戚謹文 Chi, Chin-Wenwpe28.jpg (5450 個位元組) 

專長:腫瘤生化學

E-mailchinwenchi@gmail.com

經歷:1991- 台北榮總醫學研究部研究員

學歷:1986 美國紐約州立大學生理學博士

研究興趣:1.探討腫瘤中類固醇荷爾蒙接受體的功能。
                    2.
研究荷爾蒙對腫瘤細胞及正常細胞氧化過程的影響。
                    3.
利用活體及體外肝癌模式分析荷爾蒙及藥物對肝癌生長的影響。
 

代表著作

 

1. Liu S.-I., Chi C.-W., Lui W.-Y., Mok K.-T., Wu C.-W., and Wu S.-N. (l998) Correlation of hepatocyte growth factor-induced proliferation and calcium -activated potassium current in human gastric cancer cells. Biochim Biophys Acta 1368: 256-266.

2. King K.-L., Hwang J.-J., Chau G.-Y., Tsay S.-H., Chi C.-W., Lee T.-G., Wu L.-H., Wu C.-W., and Lui W.-Y. (l998) Ki-67 expression as a prognostic marker in patients with hepatocellular carcinoma. J Gastroenterol Hepatol 13:273-279.

3. Chang T.-J., Tsai T.-C., Wu Y.-L., Yang H.-M., Chi C.-W., Yang A.-H., and Lee C.-H. (1998) Abnormal transcripts of FHIT gene in thyroid cancer. Oncology Reports 5: 245-247.

4. Lui W.-Y., Chang Y.-F., Li L. L., Ho L.-K., Su T.-L., Chen J.-Y., Liu T.-Y., P'eng F.-K., and Chi C.-W.* (l998) Differential Paclitaxel-induced cytotoxicity in rodent and human hepatoma cell lines. Anticancer Research 18: 3339-3346.

5. Lee C.-H., Hsu L.-S., Chi C.-W., Chen G.-D., Yang A.-H., and Chen J.-Y. (l998) High frequency of rearrangement of the RET proto-oncogene (RET/PTC) in Chinese papillary thyroid carcinomas. J Clinical Endocrinol and Metabolism 83: 1629-1632.

6. Lee L.-S., Chi C.-W., Liu H.-C., Cheng C.-L., Li M.-J., and Lin S.-Y. (l998) Assessment of protein conformation in human benign and malignant astrocytomas by reflectance Fourier transform infrared microspectroscopy. Oncology Research 10: 23-27.

7. Wu C.-W., Hsieh M.-C., Lo S.-S., Lui W.-Y., P'eng F.-K., and Chi C.-W. (l998) Serum progesterone levels in patients with gastric carcinoma before and after gastrectomy. Cancer 83: 445-448

8. Hsu L.-S., Tsou A.-P., Chi C.-W., Lee C.-H., and Chen J.-Y. (l998) Cloning, expression and chromosomal localization of human Ca+2/calmodulin-dependent protein kinase kinase. J Biomedical Science 5: 141-149.

9. Ho C.-K., Chi C.-W., Yu K.-J., and Wang S.-Y. (l998) Tamoxifen-mediated anti-cellular effect against a choriocarcinoma cell line. Int J Oncology 12: 1171-1176.

10. Tsou A.-P., Wu K.-M., Tsen T.-Y., Chi C.-W., Chiu J.-H., Lui W.-Y., Hu C.-P., Chang C, Chou C.-K., and Tsai S.-F. (l998) Parallel hybridization analysis of multiple protein kinase genes: Identification of gene expression patterns characteristic of human hepatocellular carcinoma. Genomics 50: 331-340.

11. Wang J.-J., Chern Y.-T., Liu T.-Y., and Chi C.-W.* (l998) In vitro and in vivo growth inhibition of cancer cells by admantylmaleimide derivatives. Anticancer Drug Design 13:779-796.

12. Wu C.-W., Li A. F.-Y, Chi C.-W., Chung W.-W., Liu T.-Y., Lui W.-Y., and P'eng F.-K. (l998) Hepatocyte growth factor and Met/HGF receptors in patients with gastric adenocarcinoma. Oncology Reports 5: 817-822.

13. Lin J.-S., Lu C.-W., Huang C.-J., Wu P.-F., Robinson D., Kung H.-J., Chi C.-W., Wu C.-W., Yang W.-K., Whang-Peng J. J.-K., and Lin W.-C. (l998) Protein-tyrosine kinase and protein -serine/threonine kinase expression in human gastric cancer cell lines. J Biomedical Science 5: 101-110.

14. Lin H.-L., Chang Y.-F., Liu T.-Y., Wu C.-W., and Chi C.-W.* (l998) Submicromolar Paclitaxel induces apoptosis in human gastric cancer cells at early G1 phase. Anticancer Research 18: 3443-3450..

15. Lee C.-H., Kao H.-L., Lin H.-S., P'eng F.-K., and Chi C.-W. (l998) Estrogen receptors and glucocorticoid receptors in human well-differentiated thyroid cancer. Int J Mol Med 2: 229-233.

16. Wu C.-W., Chi C.-W., Hsieh M.-C., Chao M.-F., Lui W.-Y., and P'eng F.-K. (l998) Serum tumor necrosis factor in patients with gastric cancer. Anticancer Research 18: 1597-1600.

17. Wu C.-W., Chi C.-W., Su T.-L., Liu T.-Y., Lui W.-Y., and P'eng F.-K. (l998) Serum hepatocyte growth factor level associate with gastric cancer progression. Anticancer Research 18: 3657-3660.

18. Wu C.-W., Lin Y.-Y., Chen G.-D., Chi C.-W., Carbone D. P. and Chen J.-Y. (l999) Serum anti-p53 antibodies in gastric adenocarcinoma patients are associated with poor prognosis, lymph node metastasis and poorly differentiated nuclear grade. British J Cancer 80: 483-488.

19. Lin H.-L., Liu T.-Y., Lui W.-Y., and Chi C.-W.* (l999) Up-regulation of multidrug resistance transporter expression by berberine in human and murine hepatoma cells. Cancer 85:1937-1942.

20. Liu T.-Y, Chen C.-C., Chen C.-L., and Chi C.-W. (l999) Safrole induced oxidative damage in the liver of Sprague-Dawley rats. Food and Chemical Toxicology 37:697-702.

21. Lin H.-L., Liu T.-Y., Wu C.-W., and Chi C.-W.* (l999) Berberine modualtes expression of mdr 1 gene product and the responses of digestive tract cancer cells to paclitaxel. British J Cancer 81: 416-422.

22. Chang Z.-N., Peng H.-J., Lee W.-C., Chen T.-S., Chua K.-Y., Tsai L.-C., Chi C.-W., and Han S.-H. (l999) Sequence polymorphism of the group 1 allergen of Bermuda grass pollen. Clinical and Experimental Allergy 29: 488-496.

23. Chou F.-I., Lui W.-Y., Wei Y.-Y., Chung R.-J, Kai J.-J., and Chi C.-W. (l999) Preparation and in vitro evaluation of B-lipiodol as a boron delivery agent for neutron capture therapy of hepatoma. Anticancer Research 19: 1759-1764.

24. Lin W.-C., Li A. F.-Y., Chi C.-W., Chung W.-W., Huang C.-L., Lui W.-Y., Kung H.-J., and Wu C.-W. (l999) tie-1 protein tyrosine kinase: A novel independent prognostic marker for gastric cancer. Clinical Cancer Res 5: 1745-1751.

25. Chen C. -L., Chi -C. -W., Chang K. -W., and T. -Y. Liu (l999) Safrole-like DNA adducts in oral tissue from oral cancer patients with a betal quid chewing history. Carcinogenesis 20: 2331-2334.

26. Sung Y.-J., Juan C.-C., Lee H.-C., Yin P.-H., Chi C.-W., Ku H.-H., Li A. F.-Y., Wei Y.-H., and Tsay H.-J. (l999) Oxidative stress is insignificant in N1S1-transplanted hepatoma despite markedly declined activities of the antioxidant enzymes. Oncology Reports 6: 1313-1319.

27. Lee D. -W., Liu H.-C., Liu T.-Y., Chi C.-W., and Hong C.-J. (2000) No association between butyrylcholinesterase K-variant and Alzheimer’s disease in Chinese. Am J. Med Genet 96: 167-169.

28. Lui W.-Y., Lin H.-L., Chau G.-Y., Liu T.-Y., and Chi C.-W. (2000) Male predominance in hepatocellular carcinoma: new insight and a possible therapeutic alternative. Medical Hypothesis 55: 348-350.

29. Chau G.-Y., Wu C.-W., Lui W.-Y., Chang T.-J., Kao H.-L., Wu L.-H., King K.-L., Loong C.-C., Hsai C.-Y., and Chi C.-W.* (2000) Serum interleukin 10 but not interleukin 6 related with clinical outcome in patients with resectable hepatocellular carcinoma. Ann Surg 231:552-558.

30. Tang G.-J., Huang S.-L., Yien H.-W., Chen W.-S., Chi C.-W., Wu C.-W., Lui W.-Y., Chiu J.-H., and Lee T.-Y. (2000) Tumor necrosis factor gene polymorphism and septic shock in surgical infection. Critical Care Medicine 28: 2733-2736..

31. Chen C. -L., Chi -C. -W., and T. -Y. Liu (2000) Enhanced hydroxychavicol-induced cytotoxic effects in glutathione-depleted HepG2 cells. Cancer Letter 155: 29-35.

32. Wu C.-W., Li A. F.-Y., Chi C.-W., Huang C.-L., Shen K.-H., Lui W.-Y., and Lin W.-c. (2000) Human gastric cancer kinase profile and prognostic significance of MKK4 kinase. Am J Pathol 156:2007-2015.

33. Lee H.-C., Yin P.-H., Lu C.-Y., Chi C.-W., and Wei Y.-H. (2000) Increase of mitochondria and mitochondrial DNA in response to oxidative stress in human cells. Biochem J. 348:425-432.

34. Lin H.-L., Liu T.-Y., Chau G.-Y., Lui W.-Y., and Chi C.-W.* (2000) Comparison of 2-methoxyestradiol, docetaxel and paclitaxel induced apoptosis in hepatoma cells and its relation to reactive oxygen species. Cancer 89: 983-994.

35. King K.-L., Li A. F.-Y., Chau G.-Y., Chi C.-W., Wu C.-W., Huang C.-L., and Lui W.-Y. (2000) Prognostic significance of heat shock protein –27 expression in hepatocellular carcinoma and its relation to histological grading and survival. Cancer 88: 2464-70.

36. Shen K.-H., Chi C.-W., Lo S.-S., Kao H.-L., Lui W.-Y., and Wu C.-W. (2000) Serum matrix metallopreteinase-9 level associated with stromal reaction in patients with gastric cancer. Anticancer Research 20: 1307-1310.

37. Wang J.-J., Liu T.-Y., Yin P.-H., Wu C.-W., Chern Y.-T., and Chi C.-W.*. (2000) Admantyl maleimide induced changes in adhesion molecules and ROS are involved in apoptosis of human gastric cancer cells. Anticancer Research 20: 3067-3074.

38. Lin S.-B., Wu L.-C., Huang S.-L., Hsu H.-L., Hsieh S.-H., Chi C.-W., and Au L.-C. (2000) In vitro and in vivo suppression of growth of rat liver epithelial tumor cells by antisense oligonucleotide against prtoein kinase C-alpha. J Hepatology 33: 601-608.

39. Chen J.-H., Liu T.-Y., Wu C.-W., and Chi C.-W.* (2001) Nonsteroidal anti-inflammatory drugs for treatment of advanced gastric cancer: cyclooxygenase-2 is involved in hepatocyte growth factor mediated tumor development and progression. Medical Hypothesis 57: 503-505.

40. Wu C.-W., Chen G.-D., Jiang K.-C., Li A., Chi C.-W., Lo S.-S., and Chen J.-Y. (2001) A genome-wide study of microsatellite instability in advanced gastric cancer. Cancer 92: 92-101.

41. Tseng L.-M., Hsu C.-Y., Wang H.-C., Liu J. M., Chang H.-M., , Lo S.-S., Wu C.-W., Lui W.-Y., and Chi C.-W.* (2001) Tie-1 tyrosine kinase is an independent prognostic indicator for invasive breast cancer. Anticancer Research 21: 2163-2170.

42. Lin H.-L., Liu T-Y, Wu C.-W., Chi C.-W.* (2001) 2-Methoxyestradiol-induced caspase-3 activation and apoptosis occurs via G2/M arrest-dependent and -independent pathways in human gastric cancer cells. Cancer 92: 500-509.

43. Lee L.-M., Pan C.-C., Cheng C.-J., Chi C.-W., and Liu T.-Y. (2001) Expression of cyclooxygenase-2 in prostate adenocarcinoma and benign prostatic hyperplasia. Anticancer Research 21: 21: 1291-1294.

44. Hsu L.-S., Chen G.-D., Lee L.-S., Chi C.-W., Cheng J.-F., and Chen J.-Y. (2001) Human Ca2+/calmodulin-dependent protein kinase kinase b gene encodes multiple isoforms that display distinct kinase activity. J Biol Chem 276: 31113-31123.

45. Lee H.-C., Yin P.-H., Yu T.-N., Chang Y.-D., Hsu W.-C., Kao S.-Y., Chi C.-W., Liu T.-Y., and Wei Y.-H. (2001) Accumulation of mitochondrial DNA deletions in human oral tissues- effects of betal quid chewing and oral cancer. Mutation Res 493: 67-74.

46. Liu H.-C., Hong C.-J., Liu C.-Y., Lin K.-N., Tsai S.-J., Liu T.-Y., Chi C.-W., and Wang P.-N. (2001) Association analysis of the 5-HT6 receptor polymorphism C267T with depression in patients with Alzheimer’s disease. Psychiatry Clin Neurosci 55: 427-429.

47. Liu C.-Y., Hong C.-J., Liu T.-Y., Lin K.-N., Wang P.-N., Chi C.-W., Chuang Y.-Y., and Liu H.-C. (2002) Lack of association between the apoE genotype and depression in Alzheimer’s disease. J. Geriatric Psychiatry and Neurology: 15: 20-23.

48. Chiu E.-J., Lin H.-L., Chi C.-W., Liu T.-Y., and Lui W.-Y. (2002) Estrogen therapy for hepatectomy patients with poor liver function? Medical Hypotheses 58: 516-518.

49. Chen C. -L., Chi -C. -W., and T. -Y. Liu (2002) Hydroxy radical formation and oxidative DNA damage induced by areca quid in vivo J Toxicol Environ Health (Part A) 65: 327-336.

50. Lui W.-Y., Chi C.-W.*, Chang Y.-F., Chu H.-W., Hsieh C.-C., Yin P.-H., Liu T.-Y., Ou Y.-R., and P’eng F.-K. (2002) In vivo and in vitro growth stimulation of murine hepatoma cells by glucocorticoid. Anticancer Research 22: 1413-1422.

51. Wang J.-J., Chern Y.-T., Chang Y.-F., Liu T.-Y., and Chi C.-W.* (2002) Dimethyladmantyl-maleimide induced in vitro and in vivo growth inhibition of human colon cancer Colo205 cells. Anticancer Drugs 13: 533-543.

52. Lin W.-Y., Chi, C.-W., Ho Y.-J., Wu I.-C., Chung Y.-T., Chen S.-D., Chou F.-I., Kai J.-J., Lui W.-Y., Chen T.-J., and Lin YC. (2002) Boron-lipiodol: a potential new drug for the treatment of liver tumors. Anticancer Research 22: 3989-3992.

53. Wu C.-W., Chen G.-D., Fann C S.-J., Lee A F.-Y., Chi C.-W., Liu J. M., Weier U., and Chen J.-Y. (2002) Clinical implications of chromosomal abnormalities in gastric adenocarcinoma. Genes Chromosomes and Cancer 35: 219-231.

54. Wu C.-W., Chi C.-W., and Lin W.-c (2002) Gastric cancer: prognostic and diagnostic advances. Exp. Rev. Mol. Med. 21 March, http://www-ermm.cbcu.cam.ac.uk/02004337h.htm.

55. Wu C.-W., Lee A F.-Y., Chi C.-W., Lai C.-H., Huang C.-L., Lo S.-S., Lui W.-Y., and Lin W.-c (2002) Clinical significance of AXL kinase family in gastric cancer. Anticancer Research 22: 1071-1078.

56. Lin H.-L, WY Lui W.-Y., TY Liu T.-Y., Chi C.-W.* (2003) Reversal of Taxol-resistance in hepatoma by cyclosporin A : involvement of the PI-3 kinase-AKT 1 pathway. British J Cancer (in press).

57. Tsou A.-P., Yang C.-W., Huang C.-Y. F., Yu R. C.-T., Lee Y.-C. G., Chang C.-W., Chen B.-R., Chung Y.-F., Fann M.-J., Chi C.-W., Chiu J.-H., and Chou C.-K (2003) Identification of a novel cell cycle regulated gene, HURP, overexpressed in human hepatocellular carcinoma. Oncogene 22: 298-307.

(Chi C.-W.* indicate corresponding author)

 

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