蔣維凡副教授 (Wei-Fan Chiang)

個人簡歷

http://www.ym.edu.tw/sod/teacher/ChiangWF/CWFimg.png

學歷(Educations & Post-graduate training)
國立陽明大學牙醫系 學士
國立成功大學口腔醫學研究所 碩士

現職(Current position)
柳營奇美醫院牙醫部 主任(Chief, Department of Dentistry, Chi-Mei Medical Center, Liouying, Taiwan)
柳營奇美醫院病歷資訊管理室 主任(Chief, Department of Management in Medical Records & Information, Chi-Mei Medical Center, Liouying, Taiwan)
陽明大學牙醫系 副教授 (Associate Professor, National Yang-Ming University, Taipei, Taiwan)
中華民國口腔顎面外科學會 理事 (Director, ROC(Taiwan) Association of Oral & Maxillofaical Surgeons, Taiwan)

經歷(Professional appointments)
2003/06~2008/01 Visiting Staff, Chi-Mei Medical Center, Yongkang
2007/03~2011/02 Supervisor, Chinese Association of Oral and Maxillofacial Surgery
2008/02~2008/07 Visiting Scholar  Southwestern Medical Center, USA
2008/08~2009/01 Visiting Scholar Texas Medical Center, USA
2007/08~2013/07 Assistant Professor, National Yang-Ming University, Taiwan

專長(Specificity)
口腔外科腫瘤診療(Surgical Oral Oncology)
顏面外傷診療(Facial Traumatology)
正顎手術(Orthognathic Surgery)

單位:柳營奇美醫院 牙醫部

職稱:部主任

聯絡電話(Telephone)886-6-6226999 ext 77158

電子郵件(E-mail)bigfanfan@yahoo.com.tw

研究方向(Fields of Research)

口腔癌分子生物學(Molecular Oncology)、口腔疾病流行病學(Epidemiology of oral diseases)

研究計畫(Grant)

奇美醫院院內計畫

  1. Explore the signaling of Akt/IKKβ/IKB-α/fibronectinin the malignant transformation of verrucous hyperlpasia (CLFHR9926)Principle InvestigatorDuration: 2010/07/01~2011/06/30
  2. The suitable internal gene for real-time PCR in oral precancers and oral cell line(CLFHR10015)
    Principle Investigator
    Duration: 2011/07/01~2012/06/30
  3. 台灣口腔癌病患自我超越與憂鬱之相關研究(CLFHR10032)co-Principle InvestigatorDuration: 2011/07/01~2012/09/30
  4. Verfication fo body fluid in oral carcinomagensisi using high through-put analysis platform (CLFHR10126)
    Principle Investigator
    Duration: 2012/07/01~2013/06/30
  5. 口腔癌病患體重流失相關因素之探討(CLFHR10219)
    co-Principle Investigator
    Duration: 2013/01/01~2013/12/31
  6. The role of carcinoembryonic antigen-related cell adhesion molecule 6 (CEACAM6) in oral cancer progression and drug resistance.(CLFHR10222)
    Principle Investigator
    Duration: 2013/07/01~2014/06/30
  7. Salivary autoantibodies as noninvasive diagnostic markers of oral cavity squamous cell carcinoma. (CLFHR10323)
    Principle Investigator
    Duration: 2014/07/01~2015/06/30

奇美高醫合作計畫

  1. 本土性口腔癌細胞株之建立與其特性之分析(100CM-KMU-05)
    Principle Investigator
    ,執行日期:2011/05/01~2012/04/30
  2. 利用微型核糖核酸陣列研究calreticulin在口腔癌所扮演之角色(101-CM-KMU-03)
    Principle Investigator
    ,執行日期:2012/05/01~2013/04/30
  3. The role of p22phox in cisplation resistance of oral squamous cell carcinoma.(102-CM-KMU-03)
    Principle Investigator
    ,執行日期:2013/05/01~2014/04/30

奇美長庚合作計畫

  1. 利用高通量多重生物標的分析技術平台快速有效驗證癌症體液生物標誌(CLFHR10126)
    Principle Investigator
    ,執行日期:2012/07/01~2013/06/30

奇美北醫合作計畫

  1. 探討癌胚抗原相關細胞黏附分子6在口腔癌侵犯性的角色(103CM-TMU-01)
    Principle Investigator
    ,執行日期:2014/03/01~2015/02/28

奇美陽明合作計畫

  1. 以兒茶酚胺刺激唾液中上皮生長因子濃度在口腔癌癌化中角色之研究
    Principle Investigator
    ,執行日期:2011/08/01~2012/07/31

國科會計畫

  1. 建立以低侵襲性採樣檢體的口腔癌早期診斷模式(3年計畫)NSC 97-2314-B-384 -003 -MY3
    Principle Investigator
    ,執行日期:2008/08/01~2011/07/31
  2. 口腔腫瘤銀行與細胞株的建立、維護與管理(3年計畫)
    co-Principle Investigator
    ,執行日期:2009/08/01~2012/07/31

得獎紀錄(Special awards)

  1. Award for Excellent Study.
    The Congress on Oral and Maxillofacial Surgery, 2004, 2005, 2006, 2012.
  2. Award for Excellence.
    The 6th Asian Congress on Oral and Maxillofacial Surgery, 2004.
  3. Award for Excellent Youth Representative
    Chi-Mei Hospital, Yongkang, Tainan, 2005
  4. Award for the Yearly Best Study
    Chi Mei Hospital, Liouying, 2008, 2010, 2011
  5. Award for Annual Excellent Doctors in Taiwan
    Common Wealth Magzine 2009
  6. Award for Excellent Teacher
    Chimei hospital, Liouying 2011, 2014

著作(Referred publications)

  1. Tseng MY, Liu SY, Chen HR, Wu YJ, Chiu CC, Chan PT, Chiang WF, et al. Serine protease inhibitor (SERPIN) B1 promotes oral cancer cell motility and is over-expressed in invasive oral squamous cell carcinoma. Oral Oncol 2009; 45(9): 771–6. SCI (IF: 2.695;  Dentistry,Ranking: 11/81=13.3%)                                      
  2. Wu MH, Hong TM, Cheng HW, Pan SH, Liang YR, Hong HC, Chiang WF, e al.  Galectin-1-mediated tumor invasion and metastasis, up-regulated matrix metalloproteinase expression, and reorganized actin cytoskeletons. Mol Cancer Res 2009; 7(3): 311–8.       SCI (IF: 4.353 ; Oncology, Ranking: 46/197 = 23.4%)                                      
  3. Chiu CT, Chuang CY, Chang SW, Lee SY, Wang DJ, Liu YC, Liu SY, Yen CY, Chiang WF*. Expression of matrix metalloproteinases in oral cancer patients who are betel quid users.   Taiwan J Oral Maxillofac Surg 2009; 19: 313–27.
  4. Huang JJ, Lin WN, Huang CW, Li CH, Huang KC, Chiang WF, et al. Analysis and manipulation using EIS for characteristic parameters of biological tissues in vitro.   IFMBE Proceedings 2009; 25: 824–7.                                                            
  5. Lin SC, Liu CJ, Lin JA, Chiang WF, Hung PS, Chang KW.  miR-24 up-regulation in oral carcinoma: Positive association from clinical and in vitro analysis.  Oral Oncol  2010; 46(3): 204–8.  SCI (IF: 2.695;  Dentistry,Ranking: 11/81=13.3%)
  6. Liu SY, Lu CL, Yen CY, Liaw GA, Chiou CT, Chen YC, Liu YC, Chiang WF*. Surgical outcomes and prognostic factors of oral cancer associated to betel quid chewing and tobacco smoking in Taiwan.    Oral Oncol 2010; 46(4):276–82. hen YL. Fatty-acid binding protein 5 promotes cell proliferation and invasion in oral squamous cell carcinoma. J Oral Pathol Med 2010; 39(4): 342–8. SCI (IF: 2.055 ; Dentistry,Ranking: 20/81 = 24.1%)                                         
  7. Chiang WF, Liu SY , Lu NM, Lu CL, Yen CY, Liaw CA, et al. The prognostic role of tumor thickness in oral caner.  Taiwan J Oral Maxillofac Surg 2010; 21: 173–91.                                                    
  8. Chiu CT, Chiang WF, Chuang CY, Chang SW. Resolution of oral biphosphonate and steroid-related osteonecrosis of the jaw—a serial case analysis. J Oral Maxillofac Surg 2010; 68(5): 1055–63. SCI (IF: 1.640 ; Dentistry,Ranking: 27/81 = 33.3%)
  9. Chiu CC, Chen BH, Hour TC, Chiang WF, Wu YJ, Chen CY, et al.. Betel quid extract promotes oral cancer cell migration by activating a muscarinic M4 receptor-mediated signaling cascade involving SFKs and ERK1/2. Biochem Biophys Res Commun. 2010; 399(1): 60–5.  SCI (IF: 2.406 ; Biochemistry & Molecular Biology, Ranking: 181/290 = 62.4%)   
  10. Liu YC, Lin MH, Liu SY, Chiang WF, Chen LL, Chen TC, et al. Possible Mechanism of Betel-quid-extract-induced Expression of Matrix Metalloproteinase-2.  J Formos Med Assoc 2010;109(11):838–47. SCI (IF:1.000 ; Internal Medicine, Ranking: 81/155 = 52.3%)
  11. Lin MH, Hsieh WF, Chiang WF, Hong WZ, Hsu YR, et al. Autophagy induction by the 30-100kDa fraction of areca nut in both normal and malignant cells through reactive oxygen species. Oral Oncol 2010; 46(11): 822–8. SCI (IF: 2.695;  Dentistry,Ranking: 11/81=13.3%)
  12. Yang RW, Chang MT, Chou WY , Guan WH, Chiu CT, Chiang WF* Reconstruction of maxilla edentulous ridge by ridge splitting technique and inlay block iliac graft--A case report Taiwan J Oral Maxillofac Surg 2010; 21: 280–95.
  13. Wu MH, Hong HC, Hong TM, Chiang WF, Jin YT, Chen YL. Targeting galectin-1 in carcinoma-associated fibroblasts inhibits oral squamous cell carcinoma metastasis by downregulating MCP-1/CCL2 expression. Clin Cancer Res 2011; 17(6): 1306–16. SCI (IF:7.837; Oncology,Ranking: 12/197 = 6.1%)                                            
  14. Chiang WF, Hung PS, Liu SY, Yuan TC, Chang KW, Chen YP, Liu YC, Lin SC.  ZASC1 expression increases the oncogenic potential of oral carcinoma. Oral Dis  2011; 17(1):53–9. SCI (IF: 2.377 ; Dentistry,Ranking: 17/81=20.5%)
  15. Tu HF, Chang KW, Chiang WF, Liu CJ, Yu EH, Liu ST, Lin SC. The frequent co-expression of the oncogenes PIK3CA and PAK1 in oral carcinomas. Oral Oncol2011; 47(3): 211–6. SCI (IF: 2.695;  Dentistry,Ranking: 11/81=13.3%)
  16. Yen CY, Lin MH, Liu SY, Chiang WF, Hsieh WF, Cheng YC, Hsu KC, Liu YC. Arecoline-mediated inhibition of AMP-activated protein kinase through reactive oxygen species is required for apoptosis induction. Oral Oncol 2011; 47(5): 345–51.  SCI (IF: 2.695;  Dentistry,Ranking: 11/81=13.3%)
  17. Chiang WF, Ho HC, Chang HY, Chiu CC, Chen YL, et al. Expression of Rho GDP-dissociation inhibitor alpha is essential for oral cancer cell migration and predicts poor survival of oral squamous cell carcinoma. Oral Oncol2011; 47(6): 452–8. SCI (IF: 2.695;  Dentistry,Ranking: 11/81=13.3%)                                          
  18. Fan LC, Chiang WF, Liang CH, Tsai YT, Wong TY, Chen KC, Hong TM, Chen YL. Alpha-catulin knockdown induces senescence in cancer cells. Oncogene 2011;30(23):2610–21.SCI (IF:7.357 ; Oncology, Ranking: 19/197 = 9.6%)
  19. Chiu CT, Li CF, Li JR, Wang J, Chuang CY, Chiang WF, et al. Candida invasion and influences in smoking patients with multiple oral leucoplakias - a retrospective study.  Mycoses. 2011; 54(5):e377–e383  SCI (IF: 1.278 ; Mycology, Ranking: 16/23 = 69.6%)
  20. Cheng CW, Yong RW, Lin CY, Min-Te Chang MT, Chen CJ, Chiang WF* Two-Year Treatment Outcomes of Mandibular Fractures in a Suburban Hospital of Taiwan.  Taiwan J Oral Maxillofac Surg 2011;22(3):175–88
  21. Chang YC, Yu HC, Yang JW, Guan WH, Liao KA, Wu TC, Lu NM, Tseng CC, Chiang WF*. Metachronous Oral Carcinoma with Occult Metastasis to Parotid Node: A Case Report. Taiwan J Oral Maxillofac Surg 2012;23(1):10–24.
  22. Yu HC, Chang YC, Guan WH, Yang RW, Chen CA, Wu TC, Tsui YK, Lin CN, Chiang WF*. Venous Vascular Malformation with Phleboliths at Submental Region: A Case Report. Taiwan J Oral Maxillofac Surg 2012;23(2):114–24.
  23. Yang YH, Chang YC, Chang MT, Chiang WF*. Bisphosphonate Treatment of Refractory Craniofacial Fibrous Dysplasia Combined with Osteomyelitis: A Case Report.Taiwan J Oral Maxillofac Surg 2012;23(4):301–13.
  24. Chiu LF, Huang PY, Chiang WF, Wong TY, Lin SH, Lee YC et al. Oral cancer diagnostics based on infrared spectral markers and wax physisorption kinetics. Anal Bioanal Chem 2013:405(6): 1995–2007. SCI (IF: 3.659; Analytical Chemistry, Ranking:9/75=17.8%)
  25. Chang KW, Chu TH, Gong NR, Chiang WF, Yang CC, Liu CJ, et al. miR-370 modulates insulin receptor substrate-1 expression and inhibits the tumor phenotypes of oral carcinoma Oral Dis  2013;19(6):611-9.  SCI (IF: 2.377 ; Dentistry,Rank: 17/81=20.5%)
  26. Chiang WF, Hwang TZ, Hour TC, et al. Calreticulin, an endoplasmic reticulum-resident protein, is highly expressed and essential for cell proliferation and migration in oral squamous cell carcinoma. Oral Oncol2013;49(6):534-41.  SCI (IF: 2.695;  Dentistry, Ranking: 11/81=13.3%)
  27. Wang HC, Chiang WF, Huang HH, Hunag SK, Chiang HC. Promoter hypermethylation of the gene encoding heat shock protein B1 in oral squamous carcinoma cells. Oral Surg Oral Med Oral Pathol Oral Radiol 2013;115(3):376-84. SCI (IF: 1.495;  Dentistry, Ranking: 33/83=39.8%)
  28. Chen JC, Chang YK, Chiang WF, Lu D. Palatal diffuse large B-cell lymphoma masquerading as an infiltrative bony mass. J Dent Sci 2013; 8: 98-99. SCI (IF:0.347;  Dentistry,Ranking: 80/81=95.2%)
  29. Yen CY, Chiang WF, Liu SY, et al. Long-term stimulation of areca nut components results in increased chemoresistance through elevated autophagic activity. J Oral Pathol Med  2014; 43(2): 91-6 SCI (IF: 2.055 ; Dentistry, Rank: 20/81 = 24.1%)
  30. Chen IC, Chiang WF, Liu SY, Chen PF, Chiang HC. Role of SIRT3 in the regulation of redox balance during oral carcinogenesis. Mol Cancer  2013;12:68. SCI (IF: 5.134; Oncology, Ranking: 33/197=16.8%)
  31. Chen IC, Chiang WF, Chen PF, Chiang HC. Stress-responsive deacetylase SIRT3 is pp-regulated by areca nut extract-induced oxidative stress in human oral keratinocytes. J Cell Biochem 2014;115(2):328–39. SCI (IF: 3.062;  Biochemistry & Molecular Biology, Ranking: 125/290=43.1%)
  32. Wang LH, Huang WC, Chan SH, Jang TH, Chang JW, Ko YC, Yen TC, Chiang SL, Chiang WF, et al. miRNA-491-5p and GIT1 serve as modulators and biomarkers for oral squamous cell carcinoma (OSCC) invasion and metastasis. Cancer Res 20131;74(3):751-64. SCI (IF: 8.650; Oncology, Ranking: 11/197=5.6%)
  33. Wu MH, Ying NW, Hong TM, Chiang WF, Lin YT, Chen YL. Galectin-1 induces vascular permeability through the neuropilin-1/vascular endothelial growth factor receptor-1 complex. Angiogenesis  2014 (In press). SCI (IF: 3.972; Oncology, Ranking: 11/68=16.2%)
  34. Wu CC, Chang YT, Chang KP, Liu YL, Liu HP, Lee IL, Yu JS, Chiang WF*. Salivary auto-antibodies as noninvasive diagnostic markers of oral cavity squamous cell carcinoma.    Cancer Epidemiol Biomarkers Prev 2014 (In press).  SCI (IF: 4.559; Public, environmental & occupational health, Ranking: 10/161=6.2%)
  35. Wang HC, Chiang WF, Huang HH, Shen YY, Chiang HC. Src-homology 2 domain-containing tyrosine phosphatase 2 promotes oral cancer invasion and metastasis. BMC Cancer 2014 (In press).  SCI (IF: 3.333; Oncology, Ranking: 73/197=37.1%)

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更新日期: 2015-05-15 2:34 PM