Dr. Ming-Zong Lai, Professor

Institute of Molecular Biology, Academia Sinica
Phone: 886-2-2789-9236
E-mail: mblai@gate.sinica.edu.tw


1974, B.S.@ Pharmacy
@@@@@@ National Taiwan University

1979, M.S.@ University of Illinois College of Medicine at Chicago, USA

1984, Ph.D.@University of California at San Francisco, USA

1984 - 1988@Postdoc Fellow
@@@@@@ MIT, USA


1. Cross-talk between activation signals and apoptotic signals

2. Mechanism of tolerance induction in T cells

3. Regulation of death receptor apoptotic signal transduction

4. Role of activation signal and apoptotic signal in T cell development


1. Hsu, S.-C., Wu, C.-C., Luh, T.-Y., Chou, C.-K., Han, S.-H., and Lai MZ. (1998) Apoptotic signal of Fas is not mediated by ceramide. Blood 91: 2658-2663.

2. Liang, H.-E., Hsueh, Y.-P., Wu, C.-C., Hsu, S.-C., Han, S.-H., and Lai, M.-Z. (1998) Atypical signaling defects prevent IL-2 gene expression in lpr/lpr CD4-CD8- cells. J. Biomed. Sci. 5: 297-304.

3. Feng, M.-H. L., Chou, D.-L., Liaw, Y.-C., and Lai, M.-Z.* (1998) Conserved T cell receptor Class II MHC contact detected in a T-lymphocyte population. Immunology 95: 185-192.

4. Yeh, J.-H., Hsu, S.-C., Han, S.-H., and Lai, M.-Z.* (1998) Mitogen activated kinase kinase antagonized FADD-mediated apoptosis by induced FLIP expression. J. Exp. Med. 188: 1795-1802.

5. Hong, M., Lai, M.-D., Lin, Y.-S., and Lai, M.-Z.* (1999) Antagonism of p53-mediated apoptosis by mitogenic activation. Cancer Research 59: 2847-2852.

6. Hsu, S.-C., Gavrilin, M., Tsai, M.-H., Han, J., and Lai, M.-Z.* (1999) p38 mitogen activated protein kinase is involved in Fas ligand expression. J. Biol. Chem. 274: 25769-25776.

7. Hsu, S.-C., Gavrilin, M., Lee, H.-H., Wu, C.-C., Han, S.-H., and Lai, M.-Z.* (1999) NF-B-dependent Fas ligand expression. Eur. J. Immunol. 29: 2948-2956.

8. Yu, C.-T., Shih, H.-M., and Lai, M.-Z*. (2001) Multiple signals required for CREB-CBP interaction induced by CD3/CD28 costimulation. J. Immunol. 166: 284-292.

9. Chen, Y., and Lai, M.-Z*. (2001) JNK-induced apoptosis is independent of Fas ligand in Jurkat T cells. J. Biol. Chem. 276: 8350-8357.

10. Yu, C.-T., Feng, M.-H. L., Shih, H.-M., and Lai, M.-Z*. (2002) Increased p300 expression abrogates glucocorticoid receptor-T cell receptor antagonism but does not affect thymocyte positive selection. Mol. Cell. Biol. 22: 4556-4566.

11. Hsu, S.-C., Wu, C.-C., Han, J., and Lai, M.-Z*. (2003) Involvement of p38 mitogen activated protein kinase in different stages of thymocyte development. Blood 101: 970-976.

12. Wang, J.-M., Lai , M.-Z., and Yang-Yen, H.-F*. (2003) IL-3 stimulation of the mcl-1 gene transcription involves activation of the PU.1 transcription factor through a p38 MAPK-dependent pathway. Mol. Cell. Biol. 23: 1896-1909.

13. Lin, D.-Y., Lai , M.-Z., Ann, D. K., and Shih, H.-M*. (2003) Promyelocytic leukemia protein (PML) functions as a glucocorticoid receptor co-activator by sequestering Daxx to the PML oncogenic domains (PODs) to enhance its transactivation potential. J. Biol. Chem. 278: 15958-15965.

14. Wu, C.-C., Hsu, S.-C., Shih, H.-M., and Lai, M.-Z*. (2003) NFATc is a target of p38 mitogen activated protein kinase in T cells. Mol. Cell. Biol. 23: 6442-6454.

15. Huang, H.-L., Fang, L.-W., Lu, S.-P., Chou, C.-K., Luh, T.-Y., and Lai, M.-Z*. (2003) DNA-damaging reagents induce apoptosis through reactive oxygen species-dependent Fas aggregation. Oncogene 22: 8168-8177.

16. Tai, T.-S., Fang, L.-W., and Lai, M.-Z*. (2004) c-FLICE inhibitory protein expression inhibits T cell activation. Cell Death Diff. 11: 69-79.

17. Fang, L.-W., Tai, T.-S., Yu, W.-N., Liao, F., and Lai, M.-Z*. (2004) Phosphatidylinositide 3-kinase priming couples c-FLIP to T cell activation. J. Biol. Chem. 279: 13-18.

18. Wu, Y.-Y., Chang, Y.-C., Hsu, T.-L., Hsieh, S.-L., and Lai, M.-Z*. (2004) Sensitization of cells to TRAIL-induced apoptosis by decoy receptor 3. J. Biol. Chem. 279: 44211-44218.

19. Liu, W.-H., and Lai, M.-Z*. (2005) Deltex regulates T cell activation by targeted degradation of active MEKK1. Mol. Cell. Biol. 25: 1367-1378.

Members of Laboratory