瑀 博士 (Dr. Yeu Su)

 

學歷: 

台大藥學學士, 1982

台大生化碩士, 1984

美國 University of Wisconsin-Madison分子生物學博士, 1986-1991

 

經歷:

博士後研究, Johns Hopkins Oncology Center, 1991-1993

副教授 陽明大學藥理所     1993--2000 

副教授    陽明大學生藥所     2000--2004

教授        陽明大學生藥所     2005--present

 

研究方向:

  1. 胸線素β4基因的異常表現對大腸直腸癌及正常腸道細胞之影響

  2. 間葉幹細胞分化之調控

  3. 癌症幹細胞之研究

在陽明大學發表之論文:

  1. Tang R-Y. and Su Y. (1997) Construction of a cell-based high-flux assay for the rev protein of HIV-1. J. Virol. Methods 65, 153-158.

  2. Su Y., Chang C.L., Lee S.S., Chen W.C. and Huang C.F. (1998) In vitro cytotoxic activity of 1-decarboxy-3-oxo-ceanothic acid in a human ovarian adenocarcinoma cell line. Res. Comm. Mol. Pathol. & Pharmacol. 100, 313-326.

  3. Lee S.S., Chen W.C., Huang C.F. and Su Y. (1998) Preparation and cytotoxic effect of ceanothic acid derivatives. J. Nat. Prod. 61, 1343-1347.

  4. Su Y., Chang S-L. and Hsiao H-L. (2000) Characterization of a 5-flanking region supporting the transcription of mouse thymosin b -4 in mouse NIH3T3 cells. Mol.Cell. Biochem. 203, 163-167.

  5. Su Y., Sun C-M., Chuang H.H. and Chang P.T. (2000) Studies on the cytotoxicmechanisms of ginkgetin in a human ovarian adenocarcinoma cell line. Naunyn-Schmiedeberg's Arch. Pharmacol. 362, 82-90.

  6. Chang P.T. and Su Y. (2000) Protocol for quantitative and qualitative analyses of in vitro aggregation of synthetic b-amyloid: a method applicable to the identification of substances that may have therapeutic efficacy for Alzheimer's disease. Brain Res. Protocols. 6, 6-12.

  7. Su Y. and Chang P.T.2001Acidic pH promotes the formation of toxic fibrils from ß-amyloid peptides. Brain Res. 893, 287-291.

  8. Lai G.H., Chen C.F., Su Y., Ho L.T. and Lin A.M.(2001) Lack of protective effect by intermittent hypoxia on MPTP-induced neurotoxicity in mice. Ann. NY Acad. Sci. 939, 33-44.

  9. Su Y. and Lee H.R. (2002). A high throughput system for identifying human interleukin-2 inducers and/or repressors based on the expression of a reporter gene in Jurkat T cells. Anal. Biochem. 303, 202-206.

  10. Wang W-S, Chen P-M , Hsiao H-L, Ju S-Y. and Su Y. (2003) Overexpression of the thymosin β-4 gene is associated with malignant progression of SW480 colon cancer cells. Oncogene. 22, 3297-3306.  

  11. Wang W-S, Chen P-M , Hsiao H-L, Wang W.S., Chen P.M., Hsiao H.L., Wang H.S., Liang W.Y. and Su Y. (2004) Overexpression of the thymosin β-4 is associated with increased invasion of SW480 colon carcinoma cells and the distant metastasis of human colorectal carcinoma. Oncogene 23, 6666-6671.

  12. Lee O.K., Ko Y.C., Kuo T.K., Chou S.H., Li H.J., Chen W.M., Chen T.H. and Su Y. (2004) Fluvastatin and lovastatin but not pravastatin induce neuroglial differentiation in human mesenchymal stem cells. J. Cell Biochem.93, 917-928.

  13. Sun K.H., Sun G.H., Su Y., Chang C.I., Chuang M.C., Wu W.L., Chu C.Y. and Tang S.J. (2004) Acidic-rich region of amyloid precursor protein induces glial cell apoptosis. Apoptosis. 9, 833-841.

  14. Yang F.L., Lu C.P., Chen C.S., Chen M.Y., Hsiao H.L., Su Y., Tsay S.S., Zou W and Wu S.H. (2004) Structural determination of the polar glycoglycerolipids from thermophilic bacteria Meiothermus taiwanensis. Eur. J. Biochem. 271, 4545-4551.

  15. Hsiao H.L. and Su Y. (2005) Identification of the positive and negative cis-elements involved in modulating the constitutive expression of mouse thymosin β-4 gene Mol. Cell Biochem. 272, 75-84.

  16. Yang S.P., Li H.J. and Su Y. (2005) Molecular cloning and structural characterization of the functional human thymosin β-4 gene. Mol. Cell Biochem. 272, 97-105.

  17. Hsiao H.L. H.L., Wang W.S., Chen P.M. and Su Y. (2006) Overexpression of thymosin β-4 renders SW480 colon carcinoma cells more resistant to apoptosis triggered by FasL and two topoisomerase II inhibitors via downregulating Fas and upregulating Survivin expression, respectively. Carcinogenesis. 27, 936-944.

  18. Wang W.S., Chen P.M. and Su Y. (2006) Colorectal carcinoma: from tumorigenesis to treatment. Cell. Mol. Life Sci. 63, 663-71.

  19. Wang W.S., Chen P.M., Wang H.S., Liang W.Y. and Su Y. (2006) Matrix metalloproteinase-7 increases resistance to Fas- mediated apoptosis and is a poor prognostic factor of patients with colorectal carcinoma. Carcinogenesis. 27, 1113-1120.

  20. Huang S.C., Hu C.H. Tang, M.C., Wang W.S., Chen P.M. and Su Y. (2007) Thymosinβ4 triggers an epithelial-mesenchymal transition in colorectal carcinoma by upregulating integrin-linked kinase. Oncogene 26, 2781-90

  21. Ho J.H., Chuang C.H., Ho C.Y., Shih V.Y., Lee O.K. and Su Y. (2007) Internalization is essential for the anti-apoptotic effects of exogenous thymosin β4 on human corneal epithelial cells. Invest. Ophthalmol. Vis. Sci. 48, 27-33

  22. Lien C.Y., Lee O.K. and Su Y. (2007) Cbfb enhances the osteognic differentiation of both human and mouse mesenchymal stem cells induced by Cbfa-1 via reducing its ubiquitination-mediated degradation. Stem Cells 25, 1462-1468.

  23. Wang W.S., Chen P.M., Chiou T.J., J.H. Liu J.H., .Ho C.T, Lin J.K., Lin, T.C., Wang H.S., Liang W.Y. and Su Y. (2007) The R497K polymorphism of EGFR is a favorable prognostic factor for patients with colorectal carcinoma. Clin. Cancer Res. 13, 3597-3604.

  24. Lee H.J., Su Y., Lui W.Y., Chau G.Y., Yin P.H., Lee H.C. and Chi C.W. (2008) Peroxisome proliferator-activated receptor gamma coactivator-1a (PGC-1a) upregulated E-cadherin expression in HepG2 cells. FEBS Lett. 582, 627-634.

  25. Ho H.C., Tseng K.C., Ma W.H., Chen K.H., Lee O.K. and Su Y. (2008) Thymosin β4 upregulates anti-oxidative enzymes and protects human cornea epithelial cells against oxidative damage. Br. J. Ophthalmol. 92, 992-997.

  26. Lien C.Y., Ho C.Y., Lee O.K., Blunn G.W. and Su Y. (2009) Restoration of bone mass and strength in glucocorticoid-treated mice by systemic transplantation of CXCR4 and Cbfa-1 co-expressing mesenchymal stem cells. J. Bone Miner. Res. 5, 837-48.

 

Manuscript submitted:

  1. Ho H.C., Chen K.H., Ho S.I., Su Y. and Lee O.K.S. Thymosin beta-4 protects corneal endothelial cells from UVB-induced apoptosis but not necrosis. Eye

Manuscript in preparation:

  1. Lien C.Y., Su C.H., Huang Y.F. and Su Y. Upregulation of Cbfb is crucial for SDF-1/CXCR4 signaling-enhanced osteogenic differentiation of mouse mesenchymal stem cells triggered by Cbfa-1

 

 

  聯絡電話:(02)2826-7143  傳真:(02)2825-0883 Email:yeusu@ym.edu.tw