§ 最 新 發 表 §

**Biophotonics**
S.Chakraborty, S.Y. Hu, S.H. Wu, A. Karmenyan*, and Arthur Chiou*. The interaction affinity between Vascular Cell Adhesion Molecule-1 (VCAM-1) and Very Late Antigen-4 (VLA-4) analyzed by quantitative FRET. Accepted for publication in PLoS One 2015
H. Lin, M.C. Kao, C.M. Lai, J.C. Huang, and W.C.Kuo*, “All fiber optics circular-state swept source polarization-sensitive optical coherence tomography,” Journal of Biomedical Optics, 19(2), 021110 (2014)
M.K Lu, F.C Chang, W.Z Wang, C.C Hsieh, and F.J. Kao*, “Compact LED Ring for Background Lighting in Thoracic Surgery ” , J. Biomed. Opt., Accepted, (2014).
Y.Q. Chen, P.T. Su, Y.H. Chen, M.T. Wei, C.H. Huang, K.Osterday, Juan C. del Álamo*, W.J. Syu*, Arthur Chiou* “The Effect of Enterohemorrhagic E. coli Infection on the Cell Mechanics of Host Cells,” Plos One 2014, 9(11): e112137.
S. Chakraborty, S.Y. Hu, Marı ́a Pilar Domingo, J. Pardo, Artashes Karmenyan*, Eva Ma Ga ́ lvez*, Arthur Chiou*. “FRET Based Quantification and Screening Technology Platform for the Interactions of Leukocyte Function-Associated Antigen-1 (LFA-1) with InterCellular Adhesion Molecule-1 (ICAM-1),” Plos One 2014, 9(7): e102572
S.H. Wu, David Nunez, S.Y. Hu, Maria Pilar Domingo, Y.C. Chen, P. K. Wei, Julian Pardo*, Eva M Galvez*, Arthur Chiou*. “The effect of acidic pH on the inhibitory efficacy of peptides against the interaction ICAM-1/LFA-1 studied by surface plasmon resonance (SPR)” Biosensors and Bioelectronics 2014;56(15):159- 166
Y.Q.Chen, C.W.Chen, Y.L.Ni, Y.S.Huang, O.Lin, S. C., Lanping Amy Sung*, Arthur Chiou*. “Effect of N-ethylmaleimide, chymotrypsin, and H2O2 on the viscoelasticity of human erythrocytes: Experimental measurement and theoretical analysis” Journal of Biophotonics 2014; 7(8): 647-655.
J.-L. Xiao, D.H. Lu, and C.H. Lee, “Guiding the migration of adherent cells by using optical micropatterns,” Appl. Phys. Lett. 102, 123703 (2013).
W.C. Kuo*, C.M. Lai, Y.S. Huang, C.Y. Chang, “Balanced detection for spectral domain optical coherence tomography,” Optics Express, 21(16), 19280 (2013).
G. Deka, et al. F.J. Kao*,“ In vivo Wound Healing Diagnosis with Second Harmonic and Fluorescence Lifetime Imaging", J. Biomed. Opt., (2013).
W.K. Ong, H.-F. , C.T. Tsai, Y.J. Fu, Y.S. Wong, D.J. Yen, T.H. Chang, H.D. Huang, Oscar K.S. Lee, S. Chien, Jennifer H.C. Ho, “Green light-emitting diode irradiation activates directional stem cell motility,” Biomaterials, vol.34,(2013)
N. Mazumder,et al. and F.J. Kao*, “Revealing molecular structure and orientation with Stokes vector resolved second harmonic generation microscopy " , Methods, (2013).
N.Mazumder,et al,andF.J. Kao*,“Fluorescence Lifetime Imaging of Alterations to Cellular Metabolism by Domain 2 of the Hepatitis C Virus Core Protein , PLoS One 8(6), e66738, (2013).
J. Ge, et al, and F.J. Kao*, Fluorescence lifetime imaging with pulsed diode laser enabled stimulated emission, Optics Express, Vol. 20, Iss. 27, pp. 28216–28221 (2012). Also selected for the Virtual Journal for Biomedical Optics (VJBO), Editor Andrew Dunn and Anthony Durkin, Vol. 8, Iss. 1, February 4, (2013).
N. Mazumder, et al. F.J. Kao*, Stokes vector based polarization resolved second harmonic microscopy of starch granules,Biomedical Optics Express, (2013)
Y.Q. Chen, C.Y. Kuo, M.T. Wei, Kelly Wu, P.T. Su, C.S. Huang, Arthur Chiou*. “Intracellular viscoelasticity of HeLa cells during cell division studied by video particle-tracking microrheology” Journal of Biomedical Optics 2013;19(1):011008
G.B. Liao, Y.Q. Chen, Paul B. Bareil, Yunlong Sheng, Arthur Chiou*, M.S. Chang*. “Radiation pressure on a biconcave human Red Blood Cell and the resulting deformation in a pair of parallel optical traps” Journal of Biophotonics 2013; 7(10): 782-787.
G. Deka, K.Okano, and F.J. Kao *, “Dynamic photo-patterning of cells in situ by Q- switched Nd:YVO4 laser , J. Biomed. Opt. 19 (1), 011012,
J. Ge, et al. F.J. Kao*, Fluorescence Lifetime Imaging with Pulsed Diode Laser Enabled Stimulated Emission, Optics Express, (2012)
Y.Q. Chen, P.l. Chou, C.Y. Cheng, C.C. Chiang, M.T. Wei, C.T. Chuang, Y.L. S. Chen, and A. Chiou, "Microrheology of human synovial fluid of arthritis patients studied by diffusing wave spectroscopy," J. Biophoton., in press (2012).
W.C. Kuo, Y.S. Lai, C.M. Lai, and Y.S. Huang, "Balanced-detection spectral domain OCT with a multi-line single camera for SNR enhancement," Appl. Opt., in press (2012).
K.L. Lee, P.W. Chen, S.H. Wu, J.B. Huang, S.Y. Yang, and P.K. Wei, "Enhancing surface plasmon detection using template-stripped gold nanoslit arrays on plastic films," ACS Nano 6, 2931 (2012).
J.L. Xiao, H.J. Pan, and C.H. Lee, "Optically micropatterned culture of adherent cells," J. Biomed. Opt. 17, 075004 (2012).
T. Buryakina, P.T. Su, W. J. Syu, C. A. Chang, H.F. Fan, and F.J. Kao, "Metabolism of hela cells revealed through autofluorescence lifetime upon infection with enterohemorrhagic Escherichia Coli," J. Biomed. Opt. 17, 101503 (2012).
T. Dellwig, P.Y. Lin, and F.J. Kao, "Long-distance fluorescence lifetime imaging using stimulated emission," J. Biomed. Opt. 17, 011009 (2012).
P.Y. Lin, S.S. Lee, C.S. Chang, and F.J. Kao, "Long working distance fluorescence lifetime imaging with stimulated emission and electronic time delay," Opt. Express 20, 11445 (2012).
N. Mazumder, J. Qiu, M. R. Foreman, C. M. Romero, C.W. Hu, H.R. Tsai, P. Tӧrӧk, and F.J. Kao, "Polarization-resolved second harmonic generation microscopy with a four-channel Stokes-polarimeter," Opt. Express 20, 14090 (2012).
C.T. Li, H.F. Chen, I.W. Un, H.C. Lee, and T.J. Yen, "Study of optical phase transduction on localized surface plasmon resonance for ultrasensitive detection," Opt. Express 20, 3250 (2012).
R. S. Moirangthem, M. T. Yaseen, P.K. Wei, J.Y. Cheng, and Y.C. Chang, "Enhanced localized plasmonic detections using partially-embedded gold nanoparticles and ellipsometric measurements," Biomed. Opt. Express 3, 899 (2012).
Y.C. Kuo, J. H. Ho, T.J. Yen, H.F. Chen, and O. K. Lee, "Development of a surface plasmon resonance biosensor for real-time detection of osteogenic differentiation in live mesenchymal stem cells," PloS One 6, e22382 (2011). 
O.H. Tung, S.Y. Lee, Y.L. Lai, and H.F. Chen, "Characteristics of subgingival calculus detection by multi-photon fluorescence microscopy," J. Biomed. Opt. 16, 066017 (2011).  
C.H. Chien, W.W. Chen, J.T. Wu, and T.C. Chang, "Label-free imaging of Drosophila in vivo by coherent anti-Stokes Raman scattering (CARS) and two-photon excitation (TPE) microscopy," J. Biomed Opt. 16, 016012 (2011). 
H.Y. Hsieh, J.L. Xiao, C.H. Lee, T.W. Huang, C.S. Yang, P.C. Wang, and F.G. Tseng, "Au-coated polystyrene nanoparticles with HAR nanocorrugations via surface carboxylation shielded anisotropic etching for significant SERS signal enhancement," J. Phys. Chem. C 115, 16258 (2011). 
P.Y. Lin, H.C. Lyu, C.Y. S. Hsu, C.S. Chang, and F.J. Kao, "Imaging carious dental tissues with multiphoton fluorescence lifetime imaging microscopy," Biomed. Opt. Express 2, 149 (2011). 
C.P. Chen, A. Ganguly, C.Y. Lu, T.Y. Chen, C.C. Kuo, R.S. Chen, W.H. Tu, W. B. Fischer, K.H. Chen, and L.C. Chen, "Ultra-sensitive in situ label-free DNA detection using GaN nanowires-based extended-gate field-effect-transistor sensor," Anal. Chem. 83, 1938 (2011). 
K.L. Lee, S.H. Wu, C.W. Lee, and P.K. Wei, "Sensitive biosensors using Fano resonance in single gold nanoslit with periodic grooves," Opt. Express 19, 24530 (2011). 
C.C. Chiang, M.T. Wei, Y.Q. Chen, P.W. Yen, Y.C. Huang, J.Y. Chen, O. Lavastre, H. Guillaume, D. Guillaume, and A. Chiou, "Optical tweezers based active microrheology of sodium polystyrene sulfonate (NaPSS)," Opt. Express 19, 8847 (2011). 
R. S. Moirangthem, Y.C. Chang, and P.K. Wei, "Investigation of surface plasmon biosensing using gold nanoparticles enhanced ellipsometry," Opt. Lett. 36, 775 (2011). 

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**Biological and Medical Sciences**
C.C. Lan, E. Y. Lu, H.J. Pan, and C.H. Lee, “Directional migration of cancer cells
induced by a blue light intensity gradient,” Biomed. Opt. Express 6, 2624 (2015).
Y.F. Hsiao, H.J. Pan, Y.C. Tung, C.C. Chen*, and C.H. Lee, “Effects of hydraulic pressures on cardiomyoblasts in a microfluidic device,” Biomicrofluidics 9, 024111 (2015).
W.Y. Liao et al., “Heparin cofactor II enhances cell motility and promotes metastasis in non-small-cell lung cancer,” J. Pathol. 235, 50 (2015).
L.W.Chu, Y.L. Huang, J.H. Lee, L.Y. Huang, W.J. Chena, Y. H. Lin, J.Y. Chen, Rui Xiang, C.H. Lee, Y.H.Ping*. A single-virus tracking approach to reveal the interaction of Dengue virus with autophagy during the early stage of infection. Journal of Biomedical Optics 2014, 19, 011018 (*: corresponding author) (cover photo)
K.W.Hsu, A.M. Wang, Y.H.Ping, K.H. Huang, T.T. Huang, H.C. Lee, S.S. Lo, C.W.Chi, T.S. Yeh. Down- regulation of tumor suppressor MBP-1 by microRNA-363 in gastric carcinogenesis. Carcinogenesis 2014,
B. Patra et al., “Migration and vascular lumen formation of endothelial cells in cancer cell spheroids of various sizes,” Biomicrofluidics 8, 052109 (2014).
Y.C. Kao et al., “Modulating chemotaxis of lung cancer cells by using electric fields in a microfluidic device,” Biomicrofluidics 8, 024107 (2014).
H.J. Pan et al., “Using optical profilometry to characterize cell membrane roughness influenced by amyloid-beta 42 aggregates and electric fields,” J. Biomed. Opt. 19, 011009 (2014).
W. B. Fischer, L.H. Li, D. R. Mahato, Y.T. Wang, C.P. Chen; Viral channel proteins in intracellular protein - protein communication: Vpu of HIV-1, E5 of HPV16 and p7 of HCV. Biochim. Biophys. Acta (2014)
F.T.Liao, P.N. Yang, C.Y. Chang, S.Y. Guo, M.T.Su, and W.C. Kuo*, “Necessity of angiotensin-converting enzyme-related gene for cardiac functions and longevity of Drosophila melanogaster assessed by optical coherence tomography,” Journal of Biomedical Optics 19(1),011014 (2014)
S.Y. Guo, F.T. Liao, M.T. Su, C.Y.Chang,H.R. Su, J. C. Huang, and W.C. Kuo*, “Semi-automatic and rapid quantification of heartbeat parameters in Drosophila by using OCT imaging,” Journal of Biomedical Optic, 18 (2), (2013).
S.F. Wang , F.J. Kao, “7-Ketocholesterol induces P-glycoprotein through PI3K/mTOR signaling in hepatoma cells ", Biochemical Pharmacology ,
C.F.Lu, Y.T. Wu*. Medullo-ponto-cerebellar White Matter Degeneration Altered Brain Network Organization and Cortical Morphology in Multiple System. Brain Structure & Function 2013;PMID:23636223
Y.L. Liao, Y.T. Wu*. Using Three-Dimensional Multigrid-Based Snake and Multiresolution Image Registration for Reconstruction of Cranial Defect. Medical & Biological Engineering & Computing. 2013;51(1-2):89-101
H.H. Hu, Y.T. Wu*. Shape and curvedness analysis of brain morphology using human fetal magnetic resonance images in utero. Brain Structure & Function 2013;218(6):1451-1462
L.H. Li, H,J. Hsu, W. B. Fischer; Assembling viral channel forming proteins: Vpu from HIV-1. Biopolymers (2013)
M.H. Lin, H.J. Hsu, R. Bartenschlager, W. B. Fischer; Membrane undulation induced by NS4A of Dengue virus – a molecular dynamics simulation study. J. Biomol. Struc. Dyn. (2013)
Y.T. Wu, Quantifying cerebellar atrophy in multiple system atrophy of the cerebellar type (MSA-C) using three-dimensional gyrification index analysis. NeuroImage 2012;61(1):1-9
S.W. Kuo, H.I. Lin, J.H. Ho, Y.R. Shih, H.-F. Chen, T.J. Yen, and O. K. Lee, "Regulation of the fate of human mesenchymal stem cells by mechanical and stereo-topographical cues provided by silicon nanowires," Biomaterials 33, 5013 (2012).
C.C. Chang, M.C. Hsieh, J.C. Lin, and T.C. Chang, "Selective photodynamic therapy based on aggregation-induced emission enhancement of fluorescent organic nanoparticles," Biomaterials 33, 897 (2012).
K. Wang, W. Lu, J. Chen, S. Xie, H. Shi, H. Hsu, W. Yu, K. Xu, C. Bian, W. B. Fischer, W. Schwarz, L. Feng, and B. Sun, "PEDV ORF3 encodes an ion channel protein and regulates virus production," FEBS Lett. 586, 384 (2012).
S.P. Lin, S. Mandell, Y. Chang, P.T. Chen, M.Y. Tsou, K.H. Chan, and C.K. Ting, "Discriminant analysis for anaesthetic decision making: an intelligent recognition system for epidural needle insertion," Brit. J. Anesthesia 108, 302 (2012).
T.H. Hsu, Y.L. Kao, W.L. Lin, J.L. Xiao, P.L. Kuo, C.W. Wu, W.Y. Liao, and C.H. Lee, "The migration speed of cancer cells influenced by macrophages and myofibroblasts co-cultured in a microfluidic chip," Integr. Biol. 4, 177 (2012).
Y.C. Lee, Y.C. Yang, C.L. Huang, J.H. Lin, D.M. Yang, and N.K. Huang, "When cytokinin, a plant hormone, meets the adenosine A2A receptor: a novel neuroprotectant and lead for treating neurodegenerative disorders?" PloS One 7, e38865 (2012).
Y.C. Lee, Y.C. Yang, C.L. Huang, J.H. Lin, D.M. Yang, and N.K. Huang, "When cytokinin, a plant hormone, meets the adenosine A2A receptor: a novel neuroprotectant and lead for treating neurodegenerative disorders?" PloS One 7, e38865 (2012).
G.S. Hong, C.P. Chen, M.H. Lin, J. Krüger, C. F. W. Becker, R. H. A. Fink, and W. B. Fischer, "Molecular dynamics simulations and conductance studies of the interaction of VP1 from Polio virus and gp41 fusion peptide from HIV-1 with lipid membranes," Mol. Membr. Biol. 29, 9 (2012).
H. J. Hsu, W. B. Fischer; In silico investigations of possible routes of assembly of 3a from SARS-Co virus. J. Mol. Mod. 18, 501-514 (2011)
C.C. Chen, et al.; ORF 8a of the human severe acute respiratory syndrom coronavirus forms an ion channel: experiments and molecular dynamics simulations. Biochim. Biophys. Acta 1808, 572-579 (2011)
T.H. Huang, S.J. Chiu, P.H. Chiang, W.T. Li, S.-H. Chiou, C.T. Chen, C. A. Chang, J.C. Chen, and Y.J. Lee, "Liferative effects of n-heterocyclic indolyl glyoxylamidederivatives on human lung cancer cells," Anticancer Res. 31, 3407 (2011).
Y.B. Kuo, C.W. Fan, C. A. Chang, C.C. Chan, R.P. Hung, Y.S. Hung, K.T. Chen, J.S. Yu, Y.S. Chang, and E.C. Chan, "Identification of phospholipid Scramblase 1 as a serological marker and its prognostic value for colorectal cancer," Mol. Medicine 17, 41 (2011).
K.D. Chen, P.T. Chang, Y.H. Ping, H.C. Lee, C.W. Yeh, P.N. Wang, "Gene expression profiling of peripheral blood leukocytes identifies and validates ABCB1 as a novel biomarker for Alzheimer's disease," Neurobiol. Disease 43, 698 (2011).
C.W. Huang, H.Y. Chen, M.H. Yen, J. J. W. Chen, T.H. Young, and J.Y. Cheng, "Gene expression of human lung cancer cell line CL1-5 in response to a direct current electric field," PLoS One 6, e25928 (2011).
T.H. Hsu, J.L. Xiao, Y.W. Tsao, Y.L. Kao, S.H. Huang, W.-Y. Liao, and C.-H. Lee, “Analysis of the paracrine loop between cancer cells and fibroblasts using a microfluidic chip,” Lab Chip 11, 1808 (2011).
Y.L. Yu, R.H. Chou, L.T. Chen, W.C. Shyu, S.C. Hsieh, C.S. Wu, H.J. Zeng, S.P. Yeh, D.M. Yang, S.C. Hung, and M.C. Hung, "EZH2 regulates neuronal differentiation of mesenchymal stem cells through PIP5K1C-dependent calcium signaling," J. Biol. Chem. 286, 9657 (2011).
M. Skasko, A. Tokarev, C.-C. Chen, W. B. Fischer, S. K. Pillai, J. Guatelli, "BST-2 is rapidly down-regulated from the cell surface by the HIV-1 protein Vpu: evidence for a post-ER mechanism of Vpu-action," Virology 411, 65 (2011).
W. B. Fischer and H.-J. Hsu, "Viral channel forming proteins–modelling the target," Biochim. Biophys. Acta 1808, 561 (2011).

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**Miscellaneous**
Surojit Chattopadhyay, M. S. Liu, P. K. Roy, C. T. Wu, Non-enzymatic glucose sensing by enhanced Raman spectroscopy on flexible ‘as-grown’ CVD graphene;Analyst 140, 3935 (2015).
Pradip Kumar Roy, Abhijit Ganguly, Wei-Hsun Yang, Chien- Ting Wu, Jih-Shang Hwang, Yian Tai, Kuei-Hsien Chen, Li-Chyong Chen, Surojit Chattopadhyay,Edge promoted Ultrasensitive Electrochemical Detection of Organic Bio-molecules on Epitaxial Graphene Nanowalls; Biosensors & Bioelectronics 70, 137-144 (2015).
Yi-Fan Huang, Yi-Jun Jen, Li-Chyong Chen, Kuei-Hsien Chen, and Surojit Chattopadhyay;Design for Approaching Cicada-Wing Reflectance in Low- and High-Index Biomimetic Nanostructures; ACS Nano 9, 301-311 (2015).
Yi-Fan Huang, Chiung-Yi Chen, Li-Chyong Chen, Kuei-Hsien Chen, and Surojit Chattopadhyay, Plasmon management in index engineered 2.5D hybrid nanostructures for surface-enhanced Raman scattering; NPG Asia Materials 6, e123 (2014); doi:10.1038/am.2014.67.
Wei-Ju Liao, Pradip Kumar Roy and Surojit Chattopadhyay,An ink-jet printed, surface enhanced Raman scattering paper for food screening; RSC Adv. 4, 40487 (2014).
Abhijit Ganguly, Surojit Chattopadhyay, Kuei-Hsien Chen and Li-Chyong Chen; Production and Storage of Energy with One-Dimensional Semiconductor Nanostructures; Critical Reviews in Solid State and Materials Sciences 39, 109 (2014)
Pradip Kumar Roy, Yi-Fan Huang, and Surojit Chattopadhyay; Detection of melamine on fractals of unmodified gold nanoparticles by surface enhanced Raman scattering;J. Biomedical Optics 19, 011002 (2014)
H. C. Han, C.W. Chong, Dawei Heh, C.A. Tseng, S.B.Wang, Y.Fan Huang, Surojit Chattopadhyay, K.H. Chen, C.F. Lin, J.H. Lee, L.C. Chen;High K nanophase zinc oxide on biomimetic silicon nanotip array as super-capacitors; Nano Letters 13, 1422 (2013)
Surojit Chattopadhyay, Shoou Jinn Chang, R.S. Chen, C.W. Chong, M.S. Hu, L.C. Chen and K.H. Chen;Surface Plasmon-Enhanced Oxygen Sensing in Single Gold peapodded-Silica Nanowire; Sheng-Bo Wang, Yi-Fan Huang ; NPG Asia Materials 5, e49 (2013)
Y.F.Huang and Surojit Chattopadhyay; Nanostructure surface design for broadband and angle-independent antireflection;J. Nanophotonics 7, 073594 (2013).
K. Okano, et al. F.J. Kao,* and H. Masuhara, “In situ laser micropatterning of proteins for dynamically arranging living cells " , Lab on a Chip 13 (20), 4078-4086, (2013)
Chen, Y.F.*, Jain, A., Jiang, L., Mancuso, M., Oncescu, V. & Erickson, D. Optofluidic opportunities in global health, food, water and energy. Nanoscale 4, 4839 – 4857 (2012). (Feature Article)
Chen, Y.F., Serey, X., Sarkar, R., Chen, P. & Erickson, D.* Controlled photonic manipulation of proteins and other nanomaterials. Nano Lett. 12, 1633 – 1637 (2012).
Y.S. Sun, S.W. Peng, K.H. Lin, and J.Y. Cheng, "Electrotaxis of lung cancer cells in ordered three-dimensional scaffolds," Biomicrofluidics 6, 014102 (2012).
Surojit Chattopadhyay, L.C. Chen, and K.H. Chen; Energy production and conversion applications of one dimensional semiconductor nanostructures;NPG Asia- Materials 3, 74-81 (2011).
C.C. Wang, Y.C. Kao, P.Y. Chi, C.W. Huang, J.Y. Lin, C.F. Chou, J.Y. Cheng, and C.H. Lee, "Asymmetric cancer-cell filopodium growth induced by electric-fields in a microfluidic culture chip," Lab Chip 11, 695 (2011).

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