林慶波 助理教授
國立台灣大學, PhD
大腦連結研究室
護理館三樓319室
電話：2826-7338或分機:7338
          mailto:cplin@ym.edu.tw
　

 磁振造影技術（MRI），因其非侵入性的優點，使其得以在各相關領域蓬勃發展，本實驗室則是利用更新穎的擴散磁振造影（diffusion MRI）技術，不但將其應用在心理、生理、醫學方面，並著重於技術的發展，以期將傳統MRI及dMRI技術，更廣泛地應用在更多領域。
在心理學領域的研究中，我們將MRI與TMS、MEG、EEG等技術整合，探索不同情境下的人體反應與行為，所對應的大腦功能區為何。MRI不僅可以非侵入性的方式，得取高解析度的解剖影像，並可利用dMRI技術，顯示組織中的微小結構。藉由TMS，不同的大腦功能區因此可加以定位，而透過MEG及EEG對大腦信號傳遞的紀錄，我們更可瞭解大腦在活化後，如何將訊號傳遞到相對應的反應區。結合以上技術，將更有助我們對大腦功能及其結構的深刻瞭解。
在生理結構的研究上，我們採用dMRI技術，來突顯組織的微細結構，如大腦中的神經纖維網路。利用dMRI中的FA及ADC參數，將其與病人的病症作統計分析，這有助於病症的判斷。
在醫學的研究上，dMRI可用於腫瘤病人的術前診斷，並預測術後的回復狀況。同時，透過正常受試者及ADHD病人間的差異比較，不需藉由測定或醫師經驗的診斷，就能輕易發現病人的變化。此外，由dMRI發展出的神經纖維追蹤（Tractography / Fiber Tracking）技術，則有助觀察神經纖維的復原，及幹細胞在大腦中的作用。其他如中風、大腦的創傷與此技術的結合，也在進行中。
在工程研究上，我們發展了神經纖維追蹤（Tractography / Fiber Tracking）技術、擴散譜磁振造影（DSI）技術。DSI，相對於傳統的dMRI技術，又提供了更多組織結構上的資訊。其他如大腦影像的自動化分割（Automatic Segmentation）技術、建立蒙地卡羅模型（Monte-Carlo Simulation Model）在擴散現象的應用、DSI在神經纖維密度的研究、以及dMRI與反應時間的相關研究結合、虛擬實境及其他工具軟體的發展也如火如荼的進行中。相信未來能夠對醫學以及生物領域有更大的幫助。
　

01.Ching-Po Lin, Wen-Yih Isaac Tseng, Hui-Cheng Cheng, Jyh-Horng Chen. 2001. “Validation of Diffusion Tensor Magnetic Resonance Axonal Fiber Imaging with Registered Manganese-enhanced Optic Tracts” NeuroImage 14, 1035-1047

02. Ching-Po Lin, Van J. Wedeen , Ching Yao, Jyh-Horng Chen, Wen-Yih I. Tseng. 2003. “Validation of Diffusion Spectrum Magnetic Resonance Imaging with Registered Manganese-enhanced Optic Tracts and Phantom” NeuroImage 19, 482-495

03. Shih-Hwa Chiou, Chung-Lan Kao, Han-Tso Lin, Wen-Ser Tseng, Ren-Shyan Liu, Chen-Fun Chung, Hung-Hai Ku, Ching-Po Lin, Tai-Tong Wong. 2006 “Monitoring the Growth Effect of Xenotransplanted Human Medulloblastoma in Immunocompromised Mice Model Using In Vitro and Ex Vivo Green Fluorescent Protein Imaging” Child Nerve System (In press)

Conference paper

01.  K.H. Cho, C.H. Yeh, Y.P. Chao, J.H. Chen, C.P. Lin., 2006, “Reduce encoding of diffusion spectrum imaging with cross-term correction” In Proc ISMRM 14^th Ann Meeting, Seattle, USA, (submitted)

02. K.H. Chou, Y.H. Chou, F.Y. Chiu, Y.C. Li, W.Y. Gao, T.P. Su, W.C. Chu, C.P. Lin., 2006, “A Combination VBM/ROI method to quantitative assessment of schizophrenia with non-invasive DTI” In Proc ISMRM 14^th Ann Meeting, Seattle, USA, (submitted)

03. K.H. Cho, C.H. Yeh, Y.P. Chao, J.H. Chen, C.P. Lin., 2006, “Accuracy assessment of q-ball imaging with phantom models” In Proc ISMRM 14^th Ann Meeting, Seattle, USA, (submitted)

04. Y.C. Li, K.H. Cho, K.H. Chou, C.P. Lin., 2006, “Optimal Imaging Parameters for Minimum Angular Discrimination in Diffusion Spectrum Imaging” In Proc ISMRM 14^th Ann Meeting, Seattle , USA , (submitted)

05.F.Y. Chiu, W.Y. Guo, K.H. Chou, M.T. Chen, Y.P. Chao, H.M. Wu, D. M.T. Ho, C.P. Lin., 2006, “Using Quantitative MR Diffusion Tensor Imaging to Predict Post-surgical Outcome of Brain Tumors: A Feasibility Study” In Proc ISMRM 14^th Ann Meeting, Seattle, USA, (submitted)

06.C.H. Yeh , K.H. Cho, Y.C. Li, H.C. Lin, C.P. Lin., 2006, Optimal Encoding Points for Diffusion Spectrum Imaging: Using Bi-Gaussian Extrapolation” In Proc ISMRM 14^th Ann Meeting, Seattle, USA, (submitted)

07.Y.P. Chao, K.H. Cho, C.H. Yeh, D.Y. Chen, J.H. Chen, C.P. Lin., 2006, “Brain Segmentation by Automatic Twice PAM (ATP) with 3D Moment Invariant of DSI Pattern” In Proc ISMRM 14^th Ann Meeting, Seattle, USA, (submitted)

08. Y.Y. Tung, C.P. Lin, C. Chang., 2006, “Screening Mutagenic Mice with Ventricular Mutation: A Longitudinal Study” In Proc ISMRM 14^th Ann Meeting, Seattle , USA , (submitted)

09. Y.P. Chao, K.H. Cho, C.H. Yeh, D.Y. Chen, J.H. Chen, C.P. Lin., 2006, “Brain Segmentation using ATP (Automatic Twice PAM) in Multi Diffusion Indices” In Proc ISMRM 14^th Ann Meeting, Seattle, USA, (submitted)

10. C.P. Lin, M.D. Chen, K.H. Chou, Y.P. Chao, D. M-T Ho, W.Y. Guo., 2006 “Predict the post-surgical outcome of brain tumor using diffusion MRI” XVIII Symposium Neuroradiologicum, Adelaide , South Australia , (submitted)

11. C.H. Yeh, K.H. Cho, Y.P. Chao, C.C. Chen, S.F Chen, C.P. Lin., 2005. “Mapping Neural Degeneration with Diffusion MRI: Simulation, Phantom, and Injured Rat Brain Model” 12^th International Conference on Neural Information Processing, (oral presentation)

12. C.P. Lin, Y.H. Chou, C.H. Chou, S.W. Yang, M.E. Liu, S.Y. Lee, W.Y. Guo, T.P. Su., 2005. “Mapping Neural Deficit of Schizophrenia Brain with non-invasive Diffusion Tensor MRI” NHRI conference on Neuroscience, p.4

13. C.P. Lin, M.D. Chen, K.H. Chou, Y.P. Chao, D. M-T Ho, W.Y. Guo., 2005 “Predict the post-surgical outcome of brain tumor using diffusion MRI” 4^th Meeting of the Asian Society for Neuro-Oncology, (oral presentation)

14. C.P. Lin, K.H. Cho, Y.P. Chao., 2005. “Mapping of the Fiber Orientation Function with Spherical Encoding” In ISMRM Workshop on Methods for Quantitative Diffusion MRI of Human Brain , Alberta , Canada , p. 70

15. Y.P. Chao, K.H. Cho, C.H. Yeh, D.Y. Chen, J.H. Chen, C.P. Lin., 2005 “Segmentation of Neuroarchitecture by Classification of Diffusion Spectrum Image” In ISMRM Workshop on Methods for Quantitative Diffusion MRI of Human Brain, Alberta, Canada, p. 19

16. K.H. Cho, Y.P. Chao, Y.C. Li, J.H. Chen, C.P. Lin., 2005. “Mapping Fiber Density Distribution with Diffusion Spectrum Imaging” In ISMRM Workshop on Methods for Quantitative Diffusion MRI of Human Brain , Alberta , Canada , p. 65

17. C.H. Yeh, K.H. Cho, Y.P. Chao, K.H. Chou, C.C. Chen, S.F. Chen, C.P. Lin., 2005 “Relationship between Neural Degeneration and Fractional Anisotropy: Simulation, Phantom Model, and Injured Rat Brain Study” In ISMRM Workshop on Methods for Quantitative Diffusion MRI of Human Brain, Alberta, Canada, p. 44

18. K.H. Cho, Y.P. Chao, Y.C. Li, J.H. Chen, C.P. Lin., 2005. “Mapping Fiber Density Distribution with Diffusion Spectrum Imaging” In Proc ISMRM 13^th Ann Meeting, Miami , USA , p.577

19. Y.P. Chao, K.H. Cho, C.H. Yeh, K.H. Chou, J.H. Chen, C.P. Lin., 2005. “Mapping of Neural architecture with Multi-Lines Diffusion Tensor First Eigenvector Field” In Proc ISMRM 13^th Ann Meeting, Miami , USA , p.1347

20. P. Hagmann, S. Masip, C.P. Lin, I. Tseng, R. Meuli, V. J. Wedeen, J-P. Thiran, 2005. “A model for diffusion spectra and restoration” In Proc ISMRM 13^th Ann Meeting, Miami , USA , p.1316

21. C.P. Lin, J.H. Chen, D Tuch., 2004, “Multi-Scatter Diffusion Imaging: Calibration for Isotropic Diffusion Sensitivity” In Proc ISMRM 12^th Ann Meeting, Kyoto , Japan , p. 1201

22. H.L. Lee, C.P. Lin, W.Y. Tseng, V.J. Wedeen, J.H. Chen, 2004, “Spherical Encoding Method in Clinical Machine” In Proc ISMRM 12^th Ann Meeting, Kyoto, Japan, p.1188

23. C.P. Lin, W.Y. Tseng, J.C. Weng, V.J. Wedeen, J.H Chen, 2003. “Reduced Encoding of Diffusion Spectrum Imaging with Cross-term Correction” In 1^st International IEEE EMBS Conference on Neural Engineering, Capri Island, Italy, p. 561-563

24. K.H. Cho, T.D. Chiueh, C.P. Lin, C. K. Chen, J.H. Chen. 2003. “Reduce Noise of Echo Planar Imaging by Active Noise Cancellation” In 25th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, Cancun, Mexico (In press)

25. C.W. Wu, K.H. Chuang , S.C. Lee, C.P. Lin, J.H. Chen. 2003. “Finger Reading by Using Functional Magnetic Resonance Imaging” Human Brain Mapping , NY , USA , p1591

26. C.P. Lin, W.Y. Tseng, L.W. Kuo, V.J. Wedeen, J.H Chen. 2003 “Mapping Orientation Distribution Function with Spherical Encoding” In Proc ISMRM 11^th Ann Meeting, Toronto , Canada , p. 2120

27. J.C. Weng, C.P. Lin, L.W. Kuo, J.H. Chen, W.Y. Tseng. 2003. “Analysis of Microstructures Using MRI Q-space and K-space Diffractograms” In Proc ISMRM 11^th Ann Meeting, Toronto , Canada , p. 589

28. W.Y. Tseng, C.C. Chen, C.P. Lin, H. Liou, J.H. Chen, L.W. Kuo, V. J. Wedeen. 2003. “Diffusion Spectrum Imaging Reveals Disorganized Cytoarchitecture in the Hippocampus of Pilocarpine- induced Epileptic Rats”. In Proc ISMRM 11^th Ann Meeting, Toronto , Canada , p. 1973

29. L.W. Kuo, S.K. Song, V. J. Wedeen, C.P. Lin, J.H. Chen, W. I. Tseng. 2003. “Mean Diffusivity and Anisotropy Index Mapping of Diffusion Spectrum Imaging in a Stroke Model”. In Proc ISMRM 11^th Ann Meeting, Toronto , Canada , p. 592

30. C.P. Lin, V.J. Wedeen, C. Yao, J.H. Chen, W.Y.I. Tseng. 2002. “Validation of Diffusion Spectrum Magnetic Resonance Imaging with Registered Manganese-enhanced Optic Tracts and Phantom”. In Proc ISMRM 10^th Ann Meeting , Hawaii , USA , p. 442

31. W.Y.I. Tseng, C.P. Lin, J.H. Chen, V.J. Wedeen. 2002. “Diffusion Spectrum Imaging of Complex Cortical Cytoarchitecture in Adult Rats”. In Proc ISMRM 10^th Ann Meeting , Hawaii , USA , p. 441

32. C.P. Lin, V.J. Wedeen, C. Yao, J.H. Chen, W.Y.I. Tseng. 2002. “Validation of Diffusion Spectrum Magnetic Resonance Imaging with Registered Manganese-enhanced Optic Tracts and Phantom” In Proc ISMRM diffusion workshop, Saint-Malo , France , p.117

33. W.Y.I. Tseng, C.P. Lin, J.H. Chen, V.J. Wedeen. 2002. “Diffusion Spectrum Imaging of Complex Cortical Cytoarchitecture in Adult Rats” In Proc ISMRM diffusion workshop, Saint-Malo , France , p. 27

34. J.C. Weng, C.M. Chen, W.Y.I. Tseng, C.P. Lin, J.H. Chen. 2002. “A Global Approach for Non-invasive Axonal Fiber Tracking on Diffusion Tensor Magnetic Resonance Image”. In Proc ISMRM 10^th Ann Meeting, Hawaii , USA , p.1133

35. C.P. Lin, W.Y. Tseng, J.H. Chen. 2001. “Dependence of SNR and spatial resolution on the accuracy of DTMRI in defining local tract orientations: validated with Mn-enhanced optic tracts”. In Proc ISMRM 9^th Ann Meeting, Glasgow , UK , p.1508

36.  C.P. Lin, W.Y. Tseng, J.H. Chen. 2000. “Validation of Diffusion Tensor Magnetic Resonance Axonal Fiber Imaging” In Proc ESMRMB 17^th Ann Meeting,
 Paris, France, p.36

37.  C.P. Lin, K. H. Chuang, J. H. Chen, C. Y. Chen. 1999. “Regional Differences in Visual Cortex Activation Under Monocular And Biocular Visual Stimulation.” In
Proc ISMRM 7^th Ann Meeting , Penn. , USA . p. 1724.

38. K.H. Chuang, C.P. Lin, J.H. Chen, C.Y. Chen. 1999. “Absence of Activation in Normal-Appearing Visual Cortex Caused by Lesions in Visual Pathway:
Functional MRI and Visual Field Correlations.” In Proc ISMRM 7^th Ann Meeting , Penn. , USA . p. 748.

39. K.H. Chuang, C.P. Lin, J.H. Chen, C.Y. Chen. 1999. “Spatial Characteristics of Temporal Delay in Visual Cortex: Demonstrated by Functional MRI.” In Proc ISMRM 7^th Ann Meeting , Penn. , USA , p. 1725.