image001李新城 教授                                        

Hsin-Chen Lee, Ph.D.

 

Professor

Institute of Pharmacology,

School of Medicine,

National Yang-Ming University

 

陽明大學藥理學研究所

守仁大樓五樓512

實驗室電話: 02-2826-7327

E-mail: hclee2@ym.edu.tw

 

學歷:

1.國立陽明大學生物化學研究所 博士〔19969月至 20007月〕

2.國立陽明大學生物化學研究所 碩士〔19929月至 19946月〕

3.國立陽明醫學院醫事技術學系 學士〔19889月至 19926月〕

 

專業證照:

1.醫事檢驗師

2.考試院醫事檢驗師檢覈及格

 

經歷:

陽明大學醫學院藥理學研究所                    所長                       2014/8

陽明大學醫學系藥理學科                            主任                    2014/8

陽明大學醫學院藥理學研究所                  專任教授            2011/2

科技部生技醫藥核心設施平台辦公室       主持人                2017/8

台灣粒線體醫學暨研究學會                    常務理事            2016/1

台灣粒線體醫學暨研究學會                    理事                2006/8

台灣生醫品質保證協會                                常務監事            2017/6

台灣生醫品質保證協會                                監事                2014/6

陽明大學醫學系                              PBL tutor                    2004/8

南加大USC School of Pharmacy                 Visiting Scholar    2015/8

台北市立聯合醫院                            聘兼副研究員     2009/82010/7

陽明大學醫學院藥理學研究所                  專任副教授       2006/82011/1

台北市立聯合醫院                            聘兼助理研究員   2006/22009/7

陽明大學與中研院合辦分子醫學學程      教師                   2005/82009/7

陽明大學醫學院藥理學科                      專任助理教授     2003/82006/7

彰化基督教醫院                              研究顧問         2003/12003/12

中山醫學大學生物化學研究所                  專任助理教授     2001/82003/7

陽明大學生物化學研究所                      博士後研究       2000/82001/7

學會會員:

1.     The Taiwan Society for Biochemistry and Molecular Biology (台灣生物化學及分子生物學學會)

2.     Toxicology Society of Taiwan (中華民國毒物學學會)

3.     The Pharmacological Society in Taiwan (台灣藥理學會)

4.     The Asian Society for Mitochondrial Research and Medicine

5.     The Taiwan Society for Mitochondrial Research and Medicine(台灣粒線體醫學暨研究學會)

6.     American Chemical Society

7.     台灣生醫品質保證協會

 

榮譽:

1.     20043 榮獲陽明大學92學年度第一學期醫學系學生網路教學評鑑之優良教師

2.     20063 榮獲陽明大學94學年度第一學期醫學系學生網路教學評鑑之優良教師

3.     20069 榮獲陽明大學94學年度教學優良教師獎

4.     200611 榮獲陽明大學94學年度第二學期醫學系學生網路教學評鑑之優良教師

5.     20074 榮獲陽明大學95學年度第一學期醫學系學生網路教學評鑑之優良教師

6.     200711 榮獲陽明大學95學年度第二學期醫學系學生網路教學評鑑之優良教師

7.     20084 榮獲陽明大學96學年度第一學期醫學系學生網路教學評鑑之優良教師

8.     201011 榮獲陽明大學98學年度第二學期醫學系學生網路教學評鑑之優良教師

9.     20115 榮獲陽明大學99學年度教師學術卓越獎勵

10.  20118 榮獲教育部資深優良教師獎勵

11.  201110 榮獲陽明大學100-101學年度教師學術卓越獎勵

12.  201110 榮獲陽明大學99學年度第二學期醫學系學生網路教學評鑑之優良教師

13.  201311 榮獲陽明大學102-103學年度教師學術卓越獎勵

14.  20145 榮獲陽明大學102學年度第一學期醫學系學生網路教學評量之優良教師

15.  201410 榮獲陽明大學102學年度第二學期醫學系學生網路教學評量之優良教師

16.  201511 榮獲陽明大學103學年度第二學期醫學系學生網路教學評估之優良教師

17.  20171月榮獲陽明大學105學年度第一學期醫學系四年級PBL優良老師

 

學術期刊編審委員Editorial Board Member

1.     The Open Toxicology Journal (2007~2009)

2.     BioMedicine (2008~; Editor 2009~)

3.     Pharmacologia (2011~2014)

4.     ISRN Molecular Biology (2011~)

5.     World Journal of Gastrointestinal Oncology (Editor-in-Chief, 2011~)

6.     World Journal of Biological Chemistry (2014~)

7.     Oncology Communications (2016~)

8.     Open Biological Sciences Journal (Editor-in-Chief, 2016~)

9.     Oxidative Medicine and Cellular Longevity (2016-2017 Special Issue Guest Editor)

 

期刊審查Reviewer

Adaptive Medicine // African Journal of Biotechnology // African Journal of Pharmacy and Pharmacology // AGE // Aging-US // Annals of Surgical Oncology // Archivum Immunologiae et Therapiae Experimentalis // Archives of Medical Research // BBA - Molecular Basis of Disease // Biochemical Journal // Biologia // BioMed Research International // BioMedicine // BMC Research Notes // BMC Cancer // British Journal of Cancer // British Journal of Medicine and Medical Research // Cancer Cell International // Cancer Research // Cell Biology International // Cell Biology and Toxicology // Cell Death & Disease // Cell Proliferation // Chinese Journal of Physiology // Clinical Medicine-Oncology // Endocrine // Experimental and Therapeutic Medicine // European Journal of Clinical Investigation // European Journal of Surgical Oncology // Evidence-Based Complementary and Alternative Medicine // Experimental Biology and Medicine // Experimental Cell Research // Experimental Dermatology // Expert Opinion on Medical Diagnostics // Expert Review of Gastroenterology & Hepatology // Free Radical Biology & Medicine // Food and Chemical Toxicology // Frontiers in Bioscience // Human Mutation // Inflammation // International Journal of Biochemistry and Cell Biology // International Journal of Cancer // International Journal of Gynecological Cancer // International Journal of Molecular Sciences // International Journal of Nanomedicine // International Journal of Nutrition and Metabolism // International Journal of Oncology // International Journal of Preventive Medicine // ISRN Molecular Biology // Journal of Biomedical Science // Journal of Cancer Research and Clinical Oncology // Journal of Cellular and Molecular Medicine // Journal of Human Genetics // Journal of Leukocyte Biology // Journal of Molecular Cell Biology // Journal of Rare Diseases Research & Treatment // Journal of Surgical Oncology // Journal of the Chinese Medical Association // Journal of Translational Medicine // Mechanisms of Ageing and Development // Metabolites // Mini-Reviews in Medicinal Chemistry // Mitochondrion // Mitochondrial DNA // Molecules // Molecular Diagnosis & Therapy // Molecular Medicine Reports // Molecular Nutrition and Food Research // Mutation Research-Fundamental and Molecular Mechanisms of Mutagenesis // Neurobiology of Aging // Neurochemistry International // Neurotoxicity Research // Oncogene // Oncology Reports // Oncotarget // Oxidative Medicine and Cellular Longevity // Pharmaceuticals // Pharmacogenetics and Genomics // PLoS ONE // Protein & Cell // Radiation Oncology // Scientific Reports // Stem Cells // Stem Cells and Development // The Open Toxicology Journal // Theranostics // Toxicology in Vitro // World Journal of Biological Chemistry // World Journal of Experimental Medicine // World Journal of Gastroenterology // World Journal of Gastrointestinal Oncology (91種期刊)

 

 

圓桌教育基金會課程:

1.     第一階:改變的力量-師鐸營 (第371期)

2.     第二階:效率影響力(第80期); 為人父母(第59期)

 

導師:

1.     92-93學年度:醫學系96級四、五年級甲班導師

2.     94-97學年度:醫學系101至四年級甲班導師

3.     98-101學年度:醫學系105級一年級至四年級甲班導師

4.     103-105學年度:醫學院藥理學研究所主任導師

 

研究興趣:

1.     惡性腫瘤細胞中能量代謝與粒線體DNA變異研究

2.     粒線體功能異常於癌細胞惡化進展之角色

3.     粒線體逆向訊息傳遞於癌細胞惡化進展之角色

4.     以癌細胞粒線體作為精準治療之藥物標的

5.     能量代謝與粒線體功能於幹細胞特性維持與分化之調控

6.     粒線體於氧化壓力反應之分子機制研究

7.     粒線體於細胞程式性死亡機制之研究

8.     抗癌藥物研發與機制研究

 

著作目錄:

期刊論文

1.           Lin YC, Chang YT, Campbell M, Lin TP, Pan CC, Lee HC, Shih JC*, Chang PC* (2017) MAOA- a novel decision maker of apoptosis and autophagy in hormone refractory neuroendocrine prostate cancer cells. Sci. Rep. 7, 46338. SCI

2.           Chang YT, Lin TP, Campbell M, Pan CC, Lee SH, Lee HC, Yang MH, Kung HJ, Chang PC* (2017) REST is a crucial regulator for acquiring EMT-like and stemness phenotypes in hormone-refractory prostate cancer. Sci. Rep. 7, 42759. SCI

3.           Chen JL, Ping YH, Tseng MJ, Chang YI, Lee HC, Hsieh RH, Yeh TS* (2017) Notch1-promoted TRPA1 expression in erythroleukemic cells suppresses erythroid but enhances megakaryocyte differentiation. Sci. Rep. 7, 42883. SCI

4.           Yeh TC, Huang TT, Yeh TS, Chen YR, Hsu KW, Yin PH, Lee HC*, Tseng LM* (2016) Mir-151-3p targets TWIST1 to repress migration of human breast cancer cells. PLoS ONE 11, e0168171. SCI

5.           Wang SF, Chen MS, Chou YC, Ueng YF, Yin PH, Yeh TS, Lee HC* (2016) Mitochondrial dysfunction enhances cisplatin resistance in human gastric cancer cells via the ROS-activated GCN2-eIF2α-ATF4-xCT pathway. Oncotarget 7, 74132-74151. SCI

6.           Hsu HT, Sung MT, Lee CC, Kuo YJ, Chi CW, Lee HC, Hsia CY* (2016) PPARγ expression is inversely associated with macroscopic vascular invasion in human hepatocellular carcinoma. Int. J. Mol. Sci. 17, E1226. SCI

7.           Chen HC, Hsu HT, Weng JW, Chang YF, Hsia CY, Lee HC, Chi CW* (2016) Combined effect of honokiol and rosiglitazone on cell growth inhibition through enhanced G0/G1 phase arrest in hepatoma cells. J. Chin. Med. Assoc. 79, 415-421. SCI

8.           Hsu KW, Fang WL, Huang KH, Huang TT, Lee HC, Hsieh RH, Chi CW, Yeh TS* (2016) Notch1 pathway-mediated microRNA-151-5p promotes gastric cancer progression. Oncotarget 7, 38036-38051. SCI

9.           Hsu CC, Tseng LM, Lee HC* (2016) Role of mitochondrial dysfunction in the cancer progression. Exp. Biol. Med. 241, 1281-1295. SCI

10.        Chou SJ, Tseng WL, Chen CT, Lai YF, Chien CS, Chang YL, Lee HC*, Wei YH*, Chiou SH* (2016) Impaired ROS scavenging system in human induced pluripotent stem cells generated from patients with MERRF syndrome. Sci. Rep. 6, 23661. SCI

11.        Tsai PH, Chien Y, Chuang JH, Chou SJ, Chien CH, Lai YH, Li HY, Ko YL, Wang CY, Liu YY, Lee HC, Yang CH, Tsai TF, Lee YY, Chiou SH* (2015) Dysregulation of mitochondrial functions and osteogenic differentiation in cisd2-deficient murine induced pluripotent stem cells. Stem Cells Dev. 24, 2561-2576. SCI

12.        Li CT, Tu PC, Hsieh JC, Lee HC, Bai YM, Tsai JF, Huang HH, Wang SJ, Su TP* (2015) Functional dysconnection in the prefrontal-amygdala circuitry in unaffected siblings of bipolar I patients. Bipolar Disord. 17, 626-635. SCI

13.        Huang TT, Ping YH, Wang AM, Ke CC, Fang WL, Huang KH, Lee HC, Chi CW, Yeh TS* (2015) The reciprocal regulation loop of Notch2 pathway and miR-23b in controlling gastric carcinogenesis. Oncotarget 6, 18012-18026. SCI

14.        Hsu CC, Wu LC, Hsia CY, Yin PH, Chi CW, Yeh TS, Lee HC* (2015) Energy metabolism determines the sensitivity of human hepatocellular carcinoma cells to mitochondrial inhibitors and biguanide drugs. Oncol. Rep. 34, 1620-1628. SCI

15.        Sung MT, Hsu HT, Lee CC, Lee HC, Kuo YJ, Hua K, Hsia CY*, Chi CW* (2015) Krüppel-like factor 4 modulates migration and invasion of hepatoma cells by repressing TIMP-1 and TIMP-2. Oncol. Rep. 34, 439-446. SCI

16.        Li CT, Bai YM, Hsieh JC, Lee HC, Yang BH, Chen MH, Lin WC, Tsai CF, Tu PC, Wang SJ, Su TP* (2015) Peripheral and central glucose utilizations modulated by mitochondrial DNA 10398A in bipolar disorder. Psychoneuroendocrinology 55, 72-80. SCI

17.        Huang SW, Kao JK, Wu CY, Wang ST, Lee HC, Liang SM, Chen YJ, Shieh JJ* (2014) Targeting aerobic glycolysis and HIF-1 alpha expression enhance imiquimod-induced apoptosis in cancer cells. Oncotarget 5, 1363-1381. SCI

18.        Lee HC*, Huang KH, Yeh TS, Chi CW (2014) Somatic alterations in mitochondrial DNA and mitochondrial dysfunction in gastric cancer progression. World J. Gastroenterol. 20, 3950-3959. SCI

19.        Huang KH, Hsu CC, Fang WL, Chi CW, Sung MT, Kao HL, Li AFY, Yin PH, Yang MH, Lee HC* (2014) SIRT3 expression as a biomarker for better prognosis in gastric cancer. World J. Surg. 38, 910-917. SCI

20.        Hsu KW, Wang AM, Ping YH, Huang KH, Huang TT, Lee HC, Lo SS, Chi CW, Yeh TS* (2014) Down-regulation of tumor suppressor MBP-1 by microRNA-363 in gastric carcinogenesis. Carcinogenesis 35, 208-217. SCI

21.        Hsu CC, Lee HC*, Wei YH (2013) Mitochondrial DNA alterations and mitochondrial dysfunction in the progression of hepatocellular carcinoma. World J. Gastroenterol. 19, 8880-8886. SCI

22.        Lan YC, Chang CL, Sung MT, Yin PH, Hsu CC, Wang KC, Lee HC, Tseng LM*, Chi CW* (2013) Zoledronic acid-induced cytotoxicity through endoplasmic reticulum stress triggered REDD1-mTOR signaling pathway in breast cancer cells. Anticancer Res. 33, 3807-3814. SCI

23.        Wang SF, Chou YC, Mazumder N, Kao FJ, Nagy LD, Guengerich P, Huang C, Lee HC, Lai PS, Ueng YF (2013) 7-Ketocholesterol induces P-glycoprotein through PI3K/mTOR signaling in hepatoma cells. Biochem. Pharmacol. 86, 548-560. SCI

24.        Hsu CC, Wang CH, Wu LC, Hsia CY, Chi CW, Yin PH, Chang CJ, Sung MT, Wei YH, Lu SH, Lee HC* (2013) Mitochondrial dysfunction represses HIF-1α protein synthesis through AMPK activation in human hepatoma HepG2 cells. Biochim. Biophys. Acta-Gen. Subj. 1830, 4743-4751.SCI

25.        Lin HY, Lai RH, Lin ST, Lin RC, Wang MJ, Lin CC, Lee HC, Wang FF*, Chen JY* (2013) Suppressor of cytokine signaling 6 (SOCS6) promotes mitochondrial fission via regulating DRP1 translocation. Cell Death Differ. 20, 139-153. SCI

26.        Wu YT, Lee HC, Liao CC, Wei YH* (2013) Regulation of mitochondrial FoF1ATPase activity by Sirt3-catalyzed deacetylation and its deficiency in human cells harboring 4977 bp deletion of mitochondrial DNA. Biochim. Biophys. Acta-Mol. Basis Dis. 1832, 216-227. SCI

27.        Lee YC, Lee LM, Yang CH, Lin AMY, Huang YC, Hsu CC, Chen MS, Chi CW, Yin PH, Kuo CD, Liao JF*, Lee HC* (2013) Norcantharidin suppresses cell growth and migration with enhanced anticancer activity of gefitinib and cisplatin in human non-small cell lung cancer cells. Oncol. Rep. 29, 237-243. SCI

28.        Hung WY, Huang KH, Wu CW, Chi CW, Kao HL, Li AFY, Yin PH, Lee HC* (2012) Mitochondrial dysfunction enhanced migration via reactive oxygen species-induced b5-integrin expression in human gastric cancer SC-M1 cells. Biochim. Biophys. Acta-Gen. Subj. 1820, 1102-1110. SCI

29.        Tsai KL, Huang YH, Kao CL, Yang DM, Lee HC, Chou HY, Chen YC, Chiou GY, Chen LH, Yang YP, Chiu TH, Tsai CS, Ou HC, Chiou SH* (2012) A novel mechanism of coenzyme Q10 protects against human endothelial cells from oxidative stress-induced injury by modulating NO-related pathways. J. Nutr. Biochem. 23, 458-468. SCI

30.        Yang CW*, Chang CL, Lee HC, Chi CW, Pan JP, Yang WC (2012) Curcumin induces the apoptosis of human monocytic leukemia THP-1 cells via the activation of JNK/ERK Pathways. BMC Complement. Altern. Med. 12, 22. SCI

31.        Chang CF, Huang HJ, Lee HC, Wu RT, Lin AMY (2012) Melatonin attenuates KA-induced neurotoxicity in mouse hippocampus via inhibiting autophagy and α-synuclein aggregation. J. Pineal Res. 52, 312-321. SCI

32.        Lee HC*, Wei YH (2012) Mitochondria and aging. Adv. Exp. Med. Biol. 942, 311-327. SCI

33.        Chen LH, Chu PM, Lee YJ, Tu PH, Chi CW, Lee HC*, Chiou SH* (2012) Targeting protective autophagy exacerbates UV-triggered apoptotic cell death. Int. J. Mol. Sci. 13, 1209-1224. SCI

34.        Huang PI, Chen YC, Chen LH, Juan CC, Ku HH, Wang ST, Chiou SH, Chiou GY, Chi CW, Hsu CC, Lee HC, Chen LK, Kao CL* (2011) PGC-1α mediates differentiation of mesenchymal stem cells to brown adipose cells. J. Atheroscler. Thromb. 18, 966-80. SCI

35.        Tsai MS, Huang CH, Tsai CY, Chen HW, Lee HC, Cheng HJ, Hsu CY, Wang TD, Chang WT, Chen WJ* (2011) Ascorbic acid mitigates the myocardial injury after cardiac arrest and electrical shock. Intensive Care Med. 37, 2033-2040. SCI

36.        Huang PI, Chou YC, Chang YL, Chen KH, Song WS, Peng CH, Chien Y, Chang CH, Lee SD, Chen YJ, Kuo CH, Hsu CC, Lee HC*, Yung MC* (2011) Enhanced differentiation of three genereprogrammed induced pluripotent stem cells into adipocytes via adenoviral-mediated PGC-1alpha. Int. J. Mol. Sci. 12, 7554-7568. SCI

37.        Tseng LM, Yin PH, Yang CW, Tsai YF, Hsu CY, Chi CW, Lee HC* (2011) Somatic mutations of the mitochondrial genome in human breast cancers. Genes Chromosomes Cancer 50, 800-811. SCI

38.        Chen KD, Chang PT, Ping YH, Lee HC, Yeh CW, Wang PN* (2011) Gene expression profiling of peripheral blood leukocytes identifies and validates ABCB1 as a novel biomarker for Alzheimer's disease. Neurobiol. Dis. 43, 698-705. SCI

39.        Chen LH, Loong CC, Su TL, Lee YJ, Chu PM, Tsai ML, Tsai PH, Tu PH, Chi CW, Lee HC*, Chiou SH* (2011) Autophagy inhibition enhances apoptosis triggered by BO-1051; an N-mustard derivative; and involves the ATM signaling pathway. Biochem. Pharmacol. 81, 594-605. SCI

40.        Lee HC*, Chang CM, Chi CW (2010) Somatic mutations of mitochondrial DNA in aging and cancer progression. Ageing Res. Rev. 9S, S47-S58. SCI

41.        Zheng YW, Lee LY, Chao PL, Lee HC, Wu RT, Lin AMY* (2010) Role of autophagy in protection afforded by hypoxic preconditioning against MPP+-induced neurotoxicity in SH-SY5Y cells. Free Radic. Biol. Med. 49, 839-846. SCI

42.        Hsu CW, Yin PH, Lee HC, Chi CW, Tseng LM* (2010) Mitochondrial DNA content as a potential marker to predict response to anthracycline in breast cancer patients. Breast J. 16, 264-270. SCI

43.        Weng SW, Lin TK, Wang PW, Chen IY, Lee HC, Chen SD, Chuang YC, Liou CW* (2010) Gly482Ser polymorphism in the peroxisome proliferator-activated receptor γ coactivator-1α gene is associated with oxidative stress and abdominal obesity. Metabolism 59, 581-586. SCI

44.        Yin PH, Wu CC, Lin JC, Chi CW, Wei YH, Lee HC* (2010) Somatic mutations of mitochondrial genome in hepatocellular carcinoma. Mitochondrion 10, 174-182. SCI

45.        Hung WY, Wu CW, Yin PH, Chang CJ, Li AFY, Chi CW, Wei YH, Lee HC* (2010) Somatic mutations in mitochondrial genome and their potential roles in the progression of human gastric cancer. Biochim. Biophys. Acta-Gen. Subj. 1800, 264-270. SCI

46.        Lee HJ, Su Y, Yin PH, Lee HC, Chi CW* (2009) PPARγ/PGC-1α pathway in E-cadherin expression and motility of HepG2 cells. Anticancer Res. 29, 5057-5063. SCI

47.        Wang PN*#, Lee HC#, Wang CH, Ping YH, Liu TY, Chi CW, Lin KN, Liu HC (2009) Heteroplasmy of mitochondrial D310 mononucleotide repeat region in the blood of patients with Alzheimer's disease. J. Alzheimer’s Dis. 18, 345-353. SCI (#Equal contribution)

48.        Chang CJ, Yin PH, Yang DM, Wang CH, Hung WY, Chi CW, Wei YH*, Lee HC* (2009) Mitochondrial dysfunction-induced amphiregulin upregulation mediates chemo-resistance and cell migration in HepG2 cells. Cell. Mol. Life Sci. 66, 1755-1765. SCI

49.        Tseng LM, Yin PH, Tsai YF, Chi CW, Wu CW, Lee LM, Lee HC* (2009) Association between mitochondrial DNA 4,977 bp deletion and NAD(P)H: quinone oxidoreductase 1 (NQO1) C609T polymorphism in human breast tissues. Oncol. Rep. 21, 1169-1174. SCI

50.        Wei YH*, Wu SB, Ma YS, Lee HC (2009) Respiratory function decline and DNA mutation in mitochondria, oxidative stress and altered gene expression in aging. Chang Gung Med. J. 32, 113-132.

51.        Lee HC, Wei YH* (2009) Mitochondrial DNA instability and metabolic shift in human cancer. Int. J. Mol. Sci. 10, 674-701. SCI

52.        Weng SW, Lin TK, Liou CW, Chen SD, Wei YH, Lee HC, Chen IY, Hsieh CJ, Wang PW* (2009) Peripheral blood mitochondrial DNA content and dysregulation of glucose metabolism. Diabetes Res. Clin. Pract. 83, 94-99. SCI

53.        Tam TN*, Lee CF, Lee HC, Lin HC, Yeh C, Tung TH (2008) Mitochondrial DNA 4977 bp deletion in colorectal cancer. Gastroenterol. J. Taiwan 25, 343-355.

54.        Lee HC* (2008) Mitochondria and cancer. BioMedicine 1, 158-172.

55.        Wang SF, Yen JC, Yin PH, Chi CW, Lee HC* (2008) Involvement of oxidative stress activated JNK signaling in the methamphetamine induced cell death of human SH-SY5Y cells. Toxicology 246, 234-241. SCI

56.        Hung WY, Lin JC, Lee LM, Wu CW, Tseng LM, Yin PH, Chi CW, Lee HC* (2008) Tandem duplication/triplication correlated with poly-cytosine stretch variation in human mitochondrial DNA D-loop region. Mutagenesis 23, 137-142. SCI

57.        Lee HJ, Su Y, Lui WY, Chau GY, Yin PH, Lee HC*, Chi CW* (2008) Peroxisome proliferator-activated receptor gamma coactivator-1 alpha upregulated E-cadherin expression in HepG2 cells. FEBS Lett. 528, 627-634. SCI

58.        Hsu YC, Lee HC, Ping YH, Liu TY, Lui WY, Chi CW* (2007) Mitochondria are an essential mediator of nitric oxide/cyclic guanosine 3',5'-monophosphate blocking of glucose depletion induced cytotoxicity in human HepG2 cells. Mol. Cancer Res. 5, 923-932. SCI

59.        Chen CY, Ping YH, Lee HC, Chen KH, Lee YM, Chan YC, Lien TC, Jap TS, Lin CH, Kao LS, Chen YMA* (2007) Open reading frame 8a of the human severe acute respiratory syndrome coronavirus not only promotes viral replication but also induces apoptosis. J. Infectious Dis. 196, 405-415. SCI

60.        Lee HC, Wei YH* (2007) Oxidative Stress, mitochondrial DNA mutation, and apoptosis in aging. Exp. Biol. Med. 232, 592-606. SCI

61.        Wu CW, Ping YH, Yen JC, Chang CY, Wang SF, Yeh CL, Chi CW, Lee HC* (2007) Enhanced oxidative stress and aberrant mitochondrial biogenesis in human neuroblastoma SH-SY5Y cells during methamphetamine induced apoptosis. Toxicol. & Applied Pharmacol. 220, 243-251. SCI

62.        Lee HC*, Hsu LS, Yin PH, Lee LM, Chi CW (2007) Heteroplasmic mutation of mitochondrial DNA D-loop and 4,977-bp deletion in human cancer cells during mitochondrial DNA depletion. Mitochondrion 7, 157-163. SCI

63.        Hung WY, Lee HC*, Wei YH* (2006) Alterations of mitochondria in tumors and recent advances in the development of mitochondria-targeting chemotherapy. Chemistry (THE CHINESE CHEM. SOC., TAIPEI), 64, 435-450.

64.        Tseng LM, Yin PH, Chi CW, Hsu CY, Wu CW, Lee LM, Wei YH, Lee HC* (2006) Mitochondrial DNA mutations and mitochondrial DNA depletion in breast cancer. Genes Chromosomes Cancer 45, 629-638. SCI

65.        Ping YH#, Lee HC#, Lee JY, Wu PH, Ho LK, Chi CW, Wang JJ* (2006) Low-dose effects of 10-hydroxycamptothecin in human colon cancer. Oncol. Rep. 15, 1273-1279. SCI (#Equal contribution)

66.        Hsu LS, Lee HC, Chau GY, Yin PH, Chi CW, Lui WY* (2006) Aberrant methylation of EDNRB and p16 genes in hepatocellular carcinoma (HCC) in Taiwan. Oncol. Rep. 15, 507-511. SCI

67.        Chang MC, Hung SC, Chen WY, Chen TL, Lee CF, Lee HC, Wang KL, Chiou CC, Wei YH (2005) Accumulation of mitochondrial DNA with 4977-bp deletion in knee cartilage - an association with idiopathic osteoarthritis. Osteoarthritis Cartilage 13, 1004-1011. SCI

68.        Wu CW, Yin PH, Hung WY, Li AFY, Li SH, Chi CW, Wei YH, Lee HC* (2005) Mitochondrial DNA mutations and mitochondrial DNA depletion in gastric cancer. Genes Chromosomes Cancer 44, 19-28. SCI

69.        Lee HC*, Yin PH, Lin JC, Wu CC, Chen CY, Wu CW, Chi CW, Tam TN, Wei YH (2005) Mitochondrial genome instability and mtDNA depletion in human cancers. Ann. N.Y. Acad. Sci. 1042, 109-122. SCI

70.        Lee HC, Wei YH* (2005) Mitochondrial biogenesis and mitochondrial DNA maintenance of mammalian cells under oxidative stress. Int. J. Biochem. Cell Biol. 37, 822-834. SCI

71.        Yang JH, Lee HC, Chung JG, Wei YH* (2004) Mitochondrial DNA mutations in light-associated skin tumors. Anticancer Res. 24, 1753-1758. SCI

72.        Yin PH, Lee HC, Chau GY, Liu TY, Liu HC, Lui WY, Chi CW* (2004) Polymorphisms of estrogen-metabolizing genes and risk of hepatocellular carcinoma in Taiwan females. Cancer Lett. 212, 195-201. SCI

73.        Yin PH, Lee HC, Chau GY, Wu YT, Li SH, Lui WY, Wei YH, Liu TY, Chi CW* (2004) Alteration of the copy number and deletion of mitochondrial DNA in human hepatocellular carcinoma. Br. J. Cancer 90, 2390-2396. SCI

74.        Lee HC, Li SH, Lin JC, Wu CC, Yeh DC, Wei YH* (2004) Somatic mutations in the D-loop and decrease in the copy number of mitochondrial DNA in human hepatocellular carcinoma. Mutat. Res. 547, 71-78. SCI

75.        Lu CY, Wang EK, Lee HC, Tsay HJ, Wei YH* (2003) Increased expression of manganese-superoxide dismutase in fibroblasts of patients with CPEO syndrome. Mol. Genet. Metabol. 80, 321-329. SCI

76.        Chu CC, Huang CC, Kao LY, Kuo HC, Yu TN, Tso DJ, Lee HC, Wei YH (2003) Clinical phenotype and the G11778A mutation of mitochondrial DNA in patients with Leber’s hereditary optic neuropathy in Taiwan. Neuro-ophthalmology 26, 207-216. SCI

77.        Wei YH*, Lee HC (2003) Mitochondrial DNA mutations and oxidative stress in mitochondrial diseases. Adv. Clin. Chem. 37, 83-128. SCI

78.        Lee HC, Yin PH, Chi CW, Wei YH* (2002) Increase of mitochondrial mass in human fibroblasts under oxidative stress and during replicative cell senescence. J. Biomed. Sci. 9, 517-526. SCI

79.        Wei YH*, Lee HC (2002) Oxidative stress, mitochondrial DNA mutation, and impairment of antioxidant enzymes in aging. Exp. Biol. Med. 227, 671-682. SCI

80.        Lee YC, Wei YH, Lirng JF, Lee HC, Tso DJ, Lin KP, Wu ZA, Liu HC (2002) Wernicke’s encephalopathy in a patient with multiple symmetrical lipomatosis and the A8344G mutation of mitochondrial DNA. Eur. Neurol. 47, 126-128. SCI

81.        Kuo HC, Huang CC, Chu CC, Kao LY, Lee HC, Pang CY, Wei YH (2001) Coenzyme Q10 treatment in Leber’s hereditary optic neuropathy. J. Neuro-ophthalmol. 25, 199-207. SCI

82.        Lee HC, Wei YH* (2001) Mitochondrial alterations, cellular response to oxidative stress and defective degradation of proteins in aging. Biogerontology 2, 231-244. SCI

83.        Pang CY, Lee HC, Wei YH* (2001) Enhanced oxidative damage in human cells harboring A3243G mutation of mitochondrial DNA: Implication of oxidative stress in the pathogenesis of mitochondrial diabetes. Diabet. Res. Clin. Pract. 54 Suppl 2, S45-56. SCI

84.        Lee HC, Yin PH, Yu TN, Chang YD, Hsu WC, Kao SY, Chi CW, Liu TY, Wei YH* (2001) Accumulation of mitochondrial DNA deletions in human oral tissues-Effects of betel quid chewing and oral cancer. Mutat. Res. 493, 67-74. SCI

85.        Wei YH*, Ma YS, Lee HC, Lee CF, Lu CY (2001) Mitochondrial theory of aging matures--roles of mtDNA mutation and oxidative stress in human aging. Chin. Med. J. (Taipei) 64, 259-270.

86.        Wei YH*, Lee CF, Lee HC, Ma YS, Wang CW, Lu CY, Pang CY (2001) Increase of mitochondrial mass and mitochondrial genome in association with enhanced oxidative stress in human cells harboring 4,977 bp-deleted mitochondrial DNA. Ann. N.Y. Acad. Sci. 928, 97-112. SCI

87.        Wei YH*, Lu CY, Wei CY, Ma YS, Lee HC (2001) Oxidative stress in human aging and mitochondrial disease-Consequences of defective mitochondrial respiration and impaired antioxidant enzyme system. Chinese J. Physiol. 44, 1-11. SCI

88.        Lien LM, Lee HC, Wang KL, Chiu CC, Chiu HC, Wei YH (2001) Involvement of nervous system in maternally inherited diabetes and deafness (MIDD) with the A3243G mutation of mitochondrial DNA. Acta Neurol. Scand. 103, 159-165. SCI

89.        Lee HC, Yin PH, Lu CY, Chi CW, Wei YH* (2000) Increase of mitochondria and mitochondrial DNA in response to oxidative stress in human cells. Biochem. J. 348, 425-432. SCI

90.        Liou CW, Huang CC, Tsai JL, Liu JY, Pang CY, Lee HC, Wang EK, Wei YH (2000) Absence of maternal A3243G mtDNA mutation and reversible hyperglycemia in a patient with MELAS syndrome. Acta Neurol. Scand. 101, 65-69. SCI

91.        Thajeb P, Lee HC, Pang CY, Jeng CM, Huang SF, Wei YH (2000) Phenotypic heterogeneity in a Chinese family with mitochondrial disease and A3243G mutation of mitochondrial DNA. Chin. Med. J. (Taipei) 63, 71-76.

92.        Lee HC, Wei YH* (2000) Mitochondrial role in life and death of the cell. J. Biomed. Sci. 7, 2-15. SCI

93.        Sung YJ, Juan CC, Lee HC, Yin PH, Chi CW, Ku HH, Lee AFY, Wei YH, Tsay HJ (1999) Reduced oxidative stress in transplanted N1S1 hepatoma with markedly declined activities of antioxidant enzymes. Oncol. Rep. 6, 1313-1319. SCI

94.        Yen MY, Lee HC, Wang AG, Chang WL, Liu JH, Wei YH (1999) Exclusive homoplasmic 11778 mutation in mitochondrial DNA of Chinese patients with Leber’s hereditary optic neuropathy. Jpn. J. Ophthmol. 43, 196-200. SCI

95.        Lee HC, Lim MLR, Lu CY, Liu VWS, Fahn HJ, Zhang C, Nagley P, Wei YH* (1999) Concurrent increase of oxidative DNA damage and lipid peroxidation together with mitochondrial DNA mutation in human lung tissues during aging-Smoking enhances oxidative stress on the aged tissues. Arch. Biochem. Biophys. 362, 309-316. SCI

96.        Lu CY, Lee HC, Fahn HJ, Wei YH* (1999) Oxidative damage elicited by imbalance of free radical scavenging enzymes and the relationship with large-scale mtDNA deletions during human aging. Mutat. Res. 423, 11-21. SCI

97.        Lee HC, Lu CY, Fahn HJ, Wei YH* (1998) Aging- and smoking-associated alteration in the relative content of mitochondrial DNA in human lung. FEBS Lett. 441, 292-296. SCI

98.        Wei YH*, Lee HC, Pang CY, Lu CY, Ma YS (1998) Oxidative damage and mutation to mitochondrial DNA and age-dependent decline of mitochondrial respiratory function. Ann. N. Y. Acad. Sci. 854, 155-170. SCI

99.        Wei YH*, Pang CY, Lee HC, Lu CY (1998) Roles of mitochondrial DNA mutations and oxidative damage in human aging. Cur. Sci. 74, 887-893. SCI

100.    Liu VWS, Zhang C, Pang CY, Lee HC, Lu CY, Wei YH, Nagley P* (1998) Independent occurrence of somatic mutations in mitochondrial DNA of human skin from subjects of various ages. Human Mutat. 11, 191-196. SCI

101.    Wei YH*, Lee HC, Wang EK, Pang CY (1997) Decreased cellular respiratory function and mitochondrial DNA mutations in the human heart associated with aging and disease. Asia Pacific Heart J. 6, 197-204.

102.    Lee HC, Wei YH* (1997) The role of mitochondria in human aging. J. Biomed. Sci. 4, 319-326. SCI

103.    Lee HC, Wei YH* (1997) Mutation and oxidative damage of mitochondrial DNA and defective turnover of mitochondria in human aging. J. Formos. Med. Assoc. 96, 770-778. SCI

104.    Wei YH*, Pang CY, You BJ, Lee HC (1996) Tandem duplications and large-scale deletions of mitochondrial DNA are early molecular events of human aging process. Ann. N. Y. Acad. Sci. 786, 82-101. SCI

105.    Wei YH*, Kao SH, Lee HC (1996) Simultaneous increase of mitochondrial DNA deletions and lipid peroxidation in human aging. Ann. N. Y. Acad. Sci. 786, 24-43. SCI

106.    Li JY, Kong KW, Chang MH, Cheung SC, Lee HC, Pang CY, Wei YH (1996) MELAS syndrome associated with a tandem duplication in the D-loop of mitochondrial DNA. Acta Neurol. Scand. 93, 450-455. SCI

107.    Yen MY, Lee HC, Liu JH, Wei YH (1996) Compensatory elevation of complex II activity in Leber's hereditary optic neuropathy. Br. J. Ophthalmol. 80, 78-81. SCI

108.    Yang CY, Lam HC, Lee HC, Wei YH, Han TM, Tsai JL, Chuang YH, Lee JK (1995) MELAS syndrome associated with diabetes mellitus and hyperthyroidism: a case report from Taiwan. Clin. Endocrinol. 43, 235-239. SCI

109.    Liu CS, Chang YC, Chen DF, Huang CC, Pang CY, Lee HC, Cheng CC, Horng CJ, Wei YH (1995) Type IV hyperlipoproteinemia and moderate instability of CAG triplet expansion in the androgen-receptor gene. Lipid, sex hormone and molecular study in a Chinese family with Kennedy-Alter-Sung disease. Acta Neurol. Scand. 92, 398-404. SCI

110.    Hsu CC, Chuang YH, Tsai JL, Jong HJ, Shen YY, Huang HL, Chen HL, Lee HC, Pang CY, Wei YH (1995) CPEO and carnitine deficiency overlapping in MELAS syndrome. Acta Neurol. Scand. 92, 252-255. SCI

111.    Huang CC, Fang W, Chen RS, Lee CC, Pang CY, Lee HC, Shih KD, Wei YH (1995) Mitochondrial encephalomyopathies: CT and MRI findings and correlations with clinical features. Eur. Neurol. 35, 199-205. SCI

112.    Chiang LM, Jong YJ, Huang SC, Tsai JL, Pang CY, Lee HC, Wei YH (1995) Heteroplasmic mitochondrial DNA mutation in a patient with mitochondrial myopathy, encephalopathy, lactic acidosis and stroke-like episodes. J. Formos. Med. Assoc. 94, 42-47. SCI

113.    Yang JH, Lee HC, Wei YH* (1995) Photoageing-associated mitochondrial DNA length mutations in human skin. Arch. Dermatol. Res. 287, 641-648. SCI

114.    Tsai JL, Lee JF, Lee HC, Lee CH, Huang JY, Wei YH* (1994) Effect of zinc supplement in ethanol diet on rat liver mitochondrial respiration and oxidative phosphorylation. J. Chin. Biochem. Soc. 23, 43-52.

115.    Wu TP, Tsai JG, Chan PH, Lee HC, Wei YH (1994) Mitochondrial respiratory function in multiple symmetrical lipomatosis: report of two cases. J. Formos. Med. Assoc. 93, 513-518. SCI

116.    Liou CW, Huang CC, Chee ECY, Jong YJ, Tsai JL, Pang CY, Lee HC, Wei YH (1994) MELAS syndrome: correlation between clinical features and molecular genetic analysis. Acta Neurol. Scand. 90, 354-359. SCI

117.    Huang CC, Chen RS, Chen CM, Wang HS, Lee CC, Pang CY, Hsu HS, Lee HC, Wei YH (1994) MELAS syndrome with mitochondrial tRNALeu(UUR) gene mutation in a Chinese family. J. Neurol. Neurosurg. Psychiatry 57, 586-589. SCI

118.    Pang CY, Lee HC, Yang JH, Wei YH* (1994) Human skin mitochondrial DNA deletions associated with light exposure. Arch. Biochem. Biophys. 312, 534-538. SCI

119.    Yang JH, Lee HC, Lin KJ, Wei YH* (1994) A specific 4,977 bp deletion of mitochondrial DNA in human ageing skin. Arch. Dermatol. Res. 286, 386-390. SCI

120.    Lee HC, Pang CY, Hsu HS, Wei YH* (1994) Ageing-associated tandem duplications in the D-loop of mitochondrial DNA of human muscle. FEBS Lett. 354, 79-83. SCI

121.    Lee HC, Pang CY, Hsu HS, Wei YH* (1994) Differential accumulations of 4,977 bp deletion in mitochondrial DNA of various tissues in human ageing. Biochim. Biophys. Acta 1226, 37-43. SCI

122.    Yen TC, King KL, Lee HC, Yeh SH, Wei YH* (1994) Age-dependent increase of mitochondrial DNA deletions together with lipid peroxides and superoxide dismutase in human liver mitochondria. Free Radic. Biol. Med. 16, 207-214. SCI

123.    Yen TC, Hsu JH, Lee HC, Lee JF, Wei YH* (1992) Specific restriction fragment length polymorphism in liver mitochondrial DNA. Chin. Med. J. 50, 177-183.

124.    Yen TC, Lee HC, Liu YC, Wei YH* (1991) Effect of body irradiation on rat liver mitochondrial DNA and respiratory functions. Nucl. Sci. J. 28, 105-116.

 

*Corresponding author

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歷屆研究生

碩士班

92學年度  洪文怡,吳志瑋

93學年度  張家瑜

94學年度  王君蕙,王笙帆

96學年度  林倉鋐,林伊凡

97學年度  黃怡嘉,魏瑩瑩

98學年度  吳玲嘉,李雅君

99學年度  陳宇潔,施晉文

100學年度 黃心慧,劉耀文

101學年度 任姿樺

102學年度 羅敏慈,陳俐婷

103學年度 王玟琪,陳曉琪

104學年度 陳裕仁,翁誌軒

105學年度 徐莉琳,姚昀彤

106學年度 潘怡陵,劉芳妤

 

博士班

94學年度  洪文怡(2012/02畢業)

98學年度  許家齊(2015/07畢業)

100學年度 陳孟賢

101學年度 王笙帆(2017/02畢業)

103學年度 陳梅君

105學年度 吳嘉芸

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