Jaulang Hwang 

PhD. Biochem., University of Michigan

  1. Cellular regulation of human DNA topoisomerase.

  2. Selection and characterization of the DNA topoisomerases mutant cells.

  3. Structure and function relationship of Pseudomonas exotoxin A.

  4. Developing therapeutic vaccine.

  1. Chang, Y.-H., Hwang, J., Shang, H.-F., and Tsai, S.-T. (1996) Characterization of human DNA topoisomerase II as an autoantigen recognized by patients with IDDM. Diabetes 45, 408-414. 

  2. Shang, H.-F., Yeh, M.-L., Lin, C.-P., Hwang, J. (1996) Characterization of monoclonal antibody B7, which neutralizes the cytotoxicity of Pseudomonas aeruginosa exotoxin A. Clin-Diagn-Lab-Immunol. 3, 727-32. 

  3. Wang, L.-F., Ting, C.-Y., Lo, C.-K., Su, J.-S., Mickley, L.A., Fojo, A.T., Whang-Peng, J., and Hwang, J. (1997) Identification of mutations at DNA topoisomerase I responsible for Camptothecin resistance. Cancer Res. 57, 1516-1522. 

  4. Chen, T.-Y., Lin, C.-P., Loa, C.-C., Chen, T.-L., Shang, H.-F., and Hwang, J. (1999) A Nontoxic Pseudomonas Exotoxin A Induces Active Immunity and Passively Protective Antibody Against Pseudomonas Exotoxin A Intoxication. J. Biomed. Sci. 6, 357-363. 

  5. Chen, T.-Y., Shang, H.-F., Chen, T.-L., Lin, C.-P., Hui, C.-F., and Hwang, J. (1999) Recombinant Protein Composed of Pseudomonas aeruginosa Exotoxin A, Outer Menbrane Protein I and F as Vaccine against P. aeruginosa Infection. Appl. Micro.Biotech. 52, 524-533. 

  6. Chen, H.-J., Hwang, J. (1999) Binding of ATP to human DNA Topoisomerase I resulting in an alteration of Conformation of the Enzyme. Euro. J. Biol. 265, 367-375. 

  7. Chen, H.-J., Hwong, C.-L., Wang, C.-H., and Hwang, J. (2000) Degradation of DNA topoisomerase I by a novel trypsin-like serine protease in proliferating human T lymphocyte. J. Biol. Chem. 275, 13109-13117.
  8. Hsu, C.-T., Ting, C.-Y., Ting, C.-J., Chen, T.-Y., Lin, C.-P., Whang-Peng, J., and Hwang, J. (2000) Vaccination against GnRH using toxin receptor binding domain-conjugated GnRH repeats. Cancer Research. 60, 3701-3705.
  9. Lai, S.-L., Whang-Peng, J., Perng, R,-P., Hwang, J. (2000) Enhancement of Chemosensitivity in Lung Cancer Cells by Reconstitution of Wild-type p53 Gene. J. Biomed. Sci. 7, 64-70. 

  10. Mao Y, Desai S, Ting CY, Hwang, J., and Liu, L.F. (2001) 26S Proteasome-mediated Degradation of Topoisomerase II Cleavable Complexes. J. Biol. Chem. 276, 40652-40658.
  11. Hsu, C-T, Ting, C-Y and Hwang, J. (2003) Toxin in the development of vaccines. In: Chimeric Toxins: Mechanisms of Action and Therapeutic Application. pp.247-260. Academic Publishers. (book review).
  12. Xiao, H., Mao, Y., Deasi, SD., Zhou, N., Ting, C.-Y., Hwang, J., and Liu, L.F. (2003) The Topoisomerase IIβ Circular Clamp Arrests Transcription and Signals a 26S Proteasome Pathway. Proc. Natl. Acad. Sci. USA. 100, 3239-3244.
  13. Ting CY, Hsu CT, Hsu HT, Su JS, Chen TY, Tarn WY, Kuo YH, Whang-Peng J, Liu LF, and Hwang, J. (2003) Isodiospyrin as a novel human DNA topoisomerase I inhibitor. Biochem Pharmacol. 66, 1981-1991.