Dr. Yeu. Su, Professor

Education：　

National Taiwan University, Pharmacy, B.S.,  1982

National Taiwan University, Biochemistry, M.S., 1984

University University of Wisconsin-Madison, Molecular Biology, Ph.D, 1986-1991

Experience：

Post. Doc.,  Johns Hopkins Oncology Center,  1991-1993

 Associate Associate Prof., Inst. of Pharmacology, 1993-2000　

Associate Prof., Inst. of Biopharmaceutical Science,  2000-2004

Professor, Inst. of Biopharmaceutical Science,  2005-

Research Interests：

  1. Molecular Biology

  2. Immunopharmacology

　

Publication：

  1. Tang R-Y. and Su Y. (1997) Construction of a cell-based high-flux assay for the rev protein of HIV-1. J. Virol. Methods 65, 153-158.

  2. Su Y., Chang C.L., Lee S.S., Chen W.C. and Huang C.F. (1998) In vitro cytotoxic activity of 1-decarboxy-3-oxo-ceanothic acid in a human ovarian adenocarcinoma cell line. Res. Comm. Mol. Pathol. & Pharmacol. 100, 313-326.

  3. Lee S.S., Chen W.C., Huang C.F. and Su Y. (1998) Preparation and cytotoxic effect of ceanothic acid derivatives. J. Nat. Prod. 61, 1343-1347.

  4. Su Y., Chang S-L. and Hsiao H-L. (2000) Characterization of a 5’-flanking region supporting the transcription of mouse thymosin ß -4 in mouse NIH3T3 cells. Mol.Cell. Biochem. 203, 163-167.

  5. Su Y., Sun C-M., Chuang H.H. and Chang P.T. (2000) Studies on the cytotoxicmechanisms of ginkgetin in a human ovarian adenocarcinoma cell line. Naunyn-Schmiedeberg's Arch. Pharmacol. 362, 82-90.

  6. Chang P.T. and Su Y. (2000) Protocol for quantitative and qualitative analyses of in vitro aggregation of synthetic ß-amyloid: a method applicable to the identification of substances that may have therapeutic efficacy for Alzheimer's disease. Brain Res. Protocols. 6, 6-12.

  7. Su Y. and Chang P.T.（2001）Acidic pH promotes the formation of toxic fibrils from ß-amyloid peptides. Brain Res. 893, 287-291.

  8. Lai G.H., Chen C.F., Su Y., Ho L.T. and Lin A.M.(2001) Lack of protective effect by intermittent hypoxia on MPTP-induced neurotoxicity in mice. Ann. NY Acad. Sci. 939, 33-44.

  9. Su Y. and Lee H.R. (2002). A high throughput system for identifying human interleukin-2 inducers and/or repressors based on the expression of a reporter gene in Jurkat T cells. Anal. Biochem. 303, 202-206.

  10. Wang W-S, Chen P-M , Hsiao H-L, Ju S-Y. and Su Y. (2003) Overexpression of the thymosin ß-4 gene is associated with malignant progression of SW480 colon cancer cells. Oncogene. 22, 3297-3306.  

  11. Wang W-S, Chen P-M , Hsiao H-L, Wang W.S., Chen P.M., Hsiao H.L., Wang H.S., Liang W.Y. and Su Y. (2004) Overexpression of the thymosin ß-4 is associated with increased invasion of SW480 colon carcinoma cells and the distant metastasis of human colorectal carcinoma. Oncogene 23, 6666-6671.)

  12. Lee O.K., Ko Y.C., Kuo T.K., Chou S.H., Li H.J., Chen W.M., Chen T.H. and Su Y. (2004) Fluvastatin and lovastatin but not pravastatin induce neuroglial differentiation in human mesenchymal stem cells. J. Cell Biochem.93, 917-928.

  13. Sun K.H., Sun G.H., Su Y., Chang C.I., Chuang M.C., Wu W.L., Chu C.Y. and Tang S.J. (2004) Acidic-rich region of amyloid precursor protein induces glial cell apoptosis. Apoptosis. 9, 833-841.

  14. Yang F.L., Lu C.P., Chen C.S., Chen M.Y., Hsiao H.L., Su Y., Tsay S.S., Zou W and Wu S.H. (2004) Structural determination of the polar glycoglycerolipids from thermophilic bacteria Meiothermus taiwanensis. Eur. J. Biochem. 271, 4545-4551.

  15. Hsiao H.L. and Su Y. (2005) Identification of the positive and negative cis-elements involved in modulating the constitutive expression of mouse thymosin ß-4 gene Mol. Cell Biochem. 272, 75-84.

  16. Yang S.P., Li H.J. and Su Y. (2005) Molecular cloning and structural characterization of the functional human thymosin ß-4 gene. Mol. Cell Biochem. 272, 97-105.

  17. Hsiao H.L. H.L., Wang W.S., Chen P.M. and Su Y. (2006) Overexpression of thymosin ß-4 renders SW480 colon carcinoma cells more resistant to apoptosis triggered by FasL and two topoisomerase II inhibitors via downregulating Fas and upregulating Survivin expression, respectively. Carcinogenesis. 27, 935-944.

  18. Wang W.S., Chen P.M. and Su Y. (2006) Colorectal carcinoma: from tumorigenesis to treatment. Cell. Mol. Life Sci. 63, 663-71.

  19. Wang W.S., Chen P.M., Wang H.S., Liang W.Y. and Su Y. Matrix metalloproteinase-7 increases resistance to Fas-mediated apoptosis and is a poor prognostic factor of patients with colorectal carcinoma. Carcinogenesis. 27, 1113-1120.

  20. Huang S.C., Hu C.H. Tang, M.C., Wang W.S., Chen P.M. and Su Y. Thymosin ß4 triggers an epithelial-mesenchymal transition in colorectal carcinoma by upregulating integrin-linked kinase. Oncogene Oct. 30, 2006 Epub ahead of print

  21. Ho J.H., Chuang C.H., Ho C.Y., Shih V.Y., Lee O.K. and Su Y. (2007) Internalization is essential for the anti-apoptotic effects of exogenous thymosin ß4 on human corneal epithelial cells. Invest. Ophthalmol. Vis. Sci. 48, 27-33

  22. Lien C.Y., Lee O.K. and Su Y. (2007) Cbfb enhances the osteognic differentiation of both human and mouse mesenchymal stem cells induced by Cbfa-1 via reducing its ubiquitination-mediated degradation. Stem Cells Mar. 22, 2007 Epub ahead of print

  23. Wang W.S., Chen P.M., Chiou T.J., J.H. Liu J.H., .Ho C.T, Lin J.K., Lin, T.C., Wang H.S., Liang W.Y. and Su Y. (2007) The R497K polymorphism of EGFR is a favorable prognostic factor for patients with colorectal carcinoma. Clin. Cancer Res. (Accepted)

    24.  

Manuscript submitted:

  1. Ho H.C., Chen K.H., Ho S.I., Lee O.K. and Su Y. Exogenous thymosin ß4 protects corneal endothelial cells from UVB-induced apoptosis. Eye

  TEL：886-2-2826-7143  FAX：886-2-2825-0883

BACK TO FACULTY