Dr. Yi-Ping Hsueh, Assistant Professor

Institute of Molecular Biology, Academia Sinica
Phone: 886-2-2789-9311
E-mail: yph@gate.sinica.edu.tw


1983, B.S.°@ Biology
°@°@°@°@°@°@ National Taiwan Normal University, Taiwan

1995, Ph.D.°@Microbiology and Immunology
°@°@°@°@°@°@ National Yang-Ming Normal University, Taiwan

1995 - 1995°@Postdoctoral Research Fellow
°@°@°@°@°@°@ Institute of Molecular Biology, Academia Sinica, Taiwan

1996 - 2000°@Postdoctoral Research Fellow
°@°@°@°@°@°@ Howard Hughes Medical Institute and Dept. of Neurobiology, Harvard Medical School


°@Molecular roles of postsynaptic protein in neural development, signaling and activity.


1. Lee, M.-R., Chung, C.-S., Liou, M.-L., Wu, M., Li, W.-F., Hsueh, Y.-P., and Lai, M.-Z. (1992). Isolation and characterization of nuclear proteins that bind to T cell receptor VÉ“ decamer motif. J. Immunol. 148: 1906-1912.

2. Hsueh, Y.-P., Yang, Y.-F., Liang, H.-E., Han, S.-H., and Lai, M.-Z. (1995). Limited regulatory effect of T cell receptor-derived peptides. Cell. Immunol. 161: 218-225.

3. Hsueh, Y.-P. and Lai, M.-Z. (1995). Overexpression of activation transcriptional factor-1 in lymphomas and in activated lymphocytes. J. Immunol. 154: 5675-5683.

4. Hsueh, Y.-P. and Lai, M.-Z. (1995). JNK but not MAP kinase is sensitive to cAMP inhibition in T Lymphocytes. J. Biol. Chem. 270: 18094-18098.

5. Hsueh, Y.-P., Liang, H.-E., Ng, S.-Y., and Lai, M.-Z. (1997). CD28-Costimulation activates cyclic AMP-responsive element-binding protein in T lymphocytes. J. Immunol. 158: 85-93.

6. Kim, E., Naisbitt, S., Hsueh, Y.-P., Rao, A., Rothschild, A., Craig, A., Sheng, M. (1997). GKAP, A novel synaptic protein that interacts with the guanylate kinase-like domain of the PSD-95/SAP-97 family of channel clustering molecules. J. Cell Biol. 136: 669-678.

7. Hsueh, Y.-P., Kim, E., and Sheng, M. (1997). Disulfide-linked head-to-head multimerization in the mechanism of ion channel clustering by PSD-95. Neuron 18: 803-814.

8. Hsueh, Y.-P., Yang, F.-C., Kharazia, V., Naisbitt, S., Cohen, J. M., Weinberg, R. J., and Sheng, M. (1998). Direct interaction of CASK/LIN-2 and syndecan heparan sulfate proteoglycan and their overlapping distribution in neuronal synapses. J. Cell Biol. 142:139-151.

9. Liang, H.-E., Hsueh, Y.-P., Wu, C.-C., Hsu, S.-C., Han, S.-H., and Lai, M.-Z. (1998). Atypical signaling defects prevent IL-2 gene expression in lpr/lpr CD4-CD8- cells. J. Biomed. Sci. 5:297-304.

10. Hsueh, Y.-P. and Sheng, M. (1998). Anchoring of glutamate receptors at the synapse. Progress in Brain Research 116: 123-131.

11. Hsueh, Y.-P. and Sheng, M. (1998). Eph receptors, ephrins, and PDZs gather in neuronal synapses. Neuron 21:1227-1229. (Preview).

12. Hsueh, Y.-P. and Sheng, M. (1999). Requirement of N-terminal cysteins of PSD-95 for PSD-95 multimerization and ternary complex formation, but not for binding to potassium channel Kv1.4. J. Biol. Chem. 274: 532-536.

13. Hsueh, Y.-P. and Sheng, M. (1999). Regulated expression and subcellular localization of syndecan heparan sulfate proteoglycans and the syndecan-binding protein CASK/LIN-2 during rat brain development. Journal of Neuroscience 19:7415-7425.

14. Tiffany, A. M., Manganas, L. N., Kim, E., Hsueh, Y.-P., Sheng, M., Trimmer, J. S. (2000). PSD-95 and SAP97 exhibit distinct mechanisms for regulating K(+) channel surface expression and clustering. Journal of Cell Biology 148:147-158.

15. Hsueh, Y.-P., Wang, T.-F., Yang, F.-C., Sheng M. (2000) Nuclear translocation and transcription regulation by the membrane-associated guanylate kinase CASK/LIN-2. Nature 404:298-302.

16. Shin, H., Hsueh, Y.-P., Yang, F.-C., Kim, E., Sheng, M. (2000) An intramolecular interaction between Src homology 3 domain and guanylate kinase-like domain required for channel clustering by postsynaptic density-95/SAP90. Journal of Neuroscience 20:3580-3587.

17. Hevner, R. F., Shi, L., Justice, N., Hsueh, Y.-P. , Sheng, M., Smiga, S., Bulfone, A., Goffinet, A. M., Rubenstein, J. L. R. (2001) Tbr-1 regulates differentiation of the preplate and layer 6. Neuron 29:353-366.

18. *Hsueh, Y.-P., Roberts, A. M., Volta, M., *Sheng, M., and Roberts, R. G. (2001) Bipartite interaction between Neurofibromatosis type I protein (Neurofibromin) and syndecan transmembrane heparan sulfate proteoglycans. J. Neuroscience 21:3764-70. (*co-corresponding authors).

19. Sang, Q., Wu, J., Rao, Y., Hsueh, Y.-P., and Tan, S.-S. (2002) Slit promotes branching and elongation of neuritis of interneurons but not projection neurons from the developing telencephalon. Molecular and Cellular Neuroscience 21:250-265.

20. Wang, G.-S., Hong, C.-J., Yen, T.-Y., Huang, H.-Y., Ou, Y., Huang, T.-N., Jung, W.-G., Kuo, T.-Y., Sheng, M., Wang, T.-F., and Hsueh, Y.-P. (2004) Transcriptional Modification by a CASK interacting nucleosome assembly protein. Neuron 42:113-128.

21. Chen, Y.-K., Leng, C.-H., Olivares, H., Lee, M.-H., Chang, Y.-C., Kung, W.-M., Ti, S.-C., Lo, Y.-H., Wang, A. H.-J., Chang, C.-S., Bishop, D. K., Hsueh, Y.-P. and Wang, T.-F. (2004) Heterodimeric Complexes of Hop2 and Mnd1 Function with Dmc1 to Promote Meiotic Homologous Juxtaposition and Strand-Assimilation. Proc. Natl. Acad. Sci. USA 101:10572-10577.

22. Wang, T.-F., Ding, C.-N., Wang, G.-S., Luo, S.-C., Lin, Y.-L., Ruan, Y., Hevner, R., Rubenstein, J. L. R., Hsueh, Y.-P. (2004) Identification of Tbr-1/CASK complex target genes in neurons. J Neurochemistry 91:1483-1492.

23. Lin C.-W., Huang, T.-N., Wang, G.-S., Kuo, T.-Y., Yen, T.-Y., Hsueh, Y.-P. (2005) Neural activity- and development-dependent expression and distribution of CASK interacting nucleosome assembly protein in mouse brain. J. Comparative Neurology (in press).

24. Lin, Y.-L., Lei, Y.-T., Hong, C.-J., Peng, Y.-H. and Hsueh, Y.-P. Syndecans induces filopodia formation via the neurofibromin and cAMP pathway.(revised).

25. Hong, C.-J. and Hsueh, Y.-P. Analysis of CASK associated proteins in rat brain: a linkage to the AMPA receptor. (submitted).

Members of Laboratory