Shu-ling Fu, Professor
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Name: Shu-ling Fu, Ph.D.
 Current position: Professor
 Tel: +886-2-2826-7177¡@+886-2-2826-7000 ext. 5196
 Fax: +886-2-2822-5044
 E-mail: slfu@ym.edu.tw

Education and Experiences:
 1985 - 1989     B.S., Dept. of Agricultural Chemistry, National Taiwan University
1989 - 1990     Research Assistant, Institute of Botany, Academia Sinica
1990 - 1996     Ph.D., Dept. of Biochemistry and Cellular Biology, State University of New York at Stony Brook
1996 - 1999     Postdoctoral Research Fellow, Dept. of Molecular & Experimental Medicine, The Scripps Research Institute, La Jolla, U.S.A
1999 - 2000      Assistant Professor, Dept. of Molecular and Cellular Biology, Tzu-Chi University
2000 - 2007      Assistant Professor, Institute of Traditional Medicine, National Yang-Ming University
2007 - 2011      Associate Professor, Institute of Traditional Medicine, National Yang-Ming University
2011 - present   Professor, Institute of Traditional Medicine, National Yang-Ming University

Research Interests:

  1. Yi-Ying Chiou, Shu-Ling Fu, Wey-Jinq Lin, and Chao-Hsiung Lin (2012) ¡§Proteomics analysis of in vitro protein methylation during Src-induced transformation¡¨ Electrophoresis, 33:451-461 (SCI).

  2. Yong-Shiang Lin, Li-De Huang, Chao-Hsiung Lin, Po-Hsiung Huang, Yu-Jen Chen, Fen-Hwa Wong, Chun-Cheng Lin*, and Shu-Ling Fu* (2011) ¡§In vitro and in vivo anticancer activity of a synthetic glycolipid as TLR4 activator¡¨ Journal of Biological Chemistry, 286: 43782-43792 (SCI; co-corresponding author).

  3. Mei-Yao Wu, Shih-Kai Hung and Shu-Ling Fu* (2011) ¡§Immunosuppressive effects of fisetin in ovalbumin-induced asthma through inhibition of NF-£eB activity¡¨ Journal of Agricultural and Food Chemistry, 59: 10496-10504 (SCI; corresponding author).

  4. Kai-Wei Hsueh, Shu-Ling Fu, Chi-Ying F. Huang and Chao-Hsiung Lin (2011) ¡§Aurora-A phosphorylates hnRNPK and disrupts its interaction with p53¡¨ FEBS letters, 585: 2671-2675.

  5. Chia-Yuan Liu, Hsun-Shuo Chang, Ih-Sheng Chen, Chih-Jen Chen, Ming-Ling Hsu, Shu-Ling Fu*, Yu-Jen Chen* (2011) ¡§Costunolide causes mitotic arrest and enhances radiosensitivity in human hepatocellular carcinoma cells¡¨ Radiation Oncology, 6: 56 (SCI; co-corresponding author).

  6. Li-De Huang, Hong-Jyune Lin, Po-Hsiung Huang, Wei-Chen Hsiao, L. Vijaya Raghava Reddy, Shu-Ling Fu* and Chun-Cheng Lin* (2011) ¡§Synthesis of serine-based glycolipids as potential TLR4 activators¡¨ Organic & Biomolecular Chemistry, 9: 2492-2504 (SCI; co-corresponding author).

  7. Sheng-Hung Liu, Chao-Hsiung Lin, Shih-Kai Hung, Jen-Hwey Chou, Chin-Wen Chi, and Shu-Ling Fu* (2010) ¡§Fisetin inhibits lipopolysaccharide-induced macrophage activation and dendritic cell maturation¡¨, Journal of Agricultural and Food Chemistry, 58: 10831-10839 (SCI; corresponding author).

  8. Hsueh-Ping Chao, Cheng-Deng Kuo, Jen-Hwey Chiu and Shu-Ling Fu* (2010) ¡§Andrographolide exhibits anti-invasive activity against colon cancer cells via inhibition of MMP2 activity¡¨, Planta Medica, 76:1827-1833 (SCI; corresponding author).

  9. Shih-Kai Hung, Ling-Chien Hung, Cheng-Deng Kuo, Kuan-Yi Lee, Moon-Sing Lee, Hon-Yi Lin, Yu-Jen Chen and Shu-Ling Fu* (2010) ¡§Andrographolide sensitizes Ras-transformed cells to radiation in vitro and in vivo¡¨, International Journal of Radiation Oncology Biology Physics, 77:1232-9 (SCI; corresponding author).

  10. Yi-Fang Wu, Shu-Ling Fu, Cheng-Heng Kao, Chu-Wen Yang, Chao-Hsiung Lin, Ming-Ta Hsu and Ting-Fen Tsai (2008) ¡§Chemopreventive effect of silymarin on liver pathology in HBV X protein transgenic mice¡¨ Cancer Research, 68: 2033-2042.

  11. Fong-Pin Liang, Chao-Hsiung Lin, Cheng-Deng Kuo, Hsueh-Ping Chao, and Shu-Ling Fu* (2008) ¡§Suppression of v-Src-induced transformation by andrographolide via degradation of the v-Src protein and attenuation of the Erk-signaling pathway¡¨, Journal of Biological Chemistry, 283: 5023-5033 (SCI; corresponding author).

  12. Ling-chien Hung, Chun-cheng Lin, Shih-kai Hung, Bing-ching Wu, Mi-dan Jan, Sheng-hung Liou and Shu-Ling Fu* (2007) ¡§A synthetic analog of a-galactosylceramide induces macrophage activation via TLR4-signaling pathways¡¨, Biochemical Pharmacology, 73:1957-1970 (SCI; corresponding author).

  13. Chang-Han Chen, Pei-Jung Lu, Yu-Chia Chen, Shu-Ling Fu, Kou-Juey Wu, Ann-Ping Tsou, Yuan-Chii Gladys Lee, Tsu-Chun Emma Lin, Shih-Lan Hsu, Chi-Ying F. Huang1, and Chen-Kung Chou (2007) FLJ10540-elicited transformation is through the activation of PI3-kinase/AKT pathway .Oncogene, 26:4272-4283 (SCI).

  14. Yi-ying Chiou, Wey-jing Lin, Shu-ling Fu, and Chao-hsiung Lin (2007) ¡§Direct mass-spectrometric identification of Arg296 and Arg299 as the methylation sites of hnRNP K protein for methyltransferase PRMT1¡¨, Protein Journal, 26: 87-93 (SCI).

  15. Shu-ling Fu, Brigitte Ganter and Joseph S. Lipsick (2006) ¡§Myb Proteins inhibit fibroblast transformation by v-Rel .Molecular Cancer, 5: 54 (SCI).

  16. Jir-you Wang, Han-ning Chuang, Jen-hwey Chiu, Shu-ling Fu, Tung-hu Tsai, Ann-ping Tsou, Cheng-po Hu, Chin-wen Chi, Sheau-farn Yeh, Wing-yiu Lui, Chew-wun Wu, and Chen-kung Chou (2006) ¡§Effects of Scutellaria baicalensis Georgi on macrophage-hepatocyte interaction through cytokines related to growth control of murine hepatocytes¡¨, Experimental Biology And Medicine, 231: 444-55 (SCI).

  17. Shu-ling Fu*, Ya-hui Hsu, Pei-yeh Lee, Wen-chi Hou, Ling-chien Hung, Chao-hsiung Lin, Chiu-ming Chen, and Yu-jing Huang. (2006) ¡§Dioscorin isolated from Dioscorea alata activates TLR4-signaling pathways and induces cytokine expression in macrophages¡¨, Biochemical and Biophysical Research communications, 339:137-144 (SCI; corresponding author).

  18. Shu-Ling Fu*, Yu-Jing Huang, Fong-Pin Liang, Yung-Fen Huang, Ching-Feng Chuang, Shih-Wei Wang, and Ju-Wen Yao (2005) ¡§Malignant transformation of an epithelial cell by v-Src via tv-a-mediated retroviral infection: a new cell model for studying carcinogenesis¡¨, Biochemical and Biophysical Research communications 338, 830-838 (SCI; corresponding author).

  19. Han-Ning Chuang, Jir-You Wang, Jen-Hwey Chiu, Tung-Hu Tsai, Sheau-Farn Yeh, Shu-ling Fu, Wing-Yiu Lui and Chew-Wun Wu (2005) ¡§Enhancing effects of Schtellaria baicalensis and some of its constituents on TGF-b1 gene expression in RAW264.7 murine macrophage cell line¡¨, Planta Medica, 71: 440-445 (SCI).

  20. Ya-Hui Hsu and Shu-ling Fu* (2004) ¡§Detection of endotoxin contamination in Chinese herbs by NF-kB activity-based reporter assays¡¨ Journal of Food & Drug Analysis, Vol.12: 34-39 (SCI; corresponding author).

  21. Makoto Nishizawa, Shu-ling Fu, Kohsuke Kataoka and Peter K.Vogt (2003) ¡§Artificial oncoproteins: modified versions of the yeast bZip protein GCN4 induce cellular transformation¡¨ Oncogene, Vol. 22: 7931-7941 (SCI).

  22. Shu-ling Fu, Anke Waha and Peter K. Vogt (2000) ¡§Identification and characterization of genes upregulated in cells transformed by v-Jun¡¨ Oncogene, Vol. 19: 3537-3545 (SCI).

  23. Peter K. Vogt, Masahiro Aoki, Ivan Bottoli, Hwai-wen Chang, Shu-ling Fu, Andreas Hecht, Jason Iacovoni, Bing-Hua Jian and Ulrich Kruse (1999) ¡§A random walk in oncogene space: the quest for targets¡¨ Cell Growth and Differentiation, Vol. 10: 777-784 (SCI).

  24. Shu-ling Fu, Ivan Bottoli, Martin Goller and Peter K. Vogt (1999) "Heparin-binding epidermal growth factor-like growth factor, a v-Jun target gene, induces oncogenic transformation¡¨ Proc. Natl. Acad. Sci. USA. Vol. 96, 5716-5721 (SCI).

  25. Brigitte Ganter, Shu-ling Fu and Joseph Lipsick (1998) "D-type cyclins repress transcriptional activation by the v-Myb but not the c-Myb DNA-binding domain¡¨ EMBO J. Vol. 17: 255-268 (SCI).

  26. Shu-ling Fu and Joseph Lipsick (1997) "Constitutive expression of full-length c-Myb transforms avian cells characteristic of both the monocytic and granulocytic lineages¡¨ Cell Growth and Differentiation, Vol. 8: 35-45 (SCI).

  27. Shu-ling Fu and Joseph Lipsick (1996) "FAETL motif required for leukemic transformation by v-Myb¡¨. Journal of Virology, Vol. 70: 5600-5610 (SCI).

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