Lo, Jeng-Fan, PhD (羅正汎 教授)

Resume

Education: University of Illinois, USA
Employment:

2011 Aug -  now Professor at Institute of Oral Biology, School of Dentistry, National Yang-Ming University.
2011 Aug -  now Adjunct Professor at Department of Dentistry, School of Dentistry, National Yang-Ming University.
2008 Aug -  now Adjunct Research Fellow at Department of Dentistry, Taipei Veterans General Hospital.
2008 Aug -  2011 Jul Adjunct Associate Professor at Department of Dentistry, School of Dentistry, National Yang-Ming University.
2005 Aug -  2011 Jul Associate Professor at Institute of Oral Biology, School of Dentistry, National Yang-Ming University.
2000 Jan -  2005 Mar  Research Associate at The Scripps Research Institute, La Jolla, CA. USA.
Affiliation: Institute of Oral Biology

Tel: 886-2-28267222

Fax: 886-2-28264053

E-mail: jflo@ym.edu.tw

Fields of Specialty: Molecular Immunology, Molecular Oncology and Mouse Genetics

Research Description

Tid1, a putative tumor suppressor on oral tumorigenesis

Tid1 protein, a DnaJ cochaperone, is a human counterpart of Drosophila tumor suppressor Tid56. Tid56 null mutation causes tumorous imaginal discs resulting from incessant cell proliferation without differentiation. Others have reported the first case of a tumor-associated mutation at the human Tid1 locus, which was identified in the SF767 glioma cell line giving rise to aberrantly high levels of an hTid-1 mutant variant.
Yeast two-hybrid analyses demonstrate that Tid1 protein interacts with the ErbB families of epithelium growth factor receptors (ErbB1-4), which have been strongly implicated in the genesis of human carcinomas (unpublished data from Lo et al). In addition, over expression of Tid1 in some breast cancer cell lines decline the cell malignancy. We also show that Tid1 negatively regulates the migratory potential of breast cancer cells by inhibiting the production of interleukin-8 (IL-8), which is known to promote tumor metastasis. Further, we discover that the interaction among Tid1, CHIP and ErbB2 affects their prognostic implications on breast cancer patients. We also demonstrate that Tid1 functions as a tumor suppressor in head and neck squamous cell carcinoma.
Due to the high recurrence, high mortality and resistance to conventional therapies, the development of new chemopreventive agents for head and neck cancer applying on high risk population or patients that adjuvant to conventional treatment is an important research priority. For this, we want to elucidate the function of Tid1 in carcinogenesis. Our research will provide further evidence to support that Tid1 functions as a tumor suppressor in cancer tumorigenesis.
To further understand the physiological function of Tid1, we have successfully established a conditional knockout mice model with the deficiency of Tid1. Previously results show that Tid1 is important for early embryogenesis and T cell development.  Herein, we want to further evaluate the biological and physiological function of Tid1 in other tissues such as liver, bone marrow, colon, muscle and lymphoid organs with the transgenic mice system generated in our lab.  With the above transgenic mice system we can establish more mice models as the human disease models for further drugs screening and development.

Isolation and Characterization of Oral Cancer Stem Cells in Oral Cancer Tumorigenesis

Head and neck squamous cell carcinoma (HNSCC), including oral cancer (OC), is the sixth most prevalent malignancy worldwide, and the third most common cancer in developing nations. The prognosis of HNSCC remains dismal because more than 50% of patients die of this disease or complications within 5 years. Development of new chemotherapeutic agents for HNSCC applying on high risk population or patients that adjuvant to conventional treatment is an important research priority.
Recent data demonstrate that cancer cells are functionally heterogeneous that undergo not only proliferation but also differentiation and maturation to a certain degree. In addition, each tumor contains a small subpopulation of cells that exhibit self-renewal capacity – the so-called cancer stem cells (CSCs) or cancer initiating cells (CICs). Heterogeneity of HNSCC has been reported. However, the putative CSCs from HNSCC have not been well characterized. Thus, to uncover the existence of CSCs and identify CSCs’s markers of HNSCC should facilitate the monitoring, therapy, prevention of tumor metastasis or relapse of HNSCC. Furthermore, to screen for drug candidates that targets the CSCs of HNSCC specifically will be instrumental for future HNSCC therapy. 
Previously, we have identified the existence of CSC in head and neck cancer. Our recent data show that we successfully isolate and characterize head and neck squamous cell carcinoma CSCs (HN-CSCs), which possess both the characteristics of stem cells and malignant tumors. However, the molecular mechanisms by which to regulate the stemness and tumorigenicity remain unclear. Due to the resistance of HN-CSCs to conventional therapies, the development of new chemopreventive agents for HN-CSCs applying on high risk population or patients that adjuvant to conventional treatment is still needed. Therefore, we want to further characterize the nature and specific properties for HN-CSCs. In addition, we also want to discover new drug candidates from current drugs, herbals or traditional Chinese medicines such as the active components (single or mixed) from Antrodia Cinnamomea mycelia extract (ACME).
Overall, this research will provide further evidence to support that HN-CSCs play a major role in head and neck cancer tumorigenesis. In addition, botanic drugs targeting HN-CSCs will be developed to be the alternative and adjuvant treatment for future Head and Neck cancer therapeutics.

RESEARCH PROJECTS

年度

計畫名稱

類型

計畫內擔任之工作

執行期間

經費提供單位

2013

探討頭頸癌局部侵犯及治療抗性之整合型研究-癌幹細胞對頭頸癌局部侵犯與藥物治療抗性之探討

個人

主持人

2013/08/01 ~2014/07/31

國科會

2013

樟芝活性成分結合傳統化療藥物作為頭頸癌療法之驗證與探討

個人

主持人

2013/08/01 ~2014/07/31

國科會

2012

樟芝菌絲體活性成分標靶頭頸癌腫瘤幹細胞作為頭頸癌輔助性療法之驗證與探討

個人

主持人

2012/08/01 ~2013/07/31

國科會

2012

樟芝菌絲體活性成分標靶頭頸癌腫瘤幹細胞作為頭頸癌輔助性療法之驗證與探討

個人

主持人

2012/08/01 ~2013/07/31

國科會

2011

Tidl交互作用蛋白質在頭頸癌鱗狀上皮腫瘤細胞癌化機制之探討

個人

主持人

2011/08/01 ~2012/07/31

國科會

2010

口腔癌腫瘤幹細胞分選及其特性對口腔癌腫瘤化之探討(3/3)

個人

主持人

2010/08/01 ~2011/07/31

國科會

2010

抗輻射口腔癌之標靶藥物分子與早期或復發的生物標誌分子之開發及驗證-子計畫一:細胞膜上葡萄糖調節性蛋白Grp78作為口腔癌之早期,復發與癌幹細胞生物標誌之探討

整合

主持人

2010/08/01 ~2011/07/31

國科會

2010

口腔癌腫瘤幹細胞分選及其特性對口腔癌腫瘤化之探討(3/3)

個人

主持人

2010/08/01 ~2011/07/31

國科會

2009

口腔癌腫瘤幹細胞分選及其特性對口腔癌腫瘤化之探討(2/3)

個人

主持人

2009/08/01 ~2010/07/31

國科會

2009

篩選中藥複方與單方具抑制腫瘤幹細胞活性之研究

個人

主持人

2009/03/24 ~2009/12/31

中國醫藥研究所

2009

樟芝菌絲體活性成分標靶腫瘤幹細胞之驗證與探討

個人

主持人

2009/11/01 ~2010/10/31

產學-葡萄王生技股份有限公司

2008

口腔癌腫瘤幹細胞分選及其特性對口腔癌腫瘤化之探討(1/3)

個人

主持人

2008/08/01 ~2009/07/31

國科會

2007

Tid1,果蠅腫瘤抑制基因Tid56同源基因,在口腔鱗狀上皮腫瘤細胞癌化機制之探討(2/2)

個人

主持人

2007/08/01 ~2008/07/31

國科會

2006

Tid1,果蠅腫瘤抑制基因Tid56同源基因,在口腔鱗狀上皮腫瘤細胞癌化機制之探討(1/2)

個人

主持人

2006/08/01 ~2007/07/31

國科會

2005

Tid1,果蠅腫瘤抑制基因Tid56同源染色體,在口腔癌腫瘤化機制之探討

個人

主持人

2005/11/01 ~2006/08/31

國科會

ReVIEWER of Peer reviewers journals
  1. Annals of Oncology
  2. Cancer
  3. Cancer Letters
  4. Cell Biochemistry & Function
  5. Cellular Oncology
  6. Cell Proliferation
  7. Evidence Based Complementary and Alternative Medicine
  8. Genes, Chromosomes and Cancer
  9. International Journal of Cancer
  10. Journal of Biomedical Science
  11. Journal of Dental Sciences
  12. Journal of Experimental & Clinical Cancer Research
  13. Journal of Oral Pathology and Medicine
  14. Molecular and Cellular Biochemistry
  15. Molecular Cancer
  16. Molecular Nutrition & Food Research
  17. Molecular Medicine
  18. Neoplasia
  19. PLoS One
  20. Tumor Biology
Publication: (*: corresponding author)
  1. Jan CI, Yu CC, Hung MC, Nieh S, Lee HS, Lou MA, Wu YC, Chen CY, Huang CY, Chen FN, and Lo JF. Tid1, CHIP and ErbB2 interactions and their prognostic implications for breast cancer patients. J Pathology. 2011. 18 April (Accepted and Online). (SCI; Corresponding author)
  2. Chu CH, Lo JF, Hu WS, Lu RB, Chang MH, Tsai FJ, Tsai CH, Weng YS, Tzang BS, Huang CY. Histone acetylation is essential for ANG-II-induced IGF-IIR gene expression in H 9c2 cardiomyoblast cells and pathologically hypertensive rat heart. J Cell Physiol. 2011 Mar 16 [Epub ahead of print]. (SCI)
  3. Lo JF, Yu CC, Chiou SH, Huang CY, Jan CI, Lin SC, Liu CJ, Hu WY, Yu YH. 2011. The Epithelial-Mesenchymal Transition Mediator S 100A4 Maintains Cancer Initiating Cells in Head and Neck Cancers. Cancer Res. 71:1912-23. (SCI; Corresponding author)
  4. Wu MJ, Jan CI, Tsay YG, Yu YH, Huang CY, Lin SC, Liu CJ, Chen YS, Lo JF, Yu CC. 2010. Elimination of head and neck cancer initiating cells through targeting glucose regulated protein78 signaling. Mol Cancer. 9:283. (SCI; Corresponding author)
  5. Yu CC and Lo JF 2009. Cancer Stem-Like Cells on Tumorigenesis of Oral Squamous Cell Carcinoma. Adaptive Medicine 1: 36-42. (Corresponding author)
  6. Chen CY, Chiou SH, Huang CY, Jan CI, Lin SC, Tsai ML, Lo JF. Distinct Population of Highly Malignant Cells in a Head and Neck Squamous Cell Carcinoma Cell Line Established by Xenograft Model. Journal of Biomedical Science.  2009,16:100. (SCI; Corresponding author)
  7. Chen CY, Chiou SH, Huang CY, Jan CI, Lin SC, Hu WY, Chou SH, Liu CJ, Lo JF. 2009. Tid1 functions as a tumor suppressor in head and neck squamous cell carcinoma. J. Pathology. 219:347-355. (SCI; Corresponding author)
  8. Lee J, Hayashi M, Lo JF, Fearns C, Chu WM, Luo Y, Xiang R, Chuang TH. NF-kappaB activation primes cells to a pro-inflammatory polarized response to a TLR7 agonist. 2009. Biochem J. 421:301-10. (SCI)
  9. Liu CJ, Lo JF, Kuo CH, Chu CH, Chen LM, Tsai FJ, Tsai CH, Tzang BS, Kuo WW, Huang CY. 2009. Akt Mediates 17beta-Estradiol and/or Estrogen Receptor alpha Inhibition of LPS-Induced Tumor Necrosis Factor-alpha Expression and Myocardial Cell Apoptosis by Suppressing the JNK1/2-NFkappaB Pathway. J Cell Mol Med.13:3655-67 (SCI)
  10. Kao CL, Huang PI, Tsai PH, Tsai ML, Lo JF, Lee YY, Chen YJ, Chen YW, Chiou SH. 2009. Resveratrol-induced apoptosis and increased radiosensitivity in CD133-positive cells derived from atypical teratoid/rhabdoid tumor. Int J Radiat Oncol Biol Phys. 74:219-28. (SCI)
  11. Hung KF, Lai KC, Liu TY, Liu CJ, Lee TC, Lo JF. 2009. Asb6 upregulation by Areca nut extracts is associated with betel quid-induced oral carcinogenesis. Oral Oncol. 45:543-8. (SCI; Corresponding author)
  12. Chiou, S.H., C.C. Yu, C.Y. Huang, S.C. Lin, C.J. Liu, T.H. Tsai, S.H. Chou, C.S. Chien, H.H. Ku, J.F. Lo. 2008. Positive Correlations of Oct-4 and Nanog in Oral Cancer Stem-Like Cells and High Grade Oral Squamous Cell Carcinoma. Clinical Cancer Research. 14: 4085-4095. (SCI; Corresponding author)
  13. Chiou, S.H., C.L. Kao, Y.W. Chen, C.S. Chien, S.C. Hung, J.F. Lo, YJ Chen, HH Ku, MT Hsu, TT Wong. 2008. Identification of CD133-positive Radioresistant Cells in Atypical Teratoid/ Rhabdoid Tumor. Plos One. 3:e2090. (SCI)
  14. Lin H.L., M.H. Yang, C.W. Wu, P.M. Chen, Y.P. Yang, Y.R. Chu, C.L. Kao, H.H. Ku, J.F. Lo, J.P. Liou, C.W. Chi and S.H. Chiou. 2007. 2-Methoxyestradiol attenuates phosphatidylinositol 3-kinase/Akt pathway-mediated metastasis of gastric cancer. Int J Cancer. 121:2547-55. (SCI)
  15. Kim, S. W. M. Hayashi, J.F. Lo, C. Fearns, R. Xiang, G. Lazennec, Y. Yang, and J.D. Lee. 2005. Tid1 Negatively Regulates the Migratory Potential of Cancer Cells by Inhibiting the Production of Interleukin-8.Cancer Res. 65: 8784-8791. (SCI)
  16. Zhou, H., Y. Luo, J.F. Lo, M. Mizutani, N. Mizutani, J.D. Lee, F.J. Primus, J. C. Becker, R. Xiang, and R. A. Reisfeld. 2005. NKG2D ligand-H60 is a potent immunological stimulatory adjuvant for DNA vaccines. Proc Natl Acad Sci U S A. 102, 10846-51. (SCI)
  17. Lo, J.F., H. Zhou, R. A. Reisfeld and J.D. Lee. 2005. Tid1 is required for T cell transition from double-negative 3 to double-positive stages. The Journal of Immunology 174, 6105-6112. (SCI; First author) 
  18. Kim, S.W. T.H. Chao, R. Xiang, J.F. Lo, M. J. Campbell, C. Fearns and J.D. Lee. 2004. Tid1, the human homologue of a Drosophila tumor suppressor, reduces the malignant activity of ErbB2 in carcinoma cells. Cancer Res. 64, 7732-7739. (SCI)
  19. Lo, J.F., M. Hayashi, B. Tian, J. F. Huang, S. Takayama, J. M. Zapata, Y. Yang and J. D. Lee. 2004. Tid1, a cochaperone of the heat shock 70 protein and a mammalian counterpart of the Drosophlila tumor suppressor l(2)tid, is critical for early embryonic development and cell survival. Molecular and Cellular Biology. 24, 2226-2236. (SCI; First author)
  20. Tapping RI, K Yutaka, T.H. Chao, M. Hayashi, J.F. Lo, S.W. Kim and J.D. Lee . 2004. Investigating the Cellular BMK1/ERK5 Signaling Pathway. Methods Mol Biol. 250, 89-96.
  21. Kim, S.W., M. Hayashi, J.F. Lo, Y.Yang, J. S. Yoo and J. D. Lee. 2003. ARF4 Small GTPase Mediates EGFR-dependent PLD2 Activation. Journal of Biological Chemistry 278, 2661-2668. (SCI)
  22. Hayashi, M., R. I. Tapping, T. H. Chao, J.F. Lo, C. C. King, Y. Yang and J. D. Lee. 2001. BMK1 Mediates Growth Factor-induced Cell Proliferation through Direct Cellular Activation of Serum and Glucocorticoid-inducible Kinase. Journal of Biological Chemistry 276, 8631-8634. (SCI)
  23. Gupta, A., K. Matsui, J.F. Lo, and S. Silver. 1999. Molecular basis for resistance to silver cations in Salmonella. Nature Medicine 5, 183-8. (SCI)
  24. Silver, S., J.F.Lo, and A. Gupta. 1999. Ag+ as an Antimicrobial Agent: Clinical Uses and Bacterial Resistance. APUA (Association for Prudent Use of Antibiotics) Newsletter 17, 1-3.
  25. Silver, S., A. Gupta, K. Matsui, and J.F.Lo. 1999.  Resistance to Ag(I) cations in bacteria: environments, genes and proteins. Metal‑Based Drugs 6, 315-320. (SCI) 
  26. Lo, J.F., H.F. Wang; M.F. Tam, and T.C. Lee. 1992.  Glutathione S-transferase p in an arsenic-resistant Chinese hamster ovary cell line. Biochem.  J.  288, 977-982. (SCI, First author)
  27. Lee, T.C., M.L. Wei; W.J. Chang, I.C. Ho, J.F. Lo, K.Y. Jan, and H. Huang.  1989.   Elevation of glutathione levels and glutathione S-transferase activity in arsenic-resistant Chinese hamster ovary cells. In Vitro Cell Develop. Biol. 25, 442-448. (SCI) 

Oral presentations:

  1. Lo, J.F. Cancer Stem Cell on Oral Cancer Tumorigenesis. 2011. June. School of Dentistry,   National Taiwan University, Taipei, Taiwan.
  2. Lo, J.F. Cancer Stem Cell on Oral Cancer Tumorigenesis. 2011. April. School of Life Science, National Yang-Ming University, Taipei, Taiwan .
  3. Lo, J.F. Identification and Functional characterization of cancer stem cells on oral cancer tumorigenesis. 2010. October. Department of Life Science/Institute of Molecular Biology/Institute of Biomedical Science, National Chung Cheng University, Chiayi, Taiwan .
  4. Lo, J.F. Identification and Functional characterization of cancer stem cells on oral cancer tumorigenesis. 2010. September. Department of Biotechnology, Hungkuang University, Taichung, Taiwan.
  5. Lo, J.F. Identification and Functional characterization of cancer stem cells on oral cancer tumorigenesis. 2010. July. Department of Dentistry, Taipei Medical University, Taipei, Taiwan .
  6. Lo, J.F. Tid1 on head and neck cancer tumorigenesis. 2010. June. Chinese Medical Association Annual Meeting (Section of Dentistry), Taipei, Taiwan .
  7. Lo, J.F. Functional characterization of oral cancer stem cells on oral cancer tumorigenesis. 2009. November. Department of Biochemistry and Graduate Institute of Medical Sciences, College of Medicine, Taipei Medical University, Taipei, Taiwan.
  8. Lo, J.F. Research of cancer stem cell in HNSCC. 2009. October. The 13th Chang Gung Memorial Hospital (CGMH) Cancer Symposium, Chang Gung Memorial Hospital, Taoyuan, Taiwan.
  9. Lo, J.F. Isolation and functional characterization of oral cancer stem-like cells. 2009. June. Department of Biotechnology and Laboratory Science in Medicine and Institute of Biotechnology in Medicine, National Yang-Ming University, Taipei, Taiwan .
  10. Lo, J.F. Isolation and functional characterization of oral cancer stem-like cells on oral cancer tumorigenesis. 2009. May. Department of Life Science, Fu-Jen Catholic University, Taipei, Taiwan.
  11. Lo, J.F. Cancer stem cells. 2009. May. Graduate Institute of Exercise Science, Taipei Physical Education College, Taipei, Taiwan.
  12. Lo, J.F. Isolation and functional characterization of oral cancer stem-like cells on oral cancer tumorigenesis. 2009. March. The 24th Joint Annual Conference of Biomedical Science, Taipei, Taiwan.
  13. Lo, J.F. Isolation and functional characterization of oral cancer stem-like cells on oral cancer tumorigenesis. 2009. March. Department of Dentistry, National Defense Medical College , Taipei , Taiwan.
  14. Lo, J.F. Isolation and functional characterization of oral cancer stem-like cells on oral cancer tumorigenesis. 2009. February. Radiation Oncology Division, Cancer Center, Taipei Veterans General Hospital, Taipei , Taiwan.
  15. Lo, J.F. Isolation and functional characterization of oral cancer stem-like cells on oral cancer tumorigenesis. 2009. January. Institute of Cellular and Organismic Biology, Academia Sinica, Taipei, Taiwan .
  16. Lo, J.F. Cancer stem-like cell on oral cancer tumorigenesis. 2008. December. Asian-Pacific TCOG 12th Meeting, Taipei, Taiwan .
  17. Lo, J.F. Cancer stem-like cell on oral cancer tumorigenesis. 2008. October. The Third Annual Meeting, Taiwanese Society of Molecular Medicine, Taipei, Taiwan.
  18. Lo, J.F. Cancer stem-like cell on oral cancer tumorigenesis. 2008. June. 2008. Chinese Medical Association Annual Meeting (Section of Stem Cell and Cancer), Taipei, Taiwan.  
  19. Lo, J.F. Cancer stem-like cell on oral cancer tumorigenesis. 2008. June. 2008. Department of Dentistry, Taichung Veterans General Hospital, Taichung, Taiwan.
  20. Lo, J.F. Isolation and characterization of cancer stem-like cells in oral squamous cell carcinoma. 2007. November. National Research Institute of Chinese Medicine, Taipei, Taiwan.
  21. Lo, J.F. Conditional knockout, an ultimate tool to study the function of Tid1, a putative tumor suppressor, in early embryonic development and T cell differentiation. 2007. October. Graduate Institute of Basic Medical Science, Chinese Medical University, Taichung, Taiwan.
  22. Lo, J.F. Conditional knockout, an ultimate tool to study the function of Tid1, a putative tumor suppressor, in early embryonic development and T cell differentiation. 2007. October. Department of Medical Research and Education, Taipei Veterans General Hospital, Taipei, Taiwan.
  23. .Lo, J.F Isolation and characterization of cancer stem-like cells in oral squamous cell carcinoma. 2007. September. 2007 Retreat of Molecular Medicine Program, Taiwan International Graduate Program (TIGP) in Academia Sinica, Tauyuan, Taiwan.
  24. Lo, J.F. Tid1, a putative tumor suppressor, is required for early double negative T cell development. 2006. June. Department of Dentistry, Taipei Veterans General Hospital, Taipei, Taiwan.
  25. Lo, J.F. Conditional knockout, an ultimate tool to study the function of Tid1, a putative tumor suppressor, in early embryonic development and T cell differentiation. 2005. June. Institute of Neuroscience, National Yang-Ming University, Taipei, Taiwan.
  26. Lo, J.F. Tid1, a putative tumor suppressor, plays a role in embryogenesis, cell differentiation and tumorigenesis. 2004. June. Institute of Biochemistry and Biotechnology, Chung Shan Medical University, Taichung, Taiwan.
  27. Lo, J.F. Tid1, a putative tumor suppressor, plays a role in embryogenesis, cell differentiation and tumorigenesis. 2004. June. Institute of Zoology, Academic Sinica, Taipei, Taiwan.
  28. Lo, J.F. Tid1, a putative tumor suppressor, plays a role in embryogenesis, cell differentiation and tumorigenesis. 2004. June. Institute of Oral Biology, National Yang-Ming University, Taipei, Taiwan.

Poster presentations:

  1. Wu Y.C., L.Y. Huang, J.F. Lo. 2011. Tid1 Regulates Galectin-7 Mediated Tumorigenesis of Oral Squamous Cell Carcinoma. Annual General Meeting, American Association for Cancer Research, Orlando, Florida, April 2-6.
  2. Chang C.W., J.F. Lo. 2011. Identification and Characterization of Active Components of Antrodia Camphorata Mycelia on Targeting Cancer initiating Cell. Annual General Meeting, American Association for Cancer Research, Orlando, Florida, April 2-6.
  3. Chang C.H., J.F. Lo. 2011. Matricellular protein Cyr61/CCN1 regulates the stemness of oral cancer stem-like cells. Annual General Meeting, American Association for Cancer Research, Orlando, Florida, April 2-6.
  4. Chen Y.S., J.F. Lo. 2011. CD133/Prominin-1 Modulates epithelial-mesenchymal transition, Stemness and Tumorigenicity of Oral Squamous Cell Carcinoma-derived Cancer Initiating Cells. Annual General Meeting, American Association for Cancer Research, Orlando, Florida, April 2-6.
  5. Tan K.K., Y.G. Tsay,  J.F. Lo. 2011. Identification of biomarkers and therapeutic targets in oral squamous cell carcinomas through comparative proteomic analyses. Annual General Meeting, American Association for Cancer Research, Orlando, Florida, April 2-6.
  6. Yu C.C., S.H. Chiou, Y.H. Yu, J.F. Lo. 2010. Epithelial-mesenchymal transition mediator, S 100A4, in maintenance of head and neck cancer initiating cells. Annual General Meeting, American Association for Cancer Research, Washington, DC, April 17-21.
  7. Wu M.J., J.F. Lo, C.C. Yu. 2010. Glucose regulated protein78, a putative head and neck cancer initiating cells marker.  Annual General Meeting, American Association for Cancer Research, Washington, DC, April 17-21.
  8. Chen Y.S., J.F. Lo, C.C. Yu. 2010. CD133/prominin-1 regulates the tumorigenicity of oral squamous carcinoma cells-derived cancer initiating cells.  Annual General Meeting, American Association for Cancer Research, Washington, DC, April 17-21.
  9. Yu, C.C., S.H. Chiou, Y.H. Yu, C.J. Liu and J.F. Lo. 2009. S 100A4, a Metastatic Marker, Modulates Self-renewal and Tumorigenicity of Head and Neck Cancer Initiating Cells. Annual General Meeting, American Association for Cancer Research, Denver, CO, April 18-22.
  10. Yu, CC, S.H. Chiou, C.J. Liu and J.F. Lo. 2008. Positive Correlations of Oct-4 and Nanog in Oral Cancer Stem-Like Cells and High Grade Oral Squamous Cell Carcinoma. Annual General Meeting, American Association for Cancer Research, San Diego, CA, April 12-16.
  11. Chen, C.Y., Y.W. Liao, C.J. Liu and J.F. Lo. 2008. Characterization of Tid1, a mammalian homologue of Drosophila tumor suppressor Tid56, in oral cancer tumorigenesis. Annual General Meeting, American Association for Cancer Research, San Diego, CA, April 12-16.
  12. Yu, C.C., S.H. Chiou and J.F.Lo. 2007.  Isolation and characterization of oral cancer stem-like cells in oral squamous cell carcinoma. Annual General Meeting, American Association for Cancer Research, Los Angeles, CA, April 14-18.
  13. Chen, C.Y., Mo C.F., Yu C.J., Yan Y.T. and J.F. Lo. 2006. Elucidate the function of Tid1, a homologue of Drosophila tumor suppressor Tid56, in hematopoiesis. The 11th meeting of Society of Chinese Bioscientists in America, San Francisco, CA, July 19-23.
  14. Kim, S.W., M. Hayashi, J.F. Lo and J.D. Lee. 2005. Tid1 regulates the expression of PAI-1 gene.  Annual General Meeting, American Association for Cancer Research, Anaheim, CA, April 16-20.
  15. Lo, J. F., P. G. W. Gettins and S. Silver. 1999.  A Silver Binding Protein, SilE, of Escherichia coli Silver Resistance Plasmid pMG101. Annual General Meeting, American Society for Microbiology, Chicago, IL, May 30-June 3.
  16. Lo, J. F., P. G. W. Gettins and S. Silver. 1999.  A Silver Binding Protein, SilE, of Escherichia coli Silver Resistance Plasmid pMG101. Frontiers of NMR in Molecular Biology VI, Keystone Symposia, Breckenridge, Co, Jan 9-15.
  17. Silver, S., A. Gupta, K. Matsui, and J. F. Lo.  1998.  The molecular genetics of a new plasmid system for resistance to Ag(I) compounds in enteric bacteria. The 4th International Symposium on Gold and Silver in Medicine at the Regional Meeting of the American Chemical Society, Milwaukee, WI, June.
  18. Gupta, A., K. Matsui, J. F. Lo, and S. Silver. 1998. Plasmid mediated silver resistance in Escherichia coli: sequence, genetic analysis and diversity.  Annual General Meeting, American Society for Microbiology, Atlanta, GA, May.
  19. Gupta, A., K. Matsui, J. F. Lo, A. Hendry, and S. Silver. 1997.  Silver resistance in Escherichia coli: Sequence, physiological and genetic analysis of a plasmid resistance determinant, Poster presentation, American Society for Biochemistry and Molecular Biology Fall Symposium: Copper and Zinc Receptors in Signaling, Trafficking and Disease, Granlibakken, CA. October.
  20. Lo, J.F., M.F. Tam, and T.C. Lee.  Glutathione S-transferase p in an arsenic-resistant Chinese hamster ovary cell line.  1990, Society of Chinese Bioscientists in America Symposium, Hong Kong. June.
Last update: 2015-03-13 4:52 PM

TOP