Dr. Chuen-Miin Leu, Assistant Professor

Phone: 886-2-2826-7296
E-mail: cmleu@ym.edu.tw
Education@Research@Publications


Education

1992, B.S.@ Dept. of Zoology
@@@@@@National Taiwan University, Taiwan

1994, M.S.@ Institute of Microbiology and Immunology
@@@@@@National Yang-Ming University, Taiwan

2000, Ph.D.@Institute of Microbiology and Immunology
@@@@@@National Yang-Ming University, Taiwan

2000 - 2001@Postdoctoral fellow
@@@@@@ Veteran's General Hospital, Taipei, Taiwan

2001 - 2004@Postdoctoral fellow
@@@@@@ University of Alabama at Birmingham, USA

2005 - @@@Assistant Professor
@@@@@@ Institute of Microbiology and Immunology, National Yang-Ming University, Taiwan


Research

@@The long term research interests in the Leu lab are the functions and signal transduction pathways of transmembrane receptors in the immune system. The current focus is a recently identified family of Fc receptor homolog (FcRH) genes. The FcRH receptors are preferentially expressed on different stages of B cells. We are going to study:

1. The role of FcRH receptors in B cell activation.

2. The signal transduction pathways of FcRH receptors.

3. The cross-talks between FcRH receptors and other surface receptors on B cells.


Publications

1. Leu, C. M., Davis, R. S., Gartland, L. A., Fine, W. D., and Cooper, M. D. 2005. FcRH1: an activation co-receptor on human B cells. Blood 106: 1121-1126.

2. Davis, R. S., Ehrhardt, G. R. A., Leu, C. M., Hirano, M., and Cooper M. D. 2005. An extended family of Fc receptor relatives. Eur. J. Immunol. 35: 674-680.

3. Ehrhardt, G. R. A., Hsu, J. T., Gartland, L. A., Leu, C. M., Zhang, S., Davis, R. S., and Cooper, M. D. 2005. Expression of the immunoregulatory molecule FcRH4 defines a distinctive tissue-based population of memory B cells. J. Exp. Med. 202: 783-791.

4. Leu, C. M., Wong, F. H., Chang, C., Huang, S. F. and Hu, C. 2003. Interleukin-6 acts as an antiapoptotic factor in human esophageal carcinoma cells through the activation of both STAT3 and mitogen-activated protein kinase pathways. Oncogene 22: 7809-7818.

5. Ehrhardt, G. R. A., Davis, R. S., Hsu, J. T., Leu, C. M., Ehrhardt, A., and Cooper, M. D. 2003. The inhibitory potential of Fc receptor homolog 4 on memory B cells. Proc. Natl. Acad. Sci. USA 100: 13489-13494.

6. Liu, Y. C., Leu, C. M., Fong, F. H., Fong, W. S., Chen, S. C., Chang, C. and Hu, C. 2002. Autocrine stimulation by insulin-like growth factor-I is involved in the growth, tumorigenicity, and chemoresistance of human esophageal carcinoma cells. J. Biochem. Sci. 9: 665-674.

7. Leu, C. M., Chang, C. and Hu, C. 2000. Epidermal growth factor (EGF) suppresses staurosporine-induced apoptosis by inducing mcl-1 via the mitogen-activated protein kinase pathway. Oncogene 19, 1665-1675.

8. Liu, Y. C., Chen, S. C., Chang, C., Leu, C. M. and Hu, C. 1996. Platelet-derived growth factor is an autocrine stimulator for the growth and survival of human esophageal carcinoma cell lines. Exp. Cell Res. 228, 206-211.


Members of Laboratory