Institute of Genetics, National Yang Ming University


Ting-Fen Tsai, Adjunct Assistant Professor

蔡亭芬 副教授

Ph.D. Graduate Institute of Microbiology and Immunology, National Yang-Ming University, Taipei, Taiwan



Telephone: (02) 2826-7293

Fax: (02)2820-2449




Teaching specialities

Research specialities:

Mouse Genetics

Knockout and Transgenic Mice

Some recent publications

   Jiang, Y.-h, T. F. Tsai, J. Bressler, and A. L. Beaudet. Imprinting in Angelman and Prader-Willi syndromes. Curr. Opin. Genet. Dev. 8: 334-342 (1998). SCI

   Tsai, T. F., M. J. Wu, and T. S. Su. The usage of cryptic splice sites in citrullinemia fibroblast suggests a role of polyadenylation in splice site selection during terminal exon definition. DNACell Biol. 17: 717-725 (1998). SCI

   Tsai, T. F., A. Raas-Rothschild, Z. Ben-Neriah, and A. L. Beaudet. Prenatal diagnosis and carrier detection for a point mutation in UBE3A causing Angelman syndrome. Am. J. Hum. Genet. 63:1561-1563 (1998). SCI

   Fang, P., E. Lev-Lehman, T. F. TsaL T. Matsuura, C. S. Benton, J. S. Sutcliff, S. L. Christian, T. Kubota, D. J. Halley, H. Meijers-Heijboer, S. Langlois, J. M. Graham, Jr., J. Beuten, P. J. Willems, D. H. Ledbetter, and A. L. Beaudet. The spectrum of mutations in UBE3A causing Angelman syndrome. Hum. Mol. Genet. 8: 129-135 (1999). SCI

   Tsai, T. F., D. Armstrong, and A. L. Beaudet. Necdin deficient mice do not show lethality or the obesity and infertility ofPrader-Willi syndrome. Nature Genet. 22: 15- 16 (1999). SCI

   Jiang, Y.-h., E. Lev-Lehman , J. Bressler, T. F. Tsai, and A. L. Beaudet. Genetics of Angelman syndrome. Am. J. Hum. Genet. 65: 1-6 (1999). SCI

   Tsai, T. F., Y.-h. Jiang, Jan Bressler, D. Armstrong, and A. L. Beaudet. Paternal deletion from Snrpn to Ube3a in the mouse causes hypotonia, growth-retardation and partial lethality and provides evidence for a gene contributing to Prader-Willi syndrome. Hum. Mol. Genet. 8: 1357-1364 (1999). SCI

   Chao, H. K., T. F. Tsai. C. S. Lin, and T. S. Su. Evidence that mutational activation of the ras genes may not be involved in aflatoxin B I-induced human hepatocarcinogenesis, based on sequence analysis of the ras and p53 genes. Mol. Carcinog. 26: 69-73 (1999). SCI

   Tsai, T. F., and A. L. Beaudet. Development of a strategy to screen for mutations and drugs affecting gene expression in mouse and its application to genomic imprinting. Submitted.


    J. Bressler, T. F. Tsai, M. Y. Wu, M. Ramirez, D. Armstrong, and A. L. Beaudet. The SNRPN promoter is not required for genomic imprinting in the Prader-Willi/Angelman domain. Submitted.

    T. F. Tsai, J. Bressler, Y. H. Jiang and A. L. Beaudet. Gene targeting for 5’ Snrpn yields exclusively paternal recombinants and causes demethylation and gene activation in trans. In preparation.