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專任教師 合聘教師 兼任教師
葉添順 教授 Tien-Shun Yeh, Ph.D. Professor,
現職 國立陽明大學解剖學及細胞生物學研究所教授  
辦公室 A114 分機 7070
實驗室 B118,B120 分機 5417,5418
E-mail tsyeh@ym.edu.tw
個人網頁  
學歷 National Yang-Ming University, ROC 1996
經歷  
研究方向

1. Roles of Notch signal pathway in cancer and stem cells
2. Regulatory mechanisms of tumorigenesis and metastasis
3. Cell-based screening of anti-cancer drugs

研究著作

1. Chen, J.-L., Ping, Y.-H., Tseng, M.-J., Chang, Y.-I., Lee, H.-C., Hsieh, R.-H., Yeh, T.-S. (corresponding author). 2017. Notch1-promoted TRPA1 expression in erythroleukemic cells suppresses erythroid but enhances megakaryocyte differentiation. Sci. Reports 7:42883.
2. Yeh, T.-C., Huang, T.-T., Yeh, T.-S., Chen, Y.-R., Hsu, K.-W., Yin, P.-H., Lee, H.-C., Tseng, L.-M. 2016. miR-151-3p targets TWIST1 to repress migration of human breast cancer cells. PLoS One 11(12):e0168171.
3. Tsai, S.-Y., Chung, P.-C., Owaga, EE, Tsai, I.-J., Wang, P.-Y., Tsai, J.-I., Yeh, T.-S., Hsieh, R.-H. 2016. Alpha-mangostin from mangosteen (Garcinia mangostana Linn.) pericarp extract reduces high fat-diet induced hepatic steatosis in rats by regulating mitochondria function and apoptosis. Nutr. Metab. 13:88.
4. Wang, S.-F., Chen, M.-S., Chou, Y.-C., Ueng, Y.-F., Yin, P.-H., Yeh, T.-S., Lee, H.-C. 2016. Mitochondrial dysfunction enhances cisplatin resistance in human gastric cancer cells via the ROS-activated GCN2-eIF2α-ATF4-xCT pathway. Oncotarget 7(45):74132-74151.
5. Hsu, K.-W., Fang, W.-L., Huang, K.-H., Huang, T.-T., Lee, H.-C., Hsieh, R.-H., Chi, C.-W., Yeh, T.-S. (corresponding author). 2016. Notch1 pathway-mediated microRNA-151-5p promotes gastric cancer progression. Oncotarget 7(25):38036-38051.
6. Huang, T.-T., Ping, Y.-H., Wang, A.-M., Ke, C.-C., Fang, W.-L., Huang, K.-H., Lee, H.-C., Chi, C.-W., Yeh, T.-S. (corresponding author). 2015. The reciprocal regulation loop of Notch2 pathway and miR-23b in controlling gastric carcinogenesis. Oncotarget 6(20):18012-18026.
7. Hsu, C.-C., Wu, L.-C., Hsia, C.-Y., Yin, P.-H., Chi, C.-W., Yeh, T.-S., and Lee, H.-C. 2015. Energy metabolism determines the sensitivity of human hepatocellular carcinoma cells to mitochondrial inhibitors and biguanide drugs. Oncol. Rep. 34(3):1620-1628.
8. Wang, A.-M., Huang, T.-T., Hsu, K.-W., Huang, K.-H., Fang, W.-L., Yang, M.-H., Lo, S.-S., Chi, C.-W., Lin, J.-J., Yeh, T.-S. (corresponding author). 2014. Yin Yang 1 is a target of microRNA-34 family and contributes to gastric carcinogenesis. Oncotarget 5(13):5002-5016.
9. Hsu, K.-W., Wang, A.-M., Ping, Y.-H., Huang, K.-H., Huang, T.-T., Lee, H.-C., Lo, S.-S., Chi, C.-W., Yeh, T.-S. (corresponding author). 2014. Down-regulation of tumor suppressor MBP-1 by microRNA-363 in gastric carcinogenesis. Carcinogenesis 35(1):208-217.
10. Lee, H.-C., Huang, K.-H., Yeh, T.-S., Chi, C.-W. 2014. Somatic alterations in mitochondrial DNA and mitochondrial dysfunction in gastric cancer progression. World J. Gastroenterol. 20(14):3950-3959.
11. Hsu, K.-W., Hsieh, R.-H., Huang, K.-H, Li, A. F.-Y., Chi, C.-W., Wang, T.-Y., Tseng, M.-J., Wu, K.-J., Yeh, T.-S. (corresponding author). 2012. Activation of the Notch1/STAT3/Twist signaling axis promotes gastric cancer progression. Carcinogenesis 33(8):1459-1467.
12. Tseng, Y.-C., Tsai, Y.-H., Tseng, M.-J., Hsu, K.-W., Yang, M.-C., Huang, K.-H., Li, A.F.-Y., Chi, C.-W., Hsieh, R.-H., Ku, H.-H., Yeh, T.-S. (corresponding author). 2012. Notch2-induced COX-2 expression enhancing gastric cancer progression. Mol. Carcinogenesis 51(12):939-951.
13. Chung, L.-Y., Tang, S.-J., Sun, G-H., Chou, T.-Y., Yeh, T.-S., Yu, S.-L., Sun, K.-H. 2012. Galectin-1 promotes lung cancer progression and chemoresistance by upregulating p38 MAPK, ERK, and cyclooxygenase-2. Clin. Cancer Res. 18(15):4037-4047.
14. Lin, Y.-T., Ding, J.-Y., Li, M.-Y., Yeh, T.-S., Wang, T.-W., Yu, J.-Y. 2012. YAP regulates neuronal differentiation through Sonic hedgehog signaling pathway. Exp. Cell Res. 318(15):1877-1888.
15. Chiu, L.-H., Yeh, T.-S., Huang, H.-M., Lu, S.-J., Yang, C.-B., Tsai, Y.-H. 2012. Diverse effects of type II collagen on osteogenic and adipogenic differentiation of mesenchymal stem cells. J. Cell. Physiol. 227(6):2412-2420.
16. Lin, Y.-F., Yeh, T.-S., Chen, S.-F., Tsai, Y.-H., Chou, C.-M., Yang, Y.-Y., Huang, H.-M. 2010. Non-muscle myosin IIA (MyH9): a novel class of signal transducer mediating the activation of Gαh/PLC-δ1 pathway. Endocrinol. 151(3):876-885.
17. Yeh, T.-S. (corresponding author), Wu, C.-W., Hsu, K.-W., Liao, W.-J., Yang, M.-C., Li, A.F.-Y., Wang, A.-M., Kuo, M.-L., Chi, C.-W. 2009. The activated Notch1 signal pathway is associated with gastric cancer progression through COX-2. Cancer Res. 69(12): 5039-5048.
18. Hsu, K.-W., Hsieh, R.-H., Wu, C.-W., Chi, C.-W., Lee, Y.-H. W., Kuo, M.-L., Wu, K.-J., Yeh, T.-S. (corresponding author). 2009. MBP-1 suppresses growth and metastasis of gastric cancer cells through COX-2. Mol. Biol. Cell 20(24): 5127-5137.
19. Hwu, Y.-M., Li, S.-H., Lee, R. K.-K., Lin, M.-H., Tsai, Y.-H., Yeh, T.-S. (corresponding author). 2009. Luteinizing hormone increases platelet-derived growth factor-D gene expression in human granulosa-luteal cells. Fertil. Steril. 92(6): 2065-2068.
20. Wang, A.-M., Ku, H.-H., Liang, Y.-C., Chen, Y.-C., Hwu, Y.-M., Yeh, T.-S. (corresponding author). 2009. The autonomous Notch signal pathway is activated by baicalin and baicalein but is suppressed by niclosamide in K562 cells. J. Cell. Biochem. 106(4): 682-692.
21. Jeng, J.-Y., Yeh, T.-S., Chiu, Y.-H., Lee, Y.-C., Cheng, H.-H., Hsieh, R.-H. 2009. Linoleic acid promotes mitochondrial biogenesis and maintains mitochondrial structure for prevention of streptozotocin damage in RIN-m5F cells. Biosci. Biotechnol. Biochem. 73(6): 1262-1267.
22. Hsu, K.-W., Hsieh, R.-H., Lee, Y.-H. W., Chao, C.-H., Wu, K.-J., Tseng, M.-J., Yeh, T.-S. (corresponding author). 2008. The activated Notch1 receptor cooperates with -enolase and MBP-1 in modulating c-myc activity. Mol. Cell. Biol. 28(15): 4829-4842.
23. Hwu, Y.-M., Li, S.-H., Lee, R. K.-K., Tsai, Y.-H., Yeh, T.-S. (corresponding author), Lin, S.-Y. 2008. Increased expression of platelet-derived growth factor C messenger ribonucleic acid in uterine leiomyomata. Fertil. Steril. 89(2): 468-471.
24. Jeng, J.-Y., Yeh, T.-S., Lee, J.-W., Lin, S.-H., Fong, T.-H., Hsieh, R.-H. 2008. Maintenance of mitochondrial DNA copy number and expression are essential for preservation of mitochondrial function and cell growth. J. Cell. Biochem. 103(2): 347-357.
25. Lin, Y.-W., Lien, L.-M., Yeh, T.-S., Wu, H.-M., Liu, Y.-L., Hsieh, R.-H. 2008. 9-cis retinoic acid induces retinoid X receptor localized to the mitochondria for mediation of mitochondrial transcription. Biochem. Biophys. Res. Commun. 377(2): 351-354.
26. Hsu, K.-W., Wang, A.-M., Yeh, T.-S. (corresponding author). 2008. Roles of Notch receptor in tumorigenesis. BioMedicine 1: 17-23. (in Chinese)
27. Liao, W.-R., Hsieh, R.-H., Hsu, K.-W., Wu, M.-Z., Tseng, M.-J., Mai, R.-T., Lee, Y.-H. W., Yeh T.-S. (corresponding author). 2007. The CBF1-independent Notch1 signal pathway activates human c-myc expression partially via transcription factor YY1. Carcinogenesis 28(9): 1867-1876.
28. Mai, R.-T., Yeh, T.-S., Kao, C.-F. Sun, S.-K., Hwang, H.-H., and Lee, Y.-H. W. 2006. Hepatitis C virus core protein recruits nucleolar phosphoprotein B23 and coactivator p300 to relieve the repression effect of transcriptional factor YY1 on B23 gene expression. Oncogene 25(3): 448-462.
29. Shen, W.-W., Liu, C.-H., Yang, Y.-Y., Lin, C.-Y., Chen, K.-P., Yeh, T.-S., Leu, S.-J. 2006. Anti-heat shock protein 90 is increased in acute mania. Aust. N. Z. J. Psychiatry 40(8): 712-716.
30. Au, H.-K., Yeh, T.-S., Kao, S.-H., Shih, C.-M., Hsieh, R.-H., and Tzeng, C.-R. 2005. Calcium-dependent upregulation of mitochondrial electron transfer chain gene expressions in human luteinized granulosa cells. Fertil. Steril. 84: 1104-1108.
31. Au, H.-K., Lin, S.-H., Huang, S.-Y., Yeh, T.-S., Tzeng, C.-R., and Hsieh, R.-H. 2005. Deleted mitochondrial DNA in human luteinized granulosa cells. Ann. N.Y. Acad. Sci. 1042: 136-141.
32. Au, H.-K., Yeh, T.-S., Kao, S.-H., Tzeng, C.-R., and Hsieh, R.-H. 2005. Abnormal mitochondrial structure in human unfertilized oocytes and arrested embryos. Ann. N.Y. Acad. Sci. 1042: 177-185.
33. Yeh, T.-S., Ho, J.-D., Yang, V. W.-C., Tzeng, C.-R., and Hsieh, R.-H. 2005. Calcium stimulates mitochondrial biogenesis in human granulosa cells. Ann. N.Y. Acad. Sci. 1042: 157-162.
34. Yeh, T.-S. (corresponding author), Hsieh, R.-H., Shen, S.-C., Wang, S.-H., Tseng, M.-J., Shih, C.-M., and Lin, J.-J. 2004. Nuclear 洍I–tubulin associates with the activated Notch receptor to modulate Notch signaling. Cancer Res. 64: 8334-8340.
35. Hsieh, R.-H., Au, H.-K., Yeh, T.-S., Chang, S.-J., Cheng, Y.-F, and Tzeng, C.-R. 2004. Decreased expression of mitochondrial genes in human unfertilized oocytes and arrested embryos. Fertil. Steril. 81: 912-918.
36. Yeh, T.-S. (corresponding author), Lin, Y.-M., Hsieh, R.-H., and Tseng, M.-J. 2003. Association of transcription factor YY1 with high-molecular-weight Notch complex suppresses the transactivation activity of Notch. J. Biol. Chem. 278: 41963-41969.
37. You, L.-R., Chen, C.-M., Yeh, T.-S., Tsai, T.-Y., Mai, R.-T., Lin, C.-H., and Lee, Y.-H. Wu. 1999. Hepatitis C virus core protein interacts with cellular putative RNA helicase. J. Virol. 73: 2841-2853.
38. Yeh, T.-S., and Lee, Y.-H. W. 1998. Assembly of hepatitis delta virus particles: package of multimeric HDV genomic RNA and role of phosphorylation. Virology 249: 12-20.
39. Yeh, T.-S., Lo, S. J., Chen, P.-J., and Lee, Y.-H. W. 1996. Casein kinase II and protein kinase C modulate the hepatitis delta virus RNA replication but not empty viral particle assembly. J. Virol. 70: 6190-6198.

國立陽明大學 解剖學及細胞生物學研究所 聯絡電話:(02)28267000# 5235, 5455 傳真號碼:(02)28212884
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