Shih-Chieh Hung, M.D.,Ph.D.

 

 

 

Shih-Chieh Hung Professor

Shih-Chieh Hung Professor

TEL:+886-2-28712121 ext 3450

FAX:+886-2-28757396

Address:Stem Cell Laboratory, Department of Medical Research and Education, Veterans General Hospital-Taipei, 201, Sec. 2, Shih-Pai Rd, Taipei, Taiwan

E-mail:hungsc@vghtpe.gov.tw

 

 


 

Currently in office:

Professor, Institute of Clinical Medicine, School of Medicine, National Yang-Ming University

Investigator, Stem Cell Laboratory

Attending Physician, Orthopaedic surgeon, Veterans General Hospital-Taipei

 

Award:

陽明大學研究卓越獎助 2007-2008

 

Committee Appointments:

Peer Review Committee, National Science Council, Division of Life Science
2000 ~ present
Advisory Committee for the Orthopaedic Program in the Division of Life Science, National Science Council
2004 ~ present
Advisory Committee for the Stem Cells/Regenerative Medicine Program in the Division of Life Science, National Science Council
2007 ~ present
Advisory Committee, Institute of Cell Biology and Anatomy, National Ynag-Ming University
2006, 2007
Member of Directorate, the Formosan Association of Regenerative Medicine
2003 ~ present
Advisory Committee, Institute of Cell Biology and Anatomy, National Ynag-Ming University
2006 ~ present
Committee member, 經濟部 SBIR
2006 ~ present

 

Review:

Reviewer of journal, Haematologica
2009
Reviewer of journal, Stem Cells
2005, 2006, 2007, 2008
Reviewer of journal, Stem Cells Dev
2007, 2008
Reviewer of journal, Stem Cells
2005, 2006, 2007, 2008
Reviewer of journal, Gene Therapy
2005, 2008
Reviewer of journal, Biochemical Journal
2005
Reviewer of journal, J Biomed Mater Res
2006, 2007
Reviewer of journal, Acta Pharmacologica Sinica
2006
Reviewer of journal, J Neuroscience Method
2006
Reviewer of journal, Molecular & Cellular Proteomics
2004
Reviewer of journal, J Orthop Res
2008
Reviewer of journal, Acta Biomaterialia
2008
Reviewer of journal, Pathology - Research and Practice
2007, 2008/09/25
The Chinese Reviewer of journal, The Chinese Journal of Physiology
2007

 


Publications:

(* indicates corresponding author)

  1. CL-Yu, KL-Chang, SC-Hung, BN-Chiang, SH-Han, SR-Wang: Defective helper T cell function in IgM rheumatoid factor synthesis in patients with ankylosing spondylitis. Scandinavian journal of rheumatology 18:43-49, 1989.
  2. W-Ou, T-Kurokawa, K-Nakamura, T-Matsushida, R-Murashima, I-Kusaba, H-Okazaki, K-Mamada, R-Shiro, K-Tanaka, M-Takahashi, SC-Hung: Prevention of equinus deformity by brace and physiotherapy during leg lengthening. Journal of Physical Medicine 6:164-167, 1995.
  3. H-Okazaki, T-Kurokawa, K-Nakamura, K-Mamada, R-Shiro, K-Tanaka, W-Ou, SC-Hung, R-Murasima, I-Kusaba: Influence of length gain on axial deviation in tibial lengthening by callotasis method. Nippon External Fixator Research 6:201-202, 1995. (Japanese Journal)
  4. SC-Hung, T-kurokawa, K-Nakamura, T-Matsushita, R-Shiro, H-Okazaki: Narrowing of the hip joint space in patients with posttraumatic shortening of the femur. Eastern Japanese Orthopaedic Journal 7:47-47, 1995. (Japanese Journal)
  5. K-Tanaka, T-Kurokawa, K-Nakamura, T-Matsushida, S-Horinaka, I-Kubasa, H-Okazaki, R-Shiro, W-Ou, SC-Hung: Callus formation in femur and tibia during leg lengthening. Acta Orthopaedica Scandinavica 67:158-160, 1996.
  6. SC-Hung*, T-kurokawa, K-Nakamura, T-Matsushita, R-Shiro, H-Okazaki: Narrowing of the joint space of the hip after traumatic shortening of the femur. Journal of Bone & Joint Surgery 78B:718-721, 1996.
  7. SC-Hung*, K-Nakamura, T-Matsushita, H-Okazaki, R-Shiro, K-Mamada, K-Tanaka, W-Ou, T-kurokaw: Influence of femoral lengthening on hip joint space in post-traumatic femoral shortening. Acta Orthopaedica Scandinavica 68:541-544, 1997.
  8. SC-Hung*, K-Nakamura, R-Shiro, K-Tanaka, H-Kawahara, T-kurokawa: Effects of continuous distraction on cartilage in a moving joint: an investigation on adult rabbits. Journal of Orthopaedic Research 15:381-390, 1997.
  9. SC-Hung: Effects of unloading with motion on articular cartilage- an experimental study in adult rabbits. Ph.D. Thesis, The University of Tokyo, 1997.
  10. S-Jinno, SC-Hung, H-Okayama: Cell cycle start from quiescence controlled by tyrosine phosphorylation of Cdk4. Oncogen 18:565-571, 1999.
  11. S-Jinno, SC-Hung, H-Yamamoto, J-Lin, A-Nagata, H-Okayam: Oncogenic stumulation recruits cyclin-dependent kinase in the cell cycle start in rat fibroblast. Proceedings of National Academy of Sciences of the United States America 96:13197-13202, 1999.
  12. SC-Hung*, NJ-Chen, SL-Hsieh, H-Li, HL-Ma, WH-Lo: Isolation and characterization of size-sieved stem cells from human bone marrow. Stem Cells 20:249-258, 2002. (IF: 7.531; BIOTECHNOLOGY & APPLIED MICROBIOLOGY: 5/138)
  13. SC-Hung*, HL-Ma, TF-Huang, WH-Lo: Chondrogenesis in vitro and in vivo using human mesenchymal stem cells cultured in alginate beads. Journal of Orthopaedic Surgery ROC 19:16-22, 2002.
  14. SC-Hung*, Henrich Cheng; CY-Pan; May J-Tsai, LS-Kao, HL-Ma: In vitro differentiation of size-sieved stem cells into electrically active neural cells. Stem Cells 20:522-529, 2002. (IF: 7.531; BIOTECHNOLOGY & APPLIED MICROBIOLOGY: 5/138)

Publication 2003-2009:

  1. HL-M, SC-Hung*, SY-Lin, YL-Chen, WH-Lo: Chondrogenesis of Human Mesenchymal Stem Cells Encapsulated in Alginate Beads. Journal of Biomedical Material Research A 64:273-281, 2003. (IF: 2.612; ENGINEERING BIOMEDICAL: 7/44)
  2. SC-Hung, CK-Huang, CC-Chiang, TH-Chen, WM-Chen, WH-Lo. Monteggia type I equivalent lesion: diaphyseal ulna and radius fractures with a posterior elbow dislocation in an adult. Archives of Orthopaedic & Trauma Surgery. 2003 123(6):311-3. (IF: 0.913; ORTHOPEDICS: 30/48)
  3. SC-Hung, CK-Huang, CC-Chiang, TH-Chen, WM-Chen, WH-Lo. Monteggia type I equivalent lesion: diaphyseal ulna and radius fractures with a posterior elbow dislocation in an adult. Archives of Orthopaedic & Trauma Surgery. 2003 123(6):311-3. (IF: 0.913; ORTHOPEDICS: 30/48)
  4. SC-Hung*, CF-Chang, RJ-Lin, DM-Yang, JS-Wang, Larry LT-Ho, Wen K-Yang. Immortalization without Neoplastic Transformation of Human Mesenchymal Stem Cells by Transduction with HPV16 E6E7 Genes. International Journal of Cancer 110:313-319, 2004. (IF: 4.693; ONCOLOGY: 27/127)
  5. HL-Ma, TH-Chen, SC-Hung*. Development of a new method in promoting fracture healing: multiple cryopreserved bone marrow injections using a rabbit modell. Archive of Orthopaedic & Trauma Surgery. 124:448-454, 2004. (IF: 0.913; ORTHOPEDICS: 30/48)
  6. SC-Hung*, CF-Chang, HL-Ma, TH-Chen, Larry LT-Ho. Gene expression profiles of early adipogenesis in human mesenchymal stem cells. Gene. 340:141-150, 2004. (IF: 2.871; GENETICS & HEREDITY: 65/132)
  7. H-Cheng, MJ-Tsai, SC-Hung, SF-Tzeng. Neuronal morphological change of size-sieved stem cells induced by neurotrophic stimuli. Neuroscience Letter. 367:23-28, 2004. (IF: 2.085; NEUROSCIENCES: 125/211)
  8. CY-Chang, Hondar HT-Wu, TF-Huang, HL-Ma, SC-Hung. Imaging evaluation of meniscal injury of the knee joint; A comparative MR imaging and arthroscopic study. Clinical Imaging. 2004, 28:372-6. (IF: 0.742; RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING:78/87)
  9. HL-Ma, SC-Hung, ST-Hung, MC-Chang, TH-Chen. Osteochondral autografts transfer for post-traumatic osteochondral defect of the knee-2 to 5 years follow-up. Injury. 2004 Dec;35(12):1286-92. (IF: 1.509; ORTHOPEDICS: 18/48)
  10. SC-Hung*, Cheng-Yi Lu, Song-Kun Shyue, Hwa-Chang Liu, Larry Low-Tone Ho. Lineage Differentiation-Associated Loss of Adenoviral Susceptibility and Coxsackie-Adenovirus Receptor Expression in Human Mesenchymal Stem Cells. Stem Cells 22:1321-1329, 2004. (IF: 7.531; BIOTECHNOLOGY & APPLIED MICROBIOLOGY: 5/138)
  11. HS-Wang, SC-Hung, ST-Pong, CC-Huang, HM-Wei, Y-Kuo, YS-Fu, MC-Lai, CC-Chen. Mesenchymal Stem Cells in Wharton's Jelly of the Human Umbilical Cord. Stem Cells 22:1330-1337, 2004. (IF: 7.531; BIOTECHNOLOGY & APPLIED MICROBIOLOGY: 5/138)
  12. M-C Chang, SC-Hung, Winby Y-K Chen, T-L Chen, C-F Lee, H-C Lee, K-L Wang, C-C Chiou, Y-H Wei. Accumulation of Mitochondrial DNA with 4977-bp Deletion in Knee Cartilage -An Association with Idiopathic Osteoarthritis. Osteoarthritis & Cartilage. 13:1004-1011, 2005. (IF: 3.793; ORTHOPEDICS: 1/48)
  13. HL-Ma, TH-Chen, Larry LT- Ho, SC-Hung*. Neocartilage from Human Mesenchymal Stem Cells in Alginate- Implied timing of transplantation. Journal of Biomedical Material Research A. 74:439-46, 2005. (IF: 2.612; ENGINEERING BIOMEDICAL: 7/44)
  14. SC-Hung, WP-Deng, WK-Yang, et al. Mesenchymal stem cell targeting of microscopic tumors and tumor stroma development monitored by noninvasive in vivo positron emission tomography imaging. Clinical Cancer Research. 11:7749-7756, 2005. (IF: 6.250; ONCOLOGY: 15/132)
  15. SC-Hsieh, FF-Wang, CS-Lin, YJ-Chen, SC-Hung, YJ-Wang. The inhibition of osteogenesis with human bone marrow mesenchymal stem cells by CdSe/ZnS quantum dot labels. Biomaterials. 27:1656-1664, 2006. (IF:6.262; MATERIALS SCIENCE, BIOMATERIALS: 1/16)
  16. SC-Hung*, PY-Kuo, CF-Chang, TH-Chen, Larry LT-Ho. Alpha-smooth muscle actin expression and structure integrity in chondrogenesis of human mesenchymal stem cells. Cell Tissue Research. 324:457-466, 2006. (IF: 2.613; CELL BIOLOGY: 89/156)
  17. D-Lai, HL-Ma, SC-Hung, TH-Chen,Wu JJ-Wu. Open Bankart repair with suture anchors for traumatic recurrent anterior shoulder instability: comparison of results between small and large Bankart lesions. Knee Surgery Sports Traumatology Arthroscopy. 14:82-87, 2006. (IF: 1.626; ORTHOPEDICS: 16/48)
  18. Mien-Sheng Chu, Ching-Fang Chang, Chuan-Ching Yang, Yi-Chi Bau, Larry Low-Tone Ho SC-Hung*. Signalling pathway in the induction of neurite outgrowth in human mesenchymal stem cells. Cellular Signalling. 18:519-530, 2006. (IF: 4.147; CELL BIOLOGY: 49/156)
  19. SC-Hsieh, FF-Wang, SC-Hung, YJ-Chen, YJ-Wang. The internalized CdSe/ZnS quantum dots impair the chondrogenesis of bone marrow mesenchymal stem cells. Journal of Biomedical Material Research B. 79:95-101, 2006. (IF: 1.778; MATERIALS SCIENCE, BIOMATERIALS: 7/14)
  20. JP-Wang, TF-Huang, SC-Hung, HL-Ma, JG-Wu, TH-Chen. Comparison of idiopathic, post-trauma and post-surgery frozen shoulder after manipulation under anesthesia. International Orthopaedics. 31(3):333-7, 2007 (IF: 0.977; ORTHOPEDICS: 27/43)
  21. CF-Chang, MW-Lee, PY-Kuo, YJ-Wang YH-Tu, SC-Hung*. Three-dimensional collagen fiber remodeling by mesenchymal stem cells requires the integrin-matrix interaction. Journal of Biomedical Material Research A. 80:466-474, 2007. (IF: 2.612; ENGINEERING BIOMEDICAL: 7/44)
  22. TH-Chen, WM-Chen, KH-Hsu, CD-Ku, SC-Hung*. Sodium butyrate activates ERK to regulate differentiation of mesenchymal stem cells. Biochemical and Biophysical Research Communications. 355:913-918, 2007. (IF: 2.855; BIOCHEMISTRY & MOLECULAR BIOLOGY: 109/262)
  23. SC-Hung*, R. R. Pochampally, SC-Hsu, C. Sanchez, J. SC-Chen, Spees, D. J. Prockop. Short-term exposure of mesenchymal stem cells (MSCS) to low oxygen increases their expression of CX3CR1 and CXCR4 and their engraftment in vivo. PLoS ONE, e416, 2007.
  24. SC-Hung*, RR Pochampally, SC-Chen, SC-Hsu, and DJ Prockop. Angiogenic Effects of Human Multipotential Stromal Cells (MSCs). Conditioned Medium Activates the PI3K-Akt Pathway in Hypoxic Endothelial Cells to Inhibit Apoptosis, Increase Survival, and Stimulate Angiogenesis. Stem Cells. 25:2363-2370, 2007. (IF: 7.531; BIOTECHNOLOGY & APPLIED MICROBIOLOGY: 5/138)
  25. W-Wu, LC-Lin, SC-Hung, CW-Chi, TH-Tsai. Analysis of silibinin in rat plasma and bile for hepatobiliary excretion and oral bioavailability application. Journal of Pharmaceutical and Biomedical Analysis. 45(4):635-41, 2007. (IF: 2.761; PHARMACOLOGY & PHARMACY: 143/205)
  26. CF-Chang, KH-Hsu, SH-Chiou, LT-Ho, YS-Fu, SC-Hung*. Fibronectin and pellet suspension culture promote differentiation of human mesenchymal stem cells into insulin producing cell. Journal of Biomedical Material Research A. 15;86(4):1097-105, 2008. (IF: 2.612; ENGINEERING BIOMEDICAL: 7/44)
  27. DC-Yang, HJ-Tsay, SY-Lin, MJ-Li, MT-Lin, SC-Hung*. cAMP/PKA Regulates Osteogenesis, Adipogenesis and Ratio of RANKL/OPG mRNA Expression in Mesenchymal Stem Cells by Suppressing Leptin. PLoS ONE. 3(2):e1540, 2008
  28. JW-Wu, LC-Lin, SC-Hung, CH-Lin, CW-Chi, TH-Tsai. Hepatobiliary excretion of silibinin and pharmacokinetic effect of liver cirrhosis induced by dimethylnitrosamine. Drug Metabolism and Disposition. 36(3):589-96, 2008. (IF: 3.907; PHARMACOLOGY & PHARMACY: 34/205)
  29. CF-Yang, KY-Chou, ZC-Weng, SC-Hung, ST-Lai, CP-Hsu, JS-Wang. Cardiac myocyte progenitors from adult hearts for myocardial regenerative therapy. J Chin Med Assoc. 71(2):79-85, 2008.
  30. SH-Chiou, CL-Kao, YW-Chen, CS-Chien, SC-Hung, JF-Lo, YJ-Chen, HH-Ku, MT-Hsu, TT-Wong. Identification of CD133-positive radioresistant cells in atypical teratoid/ rhabdoid tumor. PLoS ONE. 3(5):e2090, 2008.
  31. YC-Chen, HS-Hsu, YW-Chen, TH-Tsai, CK-How, CY-Wang, SC-Hung, YL-Chang, ML-Tsai, YY-Lee, HH-Ku, SH-Chiou. Oct-4 expression maintained cancer stem-like properties in lung cancer-derived CD133-positive cells. PLoS ONE. 2008 3(7):e2637, 2008
  32. CH-Chang, HY-Lin, HW-Fang, ST-Loo, SC-Hung, YC-Ho, CC-Chen FH-Lin, HC-Liu. Chondrogenesis from immortalized human mesenchymal stem cells: comparison between collagen gel and pellet culture methods. Artif Organs. 32(7):561-6, 2008.
  33. TF-Huang, YT-Chen, TH-Yang, LL-Chen, SH-Chiou, TH-Tsai, CCTsai, MH-Chen, HL-Ma, SC-Hung*. Isolation and characterization of mesenchymal stromal cells from human anterior cruciate ligament. Cytotherapy. 10(8):806-14, 2008. (Impact factor: 3.553;Rank: 18.84%)
  34. Chen WH, Lai MT, Wu AT, Wu CC, Gelovani JG, Lin CT, Hung SC, Chiu WT, Deng WP. In vitro stage-specific chondrogenesis of mesenchymal stem cells committed to chondrocytes. Arthritis Rheum. 60(2):450-459, 2009. (Impact factor: 7.677;Rank: 4.55%)
  35. HK-Chiang, FY-Peng, SC-Hung*,YC-Feng. In situ Raman Spectroscopic Monitoring of Hydroxyapatite during the Differentiation of Human Mesenchymal Stem Cells to Osteoblasts. Journal of Raman Spectroscopy. 40:546-549, 2009. (Impact factor: 3.514;Rank: 12.82%)
  36. PC-Tsai, TW-Fu, YM-Chen, T-L-Ko, TH-Chen, YH-Shih, SC-Hung*, YS-Fu*. The Therapeutic Potential of Human Umbilical Mesenchymal Stem Cells from Wharton's Jelly in the Treatment of Rat Liver Fibrosis. Liver Transplantation. 15:484-495, 2009. (Impact factor: 3.751;Rank: 5.76%)
  37. ER-Chiang, HL-Ma, ST-Wang, SC-Hung, TH-Chen. Arthroscopic treatment for pigmented villonodular synovitis of the shoulder associated with massive rotator cuff tear. Arthroscopy. 25(7):716-21, 2009.
  38. YG-Chen, MW-Lee, YH-Tu, SC-Hung, YJ-Wang. Surface coupling of long-chain hyaluronan to the fibrils of reconstituted type II collagen. Artif Cells Blood Substit Immobil Biotechnol. 37:222-6, 2009.
  39. KS-Tsai, CY-Wang, YJ-Wang, SC-Hung*. Type I collagen promotes proliferation and osteogenesis of human mesenchymal stem cells via activation of ERK and Akt pathways. Journal of Biomedical Material Research A. In print.
  40. HJ-Chiou; SC-Hung; SY-Lin; YS-Wei; MJ-Li. Correlations among Mineral Components, Progressive Calcification Process, and Clinical Symptoms of Calcific Tendonitis. Rheumatology, In Print
  41. YJ-Wei, LC-Lin, CW-Chi, TH-Tsai , SC-Hung*. Catechin stimulates osteogenesis by enhancing PP2A activity in human mesenchymal stem cells. In revision.

 

Review Papers:

SC-Hung. Tissue engineering in cartilage. Bioindustry 2001, 12:261-265.

SC-Hung. Research and applications in mesenchymal stem cells. Bioindustry 2003, 14:

 

Patents:

A Novel Method for Isolating Mesenchymal Stem Cells. (Granted by Taiwan TPO in 2001)

A Novel Method for Isolating Mesenchymal Stem Cells. (Pending by USTPO)

Method for promoting differentiation of stem cell into insulin producing cell

(Pending by Taiwan TPO, USTPO)

 

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