專長:藥物化學、有機合成                           

電話:28267097 E-mail:lkho@ym.edu.tw

經歷:  1996- 陽明大學藥理學科教授

1997-1999 陽明大學藥理學科

                      教授兼所長及科主任

               1986-1996 陽明大學藥理學科副教授

               1992/9-12 法國國家科學院吐魯斯藥理

                            及毒理中心訪問副研究員

學歷: 1985 加拿大亞伯達大學化學博士

               1977 中原理工學院化學系學士

研究興趣:天然物具降血壓及抗病毒成分研究,

                       藥物設計與合成,分子模擬。
 

近三年代表著作

1.     Y. R. Ku, K. C. Wen, L. K. Ho, and Y. S. Chang (2000) Analysis of Synthetic Gastrointestinal Drugs in Adulterated Traditional Chinese Medicines by High Performance Capillary Electrophoresis, Jounal of Liquid Chromatography and Related Technologies, 23, 2009-2019.

2.     R. L. Jiang, Y. S. Chang, and L. K. Ho (2000) Chemical Constituents of Roots and Fruits from Coriaria intermedia, J. Chin. Med. 11, 95-102.

3.     K. L. Lu, C. L. Kuo, C. C. Chen, L. K. Ho and Y. S. Chang (2000) The Pharmacognostical Studies of Ixeris laevigata var. oldhami in Taiwan, J. Chin. Med. Sci., 1, 183-198.

4.     K. L. Lu, Y. R. Ku, K. C. Wen, L. K. Ho and Y. S. Chang (2000) Analysis of Flavonoids and Coumarins in Ixeris laevigata var. Oldhami by High-performance Liquid Chromatography, Journal of Liquid Chromatography and related Technologies, 23, 2573-2583.

5.     K. L. Lu, J. P. Wang, L. K. Ho and Y. S. Chang (2000) Evaluation of the Pharmacological Effects of Helicteres angustifolia L. in Taiwan, J. Chin. Med., 11, 143-151.

6.     T. H. Tsai, S. C. Liu, L. K. Ho, and C. F. Chen (2000) Determination of Unbound Ampicillin in Rat Blood by Microdialysis and Liquid Chromatography, Analytical Letters, 33, 3213-3224.

7.     L. K. Ho, H. J. Yu, C. T. Ho, and M. J. Don (2001) Synthesis of Naturally Ocurring Rubilactone, Mollugin, and Dihydrimollugin of Rubia Cardifolia, J. Chin. Chem. Soc., 48, 77-79.

8.     M. J. Don, Y. H. Chang, K. K. Chen, L. K. Ho, and Y. P. Chau (2001) Induction of CDK Inhibitors (p21WAF1 and p27Kip1) and Bak in the b-Lapachone-induced Apoptosis of Human Prostate Cancer Cells, Mol. Pharmaco., 59, 784-794.

9.     Y. S. Chang, Y. R. Ku, J. H. Lin, K. L. Lu, and L. K. Ho (2001) Analysis of the three lupane type triterpenoids in Helicteres angustifolia by high-performance liquid chromatography, J. Pharma. biomed. Anal., 26, 849-855.

10. K. C. Kao, Y. L. Ho, L. K. Ho and Y. S. Chang (2001) 2-Benzoxazolinone, 2-hydroxy-1,4-benzoxazin-3-one from the root of Strobilanthes cusia, J. Chin. Med., 12, 41-49.

11. Y. R. Ku, J. H. Lin, K. C. Wen, L. K. Ho and C. H. Liao (2001) Review and prospect of the analysis of synthetic therapeutic substances adulterated in traditional Chinese medicine, Ann. Rept. NLFD. Taiwan R.O.C., 19, 94-105.

12. C. Y. Chen, L. K. Ho and Y. S. Chang (2001) Evaluation of the Pharmacological Effects on Ecdysanthera utilis Hayata, J. Chin. Med. 12, 109-117.

13.  C. Y. Chen, L. K. Ho and Y. S. Chang (2001) Studies on the chemical Constitutents of Cyathula officinalis Kuan, J. Chin. Med. 12, 203-210.

14. W. F. Chiou, S. Y. Li, L. K. Ho, M. L. Hsien, and M. J. Don (2002) Synthesis and vasorelaxant activity of 4-(cyclic amido)-2H-naphthol[1,2-b]pyrans, Eur. J. Med. Chem., 37, 69-75.

15. Y. R. Ku, L. Y. Chang, J. H. Lin, and L. K. Ho (2002) Determination of matrine and oxymatrine in Sophora subprosta by CE, J. Pharma. biomed. Anal., 28, 1005-1010.

16. K. L. Lu, C. C. Tsai, L. K. Ho, C. C. Lin, and Y. S. Chang (2002) Preventive Effect of the Taiwan Folk Medicine Ixeris laevigata var. Oldhami on a-naphthylisothiocyanate and Carbon Tetrachloride Induced Acute Liver injury in Rats, Phytother. Res. 16, S45-S50.

17. Y. R. Ku, C. Y. Chen, L. K. Ho, J. H. Lin, and Y. S. Chang (2002) Analysis of Flavonoids in Vernonia paltula by High-performance Liquid Chromatography, J. Food and Drug Anal., 10, 139-142.

18. T. H. Tsai, S. C. Liu, P. L. Tsai, L. K. Ho, A. Y. C. Shum and C. F. Chen (2002) The effects of the cyclosporine A, a P-glycoprotein inhibitor, on the pharmacokinetics of baicalein in the rat: a microdialysis study, Br. J. Pharmacol., 137, 1314-1320.

 

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