Exchange program with the University of Heidelberg in Germany.
3rd Bilateral Symposium: National Yang-Ming University
and University of Heidelberg. 23rd of March 2010
Workshop on Multiscale Simulations of Biological Systems
National Yang-Ming University, 9th of April 2010
Ya-Ling Chiang has awarded a DAAD Scholarship for 2010
Mechanisms
of Function of Viral Membrane Proteins
We investigate the biophysical principles leading towards the mechanism
of function of channel
and pore forming membrane proteins from
HIV-1, HCV, SARS-CoV, Influenza
and
Polio virus (entry proteins)
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We adopt computer simulations (classical and
ab initio molecular dynamics simulations, docking approaches) and bilayer
recordings in a combined approach.
With computational techniques we are seeking for molecular details
about the
mechanism of function of the proteins. We also develop simulation strategies to derive
macroscopic quantities. Structural details for the computational
investigations
are adopted from spectroscopic techniques such as NMR, Fluorescence,
X-Ray and FTIR. From bilayer recordings functional and pharmacological data are derived. The information forms the basis for modeling and
simulating aspects essential for the proteins to operate:
self
assembly
diffusion of ions
and substrates
protein folding
membrane dynamics
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Our work supports novel developments in Antiviral
Therapy, Biotechnology and Nanomedicine.
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