翁芸芳 副教授 (Ueng, Yune-Fang, PhD)

個人簡歷

學歷

/肄業學校  國別  主修系別  學位 畢業年度
私立高雄醫學院 中華民國 藥學系 學士 1986
國立台灣大學醫學院 中華民國 生化學 碩士 1989
國立台灣大學醫學院 中華民國 生化學 博士 1993

經歷

服務單位  職稱 
國立台東大學 兼任教授(2005-
國立陽明大學口腔生物研究所 兼任副教授(2005-
私立台北醫學大學、醫學研究所 兼任副教授(1994-
國立中國醫藥研究所 研究員(2004-
國立中國醫藥研究所 副研究員(1997-2004
國立中國醫藥研究所 助理研究員(1996-1997
美國范德堡大學(Vanderbilt University)醫學院生化所暨分子毒理中心 博士後研究人員(1993-1996
國立台灣大學醫學院毒理學研究所 博士後副研究員(1993

現職:國立中國醫藥研究所研究員暨中醫基礎醫學研究組組長

專長:生化學、藥學、毒理學

其他經歷:台灣毒物學會會員、台灣毒物學會幹事、台灣藥理學會會員、台灣藥理學會訊編輯委員

學術榮譽事項陶斐榮學會之會員、榮獲國科會甲等研究獎、榮獲87年度毒藥物防治學術獎座

研究工作

    藥物之藥理療效及毒性作用與其經藥物代謝作用而排除或產生構造及活性不同之代謝產物有非常重要之相關性。在藥物代謝作用中,氧化與結合反應是重要之藥物代謝酵素作用,經運輸蛋白之排除作用與毒性及抗藥性亦息息相關。藥物代謝酵素及運輸蛋白主要分佈於動物肝臟,但也存在於肝外組織,包括:腎及腸等,組織特異之藥物代謝作用是決定外來物之生物活性的重要因子之。因此,長程研究目標為研究天然物對藥物代謝酵素及運輸蛋白之影響以探討天然毒物之毒性作用及評估中西藥之可能藥物交互作用,以提昇中藥及其他藥物臨床應用之安全性。研究模式包括:()進行體外實驗,以鼠組織微粒體探討中藥與藥物代謝酵素之交互作用、作用選擇性及機轉。進行細胞培養,探討中藥對藥物代謝酵素及藥物排除作用之交互作用及機轉。() 進行人類酵素活性重組實驗,以大腸桿菌表現人類藥物代謝酵素,探討中藥材對人類藥物代謝酵素之影響及作用機轉。() 模擬人類暴露途徑,進行體內實驗,將鼠以口服處理天然物,測定鼠肝及肝外組織微粒體藥物代謝酵素含量及活性,以探討天然物對藥物代謝酵素之影響及調控機轉

研究計 (五年內)

1. 芸香之毒性及其影響藥物代謝作用之研究(2008/8/12011/7/31)

2. 苦參對藥物代謝作用之影響(2006/8/12008/7/31)

3. 天然物對人類藥物代謝作用之影響2005/8/12006/7/31)

得獎紀錄

1. The honor member of Phi-Tau-Phi Scholastic Honor Society of the Republic of China.

2. The Research Award of Poison Control (1999) by the Foundation for Poison Control, Taiwan.

3. The Research Award (甲種) of National Science Council, Taiwan.

4. Poster Awards (with students), Toxicology Society of Taiwan,the Joint Annual Conference of Biomedical Sciences (in 2002, 2003, and 2005), Taipei, Taiwan.

期刊論文(*通訊作者)

1. Wu, G.-J., Tai, Y.-T., Chen, T.-L., Lin, L.-L., Ueng, Y.-F., and Chen, R.-M.*, Propofol specifically inhibits mitochondrial membrane potential but not complex I NADH dehydrogenase activity thus reducing cellular ATP biosynthesis and migration of macrophages. Annal. New York Acad. Sci. 1042, 168-176, 2005.

2. Ueng, Y.-F.*, Tsai, T.-H., Don, M.-J., Chen, R.-M., and Chen, T.-L., Alteration of the pharmacokinetics of theophylline by rutaecarpine, an alkaloid of the medicinal herb Evodia rutaecarpa. J. Pharm. Pharmacol. 57, 227-232, 2005.

3. Chou, Y.-C., Ueng, Y.-F.*, Chou, C.-Y., and Tien, J.-H., Dimemorfan N-demethylation by mouse liver microsomal cytochrome P450 enzymes. Life Sci., 77, 735-745, 2005.

4. Ueng, Y.-F.*, Chieh, C.-H., and Don, M.-J. Inhibition of human cytochrome P450 enzymes by the natural hepatotoxin safrole. Food Chem. Toxicol., 43, 707-712, 2005.

5. Ueng, Y.-F.*, Yu, H.-J., Lee, C.-H., Peng, C., Jan, W.-C., Ho, L.-K., Chen, C.-F., and Don, M.-J. Identification of the microsomal oxidation metabolites of rutaecarpine, a main active alkaloid of the medicinal herb Evodia rutaecarpa, J Chromatograph. A, 1076, 103-109, 2005.

6. Kuo, Y.-H., Lin, Y.-L., Don, M.-J., Chen, R.-M., and Ueng, Y.-F.*, Induction of cytochrome P450-dependent monooxygenase by extracts of the medicinal herb Salvia miltiorrhiza. J. Pharm. Pharmacol. 58, 521-527, 2006.

7. Jan, W.-C., Don, M.-J., Chen, C.-F., Ho, L.-K., and Ueng, Y.-F.*, Characterization of mouse cytochrome P450-catalyzed oxidative metabolism of rutaecarpine, an alkaloid of the herbal medicine Evodia rutaecarpa. J. Food Drug. Analysis., 14, 159-165, 2006.

8. Ueng, Y.-F.*, Jan, W.-C., Don, M.-J., Ho, L.-K., and Chen, C.-F., Oxidative metabolism of the alkaloid rutaecarpine by human cytochrome P450s. Drug Metab. Dispos., 34, 821-827, 2006.

9. Ueng, Y.-F.* and Wu, T.-S., Effects of cinnamophilin on mouse hepatic drug-metabolizing enzymes in vitro and in vivo. J. Chinese Med., 17, 135-142, 2006.

10. Tseng, J.-C., Don, M.-J., Lewis, D. F. V., Wang, S.-Y., and Ueng, Y.-F.*, Inhibition of CYP1 activity by 7,8-dehydrorutaecarpine and its methoxylated derivatives. J. Food Drug Analysis. 15, 480-487, 2007.

11. Su, C.-R., Ueng, Y.-F., Dung, N. X., Reddy, V. B., and Wu, T.-S.*, Cytochrome P450 3A4 inhibitors and other constituents of Fibraurea tinctoria. J. Nat. Prod., 70, 1930-1933, 2007.

12. Lee, H.-L., Chang, L. W., Wu, J.-P., Ueng, Y.-F., Tsai, M.-H., Hsieh, D. P. H., and Lin, P.*, Enhancements of 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK) metabolism and carcinogenic risk via NNK/Arsenic interaction. Toxicol. Appl. Pharmacol., 227, 108-114, 2008.

13. Wu, G.-J., Chen, T.-L., Ueng, Y.-F., Chen, R.-M.*, Ketamine inhibits tumor necrosis factor-alpha and interleukin-6 gene expressions in lipopolysaccharide-stimulated macrophages through suppression of toll-like receptor 4-mediated c-Jun N-terminal kinase phosphorylation and activator protein-1 activation. Toxicol. Appl. Pharmacol., 228, 105-113, 2008.

14. Pan, W.-C., Chen, R.-M., Shen, Y.-C., Chen, C.-C., and Ueng, Y.-F.*, Suppressive effect of tobacco smoke extracts on oral P-glycoprotein function and its impact in smoke-induced insult to oral epidermal cells. Toxicol.Lett. 185, 116-123, 2009.

15. Chung, Y.-T., Hsieh, L.-L., Chen, I-H., Liao, C.-T., Liou, S.-H., Chi, C.-W., Ueng, Y.-F., and Liu, T.-Y.*, Sulfotransferase 1A1 haplotypes associated with oral squamous cell carcinoma susceptibility in male Taiwanese. Carcinogenesis 30, 286–294, 2009.

16. Yen, C.-H., Hung, J.-H., Ueng, Y.-F., Liu, S.-P., Chen, S.-Y., Liu, H.-H., Chou, T.-F., Darbha R., Hsieh, L.-L., and Chen, Y.-M. A.*, Glycine N-methyltransferase affects the metabolism of aflatoxin B1 and blocks its carcinogenic effect. Toxicol. Appl. Pharmacol., 235, 296-304, 2009.

17. Ueng, Y.-F.*, Chen, C.-C., Tsai, C.-C., and Souček, P., Differential inductive profiles of hepatic cytochrome P450s by the extracts of Sophora flavescens in male and female C57BL/6JNarl mice. J. Ethnopharmacol., 126, 437-446, 2009.

18. Chou, Y.-C., Lin, M.-H., Chung, Y.-T., Liu, T.-Y., Wang, S.-Y., Chau, G.-Y., Chi, C.-W., Lee, C.-H., Souček, P., Krausz, K., Gelboin, H. V., and Ueng, Y.-F.*, The oxidative metabolism of dimemorfan by human cytochrome P450 enzymes. J. Pharm. Sci. 99, 1063-1077, 2010.

 

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