The overall goal of Dr. Hung’s research is to understand the
functions of viral proteins, viral entry and pathogenesis, and the
relationship between microbiology and immunology and oral diseases. Two main
areas of current research are as followed:
(A) The pathogenesis of herpes simplex virus:
Herpes simplex virus types 1 and 2 (HSV-1 and HSV-2), producing primary and
reactivation infections, are the causative agents of human diseases,
including gingivostomatitis, pharyngitis, herpes labialis, encephalitis, eye
and genital infection. The understanding of viral pathogenesis will help
eliminate the viruses and may reduce the diseases caused by viral infection.
The research topics include: (1) the mechanisms involved in complement
evasion of herpes simplex viruses; (2) the interaction of viral
glycoproteins and cellular receptors and the possible signal transduction
pathway involved during viral infection into cells of oral origin; and (3)
the possible correlation of herpesvirus infection and periodontal diseases.
(B) The effects of areca quid chewing on microbiology and
Areca chewing is associated with an increased risk of oral squamous cell
carcinoma and oral submucous fibrosis. Studies have also shown a higher
prevalence of periodontal disease among areca chewers than non-areca
chewers. Effects on the functions of immune cells may be one possible
mechanism by which areca quid chewing compromises the oral health. The
research topics include: (1) the effects of components of areca quid on oral
microbiology and periodontal tissues, and (2) the molecular and functional
relationship between immune system and areca-quid associated oral
- Lee Y-Y, Chan C-H, Hung S-L, Chen Y-C, Lee Y-H, and Yang S-F*. 2011. October. Up-regulation of nucleotide-binding oligomerization domain 1 in inflamed human dental pulp. Journal of Endodontics 37:1370-1375.
- Hung S-L, Chiang H-H, Wu C-Y, Hsu M-J, Chen Y-T*. 2012. October. Effects of herpes simplex virus type 1 infection on immune functions of human neutrophils. Journal of Periodontal Research 47(5): 635-644.
- Hsu M-J, Hung S-L*. 2013. June. Antiherpetic potential of 6-bromoindirubin-3’-acetoxime (BIO-acetoxime) in human oral epithelial cells. Archives of Virology 158: 1287-1296.
- Chang L-Y, Wan H-C, Lai Y-L, Chou I-C, Chen Y-T, Hung S-L*. 2013. October. Areca nut extracts increased the expression of cyclooxygenase-2, prostaglandin E2 and interleukin-1α in human immune cells via oxidative stress. Archives of Oral Biology 58(10): 1523-1531.
- Lee Y-Y, Li Y-C, Hung S-L, Chen Y-C, Lee Y-H, Yang S-F*. 2013. December. Mineral trioxide aggregate induces the release of matrix metalloproteinase-9 by human neutrophils. Journal of Dental Sciences 8: 378-384.
- Hung S-L, Lee N-G, Chang L-Y, Chen Y-T, Lai Y-L*. 2014. January. Stimulatory effects of glucose and lipopolysaccharide of Porphyromonas gingivalis on the secretion of inflammatory mediators from human macrophages. Journal of Periodontology 85(1):140-149.
- Chang L-Y, Lai Y-L, Yu T-H, Chen Y-T, Hung S-L*. 2014. June. Effects of areca nut extract on lipopolysaccharides-enhanced adhesion and migration of human mononuclear leukocytes. Journal of Periodontology 85(6): 859-867.
- Lin F-Y, Hsiao F-P, Huang C-Y, Shih C-M, Tsao N-W, Tsai C-S, Yang S-F, Chang N-C, Hung S-L* and Lin Y-W*. 2014. July. Porphyromonas gingivalis GroEL induces osteoclastogenesis of periodontal ligament cells and enhances alveolar bone resorption in rats. PLoS ONE 9(7): e102450.
- Lee Y-Y, Lin M-B, Cheng C-F, Chang L-Y, Liu T-Y, Hung S-L*. 2014. August. Inhibitory effects of the areca nut extract on expression of complement receptors and Fc receptors in human neutrophils. Journal of Periodontology 85(8): 1096-1106.
- Cheng C-F, Wu K-M, Chen Y-T, Hung S-L*. 2015. January. Bacterial adhesion to antibiotic-loaded guided tissue regeneration membranes - a scanning electron microscopy study. Journal of the Formosan Medical Association 114(1): 35-45.