Tseng H-C, Chen CW (1991) A cloned ompR-like gene of Streptomyces lividans 66 suppresses defective melC1, a putative copper-transfer gene. Molecular Microbiology 5: 1187-1196.
Chen CW, Yu T-W,
Chung H-M, Chou CF (1992) Discovery and characterization of a new
transposable element, Tn4811, in Streptomyces
lividans 66. Journal of Bacteriology 174: 7762-7769. [Abstract]
Chou C-F, Chen CW
(1992) argJ mutations are highly inducible by
ethidium bromide in proB strains of Streptomyces
lividans: Implication of pathway interactions. Biochemical
Biophysical Research Communications 189: 1101-1109.
Yu T-W, Chen CW
(1993) The unstable melC operon of Streptomyces
antibioticus is co-deleted with a Tn4811-homologous
locus. Journal of Bacteriology 175: 1847-1852.
Chen CW, Yu TW, Lin
Y-S, Kieser HM, Hopwood DA. (1993) The conjugative plasmid SLP2 of
Streptomyces lividans is a 50-kb linear DNA
molecule. Molecular Microbiology 7: 925-932.
Lin Y-S, Kieser HM, Hopwood DA, Chen
CW (1993) The chromosomal DNA of Streptomyces
lividans 66 is linear. Molecular Microbiolog 10: 923-933.
Chen CW, Lin Y-S,
Yang Y-L, Tsou M-F, Chang H-M, Kieser HM, Hopwood DA (1994) The linear
chromosomes of Streptomyces: structure and
dynamics. Actinomycetologica 8: 103-112.
Chen CW (1995) The
unstable end of the Streptomyces linear
chromosomes: A nuisance without cures? Trends in Biotechnology
13:157-160. [Manuscript]
Lee L-F, Huang Y-J, Chen CW
(1996) Isolation and characterization of two classes of ethidium
bromide-resistant mutants of Streptomyces lividans
66. Microbiology 140: 1041-1047.
Chen CW (1996) Complications and implications of
linear bacterial chromosomes. Trends
in Genetics 12: 192-196. [Manuscript]
Chang H-M, Shieh Y-T, Chen M-Y, Bibb MJ, Chen
CW (1966) The cutRS signal
transduction system of Streptomyces lividans represses
the biosynthesis of a polyketide antibiotic actinorhodin. Molecular
Microbiology 21: 1075-1085. [Abstract]
Lin Y-S, Chen CW
(1997) Instability of artificailly circularised chromosomes of Streptomyces
lividans. Molecular Microbiology 26: 709-719 [Abstract]
Chen CW (1997)
Threads of evidence - On the trail to linear bacterial chromosomes. SAJ
News. 1-29 [Read the manuscript]
Huang C-H, Chen CW
(1998) The telomeres of Streptomyces chromosomes
contain conserved palindromic sequences with potential to form complex
secondary structures. Molecular Microbiology 28: 905-916. [Abstract]
Lee L-F, Chen CW
(1998) Multidrug resistance gene in Streptomyces. Actinomycetologica 12: 148-152
Wang S-J, Chang H-M, Lin Y-S, Huang C-H, Chen
CW (1999) Streptomyces genomes:
Circular genetic maps from the linear chromosomes. Microbiology145:
2209-2220 [Read the manuscript]
Bey S-J, Tsou M-F, Huang C-H, Yang C-C, Chen
CW (2000) The homologous terminal sequence of the Streptomyces
lividans chromosome and SLP2 plasmid. Microbiology 146:
911-922 [Abstract]
Lee LF, Yeh SH, Chen CW.
(2001) Construction and synchronization of dnaA
temperature-sensitive mutants of Streptomyces.Journal
of Bacteriology 184:1214-1218. [PubMed]
Yang CC, Huang CH, Li CY, Tsay YG, Lee SC, Chen
CW. (2002) The terminal proteins of linear Streptomyces
chromosomes and plasmids: a novel class of replication priming
proteins. (2002) Molecular Microbiology 43 :297-305. [PubMed]
Bentley SD, Chater KF, Cerdeno-Tarraga AM,
Challis GL, Thomson NR, James KD, Harris DE, Quail MA, Kieser H, Harper
D, Bateman A, Brown S, Chandra G, Chen CW,
Collins M, Cronin A, Fraser A, Goble A, Hidalgo J, Hornsby T, Howarth
S, Huang CH, Kieser T, Larke L, Murphy L, Oliver K, O'Neil S,
Rabbinowitsch E, Rajandream MA, Rutherford K, Rutter S, Seeger K,
Saunders D, Sharp S, Squares R, Squares S, Taylor K, Warren T,
Wietzorrek A, Woodward J, Barrell BG, Parkhill J, Hopwood DA.(2002)
Complete genome sequence of the model actinomycete Streptomyces
coelicolor A3(2). Nature 417:141-147.[PubMed]
Lee, L.F.,
Yeh, S.H., and Chen
CW. (2002)
Construction and synchronization of
dnaA temperature-sensitive mutants of Streptomyces. J Bacteriol 184:
1214-1218. [PubMed]
Yang, C.-C., Huang,
C.-H., Li, C.-Y., Tsay, Y.-G., Lee, S.-C., and Chen
CW. (2002)
The
terminal proteins of linear Streptomyces chromosomes and plasmids: A
novel class of replication priming proteins. Mol Microbiol 43:
297-305. [PubMed]
Huang,
C.H., Chen, C.Y., Tsai, H.H., Chen, C., Lin, Y.S., and Chen
CW.
(2003) Linear plasmid SLP2 of Streptomyces lividans is a composite
replicon. Mol Microbiol 47: 1563-1576.[PubMed]
Lee, L.F., Huang,
Y.J., and Chen
CW. (2003)
Repressed multidrug resistance genes in
Streptomyces lividans. Arch Microbiol 180: 176-184. [PubMed]
Bentley, S.D., Brown, S., Murphy, L.D., Harris,
D.E., Quail, M.A., Parkhill, J., Barrell, B.G., McCormick, J.R.,
Santamaria, R.I., Losick, R., Yamasaki, M., Kinashi, H., Chen
CW.,
Chandra, G., Jakimowicz, D., Kieser, H.M., Kieser, T., and Chater, K.F.
(2004) SCP1, a 356,023 base pair linear plasmid adapted to the ecology
and developmental biology of its host, Streptomyces coelicolor A3(2).
Mol Microbiol 51: 1615-1628.[PubMed]
Weaver, D., Karoonuthaisiri, N., Tsai, H.H.,
Huang, C.H., Ho, M.L., Gai, S., Patel, K.G., Huang, J., Cohen, S.N.,
Hopwood, D.A., Chen
CW., and
Kao, C.M. (2004) Genome plasticity in Streptomyces: Identification of 1
Mb TIRs in the S. coelicolor A3(2) chromosome. Mol Microbiol 51:
1530-1550. [PubMed]
Chaconas, G., and Chen
CW. (2005)
Linear chromosomes in bacteria: no longer going around in circles. In
The Bacterial Chromosome. Higgins, N.P. (ed). Washington, D. C.:
American Society for Microbiology, pp. 525-539.
Huang, T.W., and Chen
CW. (2006)
A recA null mutation may be generated in Streptomyces coelicolor. J
Bacteriol 188: 6771-6779.[PubMed]
Tseng, S.F., Huang, T.W.,Chen
CW.,
Chern, M.K., Tam, M.F., and Teng, S.C. (2006) ShyA, a membrane protein
for proper septation of hyphae in Streptomyces. Biochem Biophys Res
Commun 343: 369-377. [PubMed]
Yang, C.-C., Chen, Y.-H., Tsai, H.-H., Huang,
C.-H., Huang, T.W., andChen
CW. (2006)
In vitro deoxynucleotidylation of terminal prortein of Streptomyces
linear chromosomes. Applied and Environmental Microbiology, Dec. 2006,
p.7959-7961. [PubMed]
Huang C.-H., Tsai, H.-H., Tsay, Y.-G., Chien,
Y.-N., Wang, S.-L., Cheng, M.-Y., Ke, C.-H., Chen
CW. (2007)
The telomere system of the Streptomyces linear plasmid SCP1 represents
a novel class. Mol. Microbioi. 63: 1710-1718. [PubMed]
Lee, L.-L., Chen, Y.-J., Kirby, R., Chen,
C., Chen
CW. (2007)
A multidrug efflux system is involved in colony growth in Streptomyces
lividans. Microbiol. 153: 924–934.[PubMed]
Chi Chen, Chen
CW. (2007)
Quantitative analysis of mutation and selection pressures on base
composition skews in bacterial chromosomes. BMC Genomics. 8:286[PubMed]
Tzu-Wen Huang, Chen
CW. (2008)
DNA Polymerase I Is Not Required for Replication of LinearChromosomes
in Streptomyces. Journal of bacteriology 190:755-758.[PubMed]
Tsai, H.-H., Huang, C.-H., Lin, A. M.,Chen
CW. (2008)
Terminal proteins of Streptomyces chromosome can target DNA into
eukaryotic nuclei. Nucleic Acid Res. In press.