林姝君 教授 (Shu-Chun Lin, PhD)

個人簡歷

http://www.ym.edu.tw/sod/teacher/LinSC/img2012.JPG

 

學歷

畢/肄業學校

主修系別

學位

國立臺灣大學

動物系

學士

國立陽明大學

微免所

碩士

美國伊利諾大學芝加哥校區

生物化學系

博士

經歷:

服務單位

職稱

口腔生物研究所所長

所長 (2012–2014)

國立陽明大學學務處

副學務長兼生輔組組長(2010-)

國立陽明大學教務處

副教務長(2006-2008)

國立陽明大學學務處

就輔組組長(2004-2006)

現職:國立陽明大學學務長

專長:腫瘤生物學、分子生物學、生物化學

聯絡電話(02) 2826-7272

傳真電話:(02) 2826-4053

電子郵件sclin@ym.edu.tw

研究方向

1.檳榔誘發之訊息活化於細胞轉型之角色

2.微型RNA異常於口腔之起癌作用

研究計畫(三年內)

編號

年度

計畫編號

計畫名稱

計畫內擔任之工作

執行期間

經費提供單位

1

2013

MOST103-2314-B-010-020-MY3 

研究在口腔癌化進程中第一型與AT序列互動結合功能蛋白區基因所扮演之角色及微RNA對其之調控機制(1/3) 

主持人

2014/08/01~2017/07/31

科技部

2

2013

NSC102-2628-B-010-006-MY3

以微型RNA轉殖鼠動物模式測試臨床前期口腔癌之防治(1/3

主持人

2013/08/01~2014/07/31

國科會

3

2012

NSC99-2628-B-010-013-MY3

致癌性微型RNA及其標靶基因調節口腔上皮細胞功能及癌化之探討(3/3

主持人

2012/08/01~2013/07/31

國科會

4

2012

NSC100-2314-B-010-027-MY3

微型RNA調控尼古丁乙醯膽鹼受器於菸草相關口腔癌化之角色(2/3)

主持人

2012/08/01~2013/07/31

國科會

5

2011

NSC99-2628-B-010-013-MY3

致癌性微型RNA及其標靶基因調節口腔上皮細胞功能及癌化之探討(2/3

主持人

2011/08/01~2012/07/31

國科會

6

2011

NSC 100-2314-B-010-027-MY3

微型RNA調控尼古丁乙醯膽鹼受器於菸草相關口腔癌化之角色(1/3)

主持人

2011/08/01~2012/07/31

國科會

7

2010

NSC 97-2314-B-010 -027 -MY3

MKP4於口腔癌化角色之功能性探討(3/3)

主持人

2010/08/01~2011/07/31

國科會

8

2010

NSC99-2628-B-010-013-MY3)

致癌性微型RNA及其標靶基因調節口腔上皮細胞功能及癌化之探討(1/3)

主持人

2010/08/01~2011/07/31

國科會

9

2009

NSC 97-2314-B-010 -027 -MY3

MKP4於口腔癌化角色之功能性探討(2/3)

主持人

2009/08/01~2010/07/31

國科會

10

2009

NSC96-2628-B-010-033-MY3

miR181微RNA家族成員於口腔癌生成與轉移之功能性探討(3/3)

主持人

2009/08/01~2010/07/31

國科會

11

2008

NSC 97-2314-B-010 -027 -MY3

MKP4於口腔癌化角色之功能性探討(1/3)

主持人

2008/08/01~2009/07/31

國科會

12

2008

NSC96-2628-B-010-033-MY3

miR181RNA家族成員於口腔癌生成與轉移之功能性探討(2/3)

主持人

2008/08/01~2009/07/31

國科會

得獎紀錄

年度

提供單位

獲獎項目

獲獎日期

2014

中華牙醫學會

指導口生所曾思學同學獲台灣葛蘭素史克口腔保健獎學金學術競賽首獎

2014-03

2011

陽明大學

指導口生所學生蔡孟妙榮獲本校100年度「陽明博士班優良論文獎學金」全校第一名

2011-

2011

陽明大學

指導口生所碩士班學生沈妏霙獲頒本校100年度「紀念尹珣若先生品學及論文優良獎學金」

2011-

2011

陽明大學

榮獲本校99學年度優良教師

2011-

2010

陽明大學

指導牙醫系楊惇茹同學獲學術論文研討會大專生組優等獎

2010-06

2010

陽明大學

 指導蔡孟妙同學榮獲陽明大學學術海報競試佳作獎

2010-06

2007~2010

陽明大學

教師學術卓越獎勵

2007-2010

2005~2009

陽明大學

牙醫學院教學認真獎

2005-2009

2009

第17屆細胞及分子生物新知研討會

指導蔡孟妙同學獲優秀壁報論文獎

Feb-09

2009

國科會

指導牙醫系楊惇茹同學獲國科會大專學生參與專題研究計畫研究創作獎

Jun-09

2008

中華牙醫學會

指導牙醫系黃彥娟同學榮獲中華牙醫學會學術競試冠軍

Aug-08

2008

生物醫學聯合年會

指導洪佩詩同學獲貼示海報優等獎

May-08

2007

第15屆細胞及分子生物新知研討會

指導曾羽辛同學獲優秀壁報論文獎

Feb-07

2006

陽明大學

指導口生所洪佩詩同學榮獲陽明大學學術海報競試優等獎

Jun-06

2005

中華牙醫學會

指導牙醫系郭璇憓同學榮獲中華牙醫學會學術競試冠軍

Sep-05

期刊論文(* 通訊作者)

  1. Hung PS, Tu HF, Kao SY, Yang CC, Liu CJ, Huang TY, Chang KW*, Lin SC* (2014) miR-31 is up-regulated in oral premalignant epithelium and contributes to the immortalization of normal oral keratinocytes. Carcinogenesis 35: 1162-71.
  2. Tseng SH, Yang CC, Yu EH, Chang C, Lee YS, Liu CJ, Chang KW*, Lin SC* (2014). K14-EGFP-miR-31 transgenic mice have high susceptibility to chemical-induced squamous cell tumorigenesis that is associating with Ku80 repression. Int J Cancer (In press).
  3. Lu WC, Kao SY, Yang CC, Tu HF, Wu CH, Chang KW*, Lin SC* (2014). EGF up-regulates miR-31 through the C/EBPβ signal cascade in oral carcinoma. Plos One (In press)
  4. Hung PS, Liu CJ, Chou CS, Kao SY, Yang CC, Chang KW. Chiu TH, Lin SC* (2013). miR-146a enhances the oncogenicity of oral carcinoma by concomitant targeting of the IRAK1, TRAF6 and NUMB genes. PLoS One 8:11, e79926.
  5. Chang KW, Kao SY, Wu YH, Tsai MM, Tu HF, Liu CJ, Lui MT, Lin SC* (2013). Passenger strand miRNA miR-31* regulates the phenotypes of oral cancer cells by targeting RhoA. Oral Oncol 49: 27 -33.
  6. Chang KW, Chu TH, Gong NR, Chiang WF, Yang CC, Liu CJ, Wu CC, Lin SC* (2013). miR-370 modulates insulin receptor substrate-1 expression and inhibits the tumor phenotypes of oral carcinoma. Oral Dis19: 611-9.
  7. Chu TH, Yang CC, Liu CJ, Lui MT, Lin SC*, Chang KW* (2013).miR-211 promotes the progression of head and neck carcinomas by targeting TGFβRII. Cancer Lett 337: 115-24.
  8. Liu CJ, Tsai MM, Tu HF, Lui MT, Cheng HW, Lin SC* (2013) miR-196a overexpression and miR-196a2 gene polymorphism are prognostic predictors of oral carcinomas. Ann Surg Oncol (In press).
  9. Tu HF, Lin SC, Chang KW* (2013). MicroRNA aberrances in head and neck cancer - pathogenetic and clinical significance (Invited review article). Current Opinion Otolaryn Head & Neck Surgery 21: 104 -11.
  10. Tu HF, Liu CJ, Chang CJ, Wang PW, Kao SY, Yang CC, Yu EH, Lin SC*, Chang KW* (2012). The association between genetic polymorphism and the processing efficiency of miR-149 affects the prognosis of patients with head and neck squamous cell carcinoma Plos ONE 7: 12:e51606.
  11. Hung PS, Chang KW, Kao SY, Chu TH, Liu CJ, Lin SC* (2012). Association between the rs2910164 polymorphism in pre-mir-146a and oral carcinoma progression. Oral Oncol 48: 404-8.
  12. Tseng YH, Chang KW, Yang CC, Liu CJ, Kao SY, Liu TY, Lin SC* (2012). Association between the areca-stimulated vimentin expression and the progression of head and neck cancers. Head and Neck 34: 245-53.
  13. Liu CJ, Lin SC (Co-first author), Yang CC, Cheng HW, Chang KW* (2012). Exploiting salivary miR-31 as a clinical biomarker of oral squamous cell carcinoma. Head and Neck 34: 219-24.
  14. Tu HF, Chang KW, Chiang WF, Liu CJ, Yu AH, Liu ST, Lin SC* (2011). The frequent co-expression of the oncogenes PIK3CA and PAK1 in oral carcinomas. Oral Oncol 47: 211-6.
  15. Yang CC, Hung PS, Wang PW, Liu CJ, Chu TH, Cheng HW, Lin SC* (2011) miR-181 as a putative biomarker for lymph node metastasis of oral squamous cell carcinoma. J Oral Pathol Med 40: 397-404.
  16. Yang CJ, Shen WG, Liu CJ, Chen YW, Lu HH, Tsai MM. Lin SC* (2011). miR-221 and miR-222 expression increased the growth and tumorigenesis of oral carcinoma cells. J Oral Pathol Med 40: 560-6.
  17. Chiang, WF, Hung PS, Liu SY, Yuan TC, Chen YP, Chang KW, Lin SC* (2011). Increase of ZASC1 gene copy number in recurrent oral carcinoma. Oral Diseases 17: 53-9.
  18. Tu HF, Liu CJ, Liu SY, Chen YP, Yu EH, Lin SC*, Chang KW* (2011) Serum DcR3 level is a predictive marker for nodal metastasis and survival among oral cancer patients. Head and Neck 33: 396-402.
  19. Lo JF*, Yu CC, Chiou SH, Huang CY, Jan CI, Lin SC, Liu CJ, Hu WY, Yu YH (2011). The epithelial-mesenchymal transition mediator S100A4 maintains cancer initiating cells in head and neck cancers. Cancer Res 71: 1912-23.
  20. Wu MJ, Jan CI, Tsay YG, Yu YH, Huang CY, Lin SC, Liu CJ, Chen YS, Lo JF, Yu CC* (2011). Elimination of head and neck cancer initiating cells through targeting glucose regulated protein78 signaling. Mol Cancer 9: 287.
  21. Tseng YH, Yang CC, Lin SC, Cheng CC, Lin SH, Liu CJ, Chang KW* (2011). Areca nut extract upregulates vimentin by activating PI3K/AKT signaling in oral carcinoma. J Oral Pathol Med 40: 160-6.
  22. Lu HH, Kao SY, Liu TY, Liu ST, Huang YP, Chang KW*, Lin SC*. (2010). Areca nut extract induced oxidative stress and up-regulated hypoxia inducing factor leading to autophagy in oral cancer cells. Autophagy 6: 725-37.
  23. Chang KW, Hung PS, Lin IY, Hou CP, Chen LK, Tsai YM, Lin SC* (2010). Curcumin induces insulin-like growth factor binding protein-5 (IGFBP-5) expression through up-regulating CCAAT/enhancer-binding protein-α (C/EBPα) in oral cancer cells. Int J Cancer 127: 9 - 20.
  24. Lin SC, Liu CJ, Lin JA, Chiang WF, Hung PS, Chang KW* (2010) miR-24 up-regulation in oral carcinoma: positive association from clinical and in vitro analysis. Oral Oncol 46: 204-8.
  25. Liu CJ, Tsai MM, Hung PS, Kao SY, Liu TY, Wu KJ, Chiou SH, Lin SC*, Chang KW* (2010). miR-31 ablates expression of the HIF regulatory factor FIH to activate the HIF pathway in head and neck carcinoma. Cancer Res 70: 1035-44.
  26. Hung PS, Chen FC, Kuang SH, Kao SY, Lin SC*, Chang KW* (2010). miR-146a induces differentiation of periodontal ligament cells. J Dent Res 89: 252-7.
  27. Liu CJ, Kao SY, Tu HF, Tsai MM, Chang KW*, Lin SC* (2010). Increase of microRNA miR-31 level in plasma could be a potential marker of oral cancer. Oral Dis 16: 360-4.
  28. Lin MH, Chang KW, Lin SC, Miner JH* (2010). Epidermal hyperproliferation in mice lacking fatty acid transport protein 4 (FATP4) involves ectopic EGF receptor and STAT3 signaling. Dev Biol 344: 707-19.
  29. Liu CJ*, Chang KW, Lin SC, Cheng HW (2009). Presurgical serum levels of matrix metalloproteinase-9 and vascular endothelial growth factor in oral squamous cell carcinoma. Oral Oncol 45: 920-5
  30. Chen CY, Chiou SH, Huang CY, Jan CI, Lin SC, Hu WY, Chou SH, Liu CJ, Lo JF* (2009). Tid1 functions as a tumor suppressor in head and neck squamous cell carcinoma. J Pathol 219:347-55.
  31. Chen CY, Chiou SH, Huang CY, Jan CI, Lin SC, Tsai ML, Lo JF* (2009). Distinct population of highly malignant cells in a head and neck squamous cell carcinoma cell line established by xenograft model. J Biomed Sci. 16:100.
  32. Lu HH, Chen LK, Cheng CY, Hung SL, Lin SC, Chang KW* (2009). Areca nut extract-treated gingival fibroblasts modulate the invasiveness of polymorphonuclear leukocytes via the production of MMP-2. J Oral Pathol Med 38:79-86.
  33. Chang KW, Liu CJ, Chu TH, Cheng HW, Hung PS, Hu WY, Lin SC* (2008). Association between high miR-211 microRNA expression and the poor prognosis of oral carcinoma. J Dent Res 87: 1063-68 (SCI)
  34. Lu HH, Liu CJ, Liu TY, Kao SY, Lin SC*, Chang KW* (2008). Areca-treated fibroblasts enhance tumorigenesis of oral epithelial cells. J Dent Res 87:1069-74 (SCI)
  35. Tu HF, Chen HW, Kao SY, Lin SC, Liu CJ*, Chang KW* (2008). MDM2 SNP 309 and p53 codon 72 polymorphism are associated with the outcome of oral carcinoma patients receiving postoperative irradiation. Radiotherapy and Oncol 87: 243-52. (SCI)
  36. Liu CJ, Kuo LT, Cheng HW, Liu TY, Chang KW*, Lin SC* (2008) Differential gene expression signature between primary and metastatic head and neck squamous cell carcinoma. J Pathol 214: 489-97 (SCI).
  37. Chiang WF, Liu SY, Lin CN, Yen CY, Chen YC, Lin SC, Chang KW* (2008). Association of epidermal growth factor receptor (EGFR) gene copy number amplification with neck lymph node metastasis in areca-associated oral carcinomas. Oral Oncol 44: 270-6 (SCI)
  38. Hung PS, Kao SY, Shih YH, Chiou SH, Liu CJ, Chang KW*, Lin SC* (2008). Insulin-like growth factor binding protein-5 (IGFBP-5) suppresses the tumorigenesis of head and neck squamous cell carcinoma. J Pathol 214: 368-76 (SCI)

研究成果圖

http://www.ym.edu.tw/sod/teacher/LinSC/Image9.gif

更新日期: 2014-09-04 10:15 AM

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