleveland) 1989;38:1273-5.
3. Fink JK, Filling-Katz MR, Sokol J, Cogan DG, Pikus A, Sonies B, Soong B, Comly ME, Pentchev P, Brady RO, Barton NW. Clinical spectrum of Niemann-Pick disease type C. Neurology 1989;39:1040-9.
4. Watanabe S, Watanabe T, Li WB, Soong BW, Chou JY. Expression of the germ cell alkaline phosphatase gene in human choriocarcinoma cells. J Bio Chem 1989;264:12611-9.
5. Soong BW, Tsai TF, Su TH, Kao KP, Hsiao KJ, Su TS. DNA polymorphism and deletion analysis of Duchenne-Becker muscular dystrophy gene in the Chinese. Am J Med Genet 1991;38:593-600.
6. Soong BW, Lui FM, Chak KF. Characterization of the cea gene of the ColE7 plasmid. Mol Gen Genet 1992;233:177-83.
7. Soong BW, Hsieh SY, Chak KF. Molecular study of the expression of the ColE7 operon. Mol Gen Genet 1994;243:477-81.
8. Soong BW, Wang JT. A comparison of the Huntington's disease associated trinucleotide repeat between Chinese and white populations. J Med Genet 1995;32:404-5.
9. Soong BW, Wang JT. A study on Huntington's disease associated trinucleotide repeat among the Chinese. Proc Natl Sci Council R.O.C.1995;19:137-42.
10. Soong BW, Cheng CH, Liu RS, Shan DE. Machado-Joseph disease: clinical, molecular, and metabolic characterization in Chinese kindreds. Ann Neurol 1997;41:446-52.
11. Chang JG, Jong YJ, Lin SP, Soong BW, Tsai CH, Yang TY, Chang CP, Wang WS. Molecular analysis of SMN gene in spinal muscular atrophy. Hum Genetics 1997;100:577-81.
12. Shan DE, Soong BW, Yeh SI, Cheng CH, Wu ZA. Genetic screening for Huntington's disease in Chinese patients with involuntary movements. Clin Neuro Neurosurg 1997;99:244-7.
13. Soong BW, Lin K.P. Correlation of peripheral nerve fiber loss and trinucleotide repeats in Machado-Joseph disease. Can J Neuro Sci 1998;25:59-63.
14. Soong BW, Liu RS. Positron emission tomography in asymptomatic gene carriers and patients with Machado-Joseph disease. J Neuro Neurosurg Psychiatr 1998;64:499-504.
15. Soong BW, Liu RS. Regional decrease in brain glucose metabolism in asymptomatic gene carriers of Machado-Joseph disease: a preliminary report. Chinese Med J 1998;61:121-6.
16. Soong BW, Lin KP. An electrophysiologic and pathologic study of peripheral nerves in individuals with Machado-Joseph disease. Chinese Med J 1998;61:181-7.
17. Chen HS, Kao KP, Soong BW, Lai TY, Lin HD. Charcot-Marie-Tooth syndrome with hypergonadotropic hypogonadism and hearing loss: a case report. Endocrinol & Diabetol 1998;11:21-6.
18. Wang V, Yeh TP, Chen CM, Yan SH, Soong BW. Usefulness of molecular testing in Huntington's disease. Chinese Med J (Taipei) 1999;62:586-90.
19. Shyu WC, Kao MC, Chou WY, Hsu YD, Soong BW. Heat shock modulates prion protein expression in human NT-2 cells. Neuroreport 2000;11:771-4.
20. Labuda M, Labuda D, Poirier J, Soong, BW, Barucha NE, Pandolfo M. The Friedreich ataxia GAA TTC repeat: an African origin for long normal alleles and an Indo-European origin for expansions? Neurology 2000;54:2322-4.
21. Swoboda KJ, Soong BW, McKenna C, Brunt ERP, Litt M, Bale J, Ashizawa T, Bennett LB, Bowcock AM, Roach ES, Gerson E, Matsuura T, Heydemann PT, Nespeca MP, Jankovic J, Leppert M, and Pta?ek LJ. Paroxysmal Kinesiogenic dyskinesia and infantile convulsions: clinical and linkage data in eleven families. Neurology 2000;55:224-30.
22. Shyu WC, Kao MC, Chou WY, Hsu YD, Soong BW. Creutzfeldt-Jakob disease heat shock protein 70 mRNA levels in mononuclear blood cells and clinical study. J Neurol 2001 in press.
23. Soong BW, Liu RS, Wu LC, Lu YC, Lee HY. Metabolic characterization of spinocerebellar ataxia type 6. Arch Neurol 2001:58: 300-4.
24. Gaspar C, Lopes-Cendes I, Hayes S, Goto J, Arvidssonn K, Dias A, Silveira I, Maciel P, Coutinho P, Lima M, Zhou Y-X.,. Soong B-W, Watanabe M, Giunti P, Stevanin G, Riess O, Sasaki H, Hsieh M, Nicholson GA, Brunt E, Higgins JJ, Lauritzen M, Tranebjaerg L, Volpini V, Wood N, Ranum L, Tsuji S, Brice A, Sequeiros J, Rouleau1GA. Ancestral origins of the Machado-Joseph disease mutation: a worldwide haplotype study. Am J Hum Genet. 2001;68: 523-8.
25.Soong, BW, Lu YC, Choo KB, Lee HY. Frequency analysis of autosomal dominant cerebellar ataxias in Taiwanese patients and clinical and molecular characterization of spinocerebellar ataxia type 6 Arch Neurol 2001:58:1105-9.
26. Lee IH, Soong BW, Lu YC, Chang YC. Dentatorubral-pallidoluysian Atrophy in Chinese. Arch Neurol 2001;58:1905-8.
27. Shan DE, Soong BW, Sun CM, Lee SJ, Liao KK, Liu RS. Spinocerebellar ataxia type 2 presenting as familial levodopa-responsive parkinsonism. Ann Neurol 2001;6:812-5.
28. Lo HS, Hogan EL , Soong BW. 5'-Flanking region polymorphism of the neuronal nitric oxide synthase gene with Parkinson's disease in Taiwan. J Neurol Sci 2002;194:11-4.
29. Soong BW, Chen JT, Lu YC. Prolonged cortical relay reflex and central conduction time in the patients with spinocerebellar ataxia type 6. 2002, submitted.
30. Chung MY, Lin MW, Soong BW. Linkage analysis of a novel spinocerebellar ataxia: SCA22. 2002, submitted.
31. Soong BW. The genetics and clinical features of autosomal dominant cerebellar ataxias: a review. Acta Neurologica Taiwanica 2002;11:49-65.
32. Lin KP, Soong BW. Peripheral neuropathy of Machado-Joseph disease in Taiwan: a morphometric and genetic study. Eur Neurol 2002;48:210-7.
33.  Lee YC, Soong BW, Lin KP, Lee HY, Wu ZA, Kao KP. Myelin protein zero gene mutations in Taiwanese patients with Charcot-Marie-Tooth disease type 1. J Neurol Sci 2003. (in print)
34.  Chung MY, Lu YC, Cheng NC, Soong BW. A novel autosomal dominant spinocerebellar ataxia (SCA22) linked to chromosome 1p21-q23. Brain 2003;126:1293-9.
35.  Chen JT, Lin YY, Lee YC, Wu JA, Soong BW, Liao KK. Prolonged central motor conduction time of lower limb muscles in spinocerebellar ataxia 6. J Clin Neurosci 2003. (in print)
36. Lee YC, Soong BW, Lin KP, Lee HY, Wu ZA, Kao KP. Myelin protein zero gene mutations in Taiwanese patients with Charcot-Marie-Tooth disease type 1. J Neurol Sci 2003. (in print)