Congratulations to Shu-I Lin,
winning the 3. Prize of the Master Thesis Competition in the Institute of Biophotonics.

Viruses and Cells - Computational Challenges and Approaches
6th - 7th of October 2017, Heidelberg University, Germany

9th Miniworkshop on Multiscale Simulations of Biological Systems
Spring 2018

     
Mechanisms of Function of Viral Membrane Proteins

We investigate the biophysical principles leading towards the generation of the structure and assembly of membrane proteins from viruses.

A combination of classical and coarse-grained molecular dynamics simulations, docking and statistical approaches is used to develop platform technologies which can be used for bioanalytical screening.

With computational techniques we are seeking for molecular details about the mechanism of function of the proteins. We also develop simulation strategies and software (programming) to derive macroscopic quantities. Structural details for the computational investigations are also adopted from NMR spectroscopy and X-ray crystallography.

The information derived, forms the basis for modeling and simulating aspects essential for the proteins to operate such as

self assembly

diffusion of ions and substrates

protein folding.

Our work supports novel developments in antiviral therapy and nanomedicine.


BBA
ISSN: 0005-2736
Imprint: ELSEVIER
BBA
ISSN: 0005-2736
Imprint: ELSEVIER
EBJ
ISSN: 0175-7571
(print version)
ISSN: 1432-1017
(electronic version)
VMP
ISBN-10: 0306484951
Publisher: Springer