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細菌遺傳學

Bacterial Genetics


八十七年第二學期(二學分)

星期二下午 1:30 -4:30 pm

遺傳所教室


Organizers:

陳文盛

(Phone: extension 7040; email: cwchen@ym.edu.tw)

劉世東

(Phone: 03-328-0292; email: cgliu@cguaplo.cgu.edu.tw)

Textbooks:

  • Primary Textbook: Discovering Molecular Genetics: A Case Study Course with Problems and Scenarios (by Jeffrey H. Miller; Cold Spring Harbor Laboratory Press)

    This book is the syllabus for an innovative and imaginative course in molecular genetics given by the author at UCLA for the past seven years.

  • Supplementary textbook: The Power of Bacterial Genetics: A literature-based course (by J. Beckwith and T. J. Silhavy; Cold Spring Harbor Laboratory Press)

    This book evloved out of courses that the authors teaches at Harvard and Princeton. A few of the papers to be discussed will be taken from this book.

    Both books may be purchased directly from CSHL Press

Schedule:

Unit

Date

Concept

Literature

Instructor

1

2/24

Introduction

陳文盛

2

3/3

Mutations in Bacteria*

Luria and Delbruck*

陳文盛

3

3/10

Fine Structure of the Gene

Benzer (1961, 1959)

陳文盛

4

3/17

The Nature of the Genetic Code

Crick et al. (1961); Gamow (1954); Brenner (1957); Crick et al. (1957); Brenner et al.(1961)

陳文盛

5

3/24

Decoding the amber and ochre Triplets

Brenner et al. (1965)

陳文盛

6

3/31

Suppressor*

To be decided*

陳文盛

7

4/8

The Search for Colinearity

Yanofsky et al. (1964, 1967); Sarabhai et al. (1964)

陳文盛

8

4/14

Conjugation and Genetic Recombination

Wollman et al. (1956); Hayes (1952, 1953)

王子堅

9

4/21

Genetic Recombination*

To be decided*

王子堅

10

4/28

In Vivo Genetic Engineering (Transduction)

Beckwith and Signer (1966); Beckwith et al. (1966); Shimada et al. (1972)

王子堅

11

5/5

Site-Directed Recombination*

To be decided*

王子堅

12

5/12

Genetic Regulatory Mechanisms (I)

Jacob and Monod (1961)

劉世東

13

5/19

Genetic Regulatory Mechanisms (I)*

To be decided

劉世東

14

5/26

Mutagenesis

Farabaugh et al. (1978); Albertini et al. (1982); Prakash and Sherman (1973); Ames et al. (1973); McCann et al. (1975); Coulondre and Miller (1977); Coulondre et al. (1978); Cupples and Miller (1989); Nghiem et al. (1988); Michaels et al. (1992)

劉世東

15

6/2

Plasmids (I)*

To be decided*

劉世東

16

6/9

Transposable Elements (I)

Hedges and Jacob (1974 ); Kleckner et al. (1975 ); Heffron et al. (1979); Bender and Kleckner (1986 ); Boeke et al. (1985 ); Shapiro (1979); Ljungquist and Bukhari (1977); Faelen and Toussaint (1976)

劉世東

17

6/16

Transposable Elements (II)

Continued

劉世東

* Papers will be taken form the supplementary textbook or elsewhere.


Useful reference books

These books provides additional materials for various parts of the course

  • The Genetics of Bacteria and their viruses (W. Hayes, 1970)
    A very extensive account of the early E. coli genetics
  • The Eighth Day of Creation (H. F. Judson, 1979)
    A detailed history account of the early period of molecular biology
    Read specific part for interesting behind-the-scene stories.
  • A short course in Bacterial Genetics (J. Miller, 1992) - two volumes
    • Laboratory manual - useful for looking up experimental procedures
    • Handbook - containing essential reference materials for E. coli genetics.
  • Escherichia coli and Salmonella: cellular and molecular biology (2nd ed. ASM Press, Neidhardt et al. 1996)
    Updated references to genetics and physiology of these two bugs


Some interesting related web sites:


How the course will be taught (or how the students will learn)"

  • Students are to study the papers beforehand, and discuss them in class.
  • The students will be divided into groups. Members of each groups will work together in studying the papers and working on the assignments.

What we ask of the students

  • The presenting group should study the papers very critically and understand them as much as possible. Look up and read the necessary references and try to work out problems among the group before bringing up to the instructors.
  • The non-presenting groups should also read the papers thoroughly. Bring all your questions to the class.
  • Everyone should consult textbooks for basic knowledge. Know the current status of the topics addressed by the classic papers.
  • Everybody should actively participate in the discussion. Both your performance in the classroom and homework will be evaluated.