張哲壽 教授 (Chang, Che-Shoa)
個人簡歷
 
學歷:美國阿拉巴馬大學牙醫學院研究所碩士
現職牙醫學系臨床合聘教授
專長:生物材料學、口腔解剖學、口腔腫瘤學、口腔顎面外科學
 
 
電子郵件chang@vghtpe.gov.tw
 
研究方向

1. 從事人工骨氫氧磷灰石之組織機械力及生物效應之研究達十五年以上。
2. 幹細胞及組織工程之研究。
3. 口腔癌病因機轉之探討。
4. 顎面矯正手術傷口癒合之研究及術前術後硬軟組織改變之研究。

研究計畫
  1. 以氫氧磷灰石表面覆蓋式植體配合氫氧磷灰石顆粒混合脫鈣冷凍乾燥異體移植骨重建局部骨缺損區之電子顯微鏡及生物力學之研究,國科會,2001/8/1~2002/7/31(NSC90-2314-B-075-101)
  2. 提昇大學基礎教育卓越計畫—子計畫三,教育部,2001/9/1~2002/8/31
  3. 氫氧磷灰石混合骨髓植入牙科植體重建骨缺損區之骨癒合及生物機械力學之研究,台北榮總,2002/1/1~2002/12/31(VGH-289)
  4. 氫氧磷灰石植體之生物效應(VI):氫氧磷灰石與生長因子對於骨再生的影響,國科會,2002/8/1~2003/7/31 (NSC91 2314 B-075-035)
  5. 血小板源生長因子以氫氧磷灰石為載體混合骨髓基質細胞對於重建缺損區骨癒合之研究,台北榮總,2003/1/1~2003/12/31 VGH-C261
  6. (總計畫)以組織工程為基礎之骨再生醫學(一),台北榮總(幹細胞計劃),2003/1/1~2003/12/31VGH-376-15
  7. 評估牙科部開放夜間門診之可行性,台北榮總台北榮總教學及發展計畫,2003/1/1~2003/12/31VGH380-1
  8. 以凝血鴐﹞ぞ袨I血清中血小板之生長因子與多孔性氫氧磷灰石及脫鈣冷凍乾燥異體移植骨混合植入大型骨缺損區之骨癒合研究,國科會,2003/8/1~2004/7/31(NSC92-2314-B-075-088)
  9. rhBMP對不同組織幹細胞骨化的調控機轉,台北榮總,2003/8/1~2004/7/31 (92-2314-B-010-036- )
  10. 應用濃縮血小板生長因子以膠原蛋白為載體,混合骨髓基質細胞填充下顎骨缺損區之骨癒合效應,台北榮總(幹細胞計劃),2004/1/1~2004/12/31 VGH-232
  11. 以組織工程為基礎之骨再生醫學 (二),台北榮總(幹細胞計劃),2004/1/1~2004/12/31VGH360-13
  12. 由脂肪細胞游離之幹細胞混合富含濃縮血小板之血清與多孔性氫氧磷灰石共同植入大型骨缺損區域之骨癒合研究,台北榮總,2005/1/1~2005/12/31VGH94-359
  13. 以組織工程為基礎之骨再生醫學 (三)子計畫三:富含脂肪萃取培養幹細胞之生物材料,混合吸附血小板分化生長因子之立體多孔海綿膠原蛋白作為載體植入骨缺損區域內,觀察其骨癒合之現象,台北榮總,2005/1/1~2005/12/31、VGH-15 、VGH-6 、VGH-7
  14. 以海綿膠原混合富含濃縮血小板之血清與多孔性氫氧磷灰石共同植入大型骨缺損區域之骨癒合研究,國科會,2005/8/1 2006/7/31 SC 94-2314-B-075-048
  15. 修飾、分離,備製二維蛋白質體晶片在醫學診斷及藥物篩選之應用(子計畫三),國科會,(94-2323-B-010-003-)
  16. 生物材料在組織工程中對骨癒合之重要性(四): 以骨形成蛋白7誘導由人類脂肪中萃取幹細胞培養於膠原蛋白立體支架再植入大缺損區促進骨癒合之研究,台北榮總(幹細胞計劃),2006/1/1~2006/12/31V95E1-011
  17. 應用protein chip探討創傷後傷口癒合過程中蛋白質之變化(二):植入骨幹細胞(BMSC)及生物材料支架觀察生長因子之變化,台北榮總,2006/1/1~2006/12/31V95C1-038
  18. 應用protein chip探討骨缺損區重建後傷口癒合過程中蛋白質之變化(三):植入萃取脂肪幹細胞混合3-D膠原蛋白支架觀察生長因子之變化,台北榮總,2007/1/1~2007/12/31V96C1-162
  19. 應用3D立體支架PLGA及膠原蛋白為骨髓幹細胞及源自脂肪幹細胞的載體在生長因子骨形成蛋白7及血管上皮生長因子誘導骨化重建顎骨大缺損癒合之研究,台北榮總,2007/1/1~2007/12/31C96E1-010
 

 
發表著作(*:corresponding author)
  1. Kao SY*, Yang J, Yang AH, Chang KW, Chang CS. 2002. Peripheral primitive neuroectodermal tumor of maxillary gingivae with metastasis to cervical lymph nodes- case report. J Oral Maxillofac Surg 60: 821-825. (SCI)
  2. Kao SY*, Tu HF, Chang CS, Yang AH, Chang KW, Lee CH. 2002. Primary ectopic thyroid carcinoma occurring in the floor of mouth and tongue- Case report. Br J Oral Maxillofac Surg 40(3): 213-5. (SCI)
  3. Kao SY*, Yeung TC, Chou IC, Chang CS. 2002. Reconstruction of the severely resorbed class-IV atrophic edentulous ridge of maxilla and mandible for implant restoration - a case report. J Oral Implantol 18: 128-132. (IM)
  4. Kao SY, Tu HF, Yang AH, Li WY, Chang CS. 2002. An oral metastatic epitheloid sarcoma occurring at the mandibular gingivae with primary lesion originating from the left wrist: a case report. Oral Surg Oral Pathol Oral Med (SCI) 40(3): 213-5.
  5. Kao SY*, We CH, Lin SC, Yap SK, Chang CS, Wong YK, Chi LY, Liu TY. 2002. Genetic polymorphism of cytochrome P4501A1 and susceptibility to oral squamous cell carcinoma and oral precancer lesions associated with smoking/betel use. J Oral Pathol Med 31: 505-511. (SCI) NSC87-2314-B-075
  6. Kao SY*, Yeung TC, Hung KF, Chou IC, Wu CH, Chang CS. 2002. Transpositioned flap vestibuloplasty combined with implant surgery in the severely resorbed atrphic edentulous ridge. J Oral Implantol 28(4): 194-199. (IM)
  7. Kao SY, Tu HF, Yang CC, Chang KW, Chang CS, Lin SC*. 2002. The retinoic acid receptor-β(RAR-β) mRNA expression in the oral squamous cell carcinoma associated with betel quid use. J Oral Pathol Med 31: 220-226. (SCI)NSC87-2314-B-075 ; NSC90-2314-B-075-103
  8. Kao SY*, Yeung TC, Lo WL, Wu CH, LuiMT, Chang CS. 2002. Rehabilitation of Dental Implants for the Post-irradiated and Marginally Resected Mandible in an Oral Cancer Patient. Chin Med J 65: 548-552. (IM)(優良雜誌)
  9. Yang CC, Tu HF, Wu CH, Chang CS, Kao SY*. 2002. In vitro growth inhibition by indomethacin on human oral squamous cell carcinoma lines synergistically suppressed by all-trans retinoic acid correlating to apoptosis. Chin Med J 65: 600-607. (IM) (優良雜誌)
  10. Iou GT, Yang J, Lo WL, Huan TY, Chang CS, Kao SY . 2002. Using minocycline sclerosing therapy for the management of chyle leakage after radical neck dissection for a recurrent oral cancer patient. Chin J Oral Maxillofac Surg 13: 10-18.
  11. Tu HF, Yang J, Chang CS, Kao SY .2002. Vestibuloplasty using palatal mucosa graft in compromised alveolar ridge due to tumor ablation surgery –a case report. Chin J Oral Maxillofac Surg 13: 40-50.
  12. Lo WL, Kao SY, Chi LY, WongYK, Chang CS*. 2003. Outcomes of oral squamous cell carcinoma in Taiwan after surgical therapy: factors affecting survival. J Oral Maxillofac Surg 61: 751-758. (SCI) NSC89-2314-B-075-113
  13. Hung KF, Lin SC, Liu CJ, Chang CS, Chang KW, Kao SY*. 2003. The biphasic differential expression of the cellular membrane protein, caveolin-1, in oral carcinogenesis. J Oral Pathol Med 32: 461-467. (SCI) NSC91-3112-B-075-002
  14. Lo WL, Chang CS, Yang AH, Kao SY*. 2003. Aspergillosis of the temporomandibular joint following irradiation of the parotid region: A case report. Int J Oral Maxillofac Surg 32: 560-562. (SCI)
  15. Tang DW, Lin SC, Chang KW, Chi CW, Chang CS, Liu TY, 2003: Elevated expression of cyclooxygenase (COX)-2 in oral squamous cell carcinoma - evidence for COX-2 induction by areca quid ingredients in oral keratinocytes. J Oral pathol Med. 32:522-9. (SCI)
  16. Kao SY, Tu HF, Chang KW, Chang CS, Yang AH, Li WY*. 2004. Epitheloid sarcoma metastasis to the gingivae: a case report. Int J Oral Maxillofac Surg 33: 205-208. (SCI)
  17. HF Tu, IT Yu, KW Chang, CS Chang, Kao SY*. 2004. Peripheral T-cell lymphoma of the maxillary gingival – a case report. Asia J Oral Maxillofac Surg 16: 184-188.
  18. Wu CH, Tu HF, Jenny Fong, Chang CS, Kao SY*. 2004. Antisense oligonucleotide therapy for oral squamous cell carcinoma in nude mouse model. Asia J Oral Maxillofac Surg 16: 109-115. (IM)NSC93-3112-B-075-003
  19. Wu CS, Chen YW, Lo WL, Lui MT, Chang CS, Kao SY. 2004. The 2002~2003 year cancer bulletin of oral squamous cell carcinoma at oral and maxillofacial surgery in TaipeiVeteransGeneralHospital. J Dent Sci 24: 15-20.
  20. Wu CS, Li YZ, Tu SF, Lo WL, Kao SY, Chang CS. 2004. Using microcopic MRI for observation of bone regeneration in animal model. J Dent Sci 24: 21-29.
  21. Yu EH, Kao SY, Chang CS. 2004. Tumor angiogenesis in cancer therapy. J Dent Sci 24: 65-70.
  22. Chen JK, Chiang HK, ChuSC, Hsiao TC, Chang CS*. 2004. Autofluorescence spectroscopy for differentiating oral benign tissues from precancerous lesions. Chin Dent J 23(3):182-188.
  23. Chou JC, Fong HJ, Kuang SH, Gi LY, FY Hwang, Lai YC, Chang CS, Kao SY, 2005: A retrospective analysis of the stability and relapse of soft and hard tissue change after bilateral sagittal split osteotomy for mandibular setback of 64 Taiwanese patients.J Oral Maxillofac Surg. 63:355-361.
  24. Liu CJ, Chang CS, Lui MT, Dang CW, Shih YH, Chang KW, 2005: Association of GST genotypes with age of onset and lymph node metastasis in oral squamous cell carcinoma. J Oral Pathol Med. 34:473-7.
  25. Kao SY*, Fong HJ, Lui MT, Chou SJ, Yeung TC, Hung KF, Wu CH, Yu EH, Wu HT, Chang CS, 2005: Implant rehabilitation of severely traumatized anterior alveolar ridge. Asian association of Oral and Maxillofacial Surgeons. 17(4):240-246.
  26. Tu HF, Liu CJ, Chang CS, Lui MT, Kao SY, Chang CP, Liu TY, 2006: The functional (-1171 5A→6A)polymorphisms of matrix metalloproteinase 3 gene as a risk factor for oral submucous fibrosis among male areca users. J Oral Pathol Med. 35:99-103. (SCI)
  27. Chen CF*, Chang CS, Chen YP, Lin TS, Su CY, Lee SY, 2006: Applications of Supercritical Fluid in Alloplastic Bone Graft: A Novel Method and in Vitro Tests. Ind.Eng. Chem. Res. 45, 3400-3405. (SCI)
  28. Lin SC, Liu CJ, Yeh WI, Lui MT, Chang KW*, Chang CS*, 2006: Functional polymorphism in NFKB1 promoter is related to the risks of oral squamous cell carcinoma occurring on older male areca (betel) chewers. Cancer letters. 243, 47-54 (SCI)
  29. Hung KF, Chang CS, Liu CJ, Lui MT, Cheng CY, Kao SY*, 2006: Differential expression of E-cadherin in metastatic lesions comparing to primary oral squamous cell carcinoma. J Oral Pathol Med. 35:589-94. (SCI)
  30. Yu EH, LuiMT, Chou SJ, Wang SJ, Hung KF, Lo WL, Chang CS, Wu CH, Kao SY:Comparison of Positron Emission Tomography and Computed Tomography for the Detection of Cervical Lymph Node Metastases of Oral Squamous Cell Carcinoma. Asian J Oral Maxillofacial Surg 18:109-115, 2006.
  31. Chen TW, Huang TY, Chen YW, Chao SY, Chang CS, Kao SY: Implant rehabilitation of severely traumatized maxillary anterior alveolar ridge with mandibular ramus autogenous bone graft- cases analysis. Chin J Oral Maxillofac Surg 18:9-19, 2007.
  32. Chou S R, Wu CH, Kao SY, Chang CS: Adult cervical cystic lymphangioma: a case report. Chin J Oral Maxillofac Surg 18:39-46, 2007
  33. J, Kao SY, Chang CS: Leiomyosarcoma of cheek: a case report. Chin J Oral Maxillofac Surg 18:58-68, 2007
  34. Chen YW, Lin JS, Fong Jenny HJ, Wong YK, Chou SJ, Wu CH, Lui MT, Chang CS, Kao SY : The Application of Methylene Blue as a Diagnostic Aid in Early Detection of Oral Cancer and Precancerous Lesions. British J Oral Maxillofacial Surg 2006 Oct 31 [Epub ahead of print] SCI.
  35. Tseng YH, Chang CS, Liu TY, Kao SY, Chang KW, Lin SC: Areca nut extract treatment down-regulates involucrin in normal human oral keratinocyte through P13K/AKT activation. Oral Oncol. 2006 Oct 24 [Epub ahead of print]
  36. Chou SJ, Wu CH, Kao SY, Chang CS: Spindle Cell Carcinoma in the Oral Cavity – A Case Report. Asia J Oral Maxillofac Surg(submitted)
  37. Chen YW, Tu Hsi-Fen, Wu TH, Lo WL, Chang CS, Chang KW, Kao SY: Sarcomas and sarcomatoid tumor after radiotherapy of oral squamous cell carcinoma: Analysis of 4 cases. Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology and Endodontology. (accepted)
  38. Kao SY, Wu HT, Ko SY, Fong HJ, Fong Y, Chang CS, Liu TY: The expression of phosphorylated Akt in oral carcinogenesis and its induction by nicotine stimulation and alkaline stimulation. J Oral Pathol Med(submitted) SCI
  39. Chen TW, Chang HS, Leung KW, Kao SY:Novel Surgical Approach to Elevate the Floor of the Maxillary Sinus Without Bone Grafting to Rehabilitate Dental Implants: Clinical and Radiographic Evaluation. J Oral Maxillofac Surg (submmitted). SCI

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