發表論文

子計畫一

JOURNAL PUBLICATIONS

1. Y-L Liao, Y-M Sun, G-Y Chau, Y-P Chau, T-C Lai, J-L Wang, J-T Horng, M. Hsiao and A-P Tsou. Identification of SOX4 target genes using phylogenetic footprinting-based prediction from expression microarrays suggests that overexpression of SOX4 potentiates metastasis in hepatocellular carcinoma. (2008) Oncogene, In press. [Impact factor: 6.582;Rank: 9.45%]

2. Gar-Yang Chau*, Annie Fan-Yau Lee, Shyh-Haw Tsay, Ying-Ru Ke, Hua-Li Kao, Fen-Hwa Wong, Ann-Ping Tsou*, and Yat-Pang Chau* (2007) Clinicopathological significance of survivin expression in patients with hepatocellular carcinoma. Histopathology, 2007; 51(2):204-218. [Impact factor: 3.216;Rank: 14.06%]

3. Gar-Yang Chau*, MD; Wing-Yiu Lui, MD; Chin-Wen Chi, PhD; Yat-Pang Chau, PhD;
Anna Fen-You Li, MD; Hua-Li Kao, MS; Chew-Wun Wu, MD (2007) Significance of serum hepatocyte growth factor levels in patients with hepatocellular carcinoma undergoing hepatic resection" Eur J Surg Oncol, In press. [SCI, IF: 3.184]

4. Chang-Han Chen, Pei-Jung Lu, Yu-Chia Chen, Shu-Ling Fu, Kou-Juey Wu, Ann-Ping Tsou , Yuan-Chii Gladys Lee, Tsu-Chun Emma Lin, Shih-Lan Hsu, Chi-Ying F. Huang and Chen-Kung Chou*. (2007) FLJ10540-elicited transformation is through the activation of PI3-kinase/AKT pathway. Oncogene 26(29):4772-4783. [Impact factor: 6.582;Rank: 9.45%]

5. Chang JL, Chen TH, Wang CF, Chiang YH, Huang YL, Wong FH, Chou CK, Chen CM. (2006) Borealin/Dasra B is a cell cycle-regulated chromosomal passenger protein and its nuclear accumulation is linked to poor prognosis for human gastric cancer. Exp Cell Res. 312(7):962-73. [SCI, IF: 6.543]

6. Chao-Chin Li, Chen-Kung Chou, Ming-Hseng Wang, Ting-Fen Tsai (2006) Overexpression of ABIN-2, a negative regulator of NF-�羠 delays liver regeneration in the ABIN-2 transgenic mice. Biochemical and Biophysical Research Communications 342: 300–309. [SCI, IF: 3.0; Rank: 21/6]

7. A. P. Tsou*, Y. M. Sun, C. L. Liu, H. D. Huang, and J. T. Horng (2006) "A Biological Data Warehousing Consisting of an Analyzing and Mining System for Identifying Transcriptional Regulatory Sites", IEEE Transactions on Information Technology in Biomedicine 10 (3):550-558. [SCI, IF: 1.376; Rank: 24/83]

8. Paul W.C. Hsu, Hsien-Da Huang, Sheng-Da Hsu, Li-Zen Lin, Ann-Ping Tsou, Ching-Ping Tseng, Peter F. Stadler, Stefan Washietl, and Ivo L. Hofacker. (2006) miRNAMap: genomic maps of microRNA genes and their target genes in mammalian genomes. NUCLEIC ACIDS RESEARCH 34:D135-D139. [SCI, IF: 7.5520; Rank: 24/264]

9. Bo-Kuan Wu, Chao-Chin Li, Huei-Jane Chen, Junn-Liang Chang, King-Song Jeng, Chen-Kung Chou, Ming-Ta Hsu, Ting-Fen Tsai. (2006) Blocking of G1/S transition and cell death in the regenerating liver of Hepatitis B virus X protein transgenic mice Biochemical and Biophysical Research Communications 340: 916–928. [SCI, IF: 3.0; Rank: 21/65]

MANUSCRIPTS IN PRREPARATION.

1. Ann-Ping Tsou*, Yat-Pang Chau, Chia-Lin Liu, Chien-Der Lin, Yi-Ying Lu, Hsin-Hui Chang, Jia-Liang Jiang , Yu-Lun Liao , S-N Kung, Jen-Hwey Chiu, Chin-Wen Chi, Chen-Kung Chou, Ming-Ta Hsu* (2008) Syn-expression of Pancreatic Exocrine Genes During Mouse Liver Regeneration. Manuscript in preparation.

2. Gar-Yang Chau*, Chu-Wen Yang, Yao-Sun Li, Cheng-Kuo Lai, Yat-Pang Chau* Chen-Kung Chou, and Ann-Ping Tsou*. (2008) Profiling of protein kinases in HCC: Diagnostic value of elevated expression of NEK2, MELK and TTK in HCC patients (2007) Manuscript in preparation.

POSTER PRESENTATIONS IN INTERNATIONAL MEETINGS

1. AP Tsou, CW Lin, WJ Hsu, CD Lin, CM Chen, GY Chau, HD Huang (2007) Has-mir-122 is implicated in intrahepatic metastasis of hepatocellular carcinoma. Presented in Keystone Symposia: MicroRNAs and siRNAs: Biological Functions and Mechanisms. (Keystone, Colorado) 1/28~2/4/2007.

2. Y.L. Liao, C.D. Lin, C.P. Hu, Yat-Pang Chau, C.K. Chou, Ming-Ta Hsu and Ann-Ping Tsou (2005) Transcriptome analysis of HBV-LS-transgenic mice: An injury-regeneration model of human hepatocarcinogenesis. Presented in Keystone Symposium: Inflammation and Cancer (Breckenridge, Colorado) 2/27~3/3/2005

3. Ann-Ping Tsou, Yat-Pang Chau, Chia-Lin Liu, Chien-Der Lin, Yi-Ying Lu, Hsin-Hui Chang, Ming-Ta Hsu (2005) Metaplasia of hepatocytes into pancreatic acinar cells during mouse liver regeneration. Presented in 45th Annual Meeting of the American Society for Cell Biology (San Francisco, CA) 12/10~12/14/2005.

LIST OF PUBLICATIONS IN “TOP” JOURNALS AND CONFERENCES

1. Y-L Liao, Y-M Sun, G-Y Chau, Y-P Chau, T-C Lai, J-L Wang, J-T Horng, M. Hsiao and A-P Tsou. Identification of SOX4 target genes using phylogenetic footprinting-based prediction from expression microarrays suggests that overexpression of SOX4 potentiates metastasis in hepatocellular carcinoma. (2008) Oncogene, In press. [Impact factor: 6.582;Rank: 9.45%]

2. Chang-Han Chen, Pei-Jung Lu, Yu-Chia Chen, Shu-Ling Fu, Kou-Juey Wu, Ann-Ping Tsou , Yuan-Chii Gladys Lee, Tsu-Chun Emma Lin, Shih-Lan Hsu, Chi-Ying F. Huang and Chen-Kung Chou*. (2007) FLJ10540-elicited transformation is through the activation of PI3-kinase/AKT pathway. 26(29):4772-4783. [Impact factor: 6.582;Rank: 9.45%]

3. Chang JL, Chen TH, Wang CF, Chiang YH, Huang YL, Wong FH, Chou CK, Chen CM. (2006) Borealin/Dasra B is a cell cycle-regulated chromosomal passenger protein and its nuclear accumulation is linked to poor prognosis for human gastric cancer. Exp Cell Res. 312(7):962-73. [SCI, IF: 6.543]

4. Paul W.C. Hsu, Hsien-Da Huang, Sheng-Da Hsu, Li-Zen Lin, Ann-Ping Tsou, Ching-Ping Tseng, Peter F. Stadler, Stefan Washietl, and Ivo L. Hofacker. miRNAMap: genomic maps of microRNA genes and their target genes in mammalian genomes. NUCLEIC ACIDS RESEARCH 2006;34:D135-D139. [SCI, IF: 7.5520; Rank: 24/264]

子計畫二

Publications:

1.Chiou SH, Kao CL, Chen YW, Chien CS, Hung SC, Lo JF, Chen YJ, Ku HH, Hsu MT, Wong TT Identification of CD133-positive radioresistant cells in atypical teratoid/rhabdoid tumor.PLoS ONE 2008 May 7;3(5):e2090

2.Wu YF, Fu SL, Kao CH, Yang CW, Lin CH, Hsu MT, Tsai TF Chemopreventive effect of silymarin on liver pathology in HBV X protein transgenic mice. Cancer Res. 2008 Mar 15;68(6):2033-42.

3.Shann YJ, Cheng C, Chiao CH, Chen DT, Li PH, Hsu MT Genome-wide mapping and characterization of hypomethylated sites in human tissues and breast cancer cell lines. Genome Res. 2008 May;18(5):791-801. Epub 2008 Feb 6.

4.Jen CH, Yang TP, Tung CY, Su SH, Lin CH, Hsu MT, Wang HW Signature Evaluation Tool (SET): a Java-based tool to evaluate and visualize the sample discrimination abilities of gene expression signatures. BMC Bioinformatics. 2008 Jan 28;9:58.

5.Yang TP, Chang TY, Lin CH, Hsu MT, Wang HW.ArrayFusion: a web application for multi-dimensional analysis of CGH, SNP and microarray data. Bioinformatics. 2006 Nov 1;22(21):2697-8. Epub 2006 Aug 25.

6.Wu BK, Li CC, Chen HJ, Chang JL, Jeng KS, Chou CK, Hsu MT, Tsai TF Blocking of G1/S transition and cell death in the regenerating liver of Hepatitis B virus X protein transgenic mice. Biochem Biophys Res Commun. 2006 Feb 17;340(3):916-28. Epub 2005 Dec 27.

One manuscript submitted to Mol. Cell Biol.
Manuscripts in preparation:

1. Regulation of Siglec-11 Expression by Oxidative Stress Through PKC-ERK pathway and Down-regulated in Human Liver and Lung Cancer Yih-Jyh Shann1, Bi-Ling Wang1, Ru-Ching Lin1,Cheng Chin1, Chi-Ming Wu4, Tsann-Long Hwang4, Hsing-Hwey Chang1, Ann-Ping Tsou2 and Ming-Ta Hsu1,3*,

2. Mapping large unmethylated DNA zones in tumor genomes using McrBC-CGH technique Chuan-Hui Chiao and Ming-Ta Hsu1,2, 3

3. Epigenetic Down-regulation of Rab37 in Lung Cancer Chiu-Yi Wu1, Yi-Ching Wang2 and Ming-Ta Hsu1,2

4. Complex translocation recombination junctions involving BCAS3 gene in MCF7 cells and evidence for interchromosomal fused transcript in normal human tissues. Mei-Xuang Huang and Ming-Ta Hsu

子計畫三

Published articles (acknowledged the grant)

1. Hsiao YC, Chang HH, Tsai CY, Jong YJ, Horng LS, Lin SF and Tsai TF*. Coat color tagged green fluorescent mouse with EGFP expressed from the RNA polymerase II promoter. Genesis 39: 122-129 (2004).

2. Wu BK, Li CC, Chen HJ, Chang JL, Jeng KS, Chou CK, Hsu MT, and Tsai TF*. Blocking of G1/S transition and cell death in the regenerating liver of Hepatitis B Virus X protein transgenic mice. Biochemical and Biophysical Research Communications 340: 916-928 (2006).

3. Li CC, Chou CK, Wang MH and Tsai TF*. Overexpression of ABIN-2, a negative regulator of NF-�羠, delays liver regeneration in the ABIN-2 transgenic mice. Biochemical and Biophysical Research Communications 342: 300-309 (2006).

4. Su JS*, Tsai TF*, Chang HM, Chao KM, Su TS, Tsai SF. Distant HNF1 site as a master control for human class I alcohol dehydrogenase gene expression. Journal of Biological Chemistry 281: 19809-19821 (2006).

5. Wu YF, Fu SL, Kao CH, Yang CW, Lin CH, Hsu MT, Tsai TF*. Chemopreventive effect of silymarin on liver pathology in HBV X protein transgenic mice. Cancer Research 68 (6): 2033-2042 (2008).

Articles in revision, submitted and in preparation (supported by the grant)

6. Li CC, Chu HY, Yang CW, Chou CK, Hsu MT and Tsai TF*. Overexpression of Aurora-A in liver leads to hyperplasia and causes a p53-dependent G2/M arrest during mouse liver regeneration. In revision.
7. Tsai CY, Chou CK, Yang CW, Lai YC, Liang CC, Chen CM and Tsai TF*. Hurp deficiency in mice leads to female infertility caused by a stroma proliferation defect during implantation. Submitted.
8. Teng YC, Tsai CY and Tsai TF*. Hepatoblast-specific beta-catenin knockout leads to failure of liver functions and perinatal lethality in the mice. In preparation.
9. Chen YF, Kao CH, Liu FC, Chen YT, Wu CY, Tsai CY, Yang CW, Tsai SF, Hsu MT and Tsai TF*. Deficiency of Gret gene located within human longevity locus causes premature ageing in mice. In preparation.

LIST OF PERSONAL ACHIEVEMENTS OF THE PIS: KEYNOTE GIVEN BY PI

Ting-Fen Tsai. Keynote Speech. Dec. 7, 2006
2006年中華實驗動物學會第九屆第二次會員大會暨學術研討會
Mouse Model for Liver Cancer and Its Potential Application to Cancer Therapeutics

PUBLICATIONS IN “TOP” JOURNALS (IF > 5.0)

1. Su JS*, Tsai TF*, Chang HM, Chao KM, Su TS, Tsai SF. Distant HNF1 site as a master control for human class I alcohol dehydrogenase gene expression. Journal of Biological Chemistry 281: 19809-19821 (2006). IF = 5.854

2. Wu YF, Fu SL, Kao CH, Yang CW, Lin CH, Hsu MT, Tsai TF*. Chemopreventive Effect of Silymarin on Liver Pathology in HBV X Protein Transgenic Mice. Cancer Research 68 (6): 2033-2042 (2008). IF = 7.656

PUBLICATIONS IN “TOP” CONFERENCES

1. Bo-Kuan Wu, Chao-Chin Li, Cheng-Heng Kao and Ting-Fen Tsai. Blocking of G1/S transition and cell death in the regenerating liver of hepatitis B virus X protein transgenic mice. American Association for Cancer Research, 97th Annual Meeting, April 1-5, 2006. Washington Convention Center, Washington, DC, USA.

2. Yi-Fan Chen, Ya-Ting Chen, Ching-Yen Tsai, Fu-Chin Liu, Shih-Feng Tsai and Ting-Fen Tsai. Knockout mouse of a gene located within human chromosome 4q22-24 exhibits progeroid phenotypes. Molecular Genetics of Aging. Oct 4-8, 2006. Cold Spring Harbor Laboratory, Cold Spring Harbor, New York, USA.

3. Yi-Fang Wu, Shu-Lin Fu, Cheng-Heng Kao and Ting-Fen Tsai. Silymarin exerted therapeutic effects on early stage of liver damages, prevented HCC formation and delayed liver carcinogenesis in the HBx transgenic mice. American Association for Cancer Research, Annual Meeting 2007, April 14-18, 2007. Los Angeles Convention center, Los Angeles, CA, USA.

4. Ching-Yen Tsai, Yi-Chen Lai, Chun-Ming Chen and Ting-Fen Tsai. Physiological role of the putative tumor suppressor gene Hurp/Dlg7: Adenomatous hyperplasia in uterine and female reproductive dysfunction in the Hurp/Dlg7 knockout Mice. American Association for Cancer Research, Annual Meeting 2007, April 14-18, 2007. Los Angeles Convention center, Los Angeles, CA, USA.

5. Jian-Yu Lin, Shigeaki Kato and Ting-Fen Tsai. Gender-dependent Hepatic Alterations and Physiological Role of Androgen/Androgen Receptor Pathway during Liver Carcinogenesis of the HBx Transgenic Mice. American Association for Cancer Research, Annual Meeting 2008, April 12-16, 2008. San Diego Convention center, San Diego, CA, USA.

6. Chao-Chin Li, Hui-Yi Chu, Chu-Wen Yang, Chen-Kung Chou, and Ting-Fen Tsai. Aurora-A Overexpression in mouse liver Leads to a Low Incidence of Hepatic Tumors and Causes p53-dependent G2/M Arrest during Liver Regeneration. American Association for Cancer Research, Annual Meeting 2008, April 12-16, 2008. San Diego Convention center, San Diego, CA, USA.

7. Ching-Yen Tsai, Chen-Kung Chou, and Ting-Fen Tsai. HURP Deficiency Leads to Female Infertility Caused by Stromal Proliferation Defect during Implantation in Mice. The CAS International Symposium on Developmental System Biology. Beijing, China, May 18-20, 2008.

8. Yuan-chi Andrea Teng, Ching-Yen Tsai and Ting-Fen Tsai. Hepatoblast-Specific ��-Catenin Knockout Leads to Failure of Liver Functions and Perinatal Lethality in the Mice. The CAS International Symposium on Developmental System Biology. Beijing, China, May 18-20, 2008.

9. Yi-Fan Chen, Cheng-Heng Kao, Chia-Yu Wu, Hui-Wen Zhuang and Ting-Fen Tsai. Deficiency of Gret Gene Which Located within Human Longevity Locus Causes Premature Ageing in Mice. The CAS International Symposium on Developmental System Biology. Beijing, China, May 18-20, 2008.

子計畫五

1.Li, H.-H., Chou, G. and Liaw, G.-J. (2004) Functional analysis of human genes using Drosophila as a model system, 第五屆分生所發育生物學研討會, 淡水.

2.林書葦和廖國楨 (2004) Identification of proteins in Torso-regulatedrepression complex, 第五屆分生所發育生物學研討會, 淡水.

3.Chou, G., Li, J., Chen, Y.-J., and Liaw, G.-J. (2004) dtlk regulates cell division through microtubules, Sir Edward Youde Memorial Fund Postgraduate conference, 香港.

4. Hsing-Hsi Li, Gash Chou, and Gwo-Jen Liaw (2005) Functional analysis of human genes using Drosophila as a model system. 第二十屆生物醫學聯合學術年會, 台北

5.Hsing-Hsi Li, Gash Chou, and Gwo-Jen Liaw (2005) Functional analysis of human genes using Drosophila as a model system. International Developmental Biology Symposium, Tung-Hai University, Taichung.

6.Yu-Chein Chen, Sue-Wei Lin, Jia-Shiun Liu and Gwo-Jen Liaw (2005) Does the torso mediated repression complex include GAGA, Z, TTK69 and HSF? 46th Annual Drosophila Research Conference, San Diego, USA.

7.Gwo-Jen Liaw, Hsing-Hsi Li, Hsiao-Yu Huang and Chuen-Sheue Chiang (2005) Dhrp/Gkap functions in the G2/M checkpoint. 46th Annual Drosophila Research Conference, San Diego, USA

8.Gash Chou and Gwo-Jien Liaw (2006) Tousled-like kinase functions in G2/M progression. 47th annual Drosophila research conference, Houston, USA.

9.Gwo-Jen Liaw, Hsing-Hsi Li, H. Shih-Sing Fan, Gash Chou, and Hsiao-Yu Huang (2008) Interplay between mars and tousled-like kinase in chromosome fidelity. Genetic analysis: Model organisms to human biology 2. San Diego, USA.

10.Hsing-Hsi Li, Chuen-Sheue Chiang, H. Gash Chou, Hsiao-Yu Huang and Gwo-Jen Liaw (2008) Interplay between mars and tousled-like kinase in chromosome fidelity in Drosophila. (ms. revised)

11.Yu-Chien Chen, Yin-Kuan Chen, Suwei Lin, Chuen-Sheue Chiang, and Gwo-Jen Liaw (2008) The Torso signaling pathway modulates a dual transcriptional switch to regulate tailless expression. (ms in prep)