地 址 :
台北市北投區(112)立農街二段155號

Address:
155, Li-Nong St. , Sec.2, Peitou, Taipei , Taiwan

電話 /Tel: 02-2826-7389
傳真 /Fax: 02-2827-3123

Email: ibs@ym.edu.tw
http://www.ym.edu.tw/ibs

 

謝仁俊 教授 Prof. Jen-Chuen Hsieh, MD, Ph.D

陽明大學 神經科學研究所 專任教授

陽明大學 腦科學研究所 合聘教授
陽明大學 衛生資訊與決策研究所 兼任教授
臺北榮總 教研部整合性腦功能研究小組 主持人
Tel: (02) 2875-7480
E-mail : jchsieh@ym.edu.tw
 

研究專長

臨床神經精神醫學
神經醫學、神經麻醉及疼痛醫學、精神藥理學、精神醫學、生物精神醫學、復健醫學、睡眠醫學
認知神經科學
神經心理學、神經語言學、語言心理學、認知神經心理學、認知心理學、記憶 / 閱讀歷程及注意

 

研究概況

以腦科學的角度切入,研究範疇含蓋神經醫學、精神醫學、復健醫學、認知神經科學、疼痛醫學、神經生理及藥理學、傳統醫學、醫學物理、影像醫學、醫學工程及人機介面等相關領域。重點主題在各種精神疾患、運動系統、表皮性及內臟疼痛、周邊及脊髓與中樞神經損傷、中風病人之腦部改變等等的中樞機轉、心算之腦部表徵等,及技術上各項腦功能研究之模式分析技術及硬軟體發展。

 

得獎記錄

2005 Award for Outstanding Alumnus, National Yang-Ming University
2004 Outstanding Research Award, National Science Council, Taiwan
2003 Min-Tsai Outstanding Medical Reserach Award, Min-Tsai Foundation
2003 The TECO Technology Award (biotechnology), TECO Technology Foundation
2003 Medical Treatment Technology Innovation Award, Taipei Veterans General Hospital
1999 Outstanding Academic Achievement Award, Taipei Veterans General Hospital
1997 Medical Treatment Technology Innovation Award, Taipei Veterans General Hospital
1995 Astra Pain Research Award
1994 Young Researcher Award, The Scandinavian Association for the Study of Pain
1989, 1990, 1991 Annual Research Award, The Society of Anesthesiologist of Taiwan, R.O.C.

 

發表論文

Yu-Zu Wu, David M.Niddame, Chun-Chuan Chene, Kwong-Kum Liao, Chou-Ming Cheng, Li-Fen Chen, Po-Lei Lee, Shyan-Shiou Chen, Tzu-Chen Yeh, Jen-Chuen Hsieh. (2006) Effects of cognitive demands on postmovement motor cortical deactivation. NeuroReport, 17(4):371-375.

Ya-Wei Cheng, Ovid J.L.Tzeng, Jean Decetye, Toshiaki Imadaf, Jen-Chuen Hsieh. (2006) Gender differences in the human mirror system: a magnetoencephalography study. Neuroreport. 17(11):1115-1119

P. H. Li Lieber, A. S. Shiao, L. F. Chen, D. M. Niddam, S. Y. Chang, C. F. Lien, S. K. Lee, and J. C. Hsieh (2006) Healthy-side dominance of middle- and long-latency neuromagnetic fields in idiopathic sudden sensorineural hearing loss. European Journal of Neuroscience, P1–10

Lu C-L, Pasricha P J , Hsieh J-C, Lu R-H, Lai C-R, Wu L-L, Chang F-Y, Lee S-D (2005) Changes of the Neuropeptides Content and Gene Expression in Spinal Cord and Dorsal Root Ganglion After Noxious Colorectal Distension. Regulatory Peptide 131:66-73

Lu C-L, Chang F-Y, Hsieh J-C (2005) Is somatosensory cortex activated during proximal stomach stimulation and the role of insula in visceral pain, Gastroenterology 128(5): 1529-1530

Lee P-L, Wu W-T , Wu C-H, Chen L-F, Yeh T-C, Hsieh J-C. (2005) Visual evoked potential (VEP) actuated brain computer interface: A brain-actuated cursor system, Electronic Letter 21:832-834.

Cheng-Kuang Lee, Chia-Wei Sun, Po-Lei Lee, Hsiang-Chieh Lee, C. C. Yang, Cho- Pei Jiang, Yuh-Ping Tong, Tzu-Chen Yeh, and Jen-Chuen Hsieh. (2005) Study of photon migration with various source detector separations in near-infrared spectroscopic brain imaging based on three dimensional Monte Carlo modeling. Optics Express, 13:8339-8348. (IF=3.79)

Kung Y-Y, Chen F-P, Hwang S-J, Hsieh J-C, Lin Y-Y (2005) Convulsive Syncope: An Unusual Complication of Acupuncture Treatment in the Elderly, Journal of Alternative and Complementary Medicine 11(3):535-7

Hsiao F-J, Hsieh J-C, Chang Y, Lin Y-Y (2005) The effects of face spatial frequencies on cortical processing revealed by magnetoencephalography, Neurosci Let 380:54-59.

Lee C-Y, Tsai J-L, Kuo W-J, Yeh T-C, Wu Y-T, Ho L-T, Hung DL, Tzeng O-JL, Hsieh J-C (2004) Neuronal correlates of consisency and frequency effects on Chinese character naming: event-related fMRI study. Neuroimage, 23:1235-1245

Kuo W-J, Yeh T-C, Lee J-R, Chen L-F, Lee P-L, Chen S-S, Ho L-T, Hung DL, Tzeng O-JL, Hsieh J-C (2004) Orthographic and phonololgical processing of Chinese characters: an fMRI study. Neuroimage, 2004;21:1721-1731.

Chiu J-H, Chung M-S, Cheng H-C, Yeh T-C, Hsieh J-C, Chang C-Y, Kuo W-Y, Cheng H, Ho L-T (2003) Different central manifestations in response to electroacupuncture at analgesic and nonanalgesic acupoints in rats: a manganese-enhanced functional magnetic resonance imaging study. Can J Vet Res, 67:94-101.

Kao Y-H, Guo W-Y, Wu Y-T, Liu K-C, Chai W-Y, Lin C-Y, Hwang Y-S, Liou JKA, Wu H-M, Cheng H-C, Yeh T-C, Hsieh J-C, Mu HTM (2003) Hemodynamic segmentation of MR brain perfusion images using independent component analysis, thresholding, and Bayesian estimation. Magn Reson Med, 49:885-894.

Kuo W-J, Yeh T-C, Lee C-Y, Wu Y-T, Chou C-C, Ho L-T, Hung DL, Tzeng O-J, Hsieh J-C (2003) Frequency effects of Chinese character processing in the brain: an event-related fMRI study. Neuroimage, 18:720-730.

Lee P-L, Wu Y-T, Chen L-F, Chen Y-S, Cheng C-M, Yeh T-C, Ho L-T, Chang M-S, Hsieh J-C (2003) ICA-based spatiotemporal approach for single-trial analysis of post-movement MEG beta synchronization. Neuroimage, 20:2010-2030.

Li LPH, Shiao A-S, Lin Y-Y, Chen L-F, Niddam DM, Chang S-Y, Lien C-F, Chou N-S, Ho L-T, Hsieh J-C (2003) Healthy-side dominance of cortical neuromagnetic responses in sudden hearing loss. Ann Neurol, 53:810-815.

Lin Y-Y, Chang K-P, Hsieh J-C, Yeh T-C, Yu H-Y, Kwan S-Y, Yen D-J, Yiu C-H, Hari R (2003) Magnetoencephalographic analysis of bilaterally synchronous discharges in benign rolandic epilepsy of childhood. Seizure, 12:448-455.

Lin Y-Y, Shih Y-H, Hsieh J-C, Yu H-Y, Yiu C-H, Wong T-T, Yeh T-C, Kwan S-Y, Ho L-T, Yen D-J, Wu Z-A, Chang M-S (2003) Magnetoencephalographic yield of interictal spikes in temporal lobe epilepsy. Comparison with scalp EEG recordings. Neuroimage, 19:1115-1126.

Lin Y-Y, Wu Z-A, Hsieh J-C, Yu H-Y, Kwan S-Y, Yen D-J, Yiu C-H, Ho L-T (2003) Magnetoencephalographic study of rhythmic mid-temporal discharges in non-epileptic and epileptic patients. Seizure, 12:220-225.

Lin Y-Y, Shih Y-H, Chang K-P, Lee WT, Yu H-Y, Hsieh J-C, Yeh T-C, Wu Z-A, Ho L-T (2003) MEG localization of rolandic spikes with respect to SI and SII cortices in benign rolandic epilepsy. Neuroimage, 20:2051-2061.

Lu C-L, Chen L-F, Wu Y-T, Yeh T-C, Chang F-Y, Lee S-D, Hsieh J-C (2004) Neuronal correlates of gastric pain induced by fundus distention: a 3T-fMRI study. Neurogastroenterology & Motility, 16:575-587

Chan Y-H, Chou C, Chang H-F, Yau H-F, Wu J-S, Hsieh J-C (2003) The measurement of optical properties of a multiple scattering medium based on diffused photon pair density wave. SPIE proceeding

Lin Y-Y, Shih Y-H, Chen J-T, Hsieh J-C, Yeh T-C, Liao K-K, Kao C-D, Lin K-P, Wu Z-A, Ho L-T (2003) Differential effects of stimulus intensity on peripheral and neuromagnetic cortical responses to median nerve stimulation. Neuroimage, 20(2):909-917.

Lin Y-Y, Yiu C-H, Yu H-Y, Hsieh J-C, Yeh T-C, Kwan S-Y, Yen D-J, Chang K-P, Shih Y-H, Wong T-D (2003) Magnetoencephalographic characteristics of interictal spikes in medial temporal lobe epilepsy. Acta Neuro Taiwanica, 12:15-23.

Wu Y-T, Chen L-F, Chen H-Y, Lee P-L, Yeh T-C, Hsieh J-C (2003) A wavelet-based approach for color image registration. JIST, 47:185-199.

Chang H-F, Chan Y-S, Yih J-N, Yau H-F, Hsieh J-C, Chou C (2002) Angular distribution of Zeeman photon pairs in a highly scattering medium. Proc SPIE, 4819:28-34.

Duann JR, Jung T-P, Kuo W-J, Yeh T-C, Makeig S, Hsieh J-C, Sejnowski TJ (2002) Single-trial variability in event-related BOLD signals. Neuroimage, 15:823-835.

Hsieh J-C, Cheng H, Hsieh H-M, Liao K-K, Wu Y-T, Yeh T-C, Ho L-T (2002) Loss of interhemispheric inhibition on the ipsilateral primary sensorimotor cortex in patients with brachial plexus injury: fMRI study. Ann Neurol, 51:381-385.

Lee P-L, Chen L-F, Wu Y-T, Chiu H-F, Shyu K-K, Yeh T-C, Hsieh J-C (2002) Classifying MEG 20Hz rhythmic signals of left, right index finger movement and resting state using radial basis functions network. J Med Biol Engineering, 22:147-152.

Lin Y-Y, Yu H-Y, Hsieh J-C, Yeh T-C, Chang K-P, Yiu C-H, Kwan S-Y, Yen D-J, YH S, TD W (2002) Magnetoencephalography and its usefulness in epilepsy surgery. Chin J Radiol, 27:85-91.

Niddam DM, Yeh T-C, Wu Y-T, Lee P-L, Ho L-T, Arendt-Nielsen L, Chen AC, Hsieh J-C (2002) Event-related functional MRI study on central representation of acute muscle pain induced by electrical stimulation. Neuroimage, 17:1437-1450.

Wu Y-T, Chen H-Y, Chen L-F, Lee P-L, Yeh T-C, Hsieh J-C (2002) Fetal heart tracking in ultrasound image sequences using coarse-to-fine wavelet. J Med Biol Engineering, 22:67-74.

Wu Y-T, Chen L-F, Lee P-L, Yeh T-C, Hsieh J-C (2002) Discrete signal matching using coarse-to-fine wavelet basis function. Pattern Recognition, 36:171-192.

Chiu J-H, Cheng H-C, Tai CH, Hsieh J-C, Yeh T-C, Cheng H, Lin J-G, Ho L-T (2001) Electroacupuncture-induced neural activation detected by use of manganese-enhanced functional magnetic resonance imaging in rabbits. Am J Vet Res, 62:178-182.

Hsieh J-C, Tu C-H, Chen F-P, Chen M-C, Yeh T-C, Cheng H-C, Wu Y-T, Liu R-S, Ho L-T (2001) Activation of the hypothalamus characterizes the acupuncture stimulation at the analgesic point in human: a positron emission tomography study. Neurosci Lett, 307:105-108.

Kuo W-J, Yeh T-C, Duann JR, Wu Y-T, Ho L-T, Hung D, Tzeng O-J, Hsieh J-C (2001) A left-lateralized network for reading Chinese words: a 3 T fMRI study. Neuroreport, 12:3997-4001.

Peng L-C, Chou C, Lyu C-W, Hsieh J-C (2001) Zeeman laser-scanning confocal microscopy in turbid media. Optics Letters, 26:349-351.

Yeh T-C, Chou C-C, Cheng C-M, Wu Y-T, Cheng H-C, Hsieh J-C, Guo W-Y, Teng MM-H, Chang C-Y, Ho L-T (2001) Custom-designed on-line functional MRI analysis. Chin J Radiol, 26:69-74.

Hsieh J-C, Meyerson BA, Ingvar M (1999) PET study on central processing of pain in trigeminal neuropathy. Eur J Pain, 3:51-65.

Hsieh J-C, Stone-Elander S, Ingvar M (1999) Anticipatory coping of pain expressed in the human anterior cingulate cortex: a positron emission tomography study. Neurosci Lett, 262:61-64.

Ingvar M, Hsieh J-C (1999) The Image of Pain. In: Wall PD, Melzack R (eds) Textbook of Pain. Churchill Livingstone, Edinburgh, p 215-234

Wu MT, Hsieh J-C, Xiong J, Yang C-F, Pan H-B, Chen Y-C, Tsai G, Rosen BR, Kwong K-K (1999) Central nervous pathway for acupuncture stimulation: localization of processing with functional MR imaging of the brain--preliminary experience. Radiology, 212:133-141.

Ghatan PH, Hsieh J-C, Petersson KM, Stone-Elander S, Ingvar M (1998) Coexistence of attention-based facilitation and inhibition in the human cortex. Neuroimage, 7:23-29.

Hsieh J-C, Hannerz J, Ingvar M (1996) Right-lateralised central processing for pain of nitroglycerin-induced cluster headache. Pain, 67:59-68.

Hsieh J-C, Stahle-Backdahl M, Hagermark O, Stone-Elander S, Rosenquist G, Ingvar M (1996) Traumatic nociceptive pain activates the hypothalamus and the periaqueductal gray: a positron emission tomography study. Pain, 64:303-314.
Ghatan PH, Hsieh J-C, Wirsen-Meurling A, Wredling R, Eriksson L, Stone-Elander S, Levander S, Ingvar M (1995) Brain activation induced by the perceptual maze test: a PET study of cognitive performance. Neuroimage, 2:112-124.

Hsieh J-C (1995) Central processing of pain: Functional brain imaging studies with PET. In: Dept. Clinical Neuroscience, Sect. Clinical Neurophysiology. Karolinska Institute, Sweden, Stockholm, p 124

Hsieh J-C, Belfrage M, Stone-Elander S, Hansson P, Ingvar M (1995) Central representation of chronic ongoing neuropathic pain studied by positron emission tomography. Pain, 63:225-236.

Hsieh J-C, Hagermark O, Stahle-Backdahl M, Ericson K, Eriksson L, Stone-Elander S, Ingvar M (1994) Urge to scratch represented in the human cerebral cortex during itch. J Neurophysiol, 72:3004-3008.

Liou C-Y, Hsieh J-C (1993) Post cardiopulmonary-bypass neuropsychiatric complications. Chang Kung Med. J., 16:52-58.

Lui P-W, Lu P-K, Hsieh J-C (1992) Post-operative muscle rigidity in an infant. Br. J. Anaesth., 9:419-423.

Shih Y-H, Hsieh J-C, Lee L-S (1991) Intraoperative localization of sensorimotor cortex by cortical somatosensory evoked potentials. J Formos Med Assoc, 90:1049-1054.

Hsieh J-C, Lee T-Y, Liou J-Y, Inn H-W, Wang C-H, Yang Y-D, Chan K-H, Lui P-W, Tsen K-C, Yiou T-T, et al. (1990) Early detection of cerebral dysfunction by quantitative EEG during cardiopulmonary-bypass period for open-heart surgery. Ma Zui Xue Za Zhi, 28:137-149.

Hsieh J-C, Lee T-Y, Shih Y-H, Hwang L-D, Lui P-W (1990) Demarcation and localization of primary sensor and motor areas in human cortex by cortical somatosensory. Evoked potential (Co-SEP) during operation in surgery for epilepsy and intracranial tumor. Ma Zui Xue Za Zhi, 28:285-293.

Hsieh J-C, Chan K-H, Lui P-W, Lee T-Y (1990) Clinical application of infrared thermography in diagnosis and therapeutic assessment of vascular ischemic pain. Anesth Sinica, 28:493-501.

Hsieh J-C, Shih Y-S, Hwang L-D, Lui P-K, Lui P-W, Lee T-Y, Yao C-S, Su M-S, Chung K-P (1990) Activation of epileptogenic activities by etomidate in electrocorticoencephalography (ECoG) during operation in surgery for epilepsy. Anesth Sinica, 28:127-135.

Hsieh J-C, Chou Y-H, Hsu C-C, Tsai Y-T, Wu C-C, Chang T (1988) Duplex ultrasound demonstration of splenoportal venous thrombosis and cavernous transformation of the portal vein: a case report. J Ultrasound Med ROC, 5:27-32.

Hsieh J-C, Leung H-K, Lee T-Y (1988) Epidural meperidine: a novel approach to anesthetic management for extracoporeal shock wave lithotripsy - a comparison with epidural marcaine. Anesth Sinica, 26:273-282.