張蓮鈺 副教授 (Lien-Yu Chang)

個人簡歷

http://www.ym.edu.tw/sod/teacher/ChangLY/image002.jpg

學歷

畢業學校

系別

學位

國立陽明大學

牙醫學系

博士

國立陽明大學

口腔生物研究所

碩士

國立陽明大學

牙醫系

學士

經歷

服務單位

部門

職稱

國立陽明大學

牙醫學系

助理教授

台北榮總

口腔醫學部

兼任主治醫師

台北市立聯合醫院

台北市立聯合醫院教研部

聘兼助理研究員

美國哈佛大學

附屬貝斯以色列狄更尼斯醫學中心

Research scholar

現職:口腔生物研究所副教授

專長:口腔病理學與組織學、牙醫科學

聯絡電話(02)2826-7100

傳真電話:(02)2826-4053

電子郵件:lychang@ym.edu.tw

研究方向

探討檳榔造成之病理變化與免疫調節作用

研究計畫

計畫名稱

擔任工作

起訖年月

補助或委託機構

經費總額

檳榔萃取物之免疫調節效應對肌纖維母細胞細胞凋亡之影響 (10301-62-018)

主持人

2014/01/01~2014/12/31

臺北市政府衛生局

549,162

探討巨噬細胞極化在牙周炎疾病中之角色

 (V103C-006)

共同
主持人

2014/01/01~2014/12/31

行政院國家科學委員會

600,000

抽菸與非抽菸慢性牙周炎患者高遷移率族-1 (HMGB-1) 之表現

共同
主持人

2013/01/01~2013/12/31

台北榮總

445,000

鼠李醣乳酸桿菌G菌對牙齦嚇咻單胞菌感染造成之牙周炎之影響

共同
主持人

2013/01/01~2013/12/31

台北榮總

600,000

以微陣列技術與蛋白質-蛋白質交互作用網分析檳榔萃取物之免疫失調作用(101-2314-B-010-049-)

主持人

2012/08/01~2013/10/31

行政院國家科學委員會

850,000

檳榔萃取物對人類淋巴細胞與單核球細胞細胞凋亡之影響

主持人

2012/01/01~2013/03/31

台北市政府衛生局

339,720

牙周致病菌Porphyromonas gingivalisGroEL蛋白對於人類牙周韌帶細胞及骨母細胞存活度及功能的影響

共同
主持人

2012/01/01~2012/12/31

台北榮總

525,000

檳榔對人類免疫細胞表現細胞黏著分子,爬行能力與吞噬能力之調控(99-2314-B-010-040-)

主持人

2010/08/01~2011/10/31

行政院國家科學委員會

800,000

檳榔萃取物調控免疫細胞表現IL-a, PGE2,RANKL與相關氧化壓力的機制

主持人

2010/04/01~2011/3/31

台北市政府衛生局

420,000

期刊論文(* 通訊作者)

  1. Lien-Yu Chang, Yu-Lin Lai, Tzu-Hsuan Yu, Yen-Ting Chen, Shan-Ling Hung* (2014). Effects of areca nut extract on lipopolysaccharides-enhanced adhesion and migration of human mononuclear leukocytes. Journal of Periodontology, 2014; 85: 859-867. (SCI)
  2. Lien-Yu Chang, Hsiao-Ching Wan, Yu-Lin Lai, I-Chiang Chou, Yen-Ting Chen, Shan-Ling Hung* (2013). Areca nut extracts increased the expression of cyclooxygenase-2, prostaglandin E2 and interleukin-1α in human immune cells via oxidative stress. Archives of Oral Biology, 2013 (Oct); 58(10):1523-1531. (SCI)
  3. Shan-Ling Hung, Nin-Gi Lee, Lien-Yu Chang, Yen-Ting Chen, Yu-Lin Lai* (2014). Stimulatory effects of glucose and lipopolysaccharide of porphyromonas gingivalis on the secretion of inflammatory mediators from human macrophages. Journal of Periodontology, 2014 (Jan); 85:140-149. (SCI)
  4. Guo-hao Lin, Lien-Yu Chang, Wen-Chun Lin,   Shyh-Yuan Lee, Yu-lin Lai* (2014). Interdisciplinary approach for treating a large through-and-through periapical defect using guided tissue regeneration: a case report. The international Journal of Periodontics and Restorative Dentistry 2014(Jan-Feb);34:e1-e8.
  5. W-H Ho, Y-Y Lee, L-Y Chang, Y-T Chen, T-Y Liu, S-L Hung* (2010, Jun). Effects of areca nut extract on the apoptosis pathways in human neutrophils. Journal of Periodontal Research, 45(3),P.412-P.420. (SCI).
  6. Yu-Lin Lai, Hen-Li Chen, Lien-Yu Chang, Shyh-Yuan Lee* (2010, Jan). Resubmerged technique for the management of soft tissue recession around an implant: a case report. The International Journal of Oral & Maxillofacial Implants, 25, P.201-P.204. (SCI)
  7. L-Y Chang, J-C Lin, C-W Chang, W-H Ho, Y-T Chen, J-L Peng, *S-L Hung, (2009, Aug). Inhibitory effects of safrole on phagocytosis, intracellular reactive oxygen species and the activity of myeloperoxidase released by human polymorphonuclear leukocytes. Journal of Periodontology, 80(8):1330-1337. (SCI)
  8. Lien-Yu Chang, Hsiao-Ching Wan, Yu-Lin Lai, Yu-Fu Kuo, Tsung-Yun Liu, Yen-Ting Chen and Shan-Ling*2009, AprilAreca nut extracts increased expression of inflammatory cytokines, tumor necrosis factor-α, interleukin-1β, interleukin-6 and interleukin-8, in peripheral blood mononuclear cells. Journal of Periodontal Research44: 175–183.SCI
  9. Lien-Yu Chang. Effects of areca nut extracts on the regulation of immune cell functions. 2008 (PhD Dissertation).
  10. L-Y Chang, H-C Wan, Y-L Lai, T-Y Liu, and S-L Hung* (2006). Enhancing effects of areca nut extracts on production of interleukin-6 and interleukin-8 by peripheral blood mononuclear cells. Journal of Periodontology 2006;77(12): 1969-1977. (SCI)
  11. S-L Hung, Y-Y Cheng, J-L Peng, L-Y Chang, T-Y Liu, Y-T Chen* (2005). Inhibitory effects of areca nut extracts on phagocytosis of Actinobacillus actinomycetemcomitans ATCC 33384 by neutrophils. Journal of Periodontology 2005; 76(3): 373-379.
  12. L-Y Chang, S-C Lin, C-S Chang, Y-K Wong, Y-C Hu and K-W Chang* (1999). Telomerase activity and in situ telomerase RNA expression in oral carcinogenesis. J Oral Pathol Med 1999; 28: 389-96. (SCI)

研討會發表

  1. Ya-Chun Yang, Chung-Ji Liu, Ya-Wei Chen, Yi-Chun Lin, Shan-Ling Hung, Lien-Yu Chang (2014, March). ANE-treated PBMC enhanced the contractility of fibroblasts.(#1605). The AADR Annual Meeting & Exhibition, Charlotte, NC USA, March 19-22, 2014.
  2. Ya-Chun Yang, Ya-Wei Chen, Yi-Chun Lin, Shan-Ling Hung, Lien-Yu Chang (2013, Dec). The effects of areca nut extract-treated immune cells on the activation of fibroblasts. The 19th Annual Scientific Meeting & General Assembly of Association for Dental science of R.O.C. (ADS-ROC), Taipei, Taiwan, Dec 20-22, 2013.
  3. Lien-Yu Chang, Cheng-Hsien Wu, Cheng-Chieh Yang. Gardner’s syndrome with dental abnormalities and multiple exophytic osteomas, a case report (2013, Jun). The 19th International Congress of Dento-Maxillo-Facial Radiology. (P-092, page 33). Bergen, Norway. June 22-27, 2013.                 
  4. Yu-Lin Chen, Shan-Ling Hung, I-Chiang Chou, Lien-Yu Chang. (2012, Jun). Effects of areca nut extract on the apoptotic cell death of human peripheral blood mononuclear cells. . The 34th Asia Pacific Dental Congress (APDC), and the 18th Annual Scientific Meeting & General Assembly of Association for Dental science of R.O.C. (ADS-ROC), Taipei, Taiwan, June 14-18, 2012.
  5. Lien-Yu Chang, Tzu-Husan Yu, Yi-Chun Lin , Shan-Ling Hung, Yu-Lin Lai. (2011, Aug). Areca nut extract reduces the phagocytic function of human peripheral blood mononuclear cells. . The Joint Meeting: the 22nd Annual Meeting of the Japan Society of Oral Pathology and the 5th Meeting of Asia Society of Oral and Maxillofacial Pathology, Fukuoka, Japan, August 23-25, 2011.
  6. Lien-Yu Chang, Hsiao-Ching Wan, I-Chiang Chou, Tsung-Yun Liu, Shan-Ling Hung. (2011, Mar). Areca nut extract enhanced expression of inflammatory mediators, IL-1a, GMCSF, IFN-r and actin in human immune cells.. The First International Oral Pathology Update Symposium, Taipei, Taiwan, March 26-27, 2011.
  7. Y-J CHEN, S-L HUNG, T-Y LIU, Y-C Lin and L-Y CHANG. (2010, Nov). Areca nut extract affects the expression of inflammatory genes. 2010 Annual Meeting, Association for Dental Sciences of the Republic of China (ADS-ROC)), Taipei, Taiwan, Nov.26-28.2010.
  8. Y-J CHEN, S-L HUNG, T-Y LIU, and L-Y CHANG. (2010, Sep). Areca nut extract enhance the expression of inflammatory bone-resorbing cytokines. 24th IADR-SEA Annual Scientific Meeting 2010, Taipei, Taiwan, Sept. 19-21, 2010.
  9. L-Y Chang, Y-L Lai, Y-J Chen, S-L Hung (2010, Jul). Areca nut extracts affect NF-kB and MAPK pathways in osteoblasts.. 88th IADR (International Association for Dental Research) General Session & Exhibition, Barcelona, Spain, July 14-17, 2010.
  10. L-Y Chang, H-C Wan, Y-F Kuo, and S-L Hung. (2008, Jun). Enhancing cytokine production in immune cells by areca nut extracts might be via oxidative stress. 14th International Congress, International Association of Oral Pathologists/ 62nd Annual Meeting, American Academy of Oral & Maxillofacial Pathology, San Francisco, California, USA, June 2008.

研究成果圖

Effects of Areca Nut Extract on Lipopolysaccharides-Enhanced Adhesion and Migration of Human Mononuclear Leukocytes. Journal of Periodontology, 2014; 85: 859-867.
Figure 3. ANE reduced the adhesion ability of PBMC with different treatments.

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更新日期: 2014-07-21 3:09 PM

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