Lien-Yu Chang (張蓮鈺助理教授)



PHD, Department of Dentistry, School of Dentistry, National   Yang-Ming University, Taiwan (2008)
MS, Institute of Oral Biology, National Yang-Ming University, Taiwan (1998)
DDS, Department of Dentistry, National Yang-Ming University, Taiwan (1991)

Institute of Oral Biology, School of Dentistry, National Yang-Ming University

Assistant Professor

Fields of Specialty: Oral Pathology and Histology, Dentistry

Tel:  886-2-28267100

Fax: 886-2-28264053


Research Description

Areca-associated oral pathogenesis and immune regulation

Research Project

1. 2014/01/01—2014/12/31: Immunomodulatory effects of areca nut extract on the apoptosis of myofibroblasts  (PI) (grant 10301-62-018 from Department of Health, Taipei City Government)

2. 2012/08/01—2013/10/31: Analysis of immune dysregulation by areca nut extract using microarray profiling and protein-protein interaction networks (PI) (NSC 101-2314-B-010-049)

3. 2012/01/01—2013/3/31: Effects of areca nut extract on the apoptosis of human lymphocytes and monocytes) (PI) (grant 10101-62-036 from Department of Health, Taipei City Government)

4. 2010/08/01—2011/07/31: Modulation of the expression of surface adhesion molecules, migration and phagocytosis of human immune cells by areca nut extracts (PI)  (NSC: 99-2314-B-010-040-)

5. 2011/01/01—2011/12/31: Osteoclastogenic effects of MCP-1 and MMPs induced by areca nut extracts-treated human immune cells (PI)) (grant 10001-62-046 from Department of Health, Taipei City Government)   

6. 2010/04/01—2011/03/31: Mechanisms involved in the expression of IL-1alpha, PGE2 and RANKL and cellular oxidative stress by immune cells treated with areca nut extracts) (PI)) (grant 99001-62-046 from Department of Health, Taipei City Government) 

Publication (*corresponding author)

1. Lien-Yu Chang, Yu-Lin Lai, Tzu-Hsuan Yu, Yen-Ting Chen, Shan-Ling Hung. Effects of Areca Nut Extract on Lipopolysaccharides-Enhanced Adhesion and Migration of Human Mononuclear Leukocytes. Journal of Periodontology. Posted online on September 3, 2013. (SCI).

2. Lien-Yu Chang, Hsiao-Ching Wan, Yu-Lin Lai, I-Chiang Chou, Yen-Ting Chen, Shan-Ling Hung. Areca nut extracts increased the expression of cyclooxygenase-2, prostaglandin E2 and interleukin-1α in human immune cells via oxidative stress. Archives of Oral Biology, 2013 (Oct); 58(10):1523-1531. (SCI)

3. Shan-Ling Hung, Nin-Gi Lee, Lien-Yu Chang, Yen-Ting Chen, Yu-Lin Lai. Stimulatory Effects of Glucose and Lipopolysaccharide of Porphyromonas Gingivalis on the Secretion of Inflammatory Mediators From Human Macrophages. Journal of Periodontology. (Posted online on March 28, 2013) (SCI)

4. Guo-hao Lin, Lien-Yu Chang, Wen-Chun Lin,   Shyh-Yuan Lee, Yu-lin Lai. Interdisciplinary Approach for Treating a Large Through-and-Through Periapical Defect Using Guided Tissue Regeneration: A Case Report. The international Journal of  Periodontics and Restorative Dentistry (accepted on 2012 Jun) (2014;34:XX–XX. doi: 10.11607/prd.1472)  (SCI)

5. Lien-Yu Chang, Hsiao-Ching Wan, Yu-Lin Lai, Yu-Fu Kuo, Tsung-Yun Liu, Yen-Ting Chen and Shan-Ling Hung*. Areca nut extracts increased expression of inflammatory cytokines, tumor necrosis factor-α, interleukin-1β, interleukin-6 and interleukin-8, in peripheral blood mononuclear cells. Journal of Periodontal Research. 2009; 44: 175-183.  (SCI)

6. Lien-Yu Chang, Jung-Chen Lin, Ching-Wen Chang, Yen-Ting Chen, Ji-Lung Peng, Shan-Ling Hung*. “Inhibitory Effects of Safrole on Phagocytosis, the Intracellular Reactive Oxygen Species and the Activity of Myeloperoxidase released by Human Polymorphonuclear Leukocytes” Journal of Periodontology. (2009. 3.16, accepted) (SCI)

7. Yu-Lin Lai, Hen-Li Chen, Lien-Yu Chang, Shyh-Yuan Lee. Resubmerged technique for the management of soft tissue recession around an implant: a case report. The International Journal of Oral & Maxillofacial Implants. (2009. 1.1, accepted**)(SCI)

8. Lien-Yu Chang. Effects of areca nut extracts on the regulation of immune cell functions. 2008 (PhD Dissertation)

9. Lien-Yu Chang, Hsiao-Ching Wan, Yu-Lin Lai, Tsung-Yun Liu, and Shan-Ling Hung*. Enhancing effects of areca nut extracts on production of interleukin-6 and interleukin-8 by peripheral blood mononuclear cells. Journal of Periodontology 2006;77(12):1969-1977(SCI)

10. Hung S-L, Cheng Y-Y, Peng J-L, Chang L-Y, Liu T-Y, Chen Y-T*. Inhibitory effects of areca nut extracts on phagocytosis of Actinobacillus actinomycetemcomitans ATCC 33384 by neutrophils. Journal of Periodontology 2005;76(3):373-379 (SCI).

11. Chang L-Y, Lin S-C, Chang C-S, Wong Y-K, Hu Y-C, Chang K-W*. Telomerase activity and in situ telomerase RNS expression in oral carcinogenesis. Journal of Oral Pathology and Medicine 1999;28:389-396 (SCI).