Shu-ling Fu, Professor and Director
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Name: Shu-ling Fu, Ph.D.
Current position: Professor
Tel: +886-2-2826-7177¡@+886-2-2826-7000 ext. 6429
Fax: +886-2-2822-5044
E-mail: slfu@ym.edu.tw

Education and Experiences:
1985 - 1989     B.S., Dept. of Agricultural Chemistry, National Taiwan University
1989 - 1990     Research Assistant, Institute of Botany, Academia Sinica
1990 - 1996     Ph.D., Dept. of Biochemistry and Cellular Biology, State University of New York at Stony Brook
1996 - 1999     Postdoctoral Research Fellow, Dept. of Molecular & Experimental Medicine, The Scripps Research Institute, La Jolla, U.S.A
1999 - 2000      Assistant Professor, Dept. of Molecular and Cellular Biology, Tzu-Chi University
2000 - 2007      Assistant Professor, Institute of Traditional Medicine, National Yang-Ming University
2007 - 2011     
Associate Professor, Institute of Traditional Medicine, National Yang-Ming University
2011 - present   Professor, Institute of Traditional Medicine, National Yang-Ming University

Research Interests:

  1. Functional analysis of metastasis-related genes involved in cancer progression
  2. Pharmacologic and mechanistic study of anti-cancer natural products:
    (1) oncogene-targeting natural products
    (2) chemo- and radio-sensitizers
  3. Identification and mechanistic study of novel anti-inflammatory natural products
  4. Development of synthetic TLR4 agonists for cancer immunotherapy
  5. Development of novel anti-aging nutraceuticals and pharmaceuticals

Publications:

(2011~2017)

1.    Yun-Chen Tsai, Shih-Han Chen, Lie-Chwen Lin*, and Shu-Ling Fu*(2017) ¡§Anti-inflammatory principles from Sarcandra glabra¡¨ Journal of Agricultural and Food Chemistry, in press (SCI; corresponding author).

2. Shu-ling Fu, Chien-an Chen, Ling-chien Hung, Moon-Sing Lee, Wen-yen Chiou, Hon-Yi-Lin, Yu-Chien Su, Ching-Chih Lee and Shih-Kai Hung  (2016) ¡§Preliminary results of a non-invasive method to measure tumor size and distribution in vivo¡¨ Experimental and Therapeutic Medicine, 12: 3614-3620.

3. Ya-Hsin Hsu, Yu-Ling Hsu, Sheng-Hung Liu, Hsin-Chia Liao, Po-Xuan Lee, Chao-Hsiung Lin, Lee-Chiang Lo, and Shu-Ling Fu* (2016) ¡§Development of a bifunctional andrographolide-based chemical probe for pharmacological study¡¨ PLOS one, 11: e0152770 (SCI; co-corresponding author).

3.      Shu-Ling Fu, Chun-Cheng Lin, Ming-Ling Hsu, Yu-Jen Chen* (2016) ¡¨ CCL-34, a synthetic Toll-like receptor 4 activator, modulates differentiation and maturation of myeloid dendritic cells¡¨ Oncotarget, 7:11677

4.      Yu-Ling Hsu, Chun-Chieh Yang, Tzyy-Chao Chou, Chih-Hsuan Tai, Long-Yuan Chen, Shu-Ling Fu, Jing-Jer Lin, Lee-Chiang Lo* (2016) ¡§Design, synthesis, and evaluation of cell permeable probes for protein kinases¡¨ Tetrahedron, 72: 58-68.

5.      Ya-Wei Liu, Yung-Tsung Chiu, Shu-Ling Fu, Yi-Tsau Huang* (2015) ¡¨ Osthole ameliorates hepatic fibrosis and inhibits hepatic stellate cell activation¡¨ Journal of Biomedical Science, 22:63.

6.      Tsai-Feng Li, Ching-Cheng Lin, Hui-ping Tsai, Chung-Hua Hsu*, Shu-Ling Fu* (2014) ¡§Effects of Kuan-Sin-Yin decoction on immunomodulation and tumorigenesis in mouse tumor models¡¨ BMC Complementary and Alternative Medicine, 14:488 (SCI; co-corresponding author).

7.      Yu-Chieh Su, Chih-Chia Yu, Fei-Ting Hsu, Shu-Ling Fu, Jeng-Jong Hwang, Ling-Chien Hung, Moon-Sing Lee, Wen-Yen Chiou, Hon-Yi Lin, Shih-Kai Hung (2014) ¡§Everolimus sensitizes Ras-transformed cells to radiation in vitro through the autophagy pathway¡¨ International Journal of Molecular Medicine, 34: 1417-1422.

8.      Sheng-Hung Liu, Chao-Hsiung Lin, Fong-Ping Liang, Pei-Fen Chen, Cheng-Deng Kuo, Mohd. Mujahid Alam, Barnali Maiti, Shih-Kai Hung, Chin-Wen Chi, Chung-Ming* Sun and Shu-Ling Fu* (2014) ¡§Andrographolide downregulates the v-Src and Bcr-Abl oncoproteins and induces Hsp90 cleavage in the ROS-dependent suppression of cancer malignancy¡¨ Biochemical Pharmacology, 87:229-242 (SCI; co-corresponding author)..

9.      Jen-Hao YangYi-Ying ChiouShu-ling Fu, I-Yun ShihTsai-Hsuan Weng, Wey-Jinq Lin and Chao-Hsiung Lin (2014) ¡§Arginine methylation of hnRNPK negatively modulates apoptosis upon DNA damage through local regulation of phosphorylation¡¨ Nucleic Acids Research, 42:9908-24.

10.      Yu-Ling Chang, Tzu-Hui Chen, Yi-Hsiu Wu, Guann-An Chen, Tzu-Huei Weng, Ping-Hui Tseng, Shie-Liang Hsieh, Shu-Ling Fu, Chi-Hung Lin, Chun-Jen Chen, Ching-Liang Chu, Iok In Christine Chio, Tak Wah Mak*and Nien-Jung Chen* (2014) ¡§A novel TLR2-triggered signalling crosstalk synergistically intensifies TNF-mediated IL-6 induction¡¨ Journal of Cellular and Molecular Medicine 18:1344-57.

11.  Yong-Shiang Lin, Chao-Hsiung Lin, Li-De Huang, Tung Chao, Cheng-Deng Kuo, Ling-Chien Hung, Fen-Hwa Wong, Chun-Cheng Lin* and Shu-Ling Fu* (2013) ¡§Suppression of thoc1 in cancer cell apoptosis mediated by activated macrophages is nitric oxide-dependent¡¨ Biochemical Pharmacology, 86: 242-252.

12.  Kai-Wei Hsueh, Shu-Ling Fu, Chirn-Bin Chang, Yu-Ling Chang and Chao-Hsiung Lin (2013) ¡§A novel Aurora-A-mediated phosphorylation of p53 inhibits its interaction with MDM2¡¨ BBA - Proteins and Proteomics, 1834:508-515.

13.  Yi-Ying Chiou, Shu-Ling Fu, Wey-Jinq Lin, and Chao-Hsiung Lin (2012) ¡§Proteomics analysis of in vitro protein methylation during Src-induced transformation¡¨ Electrophoresis, 33: 451-461 (SCI).

14.  Yong-Shiang Lin, Li-De Huang, Chao-Hsiung Lin, Po-Hsiung Huang, Yu-Jen Chen, Fen-Hwa Wong, Chun-Cheng Lin*, and Shu-Ling Fu* (2011) ¡§In vitro and in vivo anticancer activity of a synthetic glycolipid as TLR4 activator¡¨ Journal of Biological Chemistry, 286: 43782-43792  (SCI; co-corresponding author).

15.  Mei-Yao Wu, Shih-Kai Hung and Shu-Ling Fu* (2011) ¡§Immunosuppressive effects of fisetin in ovalbumin-induced asthma through inhibition of NF-£eB activity¡¨ Journal of Agricultural and Food Chemistry, 59: 10496-10504 (SCI; corresponding author).

16.  Kai-Wei Hsueh, Shu-Ling Fu, Chi-Ying F. Huang and Chao-Hsiung Lin (2011) ¡§Aurora-A phosphorylates hnRNPK and disrupts its interaction with p53¡¨ FEBS letters, 585: 2671-2675.

17.  Chia-Yuan Liu, Hsun-Shuo Chang, Ih-Sheng Chen, Chih-Jen Chen, Ming-Ling Hsu, Shu-Ling Fu*, Yu-Jen Chen* (2011) ¡§Costunolide causes mitotic arrest and enhances radiosensitivity in human hepatocellular carcinoma cells¡¨ Radiation Oncology, 6: 56 (SCI; co-corresponding author). `

18.  Li-De Huang, Hong-Jyune Lin, Po-Hsiung Huang, Wei-Chen Hsiao, L. Vijaya Raghava Reddy, Shu-Ling Fu* and Chun-Cheng Lin* (2011) ¡§Synthesis of serine-based glycolipids as potential TLR4 activators¡¨ Organic & Biomolecular Chemistry, 9: 2492-2504 (SCI; co-corresponding author).

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