邱士華副教授 (Chiou, Shih-Hwa, PhD)
個人簡歷
學歷
國立陽明大學臨床醫學研究所博士 
國防醫學院醫學系學士
經歷

美國Scripps研究所(TSRI)

分子生物部/腫瘤研究組

訪問學者

2007/4至2007/8

桃園榮民醫院

眼科

主任/醫師

2003/1至2004/12

美國貝克曼國家研究中心

血液骨髓移植研究室

博士後研究

2002/8至2002/12

台北榮民總醫院

眼科部/青光眼科

主治醫師

2000/1至2002/12

台北榮民總醫院

眼科部

臨床研究員

1998/7至1999/12

台北榮民總醫院

眼科部

住院總醫師

1994/7至1998/6

專長:1、幹細胞學  2、腫瘤幹細胞學  3、眼科學 
   4、活體分子基因影像  5、病毒免疫學 
現職:台北榮總教學研究部主治醫師

地址:台北市石牌路二段201號  台北榮總致德樓七樓幹細胞實驗室II (719室)

聯絡電話:(02) 28757394
電子郵件shchiou@vghtpe.gov.tw
   
研究方向
  1. 腫瘤幹細胞分離系統之建立與活化路徑之探討
  2. 腦神經幹細胞與視網膜幹細胞分化路徑之探討
  3. 巨細胞病毒IE2基因之活化路徑與巨細胞病毒視網膜炎致病機轉之研究
研究計畫(5年內)

行政院科技顧問組「幹細胞旗艦計畫」 2007年12月1日至2010年11月30日
Signal pathways and epigenetic regulation of stem cells (幹細胞之訊息途徑及表基因調控):
Subproject 2 Activation of tyrosine kinase pathways and development of combined therapy in brain tumor-derived cancer stem cells (探討腦部腫瘤幹細胞之功能性基因變異、特定酪氨酸激脢路徑活化與發展新式合併療法): 計畫主持人: 邱士華

發表著(Selected from 67 manuscripts)                   *Corresponding Author
  1. Chiou SH, Yu CC, Huang CY, Lin SC, Liu CJ, Chien CS, Ku HH, Lo JF. Positive Correlations of Oct-4 and Nanog in Oral Cancer Stem-Like Cells and High Grade Oral Squamous Cell Carcinoma. Clinical Cancer Research (In press; SCI: 6.177)
  2. Chen YC, Hsu HS, Chen YW, Tsai TH, How CK, Wang CY, Chang YL, Tsai ML, Lee YY, Chiou SH*. Oct-4 Expression Maintained Cancer Stem-like Properties in Lung Cancer-derived CD133-positive Cells. PLoS ONE 2008 July 9;3(7):e2637.
  3. Chiou SH*, Kao CL, Lo JF, Tsai ML, Ku HH, Hsu MT, Wong TT. CD133-positive atypical teratoid/rhabdoid tumor cells promote radioresistance by activation of ATM-related response and antiapoptotic activity. PLoS ONE 2008 May 7;3(5):e2090.
  4. Yang MH, Chang SY, Chiou SH, et al. Hypoxia and HIF1a induces epithelial-mesenchymal transition and co-expression of Twist and Snail predicts metastatsis of head and neck cancer. Nature Cell Biology 2008 Mar;10(3):295-305. (SCI:18.5).
  5. Yang DC, Tsay HJ, Lin SY, Chiou SH, Li MJ, Chang TJ, Hung SC. cAMP/PKA Regulates Osteogenesis, Adipogenesis and Ratio of RANKL/OPG mRNA Expression in Mesenchymal Stem Cells by Suppressing Leptin. PLoS ONE 2008 Feb 6;3(2):e1540.
  6. Huang TS, Hsieh JY, Wu YH, Jen CH, Tsuang YH, Chiou SH, et al. Functional network reconstruction reveals somatic stemness genetic maps and dedifferentiation-like transcriptome reprogramming induced by GATA2. Stem Cells 2008 Feb 28 (SCI:7.9)
  7. P-S Hung, S-Y Kao, Y-H Shih, S-H Chiou, C-J Liu, K-W Chang, S-C Lin. Insulin-like growth factor binding protein-5 suppresses the tumourigenesis of head and neck squamous cell carcinoma. Journal of Pathology 2008 Feb;214(3):368-76. (SCI: 5.9).
  8. Peng CH, Chiou SH (co-first author), Chen SJ, et al. Neuroprotection by Imipramine Against Lipopolysaccharide-induced Apoptosis in Hippocampus-derived Neural Stem Cells Mediated by Activation of BDNF and the MAPK pathway. European Neuropsychopharmacology 2008 Feb;18(2):128-40. (IF: 4.4).
  9. Lin HL, Yang MH, Wu CW, Chen PM, Yang YP, Kao CL, Ku HH, Chi CW, Chiou SH*. 2-Methoxyestradiol attenuates phosphatidylinositol 3-kinase/Akt pathway- mediated metastasis of gastric cancer. Int J Cancer 2007;121(11):2547-55. (SCI: 4.5)
  10. Yang MH, Chang SY, Chiou SH, et al. Overexpression of NBS1 induces epithelial-mesenchymal transition and co-expression of NBS1 and Sanil predicts metastatsis of head &neck cancer. Oncogene 2007;26:1459-1467 (SCI:6.9).
  11. Perng CK , Kao CL, Yang YP, Lin HT, Lin WB, Ma H, Ku HH, Chiou SH*. Culturing Adult Human Bone Marrow Stem Cells on Gelatin Scaffold with pNIPAAm as Transplanted Grafts for Skin Regeneration. Journal of Biomedical Materials Research: Part A 2007 Jul 16. (SCI: 3.1)
  12. Chang CM, Kao CL, Chang YL, Yang MC, Chen YC, Chao KC, Chiou SH*. Placenta-derived multipotent stem cells induced to differentiate into insulin-positive cells. Biochem Biophys Res Commun 2007;357(2):414-20. (SCI: 2.9)
  13. S-H Chiou, C-L Kao, Y-L Chang, C-J Yen, T-H Tsai. Evaluation of anti-FasL-induced apoptosis and neural differentiation of PC12 Cell treated by NGF using siRNA method and sampling by microdialysis. Analytical Biochemistry 2007;363:46-57. (SCI: 2.9)
  14. Chiou SH, Yi-Ping Yang, Jung-Chun Lin, Chih-Hung Hsu, Wen-Ming Hsu, Hung-Hai Ku, Cheng-Wen Wu, and Li-Jung Juan. The Immediate Early 2 Protein of Cytomegalovirus Controls Apoptosis in Human Retina by Activating Cellular FLICE-Inhibitory Protein. Journal of Immunology 2006 Nov 1;177(9):6199-206. (SCI: 6.23)
  15. Chiou SH*, Ku HH, Tsai TH, Lin HL, Chen LH, Chien CS, Lee CH, Chang YL. Moclobemide Up-regulated Bcl-2 Expression and Induced Neural Stem Cell Differentiation into Serotoninergic Neuron via ERK-Pathway. British J Pharm 2006;48:587-6. (SCI: 3.6)
  16. Chiou SH*, Chen SJ, Peng CH, Lee CH. Fluoxetine up-regulates expression of cellular FLICE-inhibitory protein and inhibites LPS-induced apoptosis in hippocampus-derived neural stem cell. Biochem Biophys Res Commun 2006;343(2):391-400. (SCI: 2.9)
  17. Chung-Lan Kao, Chiou SH*, Yann-Jang Chen, Sher Singh, Han-Tso Lin, Ren-Shyan Liu, Chin-Wen Chi, Chen-hsen Lee, Tai-Tong Wong. Increased expression of osteopontin gene in atypical teratoid/rhabdoid tumor of primary central nervous system. Modern Pathology 2005 Jun;18(6):769-78. (SCI: 3.8)
  18. Chiou SH *, Kao CL, Peng CH, Chen SJ, Tarng YW, Yang DM, Hsu WM, Kuo CD, Lee CH. A novel in vitro retinal differentiation model by co-culturing adult human bone marrow stem cells with retinal pigmented epithelium cells. Biochem Biophys Res Commun. 2005;326(3):578-85. (SCI: 2.9)
  19. Lin TY, Chiou SH*, Chen M, Kuo CD. Human lactoferrin regulate apoptosis and anti-apoptosis in PC12 cells via ERK1/2 pathway. Biochem Biophys Res Commun. 2005;337(1):330-6. (SCI: 2.9)
  20. Chiou SH, JH Liu, WM Hsu, Steve S.-L. Chen, SY Chang, LJ Juan, JC Lin, YT Yang, WW Wong, CY Liu, YS Lin, WT Liu, CW Wu. Upregulation of Fas ligand expression by human cytomegalovirus immediate-early gene 2: A novel mechanism in CMV-induced apoptosis in human retina. Journal of Immunology 2001 167:4098-4103.(SCI: 6.23)
  21. Chiou SH*, Charn-Jung Chang , Ching-Kuang Chou, Wen-Ming Hsu, Jorn-Hon Liu, Chiao-His Chiang. Increased nitric oxide (NO) levels in aqueous humor of diabetic patients with neovascular glaucoma.  Diabetes Care 1999;22(5):861-7. (SCI: 6.5)
  22. Chiou SH, Jorn-Hon Liu, Yu-Mei Chung, Wing-Wai Wong, Wen-Sung Weng, Wu-Tse Liu. Quick and easy detection of cytomegalovirus retinitis by using conjunctival swab and polymerase chain reaction in AIDS patients. AIDS 1998;12(4) 443-449. (SCI: 5.8)
中華民國專利
  1. 藥物篩選裝置 (中華民國專利:第 M308081號)  申請人: 邱士華  2007.3.21 – 2016.9.5 (US & EU Patent: 申請中)
  2. 感溫性細胞組織移植支架 Thermo-sensitive Cell-Tissue Transplanted Scaffold : Taiwan (App. No. 096143658), and US (App. No. 11/742,963) : 申請中; 申請人: 邱士華
  3. 標的篩選之系統分析方法SYSTEM AND METHODS FOR SCREENING OR ANALYZING TARGETS : Taiwan (App. No. 096140866), US (App. No. 11/875,801), and Europe (EP:07119527.5): Patent Pending; 申請人: 邱士華
  4. 一種篩選幹細胞之裝置 / A Device for Selecting Stem Cells: Taiwan Patent (App. No. 097212434): Pending; Chiou SH, et al. 申請人: 邱士華
得獎紀錄
  1. 中華民國八十九年度行政院退除役官兵輔導委員會台北榮民總醫院醫療創新獎
  2. 中華民國八十九與九十年度中央研究院生物醫學研究所臨床醫師進修獎助學金
  3. 中華民國九十三年度退輔會桃園榮民醫院優良醫師獎
  4. 中華民國九十五年度行政院退除役官兵輔導委員會優良醫師獎
  5. 中華民國九十七年度行政院退除役官兵輔導委員會台北榮民總醫院醫療創新獎
  6. 2002年-中華民國眼科醫學會-最佳論文獎
  7. 2003年國際幹細胞論壇研討會-最佳論文獎
  8. 2005年國際分子醫學影像年會-優秀青年學者獎與最佳論文獎 (德國-柯隆)

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