Dr. Wen-Long Cho, Professor

Institute of Clinical Medicine / Department of Tropical Medicine, National Yang-Ming University (NYMU)

 

Major Appointments¡G

2008~Present Institute of Clinical Medicine / Department of Tropical Medicine,NYMU Professor / Director
2003~2008 Institute and Deaprtment of Tropical Medicine, NYMU Director
2003~Present Research ofLife Science Promotion Center, National Science Coucil (NSC) Panel Reviewer
2004~Present Journal of Chinese Physiology Editorial Board
2005~Present Journal of Microbiology, Immunology and Infection Editorial Board
2005~2006 Journal of Chinese Physiology Vice Editor in Chief
2003~2004 Office of Research and Development Vice Dean
2002~ 2004 Parasitology, Medical Technology and Biotechnology Panel, NSC Panel Convener
2002 - 2003 National Public Servant Examination Committee Commissioner
2001 ~ Present Institute and Department of Parasiyology Professor
1997 ~ 2000 Institute and Department of Parasiyology Director
1994 ~ 2000 Institute and Department of Parasiyology Associate Professor
* E-mail: wenlong@ym.edu.tw
* Tel: (02) 2826-7173

 

Researh Interests¡G

  1. Antibiotic resistance mechanism of a nosocomial bacterium, Acinetobacter baumannii
  2. Molecular mechanism of Aedes aegypti immunity
  3. Molecular diagnosis of parasites
  4. Dengue virus related research

Publications¡G

  1. Raikhel, A. S., Dhadialla, T. S., Cho, W. -L., Hays, A. R. and Koller, C. N. (1990) Biosynthesis and endocytosis of yolk proteins in the mosquito. In : Molecular Insect Science (Eds. Hagedorn, H. H., Hildebrand, J. G., Kidwell, M. G., and Law, J. H.), Plenum, New York, 147-154.
  2. Cho, W.-L., Dhadialla, T. S. and Raikhel, A. S. (1991) Purification and characterization of a lysosomal aspartic protease with cathepsin D activity from the mosquito. Insect Biochem., 21, 165-176.
  3. Cho, W. -L., Deitsch, K. W. and Raikhel, A. S., (1991) An extraovarian protein accumulated in mosquito oocytes is a carboxypeptidase activated in embryos. Proc. Natl. Acad. Sci. (U. S. A.), 88, 10821-10824.
  4. Cho, W. -L., Raikhel, A. S. (1992) Cloning of cDNA for mosquito lysosomal aspartic protease. J. Biol. Chem. 267, 21823-21829.
  5. Cho, W. -L., Deitsch, K. W., Chen, J. S., Ditmer, N. T. and Raikhel, A. S. (1993) Molecular Studies of Mosquito Vitellogenesis, in: Host Regulated Developmental Mechanisms In Vector Arthropods (Eds. Borovsky, D. and Spielman, A.) 48-55.
  6. Chen, J. -S., Cho, W. -L., Raikhel, A. S. (1994) Analysis of mosquito vitellogenin cDNA. J. Mol. Biol. 237, 641-647.
  7. Deitsch, K. W., Dittmer, N., Kapitskaya, Chen, J. -S., Cho, W. -L., and Raikhel, A. S. (1995) Regulation of gene expression by 20-hydroxyecdysone in the fat body of Aedes aegypti (Diptera: Culicidae) Eur. J. Entomol. 92, 237-244.
  8. Cho, W. -L., Kapitskaya, M. Z. and Raikhel, A. S. (1995) Mosquito ecdysteroid receptor: Analysis of the cDNA and expression during vitellogenesis. Insect Biochem. Molec. Biol., 25, 19-27
  9. Sappington, T. W., Kokoza, V. A., Cho, W. -L., and Raikhel, A. S. (1996) Molecular characterization of the mosquito vitellogenin receptor reveals unexpected high homology to the Drosophila yolk protein receptor. Proc. Natl. Acad. Sci. (USA) 93, 8934-8939.
  10. Cho, W. -L, Fu, Y. -C, Chen, C. -C., and Ho, C. -M. (1996) Cloning and characterization of cDNAs encoding the antibacterial peptide, defensin A, from mosquito , Aedes aegypti. Insect Biochem. Molec. Biol. 26, 395-402.
  11. Cho, W. -L., Fu, T. -F., Chiou, J. -Y., and Chen, C. -C. (1997) Molecular characterization of a defensin gene from mosquito, Aedes aegypti. Insect Biochem. Molec. Biol. 27, 351-358.
  12. Cho, W. -L., Liu, S. H., Lee, C. H., Kuo, C. C., Chang, C. I., and Chen, C. C., (1998) Molecular cloning, characterization and tissue expression of phenoloxidase cDNA from mosquito Armigeres subalbatus inoculated with Dirofilaria immitis Microfilariae, Insect Molecular Biology, 7, 1-10.
  13. Cho, W. -L., Fu, T. -F., Chiou, J. -Y., and Chen, C. -C. (1997) Molecular characterization of a defensin gene from mosquito, Aedes aegypti. Insect Biochem. Molec. Biol. 27, 351-358.
  14. Cho, W. -L., Liu, S. H., Lee, C. H., Kuo, C. C., Chang, C. I., and Chen, C. C., (1998) Molecular cloning, characterization and tissue expression of phenoloxidase cDNA from mosquito Armigeres subalbatus inoculated with Dirofilaria immitis Microfilariae, Insect Molecular Biology, 7, 1-10.
  15. Chiou, J. -Y., Huang, S. -J., Huang, S. -T., Cho, W. -L. (1998) Identification of immune-related protein kinases from mosquitoes (Aedes aegypti), J. Biomedical Science, 5, 120-126
  16. Huang, A. -M., Chang, T. -J., Cho, W. L., Chou, C. -K. (1998) From mosquito to man: Identification of a novel protein kinase, HsHPK, which is highly expressed in human hepatoma tissues. J. Biomedical Science, 5, 135-140
  17. Kapittskaya, M. Z., Dittmer, N. T., Deitsch, K. W., Cho, W. -L., Taylor, D. G., Leff, T., Raikhel, A. S., (1998) Three isoforms of an HNF-4 transcription factor with tissue- and stage-specific expression in the adult mosquito, J. Biol. Chem. 273, 29801-29810.
  18. Cho,W. -L., Tsao, S. -M., Hays, A. R., Walter, R., Chen, J. -S., Snigirevskaya, E. S., and Raikhel, A. S. (1999) Mosquito cathepsin B-like protease involved in embryonic degradation of vitellin as a latent extraovarian precursor, J. Biol. Chem. 274, 13311-13321.
  19. Kau, M. -M., Chen, J. -J., Wang, S. -W., Cho, W. -L., Wang, P. S. (1999) Age-related impairment of aldosterone secretion in zona glomerulosa cells of ovariectomized rats. J. Investigative Medicine, 47, 425-432.
  20. Lo, Ming-Jae, Kau, Mei-Mei, Cho, W. -L., Wang, P. S. (2000) Aging effects on the secretion of corticosterone in male rats. J. Investigative Medicine. 48, 335-342.
  21. Cho,W. -L., Tsao, S. -M., Hays, A. R., Walter, R., Chen, J. -S., Snigirevskaya, E. S., and Raikhel, A. S. (1999) Mosquito cathepsin B-like protease involved in embryonic degradation of vitellin as a latent extraovarian precursor, J. Biol. Chem. 274, 13311-13321.
  22. *Vladimir Kokoza, *Abduelaziz Ahmed, *Cho, W. -L., Nijole Jasinskiene , Anthony A. James and Alexander Raikhel (2000) Engineering blood meal-activated systemic immunity in the mosquito vector. Proc. Natl. Acad. Sci. (USA) 97, 9144-9149. (NSC 90-2320-B-010-093) (*Cho, W.L., Kokoza, K. and Ahmed, A. have equal contribution indicated in the paper)
  23. Cho, W. -L. and Raikhel, A.S. (2001) A novel function of 20-hydroxyecdysone: translational repression of the lysosomal protease mRNA in the mosquito fat body. Insect Biochem. Molec. Biol. 31, 283-288.
  24. Chiao, Y. C., Cho, W. L. and Wang, P.S. (2002) Inhibition of testosterone production by propylthiouracil in rat leydig cells. Biology of Reproduction, 67, 416-422.
  25. Huang, S. J., Li, S. Y., Wu, R. C. C., Shaio, M. F., Wang, P. S. and Cho, W. L. (2003) An immune signaling kinase AaMEK3 from mosquitoes: cDNA cloning and characterization. Insect Molec. Biol.12, 595-603.
  26. *Bartholomay, L. C., *Cho, W. L., Rocheleau, T. A. Boyle, J. P., Beck, E. T., Fuchs, J. F., Liss, P., Rusch, M., Butler, K. M., Wu, R. C. C., Lin, S. P., Kou, H. Y., Tsao, I. Y., Huang, C. Y., Wu, T. T, . Hsiao, K. J., Tsai, S. F., Yang, U. C., Nappi, A. J., Perna, N. T., Chen, C. C., and Christensen, B. M. (2004) Toward a description and transcriptomes of immune-activated hemocytes from the mosquito vectors, Aedes aegypti and Armigeres subalbatus. Infection and Immunity, 72: 4114-4126. * indicates the equal contributions.
  27. Liu, I.H, Chung, Y.M, Chen, S.J, Cho, W.L. (2006) Necrotizing Retinitis Induced by Angiostrongylus cantonensis. American journal of ophthalmology, 141: 577-579
  28. Chen, T. L., Chuang, C. L., Siu, L. K., Fung, C. P., and Cho, W. L. (2007) Genomic species identification is important to delineate the pathological characteristics of Acinetobacter in tunneled, cuffed hemodialysis catheter-related bacteremia. Nephrology Dialysis Transplantation, 22, 936-938.
  29. Wu, R.C.C., Shaio, M.F., and Cho, W. L. (2007) A p38 MAP kinase regulates the expression of the Aedes aegypti defensin gene in mosquito cells. Insect Molecular Biology, (16, 389-399)
  30. Chen, T. L., Siu, L. K., Wu, R. C. C., Shaio, M. F., Huang, L. Y., Fung, C. P., Lee, C. M. and Cho, W. L. (2007) Comparison of one-tube multiplex PCR and automated ribotyping for rapid identification of Acinetobacter baumannii. Clinical Microbiology and Infection, 13, 801-806
  31. George F. Mayhew, Lyric C. Bartholomay, Hang-Yen Kou, Thomas A. Rocheleau, Jeremy F. Fuchs, Matthew T. Aliota, I-Yu Tsao, Chiung-Yen Huang, Tze-Tze Liu, Kwang-Jen Hsiao, Shih-Feng Tsai,Ueng-Cheng Yang, Nicole T. Perna, Wen-Long Cho, Bruce M. Christensen and Cheng-Chen Chen. (2007) Construction and characterization of an expressed sequenced tag library for the mosquito vector Armigeres subalbatus. BMC Genomics, 8, 462-
  32. Han-Yueh Kuo, Dung-Hung Chiang, Chien-Chun Wang, Te-Li Chen, Chang-Phone Fung, Chih-Pei Lin, Wen-Long Cho, Cheng-Yi Liu (2008) Clinical significance of Blastocystis hominis: an experience from a medical center in northern Taiwan. Journal of Microbiology, Immunology and Infection, 41, 222-226.
  33. Te-Li Chen, Roy Chen-Chih Wu, Men-Fang Shaio, Chang-Phone Fung, and Wen-Long Cho (2008) Acquisition of a Plasmid Borne blaOXA-58 Gene with an Upstream IS1008 Insertion Conferring a High Level of Carbapenem Resistance to Acinetobacter baumannii. Antimicrobial Agents and Chemotherapy, 52, 2573-2580.
  34. Li-Yueh Huang; Te-Li Chen; Po-Liang Lu; Che-An Tsai; Wen-Long Cho; Fang-Yee Chang; Chang-Phone Fung; Leung Kei Siu (2008) Dissemination of Multidrug-Resistant Acinetobacter baumannii Carrying Class 1 Integrons in Taiwan. Clinical Microbiology and Infection.14, 1010-1019.
  35. Chen HP, Lin JC, Yang SP, Lan YC, Weng WS, Tsai CH, Ho DM, Liu CY, Cho WL, Chan YJ. (2008) The type-2 variant of human cytomegalovirus glycoprotein N (gN-2) is not the rarest in the Chinese population of Taiwan: Influence of primer design. J Virol Methods, 151, 161-164.
  36. Chien-Wei Liao, Wen-Long Cho,* Ting-Chang Kao, Kua-Eyre Su, Yun-Ho Lin, Chia-Kwung Fan* (2008) Blood-brain barrier impairment with enhanced SP, NK-1R, GFAP, and Claudin-5 expressions in experimental cerebral toxocariasis. Parasite Immunology, 30, 525-534. * indicates corresponding author.
  37. Chien-Wei Liao, Chia-Kwung Fan, Ting-Chang Kao, Dar-Der Ji, Kua-Eyre Su, Yun-Ho Lin, Wen-Long Cho (2008) Brain injury-associated biomarkers of TGF-£]1, S100B, GFAP, NF-L, tTG, A£]PP, and tau were concomitantly enhanced and the UPS was impaired during acute brain injury caused by Toxocara canis in mice. BMC Infectious Diseases, 24, 84-.99.
  38. Te-Li Chen, Leung-Kei Siu, Yi-Tzu Lee, Chien-Pei Chen, Li-Yueh Huang, Roy Chen-Chih Wu, Wen-Long Cho, and Chang-Phone Fung. (2008) Acinetobacter baylyi as a Pathogen for Opportunistic Infection. Journal of Clinical Microbilogy, 46, 2938-2944.,
  39. Dung-Hung Chiang, Chien-Chun Wang, Han-Yueh Kuo, Hsin-Pai Chen, Te-Li Chen, Fu-Der Wang, Wen-Long Cho, Cheng-Yi Liu (2009) Risk factors of attributable mortality for blood-stream infection of Acinetobacter baumannii with precise species identification. Journal of Microbiology, Immunology and Infection (in press).