Chen-Kung Chou

PhD. Molecular Biology, The Albert Einstein College of Medicine


  1. Molecular mechanism of insulin action.
  2. Growth control and signal transduction pathway on human hepatoma cells.

publication  (2001-2005) :

  1. Liu MA, Huang AM, Chou CK, Liaw GJ, Wu CW.(2001)  Utilization of Drosophila eye to probe the functions of two mammalian serine/threonine kinases, Snk and HsHPK. J Biomed Sci. 8:270-7.

  2. Tsao N, Luh TY, Chou CK, Wu JJ, Lin YS, Lei HY. (2001)   Inhibition of group A streptococcus infection by carboxyfullerene. Antimicrob Agents Chemother. 45: 1788-93.

  3. Tu LC, Chou CK, Chen HC, Yeh SF.(2001)   Protein kinase C-mediated tyrosine phosphorylation of paxillin and focal adhesion kinase requires cytoskeletal integrity and is uncoupled to mitogen-activated protein kinase activation in human hepatoma cells. J Biomed Sci. 8:184-90.

  4. Lin AM, Fang SF, Lin SZ, Chou CK, Luh TY, Ho LT. (2002)  Local carboxyfullerene protects cortical infarction in rat brain. Neurosci Res. 43:317-21.

  5. Tsao N, Luh TY, Chou CK, Chang TY, Wu JJ, Liu CC, Lei HY.(2002)     In vitro action of carboxyfullerene. J Antimicrob Chemother. 49:641-9. 

  6. Chiu AW, Huang YL, Huan SK, Wang YC, Ju JP, Chen MF, Chou CK. (2002)   Potential molecular marker for detecting transitional cell carcinoma. Urology. 60:181-5.

  7. Tsou AP, Yang CW, Huang CY, Yu CT, Lee YC, Chang CW, Chen BR, Chung YF, Fann MJ, Chi CW, Chiu JH, Chou CK. (2003)  Identification of a novel cell cycle regulated gene, HURP, overexpressed in human hepatocellular carcinoma. Oncogene. 22: 298-307. 

  8. Chien CY, Liu WK, Chou CK, Su JY. (2003)   The A20-binding protein ABIN-2 exerts unexpected function in mediating transcriptional coactivation. FEBS Lett. 543:55-60.

  9. Liu WK, Chien CY, Chou CK, Su JY.(2003)   An LKB1-Interacting Protein Negatively Regulates TNFalpha-Induced NF-kappaB Activation. J Biomed Sci. 10: 242-52.

  10. Tsou AP, Chuang YC, Su JY, Yang CW, Liao YL, Liu WK, Chiu JH, Chou CK. (2003)   Overexpression of a novel imprinted gene, PEG10, in human hepatocellular carcinoma and in regenerating mouse livers. J Biomed Sci. 10:625-35.

  11. Lin YL, Shiao MS, Mettling C, Chou CK. (2003)  Cholesterol requirement of hepatitis B surface antigen (HBsAg) secretion. Virology. 314:253-60.

  12. Huang HL, Fang LW, Lu SP, Chou CK, Luh TY, Lai MZ. (2003)   DNA-damaging reagents induce apoptosis through reactive oxygen species-dependent Fas aggregation. Oncogene. 22:8168-77.

  13. Lee CH, Ni YH, Chen CC, Chou CK, Chang FH. (2003)  Synergistic effect of polyethylenimine and cationic liposomes in nucleic acid delivery to human cancer cells. Biochim Biophys Acta. 1611:55-62.

  14. Liu WK, Yen PF, Chien CY, Fann MJ, Su JY, Chou CK. (2004)   The inhibitor ABIN-2 disrupts the interaction of receptor-interacting protein with the kinase subunit IKKγ to block activation of the transcription factor NF-κB and potentiate apoptosis. Biochem. J. 378:867-76

  15. Wang YH, Lee EJ, Wu CM, Luh TY, Chou CK, Lei HY. (2004)   Inhibition of middle cerebral artery occlusion-induced focal cerebral ischemia by carboxyfullerene.

    J. Drug Del. Sci. Tech. 14:45-9.

  16. Tu LC, Chou CK, Chen CY, Chang YT, Shen YC, Yeh SF. (2004)  Characterization of the cytotoxic mechanism of Mana-Hox, an analog of manzamine alkaloids. Biochim Biophys Acta. 1672:148-56.

  17. Wang JY, Chiu JH, Tsai TH, Tsou AP, Hu CP, Chi CW, Yeh SF, Lui WY, Wu CW, Chou CK. (2005)   Gene expression profiling predicts liver responses to a herbal remedy after partial hepatectomy in mice.  Int J Mol Med.  Aug;16(2):221-31.

  18. Li Y, Fu L, Yeo H, Zhu JL, Chou CK, Kou YH, Yeh SF, Gullen E, Austin D, Cheng YC. (2005)   Inhibition of hepatitis B virus gene expression and replication by helioxanthin and its derivative. Antivir Chem Chemother.  16(3):193-201.

  19. Yu CT, Hsu JM, Lee YC, Tsou AP, Chou CK, Huang CY. Phosphorylation and stabilization of HURP by Aurora-A: implication of HURP as a transforming target of Aurora-A. (2005)   Mol Cell Biol.  Jul;25(14):5789-800.

  20. Yang CW, Su JY, Tsou AP, Chau GY, Liu HL, Chen CH, Chien CY, Chou CK. (2005)    Integrative genomics based identification of potential human hepatocarcinogenesis-associated cell cycle regulators: RHAMM as an example. Biochem Biophys Res Commun.  May 6;330(2):489-97.

  21. Wu JC, Chen TY, Yu CT, Tsai SJ, Hsu JM, Tang MJ, Chou CK, Lin WJ, Yuan CJ, Huang CY. (2005)    Identification of V23RalA-Ser194 as a critical mediator for Aurora-A-induced cellular motility and transformation by small pool expression screening. J Biol Chem.  Mar 11;280(10):9013-22.

  22. Yang CW, Hsiao CF, Chou CK. (2005)     Evaluation of experimental designs for two-color cDNA microarrays. J Comput Biol. 2005 Nov;12(9):1202-20.