|
Publications
| 86.) |
W. B. Fischer (Editorial)
Where is Computational Bioanalysis?
J. Bioanal. Biomed. (2012) in print |
| 85.) |
K. Wang, W. Lu, J. Chen, S. Xie, H. Shi, H. Hsu, W. Yu, K. Xu, C. Bian, W. B.
Fischer, W. Schwarz, L. Feng, B. Sun;
PEDV ORF3 encodes an ion channel protein and regulates virus production.
FEBS Lett. (2012) 586, 384-391 |
| 84.) |
G.-S. Hong, C.-P. Chen, M.-H. Lin, J. Krüger, C. F. W. Becker, R. H. A. Fink and W.
B. Fischer;
Molecular dynamics simulations and conductance studies of the interaction of VP1 from
Polio virus and gp41 fusion peptide from HIV-1 with lipid membranes.
Mol. Membr. Biol. (2012) 29, 9-25 |
| 83.) |
W. B. Fischer, Y.-T. Wang, C. Schindler, C.-P. Chen;
Mechanism of Function of Viral Channel Proteins and implications for drug development.
Int. Rev. Cell Mol. Biol. (2012) 294, 259-321 |
| 82.) |
H.-J. Hsu, W. B. Fischer;
In silico investigations of possible routes of assembly of ORF 3a from SARS-CoV.
J. Mol. Mod. (2011) 18, 501-514 |
| 81.) |
C.-P. Chen, A. Ganguly, C.-Y. Lu, T.-Y. Chen, C.-C. Kuo, R.-S. Chen, W.-H. Tu, W. B. Fischer, K.-H. Chen, L.-C. Chen;
Ultra-sensitive in situ Label-free DNA Detection using GaN Nanowires-based Extended-Gate
Field-Effect-Transistor Sensor.
Analyt. Chem. (2011) 83, 1938-1943 (PDF) |
| 80.) |
M. Skasko, A. Tokarev, C.-C. Chen, W. B. Fischer, S. K. Pillai, J. Guatelli;
BST-2 is rapidly down-regulated from the cell surface by the HIV-1 protein Vpu: evidence for a post-ER mechanism of Vpu-action.
Virology (2011) 411, 65-77 |
| 79.) |
W. B. Fischer, H.-J. Hsu;
From sequence to structure to mechanism – viral channel proteins.
In Sequence and Genome Analysis: Methods and Applications II.; Ed. G. Fung;
i-Concept Books (2011) Chap. 6 (link) |
| 78.) |
W. B. Fischer (Guest-Editor, Special Issue)
Viral Ion Channels
Biochim. Biophys. Acta (2011) 1808, 509-588 (link) |
| 77.) |
W. B. Fischer (Guest-Editor)
Introduction to the Special Issue on viral channel forming proteins.
Biochim. Biophys. Acta (2011) 1808, 509 |
| 76.) |
C.-C. Chen, J. Krüger, I. Sramala, H.-J. Hsu,
P. Henklein, Y.-M. A. Chen, W. B. Fischer;
ORF 8a of SARS-CoV forms an ion channel: experiments and molecular dynamics simulations.
Biochim. Biophys. Acta (2011) 1808, 572-579 (PDF) |
| 75.) |
W. B. Fischer and H.-J. Hsu;
Viral channel forming proteins – modelling the target.
Biochim. Biophys. Acta (2011) 1808, 561-571 |
| 74.) |
G. Patargias, G. Ewart, C. Luscombe, W. B. Fischer;
Ligand-protein docking studies of potential HIV-1 drug compounds using the algorithm FlexX.
Anal. Bioanal. Chem. (2010) 396, 2559-2563 |
| 73.) |
W. B. Fischer (Guest-Editor, Special Issue)
Viral Membrane Proteins Meeting held in Heidelberg, December 2008
Eur. Biophys. J. (2010) 39, 1041-1104 (link) |
| 72.) |
W. B. Fischer, G. Thiel, R. H. A. Fink;
Viral membrane proteins.
Eur. Biophys. J. (2010) 39, 1041-1042 |
| 71.) |
C.-P. Chen, C. Kremer, P. Henklein, U. Schubert, R. H. A. Fink, W. B. Fischer;
Modulating the activity of the channel forming segment of Vpr protein from HIV-1.
Eur. Biophys. J. (2010), 39, 1089-1095 |
| 70.) |
J. Krüger, W. B. Fischer;
Structural implications of mutations assessed by molecular dynamics: Vpu1-32 from HIV-1.
Eur. Biophys. J. (2010), 39, 1069-1077 |
| 69.) |
J. Krüger, W. B. Fischer;
Assembly of viral membrane proteins.
J. Chem. Theory Comput. (2009) 5, 2503-2513 (PDF) |
| 68.) |
G. Patargias, T. Barke, A. Watts, W. B. Fischer;
Model generation of viral channel forming 2B protein bundles from polio and coxsackie
viruses.
Mol. Membr. Biol. (2009) 26, 1-13 |
| 67.) |
G. Patargias, H. Martay, W. B. Fischer;
Reconstructing potentials of mean force from short steered molecular dynamics simulations of Vpu from HIV-1.
J. Biomol. Struc. Dyn. (2009) 26, 1-12 (PDF) |
| 66.) |
K. Tiewsiri, W. B. Fischer, C. Angsuthanasombat;
Lipid-induced conformation of helix 7 from the pore-forming domain
of the Bacillus thuringiensis Cry4Ba toxin: implications for the toxicity
mechanism
Arch. Biochem. Biophys. (2009) 482, 17-24 (PDF) |
| 65.) |
W. B. Fischer, J. Krüger;
Viral channel forming proteins.
Int. Rev. Cell Mol. Biol. (2009) 275, 35-63 |
| 64.) |
G. Patargias, H. Martay, J. Krüger, C.-P. Chen, Y.-T. Wang, M.-D. Lee,
C.-C. Chen, G.-S. Hong, W. B. Fischer;
Short membrane proteins from viruses: channel-pore dualism?
Proceedings From Computational Biophysics to
Systems Biology 2008, Jülich, D. (PDF) |
| 63.) |
J. Krüger, W. B. Fischer;
Viral membrane proteins: flexibility and assembly.
Proceedings From Computational Biophysics to
Systems Biology 2008, Jülich, D. (PDF) |
| 62.) |
J. Krüger, W. B. Fischer;
Exploring the conformational space of Vpu from HIV-1: a versatile
adaptable protein.
J. Comput. Chem. (2008) 29,
2416-2424 (PDF) |
| 61.) |
T. Mehnert, A. Routh, P. J. Judge, Y. M. Lam, D. Fischer, A. Watts, W.
B. Fischer;
Biophysical characterisation of Vpu from HIV-1 suggests a channel-pore
dualism.
Proteins (2008) 70, 1488-1497 (PDF) |
| 60.) |
J. Krüger, G. Patargias, H. Martay, T. Mehnert, A. Routh, P. J. Judge,
Y. H. Lam, D. Fischer, A. Watts, W. B. Fischer;
Self- Assembly of viral ion channel forming proteins.
Proceedings of the IX. Linz Winter Workshop 2007,
(2008) 31-35,
TRAUNER Druck, Linz, AT ISBN 978-3-85499-400-8 (PDF) |
| 59.) |
T. Mehnert, Y. H. Lam, P. J. Judge, A. Routh, D. Fischer, A. Watts, W.
B. Fischer;
Towards a mechanism of function of the viral ion channel Vpu from HIV-1.
J. Biomol. Struc. Dyn. (2007) 24,
589-596 (PDF) |
| 58.) |
C. G. Kim, V. Lemaitre, A. Watts, W. B. Fischer;
Drug-protein interaction with Vpu from HIV-1: proposing binding sites
for amiloride and one of its derivatives.
Anal. Bioanal. Chem. (2006) 386,
2213-2217 |
| 57.) |
V. Lemaitre, D. Willbold, A. Watts, W. B. Fischer;
Full length Vpu from HIV-1: combining molecular dynamics simulations
with NMR spectroscopy.
J. Biomol. Struc. Dyn. (2006) 5,
485-496 (PDF) |
| 56.) |
G. Patargias, N. Zitzmann, R. Dwek, W. B. Fischer;
Protein-protein interactions: modeling the hepatitis C virus ion
channel p7.
J. Med. Chem. (2006) 49,
648-655 (PDF) |
| 55.) |
W. B. Fischer;
Virale Ionenkanäle: Bildung, Modelling, Drug Targeting.
Nachr. Chem. (2005) 53,
1216-1221 (PDF) |
| 54.) |
A. Candler, M. Featherstone, R. Ali, L. Maloney, A. Watts, W. B.
Fischer;
Computational analysis of mutations in the transmembrane region of Vpu
from HIV-1.
Biochim. Biophys. Acta-Biomembr. (2005) 1716,
1-10 (PDF) |
| 53.) |
D. Pavlovic, W. Fischer, M. Hussey, D. Durantel, S. Durantel, N. Branza-Nichita, S. Woodhouse, R. Dwek, N. Zitzmann;
Long alkylchain iminosugars block the HCV p7 ion channel.
Adv. Exp. Med. Biol. (2005) 564, 3-4 |
| 52.) |
W. B. Fischer, P. J. Judge;
Viral Ion Channels.
BioForum Europe (2005) 4, 45-47 (PDF) |
| 51.) |
W. B. Fischer; (Book Editor)
Viral Membrane Proteins: Structure, Function and
Drug Design.;
Vol. 1, Kluwer Academic / Plenum Publisher, New York, (2005) ISBN
0-306-48495-1 (link) |
| 50.) |
V. Lemaitre, C. G. Kim, D. Fischer, Y. H. Lam, A. Watts, W. B. Fischer;
Defining drug interactions with the Vpu ion channel from HIV-1.
In: Viral Membrane Proteins: Structure, Function and Drug
Design. (W. B. Fischer, Ed.)
Z. Atassi, Serial Ed., Protein Reviews; Kluwer Academic / Plenum
Publishers New York (2005) Chap. 14, 187-205 |
| 49.) |
W. B. Fischer, Y. H. Lam, A. D. Ward;
Peptide containing vesicles trapped with Raman tweezers - Vpu1-32 from
HIV1.
Annual Report of the CCLRC Rutherford Appleton
Laboratory, Didcot, (2004//5) (PDF) |
| 48.) |
W. Römer, Y. H. Lam, D. Fischer, A. Watts, W. B. Fischer, P Göring, R.
B. Wehrspohn, U. Gösele, C. Steinem;
Channel activity of a viral transmembrane peptide in micro-BLMs: Vpu1-32 from HIV-1.
J. Am. Chem. Soc. (2004) 126,
16267-16274 (PDF) |
| 47.) |
V. Lemaitre, R. Ali, C. G. Kim, A. Watts, W. B. Fischer;
Interaction of amiloride and one of its derivatives with Vpu from
HIV-1: a molecular dynamics simulation.
FEBS Lett. (2004) 563, 75-81 (PDF) |
| 46.) |
W. B. Fischer [Review]
Vpu from HIV-1 on an atomic scale: experiments and computer
simulations.
FEBS Lett. (2003) 552, 39-46 (PDF) |
| 45.) |
D. Pavlovic, D. C. A. Neville, O. Argaud, B. Blumberg, R. A. Dwek, W.
B. Fischer, N. Zitzmann;
The hepatitis C virus p7 protein forms an ion channel which is
inhibited by long alkylchain iminosugar derivatives.
Proc. Natl. Acad. Sci. USA (2003) 100,
6104-6108 (PDF) |
| 44.) |
I. Sramala, V. Lemaitre, J. D. Faraldo-Gomez, S. Vincent, A. Watts, W.
B. Fischer;
Molecular dynamics simulations on the first two helices of Vpu from
HIV-1.
Biophys. J. (2003) 84,
3276-3284 (PDF) |
| 43.) |
W. B. Fischer [Trends];
Computational bioanalysis of proteins.
Anal. Bioanal. Chem. (2003) 375,
23-25 (PDF) |
| 42.) |
F. S. Cordes, A. D. Tustian, M. S. P. Sansom, A. Watts, W. B. Fischer;
Bundles consisting of extended transmembrane segments of Vpu from
HIV-1: computer simulations and conductance measurements.
Biochemistry (2002), 41,
7359-7365 (PDF) |
| 41.) |
W. B. Fischer, M. S. P. Sansom [Review];
Viral ion channels: structure and function.
Biochim. Biophys. Acta (2002), 1561,
27-45 (PDF) |
| 40.) |
W. B. Fischer, M. S. P. Sansom;
Probing the structure of viral ion channel proteins: a computational approach.
in 'Biophysical Chemistry. Membranes and Proteins'
Eds. R. H. Templer, R. Leatherbarrow, Royal Soc. Chemistry 2002 |
| 39.) |
W. B. Fischer, M. Pitkeathly, B. A. Wallace, M. S. P. Sansom;
Transmembrane peptides for applications in biosensors: NB from influenza
B.
Proceedings contribution (10 pages) to
'BioSensor 2001', Tuebingen, D (PDF)
On-line publication: http://w210.ub.uni-tuebingen.de/portal/BioSensor2001/ |
| 38.) |
F. S. Cordes, A. Kukol, L. R. Forrest, I. T. Arkin, M. S. P. Sansom, W.
B. Fischer;
The structure of the HIV-1 Vpu ion channel: modelling and simulation
studies.
Biochim. Biophys. Acta (2001), 1512,
291-298 (PDF) |
| 37.) |
A. J. Wright, S. E. Matthews, W. B. Fischer, P. D. Beer;
Novel resorcin[4]arenes as potassium selective ion channel and
transporter mimics.
Chem. Eur. J. (2001), 7,
3474-3481 (PDF) |
| 36.) |
W. B. Fischer, M. Pitkeathly, M. S. P. Sansom;
Amantadine blocks channel activity of the transmembrane segment of the
NB protein from influenza B.
Eur. Biophys. J. (2001), 30,
416-420 (PDF) |
| 35.) |
W. B. Fischer, A. Fedorowicz, A. Koll;
Structural water around ions - FTIR difference spectroscopy and
quantum-mechanical calculations.
Phys. Chem. Chem. Phys. (2001), 3,
4228-4234 |
| 34.) |
W. B. Fischer, G. Steiner, C. Kuhne, R. Salzer;
Investigation on native vesicles containing the nicotinic acetylcholine
receptor using FTIR-spectroscopy.
J. Mol. Struc. (2001), 570,
153-158 (PDF) |
| 33.) |
W. B. Fischer, M. Pitkeathly, B. A. Wallace, L. R. Forrest, G. R.
Smith, and M. S. P. Sansom;
Transmembrane peptide NB of influenza B: a simulation, structure, and
conductance study.
Biochemistry (2000), 39,
12708-12716 (PDF) |
| 32.) |
W. B. Fischer, L. R. Forrest, G. R. Smith, and M. S. P. Sansom;
Transmembrane domains of viral ion channel proteins: a molecular
dynamics simulation study.
Biopolymers (2000), 53, 529 -
538 (PDF) |
| 31.) |
W. B. Fischer, D. Schwenke, B. Leupold, S. Friedrich, G. Steiner, R.
Salzer;
Sensing local anaesthetics with nicotinic acetylcholine receptor rich
vesicles in solution - A fluorescence study.
Asian Chem. Lett. (2000), 4,
57-64 |
| 30.) |
R. Salzer, G. Steiner, S. Friedrich, Ch. Kuhne, W. Fischer;
Functional biomembranes for sensors.
Infrared Sensors & Systems, AMA Service
Wunstorf (2000) 7-12 |
| 29.) |
G. Steiner, W. Fischer, Ch. Kuhne, and R. Salzer;
Surface enhanced FTIR spectroscopy and surface plasmon resonance on
Biomembranes.
Proceed SPIE (2000), 3918, 215
- 221 |
| 28.) |
Liu
X., Lee M. J., Coleman M., Rath P., Nilsson A., Fischer W. B.,
Bizounok M., Herzfeld J., Karstens W. F. J., Raap J., Lugtenburg J.,
and Rothschild K. J.;
Detection of threonine structural changes upon formation of the
M-intermediate of bacteriorhodopsin: evidence for assignment to Thr-89.
Biochim. Biophys. Acta (1998), 1365,
363 - 372 (PDF) |
| 27.) |
W. B. Fischer, I. Unverricht, T. Dudev, R. Salzer;
Negative ions causing structural changes of the acetylcholine cation -
FTIR-spectroscopy and theoretical calculations.
Asian J. Spectrosc. (1998), 2,
125 - 130 |
| 26.) |
I. Unverricht, W. B. Fischer, A. Schrattenholz, A. Maelicke, R. Salzer;
FTIR-Spektroskopische Charakterisierung von Self Assembly Schichten mit
Ionenkanälen.
Chemie- und Biosensoren: aktuelle Anwendungen und Entwicklungstrends;
Eds.: J. P. Baselt, G. Gerlach, W. Göpel; Dresden University
Press (1998), 31 - 34 |
| 25.) |
R. Salzer, Ch. Kuhne, G. Steiner, and W. B. Fischer;
Investigation of functionalized biomembranes by ATR-SEIRA spectroscopy
with polarized light.
Proceed. SPIE (1998), 3250, 96
- 100 |
| 24.) |
Ch. Kuhne, G. Steiner, W. B. Fischer, R. Salzer;
Surface enhanced FTIR spectroscopy on membranes.
Fres. J. Anal. Chem. (1998), 360,
750 - 754. |
| 23.) |
G. Steiner, Ch. Kuhne, B. Leupolt, W. B. Fischer, and R. Salzer;
Applications of surface enhanced spectroscopic techniques to
biosystems.
Proceed. SPIE (1998), 3256,
106 - 112 |
| 22.) |
R. Salzer, W. B. Fischer, I. Unverricht, D. Schwenke, G. Steiner, A.
Schrattenholz, and A. Maelicke;
Spectroscopic investigation of nicotinic acetylcholine receptor for
application in medical diagnosis.
Proceed. SPIE (1998), 3257,
288 - 295 |
| 21.) |
Ch. Kuhne, G. Steiner, W. B. Fischer, and R. Salzer;
SEIRA Spectroscopy on Biomembranes
Conf. Proceed. API Press (1998), 430,
606 - 609 |
| 20.) |
W. B. Fischer, I. Unverricht, Ch. Kuhne, G. Steiner, A. Schrattenholz,
A. Maelicke, and R. Salzer;
Vesicles containing ion channels on crystalline surfaces - An FTIR and
Surface Enhanced FTIR Spectroscopic study.
Conf. Proceed. API Press (1998), 430,
594 - 597 |
| 19.) |
W. B. Fischer, P. Pötschke, G. Pompe, K.-J. Eichhorn, and H. W.
Siesler;
Rheo-Optical Fourier transform infrared spectroscopy of polyurethanes
and their blends with polyolefines.
Macromolecular Chemistry and Physics (1997), 198,
2057 - 2072 |
| 18.) |
W.B. Fischer, P. Pötschke, K.-J. Eichhorn and H.W. Siesler;
Rheo-optical FTIR-spectroscopy of polyurethane-polyolefine-blends
during cyclic elongation and recovery.
Microchim. Acta [Suppl.] (1997), 14,
411 - 412 |
| 17.) |
W. B. Fischer, I. Fischer, and R. Salzer;
Investigation of acetylcholine under the influence of different
electrostatic fields by FTIR difference spectroscopy.
Microchim. Acta [Suppl.] (1997), 14,
441 - 443 |
| 16.) |
W. B. Fischer, P. Wu, U. Hoffmann, K.-J. Eichhorn, H. W. Siesler, and
K. J. Rothschild;
Comparison of bacteriorhodopsin conformational changes with uniaxially
elongated aliphatic polyamide samples using FTIR difference
spectroscopy.
Microchim. Acta [Suppl.] (1997), 14,
437 - 439 |
| 15.) |
W. B. Fischer, and H.-H. Eysel;
Raman- and FTIR spectroscopic study on water structural changes in
aqueous solutions of amino acids and related compounds.
J. Mol. Struc. (1997), 415,
249 - 257 |
| 14.) |
W. B. Fischer, I. Unverricht, D. Schwenke, G. Steiner, P. Nollert, A.
Schrattenholz, A. Maelicke, and R. Salzer;
adsorption of functionalized biomembrane vesicles on crystalline
surfaces monitored by FTIR- and Surface Enhanced FTIR Spectroscopy.
Proceed. 7th European Conf. on Spectroscopy of
biological Molecules, Madrid, Spain (1997) |
| 13.) |
R. Salzer, W. Fischer, and G. Steiner;
Ionenkanäle als Signalbausteine.
CLB Chemie in Labor und Biotechnik 47,
(1996), 7, 305 - 311 |
| 12.) |
W.B. Fischer, I. Fischer, G. Steiner, A. Schrattenholz, A. Maelicke, R.
Salzer;
Structural analysis of the nicotinic-acetylcholine receptor immobilized
on crystals and phospholipids studied by FTIR-spectroscopy.
1st Int. Symp. Bioanal. Chem. Proc., Chinese Chem.
Soc., Beijing, Peop. Rep. China (1995), p. 16-17 |
| 11.) |
W. B. Fischer, S. Sonar, T. Marti, H. G. Khorana and K. J. Rothschild;
Detection of a water molecule in the active-Site of bacteriorhodopsin;
Hydrogen bonding changes during the primary photoreaction.
Biochemistry (1994), 33, 12757
- 12762 |
| 10.) |
S. Sonar, T. Marti, P. Rath, W. Fischer, M. Coleman, A. Nilsson, H.
Gobind Khorana and Kenneth J. Rothschild;
A redirected proton pathway in the bacteriorhodopsin mutant Y57D.
J. Biol. Chem. (1994), 269,
28851 - 28858 |
| 9.) |
W. Fischer, H. H. Eysel, O. F. Nielsen, J. E. Bertie;
Corrections to the baseline distortions in the OH-stretch region of
aqueous solutions.
Appl. Spectroscopy (1994), 48,
107 - 112 |
| 8.) |
W. B. Fischer and K. J. Rothschild;
Water molecules are active during the primary photoreaktion of
bacteriorhodopsin.
SPIE Vol. (1993), 2089, 118 -
119 |
| 7.) |
S. Sonar, N. Patel, W. Fischer and K. J. Rothschild;
ell-Free synthesis, functional refolding, and spectroscopic
characterization of bacteriorhodopsin, an integral membrane protein.
Biochemistry (1993), 32,
13777-13781 |
| 6.) |
K. J. Rothschild, T. Marti, S. Sonar, Y.-W. He, P. Rath, W. Fischer, O.
Bousch?and H. Gobind Khorana;
Asp96 Deprotonation and transmembrane a -helical
structural changes in bacteriorhodopsin.
J. Biol. Chem. (1993), 268,
27046-27052 |
| 5.) |
Y.-W. He, M. P. Krebs, W. B. Fischer, H. G. Khorana, K. J. Rothschild;
FTIR Difference spectroscopy of the bacteriorhodopsin mutant Tyr-185 to
Phe: Detection of a stable O-like species and characterization of its
photocycle at low temperature.
Biochemistry (1993), 32,
2282-2290 |
| 4.) |
W. B. Fischer, H. H. Eysel;
Polarized Raman spectra and intensities of aromatic amino acids
phenylalanine, tyrosine and tryptophan.
Spectrochimica Acta (1992), 48A,
725-732 |
| 3.) |
W. B. Fischer, J. E. Bertie, M. Khalique Ahmed, H. H. Eysel;
The influence of aliphatic amines and carboxylic acids on the water
structure studied by vibrational spectra of solutions.
in Proceedings of the 8th International Conference on Fourier
Transform Spectroscopy 1991, Lübeck-Travemünde, Deutschland, SPIE
Vol. (1991), 1575, 596-597 |
| 2.) |
H. H. Eysel, W. Fischer;
pH-Dependence of characteristic Raman bands of aromatic amino acids in
Spectroscopy of Biological Molecules - State of the Art
Proceedings of Third European Conference on the
Spectroscopy of Biological Molecules, Societa Editrice
Esculapio Bologna, Italy (1989), Editors A. Bertoluzza, C. Fagnano, P.
Monti, p. 87-88 |
| 1.) |
M. E. Maxon, B. Redfield, X. Cai, R. Shoeman, K. Fujita, W. Fisher, G.
Staufer, H. Weissbach, N. Brot;
Regulation of methionine synthesis in Escherichia coli: Effect of the
MetR protein on the expression of the metE and metR genes.
Proc. Natl. Acad. Sci. USA (1989), 86,
85-89 |
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