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宋晏仁 教授Yen-Jen Sung, M.D., Ph.D. Professor, National Yang-Ming Medical College, ROC 1984, Cornell University, USA 1993.
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| 研究方向(Research)： |
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1.微膠細胞發炎相關機制與神經退化疾病之關係 2.一氧化氮之氧化還原訊號在細胞功能調節中之角色 3.抗發炎中草藥之藥理作用機制 4.胚胎著床機制與發炎相關因子之關係 |
| 論文著作(Publications)： |
| 1.Chiou, W.F., Sung, Y.J., Liao, J.F., Shum, A.Y. & Chen, C.F. (1997) Inhibitory effect of dehydroevodiamine and evodiamine on nitric oxide production in cultured murine macrophages. J.NaturalProd. 60(7):708-711 |
| 2.Hong, C.Y., Huang, S.S., Wang, R., Sung, Y.J., Kwok, C.F. (1998) Thrilinolein inhibits the adhesion of neutrophils to endothelial cells. Clin. Exp. Pharmacol. Physiol. 25:99-103 |
| 3.Differential effect of B lymphocyte-induced maturation protein (Blimp-1) expression on cell fate during B cell development. J. Exp. Med. 188:515-525 |
| 4.Jea, J.C., Liu, T.C., Wang., S.Y., and Sung, Y.J. (1998) Exogenous nitric oxide enhances the growth of U937 human leukemic cells through a cyclooxygenase-mediated pathway. J. Leukoc. Biol. 64:451-458 |
| 5.Shen, Y.C., Chen, J.F., Wang, S.Y. and Sung, Y.J. (1999) Impediment to calcium influx and reactive oxygen production accounts for the inhibition of neutrophil Mac-1 upregulation and adhesion by tetrandrine. Mol. Pharmacol. 55:186-193 |
| 6.Sung, Y.J., Juan, C.C., Lee, H.C., Yin, P.H., Chi, C.C., Ku, H.H., Li, A.F.Y., Wei, Y.H., Tsay, H.J. (1999) Oxidative stress is insignificant in N1S1-transplanted hepatoma despite markedly declined activities of the antioxidant enzymes. Oncol.Reports 6:1313-1319 |
| 7.Shen, Y.C., Chen, J.F., and Sung, Y.J. (1999) Tetrandrine ameliorates ischaemia-reperfusion injury of rat myocardium through inhibition of neutrophil priming and activation. Br. J. Pharmacol. 128(7):1593-1601 |
| 8.Tarng, D.C., Huang, T.P., Liu, T.Y., Chen, H.W., Sung, Y.J., Wei ,Y.H. (2000) Effect of vitamin E-modified regenerated cellulose membrane on 8-hydroxy 2'-deoxyguanosine level in leukocyte DNA hemodialysis patients. Kidney Int. 58(2):790-799 |
| 9.Li, H.Y., Chang, S.P., Yuan, C.C., Chao, H.T., Ng, H.T., Sung, Y.J. (2001) Nitric oxide induces extensive apoptosis in endometrial epithelial cells in the presence of progesterone: involvement of mitogen-activated protein kinase pathways. Mol Hum Reprod. 2001 7(8):755-63. |
| 10. Sung, Y.J., Chien, S.C. and Chen, J.C. (2002) Segmentation of visible human data using gradient vector flow deformable model. J. Med. Biol. Eng., 22(s): s61-s67 |
| 11. Sung, Y.J., Cheng, C.I., Chen, C.S., Huang, H.B., Huang, F.L., Wu, P.C., Shiao, M.S. and Tsay, H.J. (2003) Distinct mechanisms mediate b-amyloid toxicity in PC12 and differentiated PC12 neuronal cells. J. Biomed. Sci. 10:379-388 |
| 12. Li, H.Y., Chang, S.P., Yuan, C.C., Chao, H.T., Ng, H.T. and Sung, Y.J. (2003) Induction of p38 mitogen-activated protein kinase-mediated apoptosis is involved in outgrowth of trophoblasts on endometrial epithelial cells in a model of human trophoblast-endometrial interactions. Biol. Reprod. |
| 13. Sung, Y.J., Sung, Z.L., Ho, C.L., Lin, M.T., Wang, J.S., Yang, S.C., Chen, Y.J. and Lin, C.H. (2003) Intercellular calcium waves mediate preferential cell growth toward the wound edge in polarized hepatic cells. Exp. Cell Res. |
| 14. Li HY, Chang SP, Yuan CC, Chao HT, Ng HT, and Sung, Y.J... (2003)Induction of p38 mitogen-activated protein kinase-mediated apoptosis is involved in outgrowth of trophoblasts on endometrial epithelial cells in a model of human trophoblast-endometrial interactions Biology of Reproduction . Biology of Reproduction 69(5):1515-24 |
| 15.Sheu ML, Chao KF, Sung, Y.J., Lin WW, Lin-Shiau SY, Liu SH.. (2005) Activation of phosphoinositide 3-kinase in response to inflammation and nitric oxide leads to the up-regulation of cyclooxygenase-2 expression and subsequent cell proliferation in mesangial cells. CELLULAR SIGNALLING . 17(8):975-84 |
| 16.Wang YH, Wang WY, Chang CC, Liou KT, Sung, Y.J., Liao JF, Chen CF, Chang S, Hou YC, Chou YC, Shen YC..(2006) Taxifolin ameliorates cerebral ischemia-reperfusion injury in rats through its anti-oxidative effect and modulation of NF-kappa B activation. JOURNAL OF BIOMEDICAL SCIENCE;13(1):127-41 |