25th of May 2012,10:00 a.m.
Prof Anthony Watts, Biochemistry Department, Oxford University,
Novel Electronic Interactions In Membrane Receptors – Drug Targeting And Nanobiophotonics (Abstract)
Activity Center Conference Room II, National Yang-Ming University, Taipei

International Symposium on Viral Membrane Proteins
5. -6. October 2012
National Yang-Ming University, Taipei, Taiwan

 
     
Mechanisms of Function of Viral Membrane Proteins

We investigate the biophysical principles leading towards the mechanism of function of channel and pore forming membrane proteins from viruses.

We adopt computer simulations (classical and ab initio molecular dynamics simulations, docking approaches) and bilayer recordings in a combined approach.

With computational techniques we are seeking for molecular details about the mechanism of function of the proteins. We also develop simulation strategies to derive macroscopic quantities. Structural details for the computational investigations are adopted from spectroscopic techniques such as NMR, Fluorescence, X-Ray and FTIR. Functional and pharmacological data will be derived from bilayer recordings.

The information forms the basis for modeling and simulating aspects essential for the proteins to operate:

self assembly

diffusion of ions and substrates

protein folding

hydrogen bonding.

Our work supports novel developments in Antiviral Therapy and Nanomedicine.



BBA
ISSN: 0005-2736
Imprint: ELSEVIER

EBJ
ISSN: 0175-7571
(print version)
ISSN: 1432-1017
(electronic version)

VMP
ISBN-10: 0306484951
Publisher: Springer