張國威 教授 (Kuo-Wei Chang, DDS, PhD)

個人簡歷

http://www.ym.edu.tw/sod/teacher/ChangKW/img1.JPG 

學歷

/肄業學校

國別

主修系別

學位

畢業年度

國立陽明醫學院

中華民國

牙醫學系

學士

1983

西北大學

美國

牙醫學院口腔病理系

專科醫師訓練

1994

西北大學

美國

醫學院病理系

博士

1995

經歷

服務單位 

服務部門 

職稱 

服務期間

台北榮總

口腔醫學部

兼任研究員

2006-2014

中華民國口腔病理學會

專科醫師

 

2000-2014

中華民國口腔病理學會

理學會

理事長 

2004-2006

國立陽明大學 

口腔生物研究所

所長 

2000-2006

現職:國立陽明大學牙醫學院牙醫學系教授兼系主任

專長:口腔病理學、腫瘤生物學、分子病理學

聯絡電話(02) 2826-7223

傳真電話(02) 2826-4053

電子郵件 ckcw@ym.edu.tw

研究方向

1.口腔癌化早期分子診斷
2.
口腔癌轉移之分子機制與阻斷

研究計畫

年度

計畫名稱

類型

執行期間

經費提供單位

2013

探討致癌因子調升miR-31標靶抑癌基因而增強口腔癌進行之機制(1/3NSC102-2628-B-010-011-MY3

主持人

2013/08/01~2014/07/31

國科會

2012

檳榔翠取物調控微型RNA於口腔癌化之的功能探討(3/3

主持人

2012/08/01~2013/07/31

國科會

2012

pre-miR-187生成之導引股及過客股微型RNA在口腔癌化之臨床及功能角色探討(1/3)

主持人

2012/08/01~2013/07/31

國科會

2011

檳榔翠取物調控微型RNA於口腔癌化之的功能探討(2/3

主持人

2011/08/01~2012/07/31

國科會

2010

檳榔萃取物調控微型RNA於口腔癌化之的功能探討 (1/3)

主持人

2010/08/01~2011/07/31

國科會

2010

口腔癌之L-selectin (SELL)過度表現之機制與功能探討(3/3)

主持人

2010/08/01~2011/09/30

國科會

2010

NFKB1miR-146a基因多型性與口腔癌進行之研究

主持人

2010/01/01-2010/12/31

台北榮民總醫院

2010

miR-31* 過客股微型RNA在口腔癌化角色及轉譯診斷效益之研究

主持人

2010/01/01-2010/12/31

台北榮民總醫院 
基因體醫學計畫

2009

微型RNA調控牙周韌帶細胞生理功能之角色

主持人

2009/01/01-2009/12/31

台北榮民總醫院

2009

口腔癌之L-selectin (SELL)過度表現之機制與功能探討(2/3)

主持人

2009/08/01~2010/07/31

國科會 

2009

位於染色體3q26-27之新穎鋅指致癌蛋白 ZASC1於口腔癌化角色之探討(3/3)

主持人

2009/08/01~2010/07/31

國科會 

2008

微型RNA miR-31對口腔癌細胞之類胰島素生長因子結合蛋白-7(IGFBP-7)之調控

主持人

2008/01/01-2008/12/31

台北榮民總醫院

2008

口腔癌之L-selectin (SELL)過度表現之機制與功能探討(1/3) 

主持人  

2008/08/01~2009/07/31 

國科會 

2008

位於染色體3q26-27之新穎鋅指致癌蛋白 ZASC1於口腔癌化角色之探討(2/3)

主持人  

2008/08/01~2009/07/31 

國科會 

2007

檳榔成份誘發之活性氧壓力對口腔角質細胞週期之影響

主持人

2008/08/01~2009/07/31

國科會 

2007

位於染色體3q26-27之新穎鋅指致癌蛋白 ZASC1於口腔癌化角色之探討(1/3) 

主持人  

2007/08/01~2008/07/31 

國科會 

2007

PI3K/AKT/PAK訊息路徑及11q13致癌基因註解於口腔癌轉移監控及標靶治療之研究(2/2) 

主持人  

2007/08/01~2008/07/31 

國科會 

獲獎項目

年度 

提供單位 

得獎紀錄 

2013

陽明大學

指導口生所碩士班學生葉俐瑩獲頒本校102年度「紀念尹珣若先生品學及論文優良獎學金」

2013

陽明大學

指導口生所碩士班學生葉俐瑩獲頒本校102年度「學術論文研討會」優等獎

2012

陽明大學

指導口生所博士班學生朱庭慧,榮獲101學年度「博士班研究生論文比賽」第一名

2011

中華牙醫學會

指導申葳同學獲中華牙醫學會學術競試優等獎

2009

國立陽明大學

指導研究生呂萱萱獲陽明博士班優良論文獎學金論文比賽優等獎

2009

中華民國齒顎矯正學會

指導研究生陳芳津獲陳坤智教授獎學金論文獎

2008

榮總台灣聯合大學

96年合作研究計畫成果發表會壁報展示第二名

2007-2010

國立陽明大學

教師學術卓越獎勵

2007

國立陽明大學

指導謝宗明同學獲學術海報比賽基礎研究組優等獎

2006

國立陽明大學

教學卓越獎

期刊論文(* 通訊作者)

  1. Liu CJ, Shen WG, Peng SY, Chang HW, Kao SY, Lin SC, Chang KW* (2014). miR-134 induces oncogenicity and metastasis in head and neck carcinoma through targeting WWOX gene. Int J Cancer 134: 811-21.   
  2. Hung PS, Tu HF, Kao SY, Yang CC, Liu CJ, Huang TY, Chang KW*, Lin SC* (2014) miR-31 is up-regulated in oral premalignant epithelium and contributes to the immortalization of normal oral keratinocytes. Carcinogenesis 35: 1162-71.
  3. Yu EH, Lui MT, Tu HF, Wu CH, Lo WL, Chang KW*, Kao SY* (2014). Oral carcinoma with perineural invasion has higher nerve growth factor expression and worse prognosis. Oral Dis 20: 268-74.
  4. Tseng SH, Yang CC, Yu EH, Chang C, Lee YS, Liu CJ, Chang KW*, Lin SC* (2014). K14-EGFP-miR-31 transgenic mice have high susceptibility to chemical-induced squamous cell tumorigenesis that is associating with Ku80 repression. Int J Cancer (In press)
  5. Lu WC, Kao SY, Yang CC, Tu HF, Wu CH, Chang KW*, Lin SC* (2014). EGF up-regulates miR-31 through the C/EBPβ signal cascade in oral carcinoma. Plos One (In press)
  6. Li WC, Lee PL, Chou IC, Chang WJ, Lin SC, Chang KW* (2014). Molecular and cellular cues of diet associated oral carcinogenesis – with an emphasis on areca nut induced oral cancer development. J Oral Pathol Med (In press; Invited review)
  7. Liu CJ, Shen WG, Peng SY, Chang HW, Kao SY, Lin SC, Chang KW* (2013). miR-134 induces oncogenicity and metastasis in head and neck carcinoma through targeting WWOX gene. Int J Cancer (In press) 
  8. Yu EH, Lui MT, Tu HF, Wu CH, Lo WL, Chang KW*, Kao SY* (2013). Oral carcinoma with perineural invasion has higher nerve growth factor expression and worse prognosis. Oral Dis (In press) 
  9. Chu TH, Yang CC, Liu CJ, Lui MT, Lin SC*, Chang KW* (2013).miR-211 promotes the progression of head and neck carcinomas by targeting TGFβRII. Cancer Letters 337: 115-24.
  10. Chang KW, Chu TH, Gong NR, Chiang WF, Yang CC, Liu CJ, Wu CC, Lin SC* (2013). miR-370 modulates insulin receptor substrate-1 expression and inhibits the tumor phenotypes of oral carcinoma. Oral Dis 19: 611-9.
  11. Tu HF, Lin SC, Chang KW* (2013). MicroRNA aberrances in head and neck cancer - pathogenetic and clinical significance. Current Opinion Otolaryn Head & Neck Surgery 21: 104 -11 (Invited Review). 
  12. Chang KW, Kao SY, Wu YH, Tsai MM, Tu HF, Liu CJ, Lui MT, Lin SC* (2013). Passenger strand miRNA miR-31* regulates the phenotypes of oral cancer cells by targeting RhoA. Oral Oncol 49: 27 -33.
  13. Tu HF, Liu CJ, Chang CJ, Wang PW, Kao SY, Yang CC, Yu EH, Lin SC*, Chang KW* (2012). The association between genetic polymorphism and the processing efficiency of miR-149 affects the prognosis of patients with head and neck squamous cell carcinoma. Plos One 7: 12; e51606 (SCI).
  14. Wang MC, Hung PS, Tu HF, Shih WY, Li WC, Chang KW* (2012). Lipopolysaccharideinduces the migration of human dental pulp cells by up-regulating miR-146a. J Endod 38: 1598-1603 (SCI).
  15. Liu CJ, Lin SC, Yang CC, Cheng HW, Chang KW* (2012). Exploiting salivary miR-31 as a clinical biomarker of oral squamous cell carcinoma. Head and Neck 34: 219-24 (SCI).
  16. Tseng YH, Chang KW (Co-first author), Yang CC, Liu CJ, Kao SY, Liu TY, Lin SC* (2012). Association between the areca-stimulated vimentin expression and the progression of head and neck cancers. Head and Neck 34: 245-53 (SCI).
  17. Hung PS, Chang KW (Co-first authors), Kao SY, Chu TH, Liu CJ, Lin SC* (2012). Association between the rs2910164 polymorphism in pre-mir-146a and oral carcinoma progression. Oral Oncol 48: 404-8 (SCI).
  18. Tu HF, Liu CJ, Liu SY, Chen YP, Yu EH, Lin SC *, Chang KW * (2011) . Head and Neck 33(3): 396-402 (SCI).
  19. Tseng YH, Yang CC, Lin SC, Cheng CC, Lin SH, Liu CJ, Chang KW * (2011). Areca nut extract upregulates vimentin by activating PI3K/AKT signaling in oral carcinoma. J Oral Pathol Med 40(2): 160-6 (SCI)
  20. Liu CJ, Lin SC, Yang CC, Cheng HW, Chang KW * (2011). Exploiting salivary miR-31 as a clinical biomarker of oral squamous cell carcinoma. Head and Neck (In press) (SCI).
  21. Tu HF, Chang KW (Co-first author), Chiang WF, Liu CJ, Yu AH, Liu ST, Lin SC * (2011). The frequent co-expression of the oncogenes PIK3CA and PAK1 in oral carcinomas. Oral Oncol 47 (3): 211-6 (SCI)
  22. Tseng YH, Chang KW (Co-first author), Yang CC, Liu CJ, Kao SY, Liu TY, Lin SC * (2011). Association between the areca-stimulated vimentin expression and the progression of head and neck cancers. Head and Neck (In press) (SCI).
  23. Liu CJ, Tsai MM, Hung PS, Kao SY, Liu TY, Wu KJ, Chiou SH, Lin SC*, Chang KW* (2010). miR-31 ablates expression of the HIF regulatory factor FIH to activate the HIF pathway in head and neck carcinoma. Cancer Res 70: 1035-44 (SCI).
  24. Chang KW, Hung PS, Lin IY, Hou CP, Chen LK, Tsai YM, Lin SC* (2010). Curcumin induces insulin-like growth factor binding protein-5 (IGFBP-5) expression through up-regulating CCAAT/enhancer-binding protein-α (C/EBPα) in oral cancer cells. Int J Cancer 127: 9 - 20 (SCI).
  25. Hung PS, Chen FC, Kuang SH, Kao SY, Lin SC*, Chang KW* (2010). miR-146a induces differentiation of periodontal ligament cells. J Dent Res 89: 252-7. (SCI)
  26. Lin SC, Liu CJ, Lin JA, Chiang WF, Hung PS, Chang KW* miR-24 up-regulation in oral carcinoma: positive association from clinical and in vitro analysis. Oral Oncol 46: 204-8 (SCI).
  27. Liu CJ, Kao SY, Tu HF, Tsai MM, Chang KW*, Lin SC* (2010). Increase of microRNA miR-31 level in plasma could be a potential marker of oral cancer. Oral Dis 16: 360-4 (SCI)
  28. Kao SY, Chen YP, Tu HF, Liu CJ, Yu AH, Wu CH, Chang KW*. Nuclear STK15 expression is associated with aggressive behavior of oral carcinoma cells in vivo and in vitro. J Pathol 222: 99-109 (SCI).
  29. Tu HF, Liu CJ, Liu SY, Chen YP, Yu EH, Lin SC*, Chang KW* (2010) . Head and Neck (In press) (SCI).
  30. Lu HH, Chen LK, Cheng CY, Hung SL, Lin SC, Chang KW* (2009). Areca nut extract-treated gingival fibroblasts modulate the invasiveness of polymorphonuclear leukocytes via the production of MMP-2. J Oral Pathol Med 38:79-86 (SCI)
  31. Chang KW, Liu CJ, Chu TH, Cheng HW, Hung PS, Hu WY, Lin SC* (2008). Association between high miR-211 microRNA expression and the poor prognosis of oral carcinoma. J Dent Res 87: 1063-68 (SCI).
  32. Lu HH, Liu CJ, Liu TY, Kao SY, Lin SC*, Chang KW* (2008). Areca-treated fibroblasts enhance tumorigenesis of oral epithelial cells. J Dent Res 87:1069-74 (SCI)
  33. Tu HF, Chen HW, Kao SY, Lin SC, Liu CJ*, Chang KW* (2008). MDM2 SNP 309 and p53 codon 72 polymorphism are associated with the outcome of oral carcinoma patients receiving postoperative irradiation. Radiotherapy and Oncol 87: 243-52. (SCI)
  34. Liu CJ, Kuo LT, Cheng HW, Liu TY, Chang KW*, Lin SC* (2008) Differential gene expression signature between primary and metastatic head and neck squamous cell carcinoma. J Pathol 214: 489-97 (SCI).
  35. Hung PS, Kao SY, Shih YH, Chiou SH, Liu CJ, Chang KW*, Lin SC* (2008). Insulin-like growth factor binding protein-5 (IGFBP-5) suppresses the tumorigenesis of head and neck squamous cell carcinoma. J Pathol 214: 368-76 (SCI)
  36. Chiang WF, Liu SY, Lin CN, Yen CY, Chen YC, Lin SC, Chang KW* (2008). Association of epidermal growth factor receptor (EGFR) gene copy number amplification with neck lymph node metastasis in areca-associated oral carcinomas. Oral Oncol 44: 270-6 (SCI)
  37. Shieh TM, Lin SC, Liu CJ, Chang SC, Ku TH, Chang KW* (2007). Association of expression aberrances and genetic polymorphisms of lysyl oxidase (LOX) with areca-associated oral tumorigenesis. Clin Cancer Res 13: 4378-85 (SCI)
  38. Tseng YH, Chang CS, Liu TY, Kao SY, Chang KW*, Lin SC* (2007). Areca nut extract treatment down-regulates involucrin in normal human oral keratinocyte through AKT activation. Oral Oncol 43: 670-9 (SCI)
  39. Ko SY, Lin SC, Wong YK, Liu CJ, Chang KW*, Liu TY* (2007). Increase of disintegrin metalloproteases 10 (ADAM10) expression in oral squamous cell carcinoma. Cancer Letters 245: 33-43 (SCI)
  40. Liu CJ, Lui MT, Chen HL, Lin SC, Chang KW* (2007). MICA and MICB overeexpression in oral squamous cell carcinoma. J Oral Pathol Med 36: 43 – 7 (SCI)

研究成果圖

http://www.ym.edu.tw/sod/teacher/ChangKW/Image8.gif

更新日期: 2014-09-04 9:58 AM

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