姓名 郭正典                   

  本所行政職別 臨床合聘教授
  專任職務 台北榮總教研部主治醫師兼醫研科主任
    台北榮總教研部生物物理研究室研究員
  兼任職務 陽明大學急重症醫學研究所教授
    陽明大學醫學系教授
  專長 生物物理、心率變異度分析、呼吸治療、重症治療
  聯絡電話 (02)2875-7745
個人履歷著作

 

個人部落格

 

個人履歷

一、個人資料
姓名:

郭正典

英文姓名: Cheng-Deng Kuo
學歷: 台北醫學院醫學士、陽明大學臨床醫學研究所博士
現職: 台北榮總教學研究部主治醫師兼醫學研究科主任
教職: 陽明大學急重症醫學研究所教授兼所長
性別:
國籍: 台灣國
住址: 台北榮總教學研究部生物物理研究室
電話: (02) 2875-7745
傳真: (02) 2871-0773
電子信箱: cdkuo@vghtpe.gov.tw

二、教育背景

模擬人SimMan的實務訓練(Southern Health Simulation Centre, Monash Medical Center, Melbourne, Australia)

       紐西蘭奧克蘭醫院重症加護醫學科進修

         國立陽明大學臨床醫學研究所博士

         清華大學物理系旁聽

         台北醫學院醫學系醫學士

   
三、經歷

        國立陽明大學傳統醫藥學研究所合聘教授

        台北榮總教研部臨床訓練技術中心主任

        台北榮總呼吸治療科主治醫師

        台北榮總呼吸治療科總醫師

        台北榮總呼吸治療科住院醫師

        清華大學醫務室醫師

        台北榮總胸腔部住院醫師

        台北市立仁愛醫院實習醫師
   
四、學術現職

        國立陽明大學急重症醫學研究所所長

        國立陽明大學急重症醫學研究所合聘教授

        國立陽明大學醫學系內科學系兼任教授
   
五、國際期刊評審

        Circulation

      American Journal of Cardiology

        International Journal of Cardiology

        Anesthesiology

        Fertility & Sterility

        IEEE Transaction on Biomedical Engineering

        Brain Research

        Medical Education

 

   
六、社會團體

        台灣心會總會總會理事

        台灣北社社員

        台灣醫社社長

        台北榮總足球社副社長

 

   
七、研究獎助

1.   國科會專題 A 計劃(2003年):三維電圖自動判讀系統的研發 (The development of automatic diagnosis system of 3D ECG) ( NSC92-2314-B-075-116 )

   
八、學術榮譽

1.    2002年生物醫學工程年會壁報比賽「醫用電子與儀表」類「優等」:影像模式12導程心電圖病症資料庫系統(張敏軒,江惠華,房同經,郭正典)

2.    台北榮總醫療技術創新獎首獎(2002年):三維心電圖的研發 (First Prize of Medical Technology Innovation, Taipei Veterans General Hospital, 2002, For the invention of 3D ECG)( Huihua Kenny Chiang, Chao-Wei Chu, Gau-Yang Chen, Cheng-Deng Kuo.* A new 3D display method for 12-lead ECG. IEEE Trans Biomed Eng 2001; 48: 1195-1202)

 

著作

近五年之著作(2003-2008)

1.      Cheng-Deng Kuo*, Gau-Yang Chen, Yia-Yi Wang, Ming-Jung Hung, Jen-Lin Yang. Characterization and quantification of the return map of RR intervals by Pearson coefficient in patients with acute myocardial infarction. Auton Neurosci Basic Clin 2003;105:145-52. SCI (IF=1.304, Ranking =156/200=78.0% in NEUROSCIENCES)

2.      Wan-An Lu, Cheng-Deng Kuo*. The effect of Wai Tan Kung on autonomic nervous modulation in the elderly. J Biomed Sci 2003; 10:697-705. SCI (IF = 1.668; Ranking = 43/76 = 56.58% in MEDICINE, RESEARCH & EXPERIMENTAL). [Kommentar by Wolfgang Marktl, Wien. Traditionelle chinesische Medizin und moderne Messmethodik. Forsch Komplementärmed 2006;13:315–316]

3.      Wan-An Lu, Cheng-Deng Kuo*. The effect of Tai Chi Chuan on the autonomic nervous modulation in older persons. Med Sci Sport Exerc 2003; 35: 1972-1976. SCI (IF = 2.909; Ranking = 5/73 = 6.85% in SPORT SCIENCES).

4.      張榮森、陳建宇、林慶煌、劉宇傑、郭正典。疊紋技術應用於全域諸穴道點之震動量測。中華針灸醫學會雜誌 2003; 5: 27-35 (Rong-Seng Chang, Chien-Yue Chen, Chin-Hwang Lin, Yue-Jei Liu, Cheng-Deng Kuo. The global measurement of dynamic vibration of acupoints by Moiré technology [Chinese]. J Chin Med Assoc Acup 2003; 5:27-35)

5.      Shu-Ming Chen*, Jyh-Fei Liao, Cheng-Deng Kuo, Low-Tone Ho. Intestinal absorption and biliary secretion of zinc in rats with chronic renal failure. Nephron Physiol 2004; 96:113-120. SCI

6.      Shih-Hwa Chiou*, Chung-Lan Kao, Chi-Hsien Peng, Shih-Jen Chen, Yih-Wen Tarng, Hung-Hai Ku, Yu-Chih Chen, Yi-Ming Shyr, Ren-Shyan Liu, Chien-Jen Hsu, De-Ming Yang, Wen-Ming Hsu, Cheng-Deng Kuo, Chen-Hsen Lee. A novel in vitro retinal differentiation model by co-culturing adult 3 human bone marrow stem cells with retinal pigmented epithelium cells. Biochem Biophys Res Comm 2005; 326: 578-585. SCI (IF = 2.855; Ranking = 24/66 = 36.36% in BIOPHYSICS)

7.      Shu-Ming Chen*, Cheng-Deng Kuo, Jyh-Fei Liao, Low-Tone Ho. Effect of parathyroid hormone on plasma zinc concentration in rat with chronic renal failure. Chinese J Physiol 2005; 48: 121-128. SCI (IF = 0.702; Ranking = 68/78 = 87.18% in PHYSIOLOGY)

8.      Yu-Jen Chen, Chwen-Jen Shieh, Tung-Hu Tsai, Cheng-Deng Kuo, Low-Tone Ho, Tsung-Yun Liu, Hui-Fen Liao*. Inhibitory effect of norcantharidin, a derivative compound from blister beetles, on tumor invasion and metastasis in CT26 colorectal adenocarcinoma cells. Anti-Cancer Drugs 2005; 16: 293-299. SCI (IF = 2.245; Ranking = 86/199 = 43.22% in PHARMACOLOGY & PHARMACY)

9.      Sheng-Teng Huang, Gau-Yang Chen*, Huey-.Ming Lo, Jaung-Gang Lin, Yin-Shiung Lee and Cheng-Deng Kuo*. Increase in the vagal modulation by acupuncture at Neiguan point in the healthy subjects. Am J Chinese Med 2005; 33: 157-164. SCI (IF = 0.710; Ranking = 69/103= 66.99% in MEDICINE, GENERAL & INTERNAL)

10.    Cheng-Deng Kuo*. The uncertainties in radial position and radial momentum of an electron in the non-relativistic hydrogen-like atom. Ann Phys 2005; 316: 431-439. SCI (IF = 3.019; Ranking = 11/68 = 16.18% in PHYSICS, MULTIDISCIPLINARY)

11.    I-Hsien Liu, Shih-Jen Chen, Hung-Hai Ku, Chung-Lan Kao, Fu-Ting Tsai, Wen-Ming Hsu, Chih-Wen Lo, Yao-Haur Kuo, Cheng-Deng Kuo, Chen-Hsen Lee, Shih-Hwa Chiou*. Comparison of the proliferation and differentiation ability between adult rat retinal stem cells and cerebral cortical-derived neural stem cells. Ophthalmologica 2005; 219: 171-6. SCI (IF = 1.051; Ranking = 29/45 = 64.44% in OPHTHALMOLOGY)

12.    Tsung-Yao Lin, Shih-Hwa Chiou, Mei Chen, Cheng-Deng Kuo*. Human lactorferrin exerts bi-directional actions on PC12 cell survival via ERK1/2 pathway. Biochem Biophys Res Comm 2005; 337: 330-336. SCI (IF = 2.855; Ranking = 24/66 = 36.36 % in BIOPHYSICS)

13.    Hsiang-Tai Chao, Cheng-Deng Kuo*, Yi-Ju Su, Shin-Shin Chuang, Ya-Jing Fang, Low-Tone Ho. Short-term effect of transdermal estrogen on the autonomic nervous modulation in postmenopausal women. Fert Steril 2005; 84: 1477-83. SCI (IF = 3.277; Ranking = 5/59 = 8.47 % in OBSTETRICS & GYNECOLOGY)

14.    Shu-Ming Chen*, Cheng-Deng Kuo, Low-Tone Ho, Jyh-Fei Liao. Effect of hypothyroidism on intestinal zinc absorption and renal zinc disposal in rats with chronic renal failure. Jpn J Physiol 2005; 55: 215-223. SCI (IF = 1.081; Ranking = 60/78 = 76.9 % in Physiology)

15.    Hui-Fen Liao, Cheng-Deng Kuo, Yuh-Cheng Yang, Chin-Ping Lin, Hung-Chi Tai, Yu-Yawn Chen and Yu-Jen Chen*. Resveratrol enhances radiosensitivity of human non-small cell lung cancer NCI-H838 cells accompanied by inhibition of nuclear factor-kappa B activation. J Rad Res 2005; 46: 387-393. SCI (IF = 1.709; Ranking = 21/65 = 32.31 % in BIOLOGY)

16.    Wei-Lung Chen, Gau-Yang Chen, Cheng-Deng Kuo*. Hypoxemia and autonomic nervous dysfunction in patients with chronic obstructive pulmonary disease. Respir Med 2006; 100: 1547-1553. SCI (IF = 2.086 Ranking = 30/74 = 40.54% in CARDIAC & CARDIOVASCULAR SYSTEMS)

17.    Po-Ching Chen, Steven Lee, Cheng-Deng Kuo*. Delineation of T wave in ECG by wavelet transform using multiscale differential operator. IEEE Trans Biomed Eng 2006; 53:1429-1433. SCI (IF = 2.302; Ranking = 11/42 = 26.19% in ENGINEERING, BIOMEDICAL)

18.    Shin-Shin Chuang, Chun-Che Shih, Jen-Lin Yang, Steven Lee, Cheng-Deng Kuo*. Power spectral analysis of finger plethysmographic waveform in patients with coronary artery disease and after coronary artery bypass graft surgery. Circ J 2006; 70: 1337-1343. SCI (IF = 2.135, Ranking = 28/74 = 37.84% in CARDIAC & CARDIOVASCULAR SYSTEMS).

19.    Wan-An Lu, Cheng-Deng Kuo*. Comparison of Tai Chi Chuan and Wai Tan Kung on the autonomic nervous modulation and hemodynamics in the elderly. Am J Chin Med 2006; 34: 959-968. SCI (IF = 0.710; Ranking = 69/103 = 66.99% in MEDICINE, GENERAL & INTERNAL)

20.    楊惠文、陳品堂、陳隆景、黃英哲、巫春蓮、程雅琳、尹彙文、郭正典、陳祖裕*。以病人模擬器進行急重症醫療處置訓練之經驗。醫學教育 2006; 10: 126-134

21.    葛謹、郭正典、廖又生。醫療糾紛刑事過失責任――醫療糾紛鑑定委員會決定鑑定結果之評析。國立交通大學科技法律研究所 劉尚志主編,2006年全國科技法律研討會論文集 2006; 669-697

22.    Chien-Chih Chen, Chee-Fah Chong, Cheng-Deng Kuo, Tzong-Luen Wang*. Silent myocardial ischemia in coronary artery disease patients under aspirin therapy presenting with upper gastrointestinal hemorrhage. J Gastroenterol Hepatol 2007; 22: 13-17. SCI (IF = 1.785; Ranking = 33/48 = 68.75% in GASTROENTEROLOGY & HEPATOLOGY)

23.    Tain-Hsiung Chen, Wei-Ming Chen, Ke-Hsun Hsu, Cheng-Deng Kuo, Shih-Chieh Hung*. Sodium butyrate activates ERK to regulate differentiation of mesenchymal stem cells. Biochem Bioph Res Comm 2007; 355: 913–918. SCI (IF = 2.855; Ranking = 24/66 = 36.36% in BIOPHYSICS)

24.    Chien-Yue Chen, Cheng-Deng Kuo*, Yan-Kwang Chen. The most appropriate Daubechies mother wavelet for multiresolution analysis of heart rate variability. WSEAS Trans Inform Sci Appl 2007; 4: 674-679. EI

25.    Chien-Yue Chen, Rong-Seng Chang*, Ching-Huang Lin, Cheng-Deng Kuo*. Pulse measurement based on Moiré diagnostic system. WSEAS Trans Syst 2007; 6: 686-692. EI

26.    Wei-Lung Chen, Cheng-Deng Kuo*. Characteristics of heart rate variability can predict impending septic shock in emergency department patients with sepsis. Acad Emerg Med 2007; 14:392–397. SCI (IF = 1.741; Ranking = 4/11 = 36.36% in EMERGENCY MEDICINE)

27.    Chien-Chih Chen, Chee-Fah Chong, Cheng-Deng Kuo, Tzong-Luen Wang*. A risk score to predict silent myocardial ischemia in patients with coronary artery disease under aspirin therapy presenting with upper gastrointestinal hemorrhage. Am J Emerg Med 2007; 25: 406–413. SCI (IF = 1.518; Ranking = 5/11 = 45.5% in EMERGENCY MEDICINE)

28.    Hui-Fen Liao, Shu-Li Su, Yu-Jen Chen, Chin-Hung Chou, Cheng-Deng Kuo*. Norcantharidin preferentially induces apoptosis in human leukemic Jurkat cells without affecting viability of normal blood mononuclear cells. Food Chem Toxicol 2007; 45: 1678–1687 SCI. (IF = 2.393; Ranking = 7/96 = 7.0 % in FOOD SCIENCE & TECHNOLOGY)

29.    Shu-Ming Chen*, Cheng-Deng Kuo, Low-Tone Ho, and Jyh-Fei Liao. Zinc deficiency increases platelet oxidative stress in nephrectomized rats. Biol Trace Elem Res. 2007;118:111-119. SCI (IF = 1.007; Ranking = 219/262 = 83.6% in BIOCHEMISTRY & MOLECULAR BIOLOGY)

30.    Yu-Jen Chen, Cheng-Deng Kuo#, Yin-Meng Tsaic, Chih-Chia Yu, Guang-Sheng Wang and Hui-Fen Lia.* Norcantharidin induces anoikis through Jun-N-terminal kinase activation in CT26 colorectal cancer cells. Anti-Cancer Drugs 2008;19:55–64. SCI (IF = 2.245; Ranking = 86/199 = 43.22% in PHARMACOLOGY & PHARMACY)(#: co-first author)

31.    Tsung-Yao Lin, Cheng-Deng Kuo*. Bovine lactoferrin protects RSC96 Schwann cells from TNF-a-induced growth arrest via ERK1/2. Neuroscience. 2008; 151: 396-402. SCI (IF = 3.427; Ranking = 63/200 = 31.5% in NEUROSCIENCES)

32.    I-Chun Lin, Shu-Li Su, Cheng-Deng Kuo*. Induction of cell death in RAW 264.7 cells by alpha-lactalbumin. Food Chem Toxicol. 2008; 46: 842–853. SCI (IF = 2.393; Ranking = 7/96 = 7.0 % in FOOD SCIENCE & TECHNOLOGY)

33.    Fong-Pin Liang, Chao-Hsiung Lin, Cheng-Deng Kuo, Hsueh-Ping Chao and Shu-Ling Fu*. Suppression of v-SRC transformation by andrographolide via degradation of the v-SRC protein and attenuation of the ERK-signaling pathway. J Biol Chem 2008; 283: 5023–5033. SCI. (IF = 5.808, Ranking = 39/262 = 14.89% in BIOCHEMISTRY & MOLECULAR BIOLOGY)

34.    Sheng-Teng Huang, Gau-Yang Chen*, Chien-Hui Wu, Cheng-Deng Kuo.# Effect of disease activity and position on autonomic nervous modulation in patients with systemic lupus erythematosus. Clin Rheumatol 2008; 27:295–300. SCI (IF=1.459, Ranking = 15/23=65.22% in RHEUMATOLOGY) (#: co-corresponding author)

35.    Gau-Yang Chen, Tun-Jen Hsiao, Huey-Ming Lo, Cheng-Deng Kuo.* Abdominal obesity is associated with autonomic nervous derangement in healthy Asian obese subjects. Clin Nutr 2008; 27: 212-217. SCI (IF=2.474, Ranking =15/55 = 27.27% in NUTRITION & DIETETICS)

36.    Wei-Lung Chen, Jiann-Hwa Chen, Chien-Cheng Huang, Cheng-Deng Kuo*, Chun-I Huang, Liang-Shong Lee. Heart rate variability measures as predictors of in-hospital mortality in emergency department patients with sepsis. Am J Emerg Med. 2008; 26: 395-401. SCI (IF = 1.518; Ranking = 5/11 = 45.5% in EMERGENCY MEDICINE)

37.    Pin-Tarng Chen, Hung-Wei Cheng, Chia-Rong Yen, I-Wen Yin, Ying-Che Huang, Chao-Chun Wang, Mei-Yung Tsou, Wen-Kuei Chang, Huey-Wen Yien, Cheng-Deng Kuo, Kwok-Hon Chan*. Instructor-based Real-time Multimedia Medical Simulation to Update Concepts of Difficult Airway Management for Experienced Airway Practitioners. J Chin Med Assoc. 2008;71:174-9.

38.    Shing-Shoung Chiou, Cheng-Deng Kuo*. Effect of chewing a single betel-quid on autonomic nervous modulation in healthy young adults. J Psychopharmacol. In press. SCI (IF=3.255; Ranking = 28/147 = 19.0% in CLINICAL NEUROLOGY)

39.    Jen-Lin Yang, Gau-Yang Chen, Cheng-Deng Kuo*. Comparison of Effect of Five Recumbent Positions on the Autonomic Nervous Modulation in Patients With Coronary Artery Disease. Circ J. In press. SCI (IF = 2.135, Ranking = 28/74 = 37.84% in CARDIAC & CARDIOVASCULAR SYSTEMS).

40.    Shu-Ming Chen*, Cheng-Deng Kuo, Low-Tone Ho, and Jyh-Fei Liao. Effect of dietary zinc deprivation on antioxidant enzyme activity and lipid peroxidation of unstimulated platelets in five-sixths nephrectomized rats. BioMetals. Accepted. SCI (IF= 1.893; Ranking= 175/262 = 66.8% in BIOCHEMISTRY & MOLECULAR BIOLOGY)

41.    Chien-Yue Chen*, Wing-Kwong Wong, Cheng-Deng Kuo,** Yun-Tzai Liao, Ming-Da Ke. Wavelet Real Time Monitoring System: A case study of the musical influence on electroencephalography. WSEAS Trans Syst. Accepted. EI