Name

Yuh-Lin Wu

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Position

Associate Professor (2/10 - Present)

Telephone

(O) 02-2826-7081  

(Lab) 02-2826-7000 Ext. 5943

Fax No.

(02)2826-4049

Email:

ylwu@ym.edu.tw

Education

National Cheng Kung University 9/86 ¡V 6/90 B.S. Biology

National Taiwan University  9/90 ¡V 6/92  M.S. Microbiology

University of Wisconsin-Madison  9/95 ¡V 7/01 

Ph.D. Endocrinology- Reproductive-Physiology

Experience

Compulsory Military Service in Army (7/92 - 6/94)

As a second lieutenant arranging the medical missions and military training

Teaching Assistant (8/94 - 7/95) Institute of Microbiology, College of Medicine, National Taiwan University.

Teaching Assistant (1/00 - 5/00) Department of Animal Sciences, University of Wisconsin-Madison.

Postdoctoral Research (9/01 - 7/04) Department of Biochemistry and Biophysics, University of North Carolina-Chapel Hill.

Assistant Professor (8/04 - 1/10) Institute of Physiology, School of Medicine, National Yang-Ming University.

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Research Interests:

 Lab Interests:

 Molecular Endocrinology: Adopt current protocols to study endocrine functions as well as signal transduction  mechanisms:

1. G protein signaling in ovarian system and cellular differentiation process

2. Roles of RGS proteins in inflammation

3. Inflammation in ovarian system and cancer progression  

4. Functional significance of prostaglandins in adipocyte differentiation

Currently our team includes five graduate students.

Selected Recent Publications:

1.      Wu YL*, Kou YR, Ou HL, Chien HY, Chuang KH, Liu HH, Lee TS, Tsai CY, Lu ML. Glucosamine regulation of LPS-mediated inflammation in human bronchial epithelial cells. European Journal of Pharmacology 2010; In press. (*Correspondence) 

2.      Tsai CY, Lee TS, Kou YR, Wu YL*. Glucosamine Inhibits IL-1b-Mediated IL-8 Production in Prostate Cancer Cells by MAPK Attenuation. Journal of Cellular Biochemistry 2009; 108:489¡V498. (*Correspondence) 

3.      Hsu CL, Wu YL, Tang GJ, Lee TS, Kou YR. Ginkgo Biloba Extract Confers Protection from Cigarette Smoke Extract-induced Apoptosis in Human Lung Endothelial Cells: Role of Heme Oxygenase-1. Pulmonary Pharmacology and Therapeutics 2009; 22:286-296. 

4.      Su KH, Tsai JY, Kou YR, Chang AN, Hsiao SH, Wu YL, Hou HH, Pan CC, Shyue SK, Lee TS.  Valsartan Regulates the Interaction of Angiotensin II Type 1 Receptor and Endothelial Nitric Oxide Synthase via Src/PI3K/Akt Signaling. Cardiovascular Research 2009; 82:468-475. 

5.      Lee TS, Lin CY, Tsai JY, Wu YL, Su KH, Lu KY, Hsiao SH, Pan CC, Kou YR, Hsu YP, Ho LT.  Resistin increases lipid accumulation by affecting class A scavenger receptor, CD36 and ATP-binding cassette transporter-A1 in macrophages. Life Sciences 2009; 84:97-104. 

6.      Cheng YS, Lee TS, Hsu HC, Kou YR, Wu YL*. Characterization of the Transcriptional Regulation of the Regulator of G Protein Signaling 2 (RGS2) Gene during 3T3-L1 Preadipocyte Differentiation. Journal of Cellular Biochemistry 2008; 105:922-930. (*Correspondence) 

7.      Lee TS, Liu YJ, Tang GJ, Yien HW, Wu YL, Kou YR. Wood Smoke Extract Promotes Both Apoptosis and Proliferation in Rat Alveolar Epithelial Type II Cells: the Role of Oxidative Stress and Heme Oxygenase-1. Critical Care of Medicine 2008; 36:2597-2606. 

8.      Wu YL*, Chuang HH, Kou YR, Lee TS, Lu SH, Huang YC, Nishi Y, Yanase T. Regulation of LH Receptor and PGF2ƒÑ Receptor Signaling by the Regulator of G protein Signaling 2 (RGS2) in Human and Mouse Granulosa Cells. Chinese Journal of Physiology 2008; 51:282-291. (*Correspondence) 

9.      Yang YL, Tang GJ, Wu YL, Yien HW, Lee TS, Kou YR. Exacerbation of Wood Smoke-induced Acute Lung Injury by Mechanical Ventilation Using Moderately High Tidal Volume in Mice. Respiratory Physiology & Neurobiology 2008; 160:99-108. 

10.    Wu YL, Hooks S, Harden TK, Dohlman HG. Dominant-negative inhibition of pheromone receptor signaling by a point mutation in the G protein a ƒnsubunit. Journal of Biological Chemistry 2004; 279:35287-35297.

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Lab membership

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