胡岳江 副教授 (Hu, Yueh-Chiang)
個人簡歷
學歷
美國羅徹斯特大學病理暨檢驗醫學博士 ( Ph.D. of Pathology and Laboratory Medicine, University of Rochester, Rochester, New York, USA)
國立陽明大學口腔生物所碩士
高雄醫學大學醫學技術系學士
經歷
Postdoctoral Fellow, Howard Hughes Medical Institute, Whitehead Institute, MIT, Cambridge, Massachusetts, USA (2004-2008)
Postdoctoral Fellow, George Whipple Laboratory for Cancer Research, University of Rochester Medical Center, Rochester, New York, USA (2003-2004)
現職:
國立陽明大學牙醫學系專任副教授
專長:胚胎發育學 (專注於性別和生殖細胞發育學),腫瘤生物學 (專注於前列腺癌和乳癌之分子致病機轉)
聯絡電話
電子郵件hu@wi.mit.edu
發表著作
  1. Hu, Y.C.*, Yu, S.*, Pang, S.T., Altuwaijri, S. and Chang, C. (2008) Differential regulation of proliferation and invasion of androgen-dependent and -independent prostate cancer cells by androgen receptor. Clin. Cancer Res., in preparation.
  2. Koubova, J., Hu, Y.C., Goodheart, M.L and Page D.C. (2008) In mouse embryonic testes, retinoic acid induces germ cell mitosis, not full-scale meiosis or oogenesis. Genes Dev., in preparation.
  3. Miyamoto, H., Yang, Z., Chen, Y.T., Ishiguro, H., Uemura, H., Kubota, Y., Nagashima, Y., Chang, Y.J., Hu, Y.C., Tsai, M.Y., Yeh, S., Messing, E.M and Chang, C. (2007) Promotion of bladder cancer development and progression by androgen receptor signals. J. Natl. Cancer Inst. 99, 558-68.
  4. Baltus, A.E.*, Menke, D.B.*, Hu, Y.C., Goodheart, M.L., Carpenter, A.E., de Rooij, D.G. and Page, D.C. (2006) In germ cells of mouse embryonic ovaries, the decision to enter meiosis precedes premeiotic DNA replication. Nat. Genet., 38, 1430-4.
  5. Yang, L, Xie S., Jamaluddin, M.S., Altuwaijri, S., Ni J., Kim, E., Chen, YT, Hu, Y.C., Wang, L,, Chuang, K.H., Wu, C.T. and Chang C. (2005) Induction of androgen receptor expression by phosphatidylinositol 3-kinase/Akt downstream substrate, FOXO3a, and their roles in apoptosis of LNCaP prostate cancer cells. J. Biol. Chem., 280, 33558-65.
  6. Hu, Y.C.*, Wang, P.H.*, Yeh, S., Xie, C., Zhou, X., Xu, Q., Chao, H.T., Tsai, M.Y. and Chang, C. (2004) Subfertility and defective folliculogenesis in female mice lacking androgen receptor. Proc. Natl. Acad. Sci. U.S.A., 101, 11209-14.
  7. Hu, Y.C.*., Yeh, S.*, Yeh, S.D., Sampson, E.R., Li, P., Hsu, C.L., Ting, H.J., Lin, H.K., Wang, L., Kim, E. and Chang, C. (2004) Functional domain and motif analyses of androgen receptor coregulator ARA70 and its differential expression in prostate cancer. J. Biol. Chem., 279, 33438-46.
  8. Lin, H.K.*, Hu, Y.C.*, Lee, D.K. and Chang, C. (2004) Regulation of androgen receptor signaling by PTEN tumor suppressor through distinct mechanisms in prostate cancer cells. Mol. Endocrinol., 18, 2409-23.(*Co-first authors)
  9. Bao, B.Y., Hu, Y.C., Ting, H.J. and Lee, Y.F. (2004) Vitamin D suppresses prostate cancer cell growth by sensitizing the androgen receptor. Oncogene, 23, 3350-60.
  10. Ting, H.J., Hu, Y.C. and Chang, C. (2004) Actin monomer enhances supervillin-modulated androgen receptor transactivation. Biochem. Biophys. Res. Commun, 319, 393-6.
  11. Wang, L., Lin, H.K., Hu, Y.C., Xie, S., Yang, L. and Chang, C. (2004) Suppression of androgen receptor-mediated transactivation and cell growth by the glycogen synthase kinase 3b in prostate cells. J. Biol. Chem., 279,32444-52.
  12. Kang, H.Y., Cho, C.L., Huang, K.L., Wang, J.C., Hu, Y.C., Lin, H.K., Chang, C. and Huang, K.E. (2004) Nongenomic androgen activation of phosphatidylinositol 3-kinase/Akt signaling pathway in MC3T3-E1 osteoblasts. J. Bone Mine. Res., 19, 1181-90.
  13. Yang, L., Xie, S., Altuwaijri, S., Ni, J., Hu, Y.C., Chen, Y.T., Bao, B.Y. and Chang, C. (2004) Androgen suppresses PML protein expression in prostate cancer CWR22R cells. Biochem. Biophys. Res. Commun, 314, 69-75.
  14. Yeh, S.*, Hu, Y.C.*, Wang, P.H., Xie, C., Xu, Q., Zhou, X., Tsai, M.Y., Dong, Z. and Chang, C. (2003) Abnormal mammary gland development and growth retardation in female mice and MCF7 breast cancer cells lacking androgen receptor. J. Exp. Med., 198, 1899-1908.? (*Co-first authors)
  15. Lin, H.K., Hu, Y.C., Yang, L., Kan, P.Y., Altuwaijri, S. and Chang, C. (2003) Suppression vs induction of androgen receptor functions by the phosphatidylinositol 3-kinase/Akt pathway in prostate cancer LNCaP cells with different passage numbers. J. Biol. Chem., 278, 56902-7.
  16. Kim, E., Xie, S., Yeh, S.D., Lee, Y.F., Collins, L.L., Hu, Y.C., Shyr, C.R., Mu, X.M., Liu, N.C., Chen, Y.T., Wang, P.H. et al. (2003) TR4 orphan nuclear receptor induces the expression of liver apolipoprotein E/C-I/C-II gene cluster via hepatic control region. J. Biol. Chem., 278, 46919-26.
  17. Hsu, C.L., Yeh, S., Chen, Y.L., Ting, H.J., Hu, Y.C., Lin, H., Wagn, X. and Chang, C. (2003) The use of phage display technique for the isolation of androgen receptor interacting peptides with F/WXXLF/W and FXXLY new signature motifs. J. Biol. Chem., 278, 23691-8
  18. Hu, Y.C., Shyr, C.R., Che, W., Mu, X.M., Kim, E. and Chang, C. (2002) Suppression of Estrogen Receptor-mediated Transcription and Cell Growth by Interaction with TR2 Orphan Receptor. J. Biol. Chem., 277, 33571-9.
  19. Lin, H.K., Wang, L., Hu, Y.C., Altuwaijri, S. and Chang, C. (2002) Phosphorylation-dependent ubiquitylation and degradation of androgen receptor by Akt require Mdm2 E3 ligase. EMBO J, 21, 4037-48.
  20. Shyr, C.R., Hu, Y.C., Kim, E. and Chang, C. (2002) Modulation of estrogen receptor-mediated transactivation by orphan receptor TR4 in MCF-7 cells. J. Biol. Chem., 277, 14622-8.
  21. Kang, H.Y., Lin, H.K., Hu, Y.C., Yeh, S., Huang, K.E. and Chang, C. (2001) From transforming growth factor-beta signaling to androgen action: identification of Smad3 as an androgen receptor coregulator in prostate cancer cells. Proc. Natl. Acad. Sci U.S.A., 98, 3018-23.
  22. Yeh, S.*, Hu, Y.C.*, Rahman, M.*, Lin, H.K., Hsu, C.L., Ting, H.J., Kang, H.Y. and Chang, C. (2000) Increase of androgen-induced cell death and androgen receptor transactivation by BRCA1 in prostate cancer cells. Proc. Natl. Acad. Sci. U.S.A., 97, 11256-61. (*Co-first authors)
  23. Yeh, S., Kang, H.Y., Miyamoto, H., Nishimura, K., Chang, H.C., Ting, H.J., Rahman, M., Lin, H.K., Fujimoto, N., Hu, Y.C. et al. (1999) Differential induction of androgen receptor transactivation by different androgen receptor coactivators in human prostate cancer DU145 cells. Endocrine, 11, 195-202.
  24. Chang, L.Y., Lin, S.C., Chang, C.S., Wong, Y.K., Hu, Y.C. and Chang, K.W. (1999) Telomerase activity and in situ telomerase RNA expression in oral carcinogenesis. J. Oral. Pathol. Med., 28, 389-96.

 

Symposium Presentations
  1. “In germ cells of mouse embryonic ovaries, the decision to enter meiosis precedes premeiotic DNA replication”, presented at Germ Cells Meeting, Cold Spring Harbor, NY, October, 2006.
  2. “Subfertility and defective folliculogenesis in female mice lacking androgen receptor”, presented at Jensen Symposium, University of Cincinnati, Cincinnati, OH, December 2003.
  3. “Mutual Suppression Through Heterodimer Formation of Estrogen Receptor and TR2 Orphan Receptor: A New Signaling Pathway in the Steroid Receptor Superfamily”, presented at the Endocrine Society’s 82nd Annual Meeting, Toronto, Canada, June 2000.
  4. “The Functional Correlation of BRCA1 and the Androgen Receptor in the Prostate Cancer Cells”, poster and exhibition at the Endocrine Society’s 82nd Annual Meeting, Toronto, Canada, June 2000.
  5. “A bi-directional suppression between estrogen receptor and TR2 orphan nuclear receptor signalling pathway“, presented at the 1999 Gordon Research Conference on Hormonal Carcinogenesis, Hilton, NH, August 1999.
  6. “Nerve Growth Factor and Its mRNA Expression in Tooth Germ”, poster and exhibition at the 75th Annual Meeting, International Association for Dental Research, Orlando, FL, June 1997.
得獎紀錄

WIPDA Education Award, Whitehead Institute, Cambridge, MA, USA (2008)
Aim for the Top University Plan Travel Award, National Yang-Ming University (2008)
Aim for the Top University Plan Travel Award, National Yang-Ming University (2006)
Grand Prize of Graduate Student Society Merit Research Award, University of Rochester, Rochester, New York, USA (2002)
Graduate Student Travel Award to the Gordon Research Conference on Hormonal Carcinogenesis, Hilton, New Hampshire, USA (1999)
Fellowship for Excellent Graduate Student, Institute of Oral Biology, National Yang-Ming University (1993-1995)

指導學生Joseph Daniele獲得麻省理工學院學生研究之最高榮譽John L. Asinari Award

 

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