林敬哲 (Lin, Jing-Jer)

學歷:

Ÿ 學士 1983,國立臺灣大學化學系

Ÿ 碩士 1985,國立陽明大學生物化學研究所

Ÿ 博士 1992, University of North Carolina at Chapel Hill, Department of Biochemistry and Biophysics

經歷:

Ÿ 博士後研究 1992-1995, Fred Hutchinson Cancer Research Center, Basic Sciences

Ÿ 博士後研究 1995-1996, Princeton University, Department of Molecular Biology

Ÿ 副教授 1996-2002, 國立陽明大學生物藥學研究所

Ÿ 教授 2002-迄今, 國立陽明大學生物藥學研究所

Ÿ 所長 2003-迄今, 國立陽明大學生物藥學研究所

專長及研究興趣:

Ÿ telomere biology, telomerase, chromosome stability

Ÿ Chinese herbs

Ÿ Cancer biology

Ÿ Aging mechanism

Ÿ Chemical proteomics

發表論文 (2000- ):

Articles:

1. Huang, H.-S., Huang, K.-F., Li, Cho-Lu., Huang, Y.-Y., Chiang, Y.-H., Huang, F.-C., and Lin, J.-J.: Synthesis, human telomerase inhibition and antiproliferative studies of a series of 2,7-bis-substituted amido-anthraquinone derivatives. Bioorg. Med. Chem., 16: 6976-6986, 2008.

2. Huang, F.-C.,Chang, C.-C., Lou, P.-J. Kuo, I.-C., Chien, C.-W., Chen, C.-T. Shieh, F.-Y., Chang, T.-C., and Lin, J.-J.: G-quadruplex stabilizer BMVC induces accelerated senescence and inhibits tumorigenic properties in cancer cells. Mole. Cancer Res. 6: 955-964, 2008.

3. Huang, H.-S., Lin, J.-J., Huang, K.-F., and Li, C.-L.: A concise paradigm for the construction of amide linker of 2,7-diamidoanthraquinone derivatives as potential telomerase inhibitors. Taiwan Pharm. J., 59: 179-187, 2007.

4. Hsieh,Y.-C., Tu, P.-J., Lee, Y.-Y., Kuo, C.-C., Lin, Y.-C., Wu, C.-F., and Lin, J.-J.: The U3 small nucleolar ribonucleoprotein component Imp4p is a telomeric DNA binding protein. Biochem. J., 408: 387-393, 2007.

5. Huang, Y.-Y., Shih, J.-W., and Lin, J.-J.: Establishing the cell-based reporter systems for the analysis of hTERT expression. Methods Mole. Biol., 405: 87-96, 2007.

6. Lin, Y.-C., Wu Lee, Y.-H., and Lin, J.-J.: Genetic analysis reveals essential and non-essential amino acids within the telomeric DNA binding interface of Cdc13p. Biochem. J., 403: 289-295, 2007.

7. Huang, H.-S., Chen, I.-B., Chen,T.-C., Huang, K.-F. Lu, W.-C., Shieh, F.-Y., Huang, Y.-Y., Huang, F.-C., and Lin, J.-J.: Synthesis and human telomerase inhibition of a series of regioisomeric disubstituted amidoanthraquinones. Chem. Pharm. Bull., 55: 284-292, 2007.

8. Tseng, S.-F., Lin, J.-J., abd Teng, S.-C.: The telomerase-recruitment domain of the telomere binding protein Cdc13p is regulated by Mec1p/Tel1p-dependent phosphorylation. Nucleic Acids Res., 21: 6327-6336, 2006.

9. Lin, S.-C., Li, W.-C., Shih, J.-W., Hong, K.-F., Pan,Y.-R., Lin, J.-J.: The tea polyphenols EGCG and EGC repress mRNA expression of human telomerase reverse transcriptase (hTERT) in carcinoma cells. Cancer Lett., 236: 80-88, 2006.

10. Lo, L.-C., Chu, C.-Y., Lin, F.-A., Pan, Y.-R., Li, Y.-K., Lin, J.-J.: Synthesis of activity probes for b-xylosidase. J. Chin. Chem. Soc., 53: 479-488, 2006.

11. Shie, T.H., Chiang, Y.-L., Lin, J.-J., Li, Y.-K., and Lo, L.-C.: Facile synthesis toward the construction of an activity probe library for glycosidases. Carbohydrate Res., 341: 443-456, 2006.

12. Lo, L.-C., Chu, C.-Y., Pan, Y.-R., Wan, C.-F., Li, Y.-K., and Lin, J.-J.: Rapid and selective isolation of b-xylosidase through an activity-based chemical approach. Biotech. J., 1: 197-202, 2006.

13. Huang, H.-S., Chou, C.-L., Guo, C.-L., Yuan, C.-L., Lu, Y.-C., Shieh, F.-Y., Lin, J.-J.: Human telomerase inhibition and cytotoxicity of regioisomeric disubstituted amidoanthraquinones and aminoanthraquinones. Bioorg. Med. Chem., 13: 1435-1444, 2005.

14. Lo, L.-C., Chiang, Y.-L., Kuo,C.-H., Liao, H.-K., Chen, Y.-J., and Lin, J.-J.: Study of the preferred modification sites of the quninone methide intermediate resulting from the latent trapping device of the activity probes for hydrolases. Biochem. Biophys. Res. Commu., 326: 30-35, 2005.

15. Yeh, T.-S., Hsieh, R.-H., Shen, S.-C., Wang, S.-H., Tseng, M.-J., Shih, C.-M., and Lin, J.-J.: Nuclear b_II–tubulin associates with the activated Notch receptor to modulate Notch signaling. Cancer Res., 64: 8334-8340. 2004.

16. Chang, C.-C., Kuo, I-C., Lin, J.-J., Lu, Y.-C., Chen, C.-T., Back, H.-T., Lou, P.-J., and Chang, T.-C.: BMVC, a novel carbazole derivative and potential antitumor agent, as a potent telomerase inhibitor and selective fluorescence marker of cancer cells. Chem. & Biodiv., 1: 1377-1384. 2004.

17. Chang, C.-C., Kuo, I.-C., Ling, I.-F., Chen, C.-T., Chen, H.-C., Lou, P.-J., Lin, J.-J., Chang, T.-C.: Detection of quadruplex DNA structures in human telomeres by a fluorescent carbazole derivative. Anal. Chem., 76: 4490-4494, 2004.

18. Hsu, C.-L., Chen, Y.-S., Tsai, S.-Y., Tu, P.-J., Wang, M.-J., and Lin, J.-J.: Interaction of Saccharomyces Cdc13p to Pol1p, Imp4p, Sir4p, and Zds2p is involved in telomere replication, telomere maintenance, and cell growth control. Nucleic Acids Res., 32: 511-521, 2004.

19. Chen, H.-L., Lu, C.-Y., Hsu, Y.-H., and Lin, J.-J.: Chromosome positional effects of gene expressions after cellular senescence. Biochem. Biophys. Res. Commu., 313: 576-586, 2004.

20. Huang, H.-S., Chiou, J.-F., Fong, Y., Hou, C.-C., Lu, Y.-C., Wang, J.-Y., Shih, J.-W., Pan, Y.-R., and Lin, J.-J.: Activation of human telomerase hTERT expression by some new symmetrical bis-substituted derivatives of the anthraquinone. J. Med. Chem., 46: 3300-3307, 2003.

21. Ko, T.-P., Lin, J.-J., Hsu, Y.-H., Hu, C.-Y., Wang, A. H.-J., and Liaw, S.-H.: Cyrstal structure of the yeast cytosine deaminase: Insights into the enzyme mechanism and evolution. J. Biol. Chem., 278: 19111-19117, 2003.

22. Hsu, Y.-H., Hu, C.-Y., Lin, J.-J., and Liaw, S.-H.: Crystallization and preliminary crystallographic analysis of a yeast cytosine deaminase. Acta Cryst. D59: 950-952, 2003.

23. Pang, T.-L., Wang, C.-Y., Hsu, C.-L., Chen, M.-Y., and Lin, J.-J.: Exposure of single-stranded telomeric DNA causes G2/M cell cycle arrest in Saccharomyces cerevisiae. J. Biol. Chem., 278: 9318-9321, 2003.

24. Chang, T.-C., Lin, J.-J., Lin, K.-C., Lin, Y.-C., Huang, W.-C., Yang, Y.-P., and Cheng, J.-Y.: Investigation of DNA-protein recognition by satellite hole spectra of labeling dye. J. Luminescence, 98: 149-152, 2002.

25. Teng, S.-C., Epstein, C. B., Tsai, Y.-L., Cheng, H.-W., Chen, H.-L., and Lin, J.-J.: Induction of global stress response in Saccharomyces cerevisiae cells lacking telomerase. Biochem. Biophys. Res. Commu., 291: 714-721, 2002.

26. Lo, L.-C., Pang, T.-L., Kuo, C.-H., Chiang, Y.-L., Wang, H.-Y., and Lin, J.-J.: Synthesis of activity probes and their mechanism-based labeling of protein tyrosine phosphatase 1B. J. Proteome Res., 1: 35-40, 2002.

27. Lin, Y.-C., Shih, J.-W., Hsu, C.-L., and Lin, J.-J.: Binding and renaturing of G-quartet DNA by Cdc13p of Saccharomyces cerevisiae. J. Biol. Chem., 276: 47671-47674, 2001.

28. Huang, H.-S., Hwang, J.-M., Jen, Y.-M., Lin, J.-J., Lee, K.-Y., Shi, C.-H., and Hsu, H.-C.: Studies on anthracenes. 1. Human telomerase inhibition and lipid peroxidation of 9-acyloxy 1,5-dichloroanthracene derivatives. Chem. Pharm. Bull., 49: 969-973, 2001.

29. Lin, Y.-C., Hsu, C.-L., Shih, J.-W., and Lin, J.-J.: Specific binding of single-stranded telomeric DNA by Cdc13p of Saccharomyces cerevisiae. J. Biol. Chem., 276: 24588-24593, 2001.

30. Lin, Y.-C., Shih, J.-W., Hsu, C.-L., and Lin, J.-J.: Renaturation and stabilization of the telomere-binding activity of Saccharomyces Cdc13(451-693)p by L-arginine. Anal. Biochem., 294: 44-47, 2001.

31. Wang, M.-J., Lin, Y.-C., Pang, T.-L., Lee, J.-M., Chou, C.-C., and Lin, J.-J.: Telomere-binding and Stn1p-interacting activities are required for the essential function of Saccharomyces cerevisiae Cdc13p. Nucleic Acids Res., 28: 4733-4741, 2000.

Reviews:

1. Hsu, Y.-H. and Lin, J.-J.: Telomere and telomerase as targets for anti-cancer and regeneration therapies. Acta. Pharmcol. Sin., 26: 513-518, 2005.