Professor Carmay Lim
Distinguished Research Fellow

Institute of Biomedical Sciences,
Academia Sinica, Taipei 115, Taiwan

 

 

Physico–chemical principles governing biological processes

Abstract:

Our research interests are to


(i) unravel the underlying physico–chemical principles governing biological processes,
(ii) develop new methods, as required, along the way and
(iii) use the above principles and methods to design molecules with potential therapeutic utility.


This talk will highlight our key accomplishments in these three areas and provide an example of how our studies help to unravel the factors governing ion selectivity in K+ and Na+ ion channels.

References:

1. Metal Binding Affinity and Selectivity in Metalloproteins: Insights from Computational Studies. Todor Dudev & Carmay Lim*, Annual Reviews in Biophysics. (2008) 37:97–116

2. Common Physical Basis of Macromolecule–Binding Sites in Proteins. Yao Chi Chen & Carmay Lim*, Nucleic Acids Res. (2008) 36:7078-7087.

3. Reformulation of Maxwell’s Equations to Incorporate Near–Solute Solvent Structure. Pei-Kun Yang & Carmay Lim*, J. Phys. Chem. B (2008), 112: 10791–10794.

4. Determinants of K+ vs. Na+ Selectivity in Potassium Channels. Todor Dudev & Carmay Lim*, J. Am. Chem. Soc. (2009) 131:8092–8101.

5. Factors Governing the Na+ vs. K+ Selectivity in Sodium Ion Channels. Todor Dudev & Carmay Lim*, J. Am. Chem. Soc. (2010) 132: 2321–2332.