Dr. Nan-Chi Chang, Professor

Phone: 886-2-2826-7114
E-mail: ncchang@ym.edu.tw
Education@Research@Publications


Education

1972, B.S.@ Biology
@@@@@@ Fu-Jen Catholic University, Taiwan

1980, M.S.@ Immunology
@@@@@@ Iowa State University, Ames IA, USA

1981, Ph.D.@Immunology
@@@@@@ Iowa State University, Ames IA, USA

1976 - 1977@Post-doctorate fellow
@@@@@@ Department of Chemistry, Arlington, Texas, USA


Research

1. Structure and Function of Ym1, a novel immune mediator expressed by activated macrophages

2. Function genomic studies of novel gene Luzp in neural and germ cells

3. Decode the function of adrenoceptor subtypes in KO-KI mouse models


Publications

1. Chang, Y.-H., Chang, N.-C., Chen, W.-M., and Chang, A.-C. Molecular characterization of a murine homologue of \2C4 adrenoreceptor subtype gene. Biochem. Mol. Biol. Internatl. 1993, 29:464-474.

2. Chang, N.-C., Jenkins, N.-A., Gilbert, D.-J., Copland, N.-G., Chang, Y.-H., Chen, W.-M., and Chang, A.-C. Assignment of two \2 adrenoreceptor subtype genes to murine chromosomes. Neurosci. Lett. 1994, 167:105-108.

3. Chen, W.-M., Chang, A.-C., Wang, C.-M., Lin, C.-C. and Chang, N.-C. Characterization of the regulatory regions of murine \2C2 subtype gene. Neurosci. Lett. 1996, 210:33-36.

4. Sun, D.-S., Chang, A.-C., Jenkins, N.-A., Gilbert, D.-J., Copland, N.-S. and Chang, N.-C. Identification, molecular characterization and chromosomal localization of the cDNA encoding a novel leucine zipper motif-containing protein. Genomics 1996, 36:54-62.

5. Fan, S.-S., Chang, N.-C., Chang, A.-C., and Yih, H.-S. Differential expression of the \1 subunit if GABAA, receptor in developing brain. Neuroreport 1997, 8:2399-2404.

6. Chang, N.-C., Hung, S.-I., Hwa, K.-Y., Kato, Ikunoshin, Chen, J.-E., Liu, C.-H. and Chang, A. C. A macrophage protein Ym1 transiently expressed during inflammation is a novel mammalian lectin. J. Biol. Chem. 2001; 276:17497-17506.

7. Sun, Y.-J., Chang, N.-C., Hung, S.-I., Chang, A. C., Chou, C.-C. and Hsiao, C.-D. The crystal structure of a novel mammalian lectin Ym1 suggests a saccharide binding site. J. Biol. Chem. 2001.;276:17507-17514.

8. Lee, M.W.-Y., Chang, A.C., Sun, D.-S., Hsu, C.-Y., Chang, N.-C. Restricted expression of LUZP in neural lineage cells: a study in embryonic stem cells. J. Biomed. Sci. 2001; 8:504-511

9. Wang, G. -S., Chang, N.-C., Wu, S. -C., Chang, A. C. Regulated expression of 2B adrenoceptor during development. Developmental Dynamics 2002; 225:142-152

10. Hung, S. -I., Chang, A. C., Kato, Ikunoshin and Chang, N.-C. Transient expression of Ym1, a heparin-binding lectin, during developmental hematopoiesis and inflammation. J. Leukoc. Biol. 2002; 72: 72-82.

11. Chen, W. -K., Chang, N. -C., Chang, Y. -H., Chan, K. -L., Wu, S. -C., Yang, T. -S., Wu, S. -M. and Chang, A. -C. Characterization of the regulatory region of Adra2c, the gene encoding murine 2C adrenoceptor subtype. J. Biomed. Sci. 2004.; 11: 886-901

12. Tsai, M. -L., Liaw, S. -H.* and Chang, N. -C.* (*corresponding authors) The crystal structure of Ym1 at 1.31 A resolution. J Structural Biology 2004; 148: 290-296


Members of Laboratory